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Volumn 78, Issue 4-5, 2009, Pages 211-225

Transcriptional profiles reveal similarities and differences in the effects of developmental neurotoxicants on differentiation into neurotransmitter phenotypes in PC12 cells

Author keywords

Acetylcholine; Catecholamines; Chlorpyrifos; Diazinon; Dieldrin; Dopamine; Metal neurotoxicity; Microarrays; Neuronal differentiation; Neurotoxicity; Nickel; Norepinephrine; Organochlorine insecticides; Organophosphate insecticides; PC12 cells

Indexed keywords

ACETYLCHOLINE; CHLORPYRIFOS; DIELDRIN; DIMPYLATE; DOPAMINE; NEUROTRANSMITTER; NICKEL; NORADRENALIN; ORGANOPHOSPHATE PESTICIDE;

EID: 58749085225     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2008.08.021     Document Type: Article
Times cited : (35)

References (78)
  • 1
    • 19044372536 scopus 로고    scopus 로고
    • Developmental exposure of rats to chlorpyrifos leads to behavioral alterations in adulthood, involving serotonergic mechanisms and resembling animal models of depression
    • Aldridge J.E., Levin E.D., Seidler F.J., and Slotkin T.A. Developmental exposure of rats to chlorpyrifos leads to behavioral alterations in adulthood, involving serotonergic mechanisms and resembling animal models of depression. Environ. Health Perspect. 113 (2005) 527-531
    • (2005) Environ. Health Perspect. , vol.113 , pp. 527-531
    • Aldridge, J.E.1    Levin, E.D.2    Seidler, F.J.3    Slotkin, T.A.4
  • 2
    • 23844498721 scopus 로고    scopus 로고
    • Alterations in central nervous system serotonergic and dopaminergic synaptic activity in adulthood after prenatal or neonatal chlorpyrifos exposure
    • Aldridge J.E., Meyer A., Seidler F.J., and Slotkin T.A. Alterations in central nervous system serotonergic and dopaminergic synaptic activity in adulthood after prenatal or neonatal chlorpyrifos exposure. Environ. Health Perspect. 113 (2005) 1027-1031
    • (2005) Environ. Health Perspect. , vol.113 , pp. 1027-1031
    • Aldridge, J.E.1    Meyer, A.2    Seidler, F.J.3    Slotkin, T.A.4
  • 3
    • 0242539881 scopus 로고    scopus 로고
    • Serotonergic systems targeted by developmental exposure to chlorpyrifos: effects during different critical periods
    • Aldridge J.E., Seidler F.J., Meyer A., Thillai I., and Slotkin T.A. Serotonergic systems targeted by developmental exposure to chlorpyrifos: effects during different critical periods. Environ. Health Perspect. 111 (2003) 1736-1743
    • (2003) Environ. Health Perspect. , vol.111 , pp. 1736-1743
    • Aldridge, J.E.1    Seidler, F.J.2    Meyer, A.3    Thillai, I.4    Slotkin, T.A.5
  • 4
    • 1042303694 scopus 로고    scopus 로고
    • Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling
    • Aldridge J.E., Seidler F.J., and Slotkin T.A. Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling. Environ. Health Perspect. 112 (2004) 148-155
    • (2004) Environ. Health Perspect. , vol.112 , pp. 148-155
    • Aldridge, J.E.1    Seidler, F.J.2    Slotkin, T.A.3
  • 5
    • 0034652131 scopus 로고    scopus 로고
    • Developmental changes in the transmitter properties of sympathetic neurons that innervate the periosteum
    • Asmus S.E., Parsons S., and Landis S.C. Developmental changes in the transmitter properties of sympathetic neurons that innervate the periosteum. J. Neurosci. 20 (2000) 1495-1504
    • (2000) J. Neurosci. , vol.20 , pp. 1495-1504
    • Asmus, S.E.1    Parsons, S.2    Landis, S.C.3
  • 6
    • 0037436396 scopus 로고    scopus 로고
    • The effects of acute pesticide exposure on neuroblastoma cells chronically exposed to diazinon
    • Axelrad J.C., Howard C.V., and McLean W.G. The effects of acute pesticide exposure on neuroblastoma cells chronically exposed to diazinon. Toxicology 185 (2003) 67-78
    • (2003) Toxicology , vol.185 , pp. 67-78
    • Axelrad, J.C.1    Howard, C.V.2    McLean, W.G.3
  • 7
    • 0029610549 scopus 로고
    • In vitro and in vivo generation of reactive oxygen species DNA damage and lactate dehydrogenase leakage by selected pesticides
    • Bagchi D., Bagchi M., Hassoun E.A., and Stohs S.J. In vitro and in vivo generation of reactive oxygen species DNA damage and lactate dehydrogenase leakage by selected pesticides. Toxicology 104 (1995) 129-140
    • (1995) Toxicology , vol.104 , pp. 129-140
    • Bagchi, D.1    Bagchi, M.2    Hassoun, E.A.3    Stohs, S.J.4
  • 8
    • 0030220246 scopus 로고    scopus 로고
    • In vitro and in vivo induction of heat shock (stress) protein (Hsp) gene expression by selected pesticides
    • Bagchi D., Bhattacharya G., and Stohs S.J. In vitro and in vivo induction of heat shock (stress) protein (Hsp) gene expression by selected pesticides. Toxicology 112 (1996) 57-68
