Signals triggered by a bacterial pore-forming toxin contribute to toll-like receptor redundancy in gram-positive bacterial recognition

Journal of Infectious Diseases

Volumn 199, Issue 1, 2009, Pages 124-133

  Gekara, Nelson O ^a   Dietrich, Nicole ^a   Lyszkiewicz, Marcin ^a   Lienenklaus, Stefan ^a   Weiss, Siegfried ^a  

^a HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 18; INTERLEUKIN 1BETA; LISTERIOLYSIN O; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; VIRULENCE FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HOST PATHOGEN INTERACTION; HOST RESISTANCE; IMMUNE RESPONSE; INFLAMMATION; INNATE IMMUNITY; LISTERIA MONOCYTOGENES; LISTERIOSIS; MAST CELL; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; BACTERIAL TOXINS; BONE MARROW; DNA PRIMERS; HEAT-SHOCK PROTEINS; HEMOLYSIN PROTEINS; INFLAMMATION; INTERLEUKIN-18; INTERLEUKIN-1BETA; LISTERIA INFECTIONS; LISTERIA MONOCYTOGENES; MAST CELLS; MICE; MICE, KNOCKOUT; MYELOID DIFFERENTIATION FACTOR 88; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 58749090209     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/595562     Document Type: Article

References (46)