    • (1996) Toxicology , vol.112 , pp. 57-68
    • Bagchi, D.1    Bhattacharya, G.2    Stohs, S.J.3
  • 9
    • 0029826426 scopus 로고    scopus 로고
    • Agonist-stimulated calcium transients in PC12 cells are affected differentially by cadmium and nickel
    • Benters J., Schafer T., Beyersmann D., and Hechtenberg S. Agonist-stimulated calcium transients in PC12 cells are affected differentially by cadmium and nickel. Cell Calcium 20 (1996) 441-446
    • (1996) Cell Calcium , vol.20 , pp. 441-446
    • Benters, J.1    Schafer, T.2    Beyersmann, D.3    Hechtenberg, S.4
  • 10
    • 33745775656 scopus 로고    scopus 로고
    • Effect of developmental exposure to chlorpyrifos on the expression of neurotrophin growth factors and cell-specific markers in neonatal rat brain
    • Betancourt A.M., Burgess S.C., and Carr R.L. Effect of developmental exposure to chlorpyrifos on the expression of neurotrophin growth factors and cell-specific markers in neonatal rat brain. Toxicol. Sci. 92 (2006) 500-506
    • (2006) Toxicol. Sci. , vol.92 , pp. 500-506
    • Betancourt, A.M.1    Burgess, S.C.2    Carr, R.L.3
  • 11
    • 36248997070 scopus 로고    scopus 로고
    • Alteration of neurotrophins in the hippocampus and cerebral cortex of young rats exposed to chlorpyrifos and methyl parathion
    • Betancourt A.M., Filipov N.M., and Carr R.L. Alteration of neurotrophins in the hippocampus and cerebral cortex of young rats exposed to chlorpyrifos and methyl parathion. Toxicol. Sci. 100 (2007) 445-455
    • (2007) Toxicol. Sci. , vol.100 , pp. 445-455
    • Betancourt, A.M.1    Filipov, N.M.2    Carr, R.L.3
  • 13
    • 33846065839 scopus 로고    scopus 로고
    • Activity-dependent neurotransmitter-receptor matching at the neuromuscular junction
    • Borodinsky L.N., and Spitzer N.C. Activity-dependent neurotransmitter-receptor matching at the neuromuscular junction. Proc. Natl. Acad. Sci. 104 (2007) 335-340
    • (2007) Proc. Natl. Acad. Sci. , vol.104 , pp. 335-340
    • Borodinsky, L.N.1    Spitzer, N.C.2
  • 14
    • 0031891765 scopus 로고    scopus 로고
    • Prenatal exposure to neurotoxicants dieldrin or lindane alters tert-butylbicyclophosphorothionate binding to GABA(A) receptors in fetal rat brainstem
    • Brannen K.C., Devaud L.L., Liu J.P., and Lauder J.M. Prenatal exposure to neurotoxicants dieldrin or lindane alters tert-butylbicyclophosphorothionate binding to GABA(A) receptors in fetal rat brainstem. Dev. Neurosci. 20 (1998) 34-41
    • (1998) Dev. Neurosci. , vol.20 , pp. 34-41
    • Brannen, K.C.1    Devaud, L.L.2    Liu, J.P.3    Lauder, J.M.4
  • 15
    • 0018184169 scopus 로고
    • Copper, manganese, zinc, nickel, cadmium and lead in human foetal tissues
    • Casey C.E., and Robinson M.F. Copper, manganese, zinc, nickel, cadmium and lead in human foetal tissues. Br. J. Nutrit. 39 (1978) 639-646
    • (1978) Br. J. Nutrit. , vol.39 , pp. 639-646
    • Casey, C.E.1    Robinson, M.F.2
  • 16
    • 4243148518 scopus 로고    scopus 로고
    • Organophosphate toxicology: safety aspects of nonacetylcholinesterase secondary targets
    • Casida J.E., and Quistad G.B. Organophosphate toxicology: safety aspects of nonacetylcholinesterase secondary targets. Chem. Res. Toxicol. 17 (2004) 983-998
    • (2004) Chem. Res. Toxicol. , vol.17 , pp. 983-998
    • Casida, J.E.1    Quistad, G.B.2
  • 19
    • 0031859987 scopus 로고    scopus 로고
    • Neurotoxicity testing: a discussion of in vitro alternatives
    • Costa L.G. Neurotoxicity testing: a discussion of in vitro alternatives. Environ. Health Perspect. 106 Suppl. 2 (1998) 505-510
    • (1998) Environ. Health Perspect. , vol.106 , Issue.SUPPL. 2 , pp. 505-510
    • Costa, L.G.1
  • 20
    • 33644664469 scopus 로고    scopus 로고
    • Current issues in organophosphate toxicology
    • Costa L.G. Current issues in organophosphate toxicology. Clin. Chim. Acta 366 (2006) 1-13
    • (2006) Clin. Chim. Acta , vol.366 , pp. 1-13
    • Costa, L.G.1
  • 21
    • 0033955358 scopus 로고    scopus 로고
    • Developmental neurotoxicity of chlorpyrifos in vivo and in vitro: effects on nuclear transcription factor involved in cell replication and differentiation
    • Crumpton T.L., Seidler F.J., and Slotkin T.A. Developmental neurotoxicity of chlorpyrifos in vivo and in vitro: effects on nuclear transcription factor involved in cell replication and differentiation. Brain Res. 857 (2000) 87-98
    • (2000) Brain Res. , vol.857 , pp. 87-98
    • Crumpton, T.L.1    Seidler, F.J.2    Slotkin, T.A.3
  • 22
    • 0034733973 scopus 로고    scopus 로고
    • Is oxidative stress involved in the developmental neurotoxicity of chlorpyrifos?
    • Crumpton T.L., Seidler F.J., and Slotkin T.A. Is oxidative stress involved in the developmental neurotoxicity of chlorpyrifos?. Dev. Brain Res. 121 (2000) 189-195
    • (2000) Dev. Brain Res. , vol.121 , pp. 189-195
    • Crumpton, T.L.1    Seidler, F.J.2    Slotkin, T.A.3
  • 23
    • 0032804284 scopus 로고    scopus 로고
    • Neonatal chlorpyrifos exposure alters synaptic development and neuronal activity in cholinergic and catecholaminergic pathways
    • Dam K., Garcia S.J., Seidler F.J., and Slotkin T.A. Neonatal chlorpyrifos exposure alters synaptic development and neuronal activity in cholinergic and catecholaminergic pathways. Dev. Brain Res. 116 (1999) 9-20
    • (1999) Dev. Brain Res. , vol.116 , pp. 9-20
    • Dam, K.1    Garcia, S.J.2    Seidler, F.J.3    Slotkin, T.A.4
  • 24
    • 0033230460 scopus 로고    scopus 로고
    • Neuronal differentiation in PC12 cells is inhibited by chlorpyrifos and its metabolites: is acetylcholinesterase inhibition the site of action?
    • Das K.P., and Barone S. Neuronal differentiation in PC12 cells is inhibited by chlorpyrifos and its metabolites: is acetylcholinesterase inhibition the site of action?. Toxicol. Appl. Pharmacol. 160 (1999) 217-230
    • (1999) Toxicol. Appl. Pharmacol. , vol.160 , pp. 217-230
    • Das, K.P.1    Barone, S.2
  • 25
    • 0028118502 scopus 로고
    • The toxicity of organophosphate compounds towards cultured PC12 cells
    • Flaskos J., McLean W.G., and Hargreaves A.J. The toxicity of organophosphate compounds towards cultured PC12 cells. Toxicol. Lett. 70 (1994) 71-76
    • (1994) Toxicol. Lett. , vol.70 , pp. 71-76
    • Flaskos, J.1    McLean, W.G.2    Hargreaves, A.J.3
  • 26
    • 0024550673 scopus 로고
    • Regulation of the differentiation of PC12 pheochromocytoma cells
    • Fujita K., Lazarovici P., and Guroff G. Regulation of the differentiation of PC12 pheochromocytoma cells. Environ. Health Perspect. 80 (1989) 127-142
    • (1989) Environ. Health Perspect. , vol.80 , pp. 127-142
    • Fujita, K.1    Lazarovici, P.2    Guroff, G.3
  • 27
    • 23044471745 scopus 로고    scopus 로고
    • Programmed and induced phenotype of the hippocampal granule cells
    • Gomez-Lira G., Lamas M., Romo-Parra H., and Gutierrez R. Programmed and induced phenotype of the hippocampal granule cells. J. Neurosci. 25 (2005) 6939-6946
    • (2005) J. Neurosci. , vol.25 , pp. 6939-6946
    • Gomez-Lira, G.1    Lamas, M.2    Romo-Parra, H.3    Gutierrez, R.4
  • 28
  • 29
    • 23744456959 scopus 로고    scopus 로고
    • Chlorpyrifos exerts opposing effects on axonal and dendritic growth in primary neuronal cultures
    • Howard A.S., Bucelli R., Jett D.A., Bruun D., and Yang D.R. Chlorpyrifos exerts opposing effects on axonal and dendritic growth in primary neuronal cultures. Toxicol. Appl. Pharmacol. 207 (2005) 112-124
    • (2005) Toxicol. Appl. Pharmacol. , vol.207 , pp. 112-124
    • Howard, A.S.1    Bucelli, R.2    Jett, D.A.3    Bruun, D.4    Yang, D.R.5
  • 30
    • 0018097837 scopus 로고
    • Nickel and strontium distribution in some mouse tissues Passage through placenta and mammary glands
    • Jacobsen N., Alfheim I., and Jonsen J. Nickel and strontium distribution in some mouse tissues Passage through placenta and mammary glands. Res. Commun. Chem. Pathol. Pharmacol. 20 (1978) 571-584
    • (1978) Res. Commun. Chem. Pathol. Pharmacol. , vol.20 , pp. 571-584
    • Jacobsen, N.1    Alfheim, I.2    Jonsen, J.3
  • 31
    • 33646361039 scopus 로고    scopus 로고
    • Chlorpyrifos affects phenotypic outcomes in a model of mammalian neurodevelopment: critical stages targeting differentiation in PC12 cells
    • Jameson R.R., Seidler F.J., Qiao D., and Slotkin T.A. Chlorpyrifos affects phenotypic outcomes in a model of mammalian neurodevelopment: critical stages targeting differentiation in PC12 cells. Environ. Health Perspect. 114 (2006) 667-672