1. Cristofaro P, Opal SM. The Toll-like receptors and their role in septic shock. Expert Opin Ther Targets 2003; 7:603-12.
2. Ulevitch RJ. Therapeutics targeting the innate immune system. Nat Rev Immunol 2004; 4:512-20.
3. Kawai T, Akira S. TLR signaling. Cell Death Differ 2006; 13:816-25.
4. Elson G, Dunn-Siegrist I, Daubeuf B, Pugin J. Contribution of Toll-like receptors to the innate immune response to Gram-negative and Gram-positive bacteria. Blood 2007; 109:1574-83.
5. Billington SJ, Jost BH, Songer JG. Thiol-activated cytolysins: structure, function and role in pathogenesis. FEMS Microbiol Lett 2000; 182:197-205.
6. Freche B, Reig N, van der Goot FG. The role of the inflammasome in cellular responses to toxins and bacterial effectors. Semin Immunopathol 2007; 29:249-60.
7. Berry AM, Yother J, Briles DE, Hansman D, Paton JC. Reduced virulence of a defined pneumolysin-negative mutant of Streptococcus pneumoniae. Infect Immun 1989; 57:2037-42.
8. Feldman C, Munro NC, Jeffery PK, et al. Pneumolysin induces the salient histologic features of pneumococcal infection in the rat lung in vivo. Am J Respir Cell Mol Biol 1991; 5:416-23.
9. Van Epps DE, Andersen BR. Streptolysin O inhibition of neutrophil chemotaxis and mobility: nonimmune phenomenon with species specificity. Infect Immun 1974; 9:27-33.
10. Gaillard JL, Berche P, Sansonetti P. Transposon mutagenesis as a tool to study the role of hemolysin in the virulence of Listeria monocytogenes. Infect Immun 1986; 52:50-5.
11. Kathariou S, Metz P, Hof H, Goebel W. Tn916-induced mutations in the hemolysin determinant affecting virulence of Listeria monocytogenes. J Bacteriol 1987; 169:1291-7.
12. Portnoy DA, Jacks PS, Hinrichs DJ. Role of hemolysin for the intracellular growth of Listeria monocytogenes. J Exp Med 1988; 167:1459-71.
13. Gekara NO, Jacobs T, Chakraborty T, Weiss S. The cholesterol-dependent cytolysin listeriolysin O aggregates rafts via oligomerization. Cell Microbiol 2005; 7:1345-56.
14. Gekara NO, Weiss S. Lipid rafts clustering and signalling by listeriolysin O. Biochem Soc Trans 2004; 32:712-4.
15. + signalling by listeriolysin O, the cholesterol-dependent cytolysin of Listeria monocytogenes. Cell Microbiol 2007; 9:2008-21.
16. Malley R, Henneke P, Morse SC, et al. Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection. Proc Natl Acad Sci U S A 2003; 100:1966-71.
17. Park JM, Ng VH, Maeda S, Rest RF, Karin M. Anthrolysin O and other gram-positive cytolysins are Toll-like receptor 4 agonists. J Exp Med 2004; 200:1647-55.
18. Srivastava A, Henneke P, Visintin A, et al. The apoptotic response to pneumolysin is Toll-like receptor 4 dependent and protects against pneumococcal disease. Infect Immun 2005; 73:6479-87.
19. Gekara NO, Weiss S. Mast cells initiate early anti-Listeria host defences. Cell Microbiol 2008; 10:225-36.
20. Guzman CA, Rohde M, Chakraborty T, et al. Interaction of Listeria monocytogenes with mouse dendritic cells. Infect Immun 1995; 63:3665-73.
21. Darji A, Chakraborty T, Niebuhr K, Tsonis N, Wehland J, Weiss S. Hyperexpression of listeriolysin in the nonpathogenic species Listeria innocua and high yield purification. J Biotechnol 1995; 43:205-12.
22. Edelson BT, Unanue ER. MyD88-dependent but Toll-like receptor 2-independent innate immunity to Listeria: no role for either in macrophage listericidal activity. J Immunol 2002; 169:3869-75.
23. Knapp S, Wieland CW, van 't Veer C, et al. Toll-like receptor 2 plays a role in the early inflammatory response to murine pneumococcal pneumonia but does not contribute to antibacterial defense. J Immunol 2004; 172:3132-8.
24. Miller LS, O'Connell RM, Gutierrez MA, et al. MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus. Immunity 2006; 24:79-91.
25. Mullaly SC, Kubes P. The role of TLR2 in vivo following challenge with Staphylococcus aureus and prototypic ligands. J Immunol 2006; 177:8154-63.
26. Seki E, Tsutsui H, Tsuji NM, et al. Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice. J Immunol 2002; 169:3863-8.
27. Torres D, Barrier M, Bihl F, et al. Toll-like receptor 2 is required for optimal control of Listeria monocytogenes infection. Infect Immun 2004; 72:2131-9.
28. Serbina NV, Kuziel W, Flavell R, Akira S, Rollins B, Pamer EG. Sequential MyD88-independent and -dependent activation of innate immune responses to intracellular bacterial infection. Immunity 2003; 19:891-901.
29. Marshall JS. Mast-cell responses to pathogens. Nat Rev Immunol 2004; 4:787-99.
30. Kayal S, Lilienbaum A, Join-Lambert O, Li X, Israël A, Berche P. Listeriolysin O secreted by Listeria monocytogenes induces NF-κB signalling by activating the IκB kinase complex. Mol Microbiol 2002; 44:1407-19.
31. Albiger B, Dahlberg S, Henriques-Normark B, Normark S. Role of the innate immune system in host defence against bacterial infections: focus on the Toll-like receptors. J Intern Med 2007; 261:511-28.
32. Kielian T, Haney A, Mayes PM, Garg S, Esen N. Toll-like receptor 2 modulates the proinflammatory milieu in Staphylococcus aureus-induced brain abscess. Infect Immun 2005; 73:7428-35.
33. Koedel U, Angele B, Rupprecht T, et al. Toll-like receptor 2 participates in mediation of immune response in experimental pneumococcal meningitis. J Immunol 2003; 170:438-44.
34. Travassos LH, Girardin SE, Philpott DJ, et al. Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition. EMBO Rep 2004; 5:1000-6.
35. Yoshimura A, Lien E, Ingalls RR, Tuomanen E, Dziarski R, Golenbock D. Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. J Immunol 1999; 163:1-5.
36. Mariathasan S, Weiss DS, Newton K, et al. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 2006; 440:228-32.
37. Sibelius U, Schulz EC, Rose F, et al. Role of Listeria monocytogenes exotoxins listeriolysin and phosphatidylinositol-specific phospholipase C in activation of human neutrophils. Infect Immun 1999; 67:1125-30.
38. Sutterwala FS, Ogura Y, Flavell RA. The inflammasome in pathogen recognition and inflammation. J Leukoc Biol 2007; 82:259-64.
39. Kim YG, Park JH, Shaw MH, Franchi L, Inohara N, Nunez G. The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands. Immunity 2008; 28:246-57.
40. Akira S. The role of IL-18 in innate immunity. Curr Opin Immunol 2000; 12:59-63.
41. Carpenter S, O'Neill LA. How important are Toll-like receptors for antimicrobial responses? Cell Microbiol 2007; 9:1891-901.
42. Daubeuf B, Mathison J, Spiller S, et al. TLR4/MD-2 monoclonal antibody therapy affords protection in experimental models of septic shock. J Immunol 2007; 179:6107-14.
43. Decker T. Sepsis: avoiding its deadly toll. J Clin Invest 2004; 113:1387-9.
44. Fort MM, Mozaffarian A, Stöver AG et al. A synthetic TLR4 antagonist has anti-inflammatory effects in two murine models of inflammatory bowel disease. J Immunol 2005; 174:6416-23.
45. Meng G, Rutz M, Schiemann M, et al. Antagonistic antibody prevents toll-like receptor 2-driven lethal shock-like syndromes. J Clin Invest 2004; 113:1473-81.
46. Iwasaki A, Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nat Immunol 2004; 5:987-95.