    • (2006) Environ. Health Perspect. , vol.114 , pp. 667-672
    • Jameson, R.R.1    Seidler, F.J.2    Qiao, D.3    Slotkin, T.A.4
  • 32
    • 33845970588 scopus 로고    scopus 로고
    • Nonenzymatic functions of acetylcholinesterase splice variants in the developmental neurotoxicity of organophosphates: chlorpyrifos, chlorpyrifos oxon and diazinon
    • Jameson R.R., Seidler F.J., and Slotkin T.A. Nonenzymatic functions of acetylcholinesterase splice variants in the developmental neurotoxicity of organophosphates: chlorpyrifos, chlorpyrifos oxon and diazinon. Environ. Health Perspect. 115 (2007) 65-70
    • (2007) Environ. Health Perspect. , vol.115 , pp. 65-70
    • Jameson, R.R.1    Seidler, F.J.2    Slotkin, T.A.3
  • 33
    • 0031718505 scopus 로고    scopus 로고
    • In vitro testing in developmental toxicity risk assessment
    • Kimmel G.L. In vitro testing in developmental toxicity risk assessment. Teratology 58 (1998) 25-26
    • (1998) Teratology , vol.58 , pp. 25-26
    • Kimmel, G.L.1
  • 34
    • 0035581423 scopus 로고    scopus 로고
    • Dieldrin-induced oxidative stress and neurochemical changes contribute to apoptopic cell death in dopaminergic cells
    • Kitazawa M., Anantharam V., and Kanthasamy A.G. Dieldrin-induced oxidative stress and neurochemical changes contribute to apoptopic cell death in dopaminergic cells. Free Radical Biol. Med. 31 (2001) 1473-1485
    • (2001) Free Radical Biol. Med. , vol.31 , pp. 1473-1485
    • Kitazawa, M.1    Anantharam, V.2    Kanthasamy, A.G.3
  • 35
    • 0038433325 scopus 로고    scopus 로고
    • Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cδ in dopaminergic cells: relevance to oxidative stress and dopaminergic degeneration
    • Kitazawa M., Anantharam V., and Kanthasamy A.G. Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cδ in dopaminergic cells: relevance to oxidative stress and dopaminergic degeneration. Neuroscience 119 (2003) 945-964
    • (2003) Neuroscience , vol.119 , pp. 945-964
    • Kitazawa, M.1    Anantharam, V.2    Kanthasamy, A.G.3
  • 36
    • 0018421443 scopus 로고
    • Post-mortem changes in high affinity choline uptake
    • Klemm N., and Kuhar M.J. Post-mortem changes in high affinity choline uptake. J. Neurochem. 32 (1979) 1487-1494
    • (1979) J. Neurochem. , vol.32 , pp. 1487-1494
    • Klemm, N.1    Kuhar, M.J.2
  • 38
    • 0032531084 scopus 로고    scopus 로고
    • Organophosphorus neuropathy target esterase inhibitors selectively block outgrowth of neurite-like and cell processes in cultured cells
    • Li W.W., and Casida J.E. Organophosphorus neuropathy target esterase inhibitors selectively block outgrowth of neurite-like and cell processes in cultured cells. Toxicol. Lett. 98 (1998) 139-146
    • (1998) Toxicol. Lett. , vol.98 , pp. 139-146
    • Li, W.W.1    Casida, J.E.2
  • 39
    • 34548452419 scopus 로고    scopus 로고
    • Unique insights into the actions of CNS agents: lessons from studies of chlorpyrifos and other common pesticides
    • Mauro R.E., and Zhang L. Unique insights into the actions of CNS agents: lessons from studies of chlorpyrifos and other common pesticides. CNS Agents Med. Chem. 7 (2007) 183-199
    • (2007) CNS Agents Med. Chem. , vol.7 , pp. 183-199
    • Mauro, R.E.1    Zhang, L.2
  • 40
    • 1542393410 scopus 로고    scopus 로고
    • Critical periods for chlorpyrifos-induced developmental neurotoxicity: alterations in adenylyl cyclase signaling in adult rat brain regions after gestational or neonatal exposure
    • Meyer A., Seidler F.J., Aldridge J.E., Tate C.A., Cousins M.M., and Slotkin T.A. Critical periods for chlorpyrifos-induced developmental neurotoxicity: alterations in adenylyl cyclase signaling in adult rat brain regions after gestational or neonatal exposure. Environ. Health Perspect. 112 (2004) 295-301
    • (2004) Environ. Health Perspect. , vol.112 , pp. 295-301
    • Meyer, A.1    Seidler, F.J.2    Aldridge, J.E.3    Tate, C.A.4    Cousins, M.M.5    Slotkin, T.A.6
  • 41
    • 0030733016 scopus 로고    scopus 로고
    • Direct actions of anticholinesterases on the neuronal nicotinic acetylcholine receptor channels
    • Nagata K., Huang C.S., Song J.H., and Narahashi T. Direct actions of anticholinesterases on the neuronal nicotinic acetylcholine receptor channels. Brain Res. 769 (1997) 211-218
    • (1997) Brain Res. , vol.769 , pp. 211-218
    • Nagata, K.1    Huang, C.S.2    Song, J.H.3    Narahashi, T.4
  • 42
    • 0026638803 scopus 로고
    • Nerve growth factor-stimulated calcium uptake into PC12 cells: uniqueness of the channel and evidence for phosphorylation
    • Nikodijevic B., and Guroff G. Nerve growth factor-stimulated calcium uptake into PC12 cells: uniqueness of the channel and evidence for phosphorylation. J. Neurosci. Res. 31 (1992) 591-599
    • (1992) J. Neurosci. Res. , vol.31 , pp. 591-599
    • Nikodijevic, B.1    Guroff, G.2
  • 43
    • 0033369584 scopus 로고    scopus 로고
    • Organophosphorus pesticides: do they all have the same mechanism of toxicity?
    • Pope C.N. Organophosphorus pesticides: do they all have the same mechanism of toxicity?. J. Toxicol. Environ. Health 2 (1999) 161-181
    • (1999) J. Toxicol. Environ. Health , vol.2 , pp. 161-181
    • Pope, C.N.1
  • 44
    • 0034775369 scopus 로고    scopus 로고
    • Developmental neurotoxicity of chlorpyrifos modeled in vitro: comparative effects of metabolites and other cholinesterase inhibitors on DNA synthesis in PC12 and C6 cells
    • Qiao D., Seidler F.J., and Slotkin T.A. Developmental neurotoxicity of chlorpyrifos modeled in vitro: comparative effects of metabolites and other cholinesterase inhibitors on DNA synthesis in PC12 and C6 cells. Environ. Health Perspect. 109 (2001) 909-913
    • (2001) Environ. Health Perspect. , vol.109 , pp. 909-913
    • Qiao, D.1    Seidler, F.J.2    Slotkin, T.A.3
  • 45
    • 20444404601 scopus 로고    scopus 로고
    • Oxidative mechanisms contributing to the developmental neurotoxicity of nicotine and chlorpyrifos
    • Qiao D., Seidler F.J., and Slotkin T.A. Oxidative mechanisms contributing to the developmental neurotoxicity of nicotine and chlorpyrifos. Toxicol. Appl. Pharmacol. 206 (2005) 17-26
    • (2005) Toxicol. Appl. Pharmacol. , vol.206 , pp. 17-26
    • Qiao, D.1    Seidler, F.J.2    Slotkin, T.A.3
  • 46
    • 1642493774 scopus 로고    scopus 로고
    • Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos
    • Qiao D., Seidler F.J., Violin J.D., and Slotkin T.A. Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos. Dev. Brain Res. 147 (2003) 183-190
    • (2003) Dev. Brain Res. , vol.147 , pp. 183-190
    • Qiao, D.1    Seidler, F.J.2    Violin, J.D.3    Slotkin, T.A.4
  • 47
  • 48
    • 0032908419 scopus 로고    scopus 로고
    • Developmental cholinotoxicants: nicotine and chlorpyrifos
    • Slotkin T.A. Developmental cholinotoxicants: nicotine and chlorpyrifos. Environ. Health Perspect. 107 Suppl. 1 (1999) 71-80
    • (1999) Environ. Health Perspect. , vol.107 , Issue.SUPPL. 1 , pp. 71-80
    • Slotkin, T.A.1
  • 49
    • 0842342126 scopus 로고    scopus 로고
    • Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphates
    • Slotkin T.A. Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphates. Toxicol. Appl. Pharmacol. 198 (2004) 132-151
    • (2004) Toxicol. Appl. Pharmacol. , vol.198 , pp. 132-151
    • Slotkin, T.A.1
  • 50
    • 2942514529 scopus 로고    scopus 로고
    • Guidelines for developmental neurotoxicity and their impact on organophosphate pesticides: a personal view from an academic perspective
    • Slotkin T.A. Guidelines for developmental neurotoxicity and their impact on organophosphate pesticides: a personal view from an academic perspective. NeuroToxicology 25 (2004) 631-640
    • (2004) NeuroToxicology , vol.25 , pp. 631-640
    • Slotkin, T.A.1
  • 51
    • 80855125087 scopus 로고    scopus 로고
    • Developmental neurotoxicity of organophosphates: a case study of chlorpyrifos
    • Gupta R.C. (Ed), Elsevier Academic Press, San Diego
    • Slotkin T.A. Developmental neurotoxicity of organophosphates: a case study of chlorpyrifos. In: Gupta R.C. (Ed). Toxicity of Organophosphate and Carbamate Pesticides (2005), Elsevier Academic Press, San Diego 293-314
    • (2005) Toxicity of Organophosphate and Carbamate Pesticides , pp. 293-314
    • Slotkin, T.A.1
  • 52
    • 40849114680 scopus 로고    scopus 로고
    • Neonatal exposure to low doses of diazinon: long-term effects on neural cell development and acetylcholine systems
    • Slotkin T.A., Bodwell B.E., Levin E.D., and Seidler F.J. Neonatal exposure to low doses of diazinon: long-term effects on neural cell development and acetylcholine systems. Environ. Health Perspect. 116 (2008) 340-348
    • (2008) Environ. Health Perspect. , vol.116 , pp. 340-348
    • Slotkin, T.A.1    Bodwell, B.E.2    Levin, E.D.3    Seidler, F.J.4
  • 53
    • 55949133560 scopus 로고    scopus 로고
    • Exposure of neonatal rats to parathion elicits sex-selective impairment of acetylcholine systems in brain regions during adolescence and adulthood
    • Slotkin T.A., Bodwell B.E., Ryde I.T., Levin E.D., and Seidler F.J. Exposure of neonatal rats to parathion elicits sex-selective impairment of acetylcholine systems in brain regions during adolescence and adulthood. Environ. Health Perspect. 116 (2008) 1308-1314
    • (2008) Environ. Health Perspect. , vol.116 , pp. 1308-1314
    • Slotkin, T.A.1    Bodwell, B.E.2    Ryde, I.T.3    Levin, E.D.4    Seidler, F.J.5
  • 54
    • 0035370072 scopus 로고    scopus 로고
    • Persistent cholinergic presynaptic deficits after neonatal chlorpyrifos exposure
    • Slotkin T.A., Cousins M.M., Tate C.A., and Seidler F.J. Persistent cholinergic presynaptic deficits after neonatal chlorpyrifos exposure. Brain Res. 902 (2001) 229-243
    • (2001) Brain Res. , vol.902 , pp. 229-243
    • Slotkin, T.A.1    Cousins, M.M.2    Tate, C.A.3    Seidler, F.J.4
  • 55
    • 33646356457 scopus 로고    scopus 로고
    • Comparative developmental neurotoxicity of organophosphate insecticides: effects on brain development are separable from systemic toxicity
    • Slotkin T.A., Levin E.D., and Seidler F.J. Comparative developmental neurotoxicity of organophosphate insecticides: effects on brain development are separable from systemic toxicity. Environ. Health Perspect. 114 (2006) 746-751
    • (2006) Environ. Health Perspect. , vol.114 , pp. 746-751
    • Slotkin, T.A.1    Levin, E.D.2    Seidler, F.J.3
  • 56
    • 34748818046 scopus 로고    scopus 로고
    • Ameliorating the developmental neurotoxicity of chlorpyrifos: a mechanisms-based approach in PC12 cells
    • Slotkin T.A., MacKillop E.A., Ryde I.T., and Seidler F.J. Ameliorating the developmental neurotoxicity of chlorpyrifos: a mechanisms-based approach in PC12 cells. Environ. Health Perspect. 115 (2007) 1306-1313
    • (2007) Environ. Health Perspect. , vol.115 , pp. 1306-1313
    • Slotkin, T.A.1    MacKillop, E.A.2    Ryde, I.T.3    Seidler, F.J.4
  • 57
    • 33845982947 scopus 로고    scopus 로고
    • Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine and divalent nickel
    • Slotkin T.A., MacKillop E.A., Ryde I.T., Tate C.A., and Seidler F.J. Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine and divalent nickel. Environ. Health Perspect. 115 (2007) 93-101
    • (2007) Environ. Health Perspect. , vol.115 , pp. 93-101
    • Slotkin, T.A.1    MacKillop, E.A.2    Ryde, I.T.3    Tate, C.A.4    Seidler, F.J.5
  • 58
    • 40749148130 scopus 로고    scopus 로고
    • Developmental neurotoxicity of low-dose diazinon exposure of neonatal rats: effects on serotonin systems in adolescence and adulthood
    • Slotkin T.A., Ryde I.T., Levin E.D., and Seidler F.J. Developmental neurotoxicity of low-dose diazinon exposure of neonatal rats: effects on serotonin systems in adolescence and adulthood. Brain Res. Bull. 75 (2008) 640-647
    • (2008) Brain Res. Bull. , vol.75 , pp. 640-647
    • Slotkin, T.A.1    Ryde, I.T.2    Levin, E.D.3    Seidler, F.J.4
  • 59
    • 23644433656 scopus 로고    scopus 로고
    • The alterations in CNS serotonergic mechanisms caused by neonatal chlorpyrifos exposure are permanent
    • Slotkin T.A., and Seidler F.J. The alterations in CNS serotonergic mechanisms caused by neonatal chlorpyrifos exposure are permanent. Dev. Brain Res. 158 (2005) 115-119
    • (2005) Dev. Brain Res. , vol.158 , pp. 115-119
    • Slotkin, T.A.1    Seidler, F.J.2
  • 60
    • 34247154767 scopus 로고    scopus 로고
    • Comparative developmental neurotoxicity of organophosphates in vivo: transcriptional responses of pathways for brain cell development, cell signaling, cytotoxicity and neurotransmitter systems
    • Slotkin T.A., and Seidler F.J. Comparative developmental neurotoxicity of organophosphates in vivo: transcriptional responses of pathways for brain cell development, cell signaling, cytotoxicity and neurotransmitter systems. Brain Res. Bull. 72 (2007) 232-274
    • (2007) Brain Res. Bull. , vol.72 , pp. 232-274
    • Slotkin, T.A.1    Seidler, F.J.2
  • 61
    • 34247116566 scopus 로고    scopus 로고
    • Prenatal chlorpyrifos exposure elicits presynaptic serotonergic and dopaminergic hyperactivity at adolescence: critical periods for regional and sex-selective effects
    • Slotkin T.A., and Seidler F.J. Prenatal chlorpyrifos exposure elicits presynaptic serotonergic and dopaminergic hyperactivity at adolescence: critical periods for regional and sex-selective effects. Reprod. Toxicol. 23 (2007) 421-427
    • (2007) Reprod. Toxicol. , vol.23 , pp. 421-427
    • Slotkin, T.A.1    Seidler, F.J.2
  • 62
    • 34250163568 scopus 로고    scopus 로고
    • Exposure to organophosphates reduces the expression of neurotrophic factors in neonatal rat brain regions: similarities and differences in the effects of chlorpyrifos and diazinon on the fibroblast growth factor superfamily
    • Slotkin T.A., Seidler F.J., and Fumagalli F. Exposure to organophosphates reduces the expression of neurotrophic factors in neonatal rat brain regions: similarities and differences in the effects of chlorpyrifos and diazinon on the fibroblast growth factor superfamily. Environ. Health Perspect. 115 (2007) 909-916
    • (2007) Environ. Health Perspect. , vol.115 , pp. 909-916
    • Slotkin, T.A.1    Seidler, F.J.2    Fumagalli, F.3
  • 63
    • 43849112141 scopus 로고    scopus 로고
    • Targeting of neurotrophic factors, their receptors, and signaling pathways in the developmental neurotoxicity of organophosphates in vivo and in vitro
    • Slotkin T.A., Seidler F.J., and Fumagalli F. Targeting of neurotrophic factors, their receptors, and signaling pathways in the developmental neurotoxicity of organophosphates in vivo and in vitro. Brain Res. Bull. 76 (2008) 424-438
    • (2008) Brain Res. Bull. , vol.76 , pp. 424-438
    • Slotkin, T.A.1    Seidler, F.J.2    Fumagalli, F.3
  • 64
    • 58749108577 scopus 로고    scopus 로고
    • T.A. Slotkin, F.J. Seidler, F. Fumagalli, Unrelated developmental neurotoxicants elicit similar transcriptional profiles for effects on neurotrophic factors and their receptors in an in vitro model, Neurotoxicol. Teratol., submitted for publication.
    • T.A. Slotkin, F.J. Seidler, F. Fumagalli, Unrelated developmental neurotoxicants elicit similar transcriptional profiles for effects on neurotrophic factors and their receptors in an in vitro model, Neurotoxicol. Teratol., submitted for publication.
  • 65
    • 0037186808 scopus 로고    scopus 로고
    • Functional alterations in CNS catecholamine systems in adolescence and adulthood after neonatal chlorpyrifos exposure
    • Slotkin T.A., Tate C.A., Cousins M.M., and Seidler F.J. Functional alterations in CNS catecholamine systems in adolescence and adulthood after neonatal chlorpyrifos exposure. Dev. Brain Res. 133 (2002) 163-173
    • (2002) Dev. Brain Res. , vol.133 , pp. 163-173
    • Slotkin, T.A.1    Tate, C.A.2    Cousins, M.M.3    Seidler, F.J.4
  • 66
    • 33749428870 scopus 로고    scopus 로고
    • Organophosphate insecticides target the serotonergic system in developing rat brain regions: disparate effects of diazinon and parathion at doses spanning the threshold for cholinesterase inhibition
    • Slotkin T.A., Tate C.A., Ryde I.T., Levin E.D., and Seidler F.J. Organophosphate insecticides target the serotonergic system in developing rat brain regions: disparate effects of diazinon and parathion at doses spanning the threshold for cholinesterase inhibition. Environ. Health Perspect. 114 (2006) 1542-1546
    • (2006) Environ. Health Perspect. , vol.114 , pp. 1542-1546
    • Slotkin, T.A.1    Tate, C.A.2    Ryde, I.T.3    Levin, E.D.4    Seidler, F.J.5
  • 67
    • 0031722618 scopus 로고    scopus 로고
    • Modeling the developmental neurotoxicity of chlorpyrifos in vitro: macromolecule synthesis in PC12 cells
    • Song X., Violin J.D., Seidler F.J., and Slotkin T.A. Modeling the developmental neurotoxicity of chlorpyrifos in vitro: macromolecule synthesis in PC12 cells. Toxicol. Appl. Pharmacol. 151 (1998) 182-191
    • (1998) Toxicol. Appl. Pharmacol. , vol.151 , pp. 182-191
    • Song, X.1    Violin, J.D.2    Seidler, F.J.3    Slotkin, T.A.4
  • 68
    • 0001073039 scopus 로고
    • Cultured PC12 cells: a model for neuronal function and differentiation
    • Celis J.E. (Ed), Academic Press, San Diego
    • Teng K.K., and Greene L.A. Cultured PC12 cells: a model for neuronal function and differentiation. In: Celis J.E. (Ed). Cell Biology: A Laboratory Handbook (1994), Academic Press, San Diego 218-224
    • (1994) Cell Biology: A Laboratory Handbook , pp. 218-224
    • Teng, K.K.1    Greene, L.A.2
  • 69
    • 38349113169 scopus 로고    scopus 로고
    • Persistent cognitive alterations in rats after early postnatal exposure to low doses of the organophosphate pesticide, diazinon
    • Timofeeva O.A., Roegge C.S., Seidler F.J., Slotkin T.A., and Levin E.D. Persistent cognitive alterations in rats after early postnatal exposure to low doses of the organophosphate pesticide, diazinon. Neurotoxicol. Teratol. 30 (2008) 38-45
    • (2008) Neurotoxicol. Teratol. , vol.30 , pp. 38-45
    • Timofeeva, O.A.1    Roegge, C.S.2    Seidler, F.J.3    Slotkin, T.A.4    Levin, E.D.5
  • 70
    • 58749098871 scopus 로고    scopus 로고
    • O.A. Timofeeva, D. Sanders, K. Seemann, L. Yang, D. Hermanson, S. Regenbogen, S. Agoos, A. Kallepalli, A. Rastogi, D. Braddy, C. Wells, C. Perraut, F.J. Seidler, T.A. Slotkin, E.D. Levin, Persistent behavioral alterations in rats neonatally exposed to low doses of the organophosphate pesticide, parathion, Brain Res. Bull., in press.
    • O.A. Timofeeva, D. Sanders, K. Seemann, L. Yang, D. Hermanson, S. Regenbogen, S. Agoos, A. Kallepalli, A. Rastogi, D. Braddy, C. Wells, C. Perraut, F.J. Seidler, T.A. Slotkin, E.D. Levin, Persistent behavioral alterations in rats neonatally exposed to low doses of the organophosphate pesticide, parathion, Brain Res. Bull., in press.
  • 71
    • 0024470369 scopus 로고
    • Release and metabolism of dopamine in a clonal line of pheochromocytoma (PC12) cells exposed to fenthion
    • Tuler S.M., Hazen A.A., and Bowen J.M. Release and metabolism of dopamine in a clonal line of pheochromocytoma (PC12) cells exposed to fenthion. Fundam. Appl. Toxicol. 13 (1989) 484-492
    • (1989) Fundam. Appl. Toxicol. , vol.13 , pp. 484-492
    • Tuler, S.M.1    Hazen, A.A.2    Bowen, J.M.3
  • 73
    • 58749084765 scopus 로고    scopus 로고
    • U.S. Environmental Protection Agency, Opportunities to Improve Data Quality and Children's Health Through the Food Quality Protection Act. Report no. 2006-P-00009, 2006: Available: http://www.epa.gov/oig/reports/2006/20060110-2006-P-00009.pdf [accessed July 7, 2006].
    • U.S. Environmental Protection Agency, Opportunities to Improve Data Quality and Children's Health Through the Food Quality Protection Act. Report no. 2006-P-00009, 2006: Available: http://www.epa.gov/oig/reports/2006/20060110-2006-P-00009.pdf [accessed July 7, 2006].
  • 74
    • 58749108209 scopus 로고    scopus 로고
    • U.S. National Library of Medicine, Superfund Chemicals in TOXMAP, 2006: Available: http://toxmap.nlm.nih.gov/toxmap/main/sfChemicals.jsp [accessed August 9, 2006].
    • U.S. National Library of Medicine, Superfund Chemicals in TOXMAP, 2006: Available: http://toxmap.nlm.nih.gov/toxmap/main/sfChemicals.jsp [accessed August 9, 2006].
  • 75
    • 0015305367 scopus 로고
    • Dieldrin toxicosis: fetotoxicosis, tissue concentrations, and microscopic and ultrastructural changes in guinea pigs
    • Uzoukwu M., and Sleight S.D. Dieldrin toxicosis: fetotoxicosis, tissue concentrations, and microscopic and ultrastructural changes in guinea pigs. Am. J. Vet. Res. 33 (1972) 579-583
    • (1972) Am. J. Vet. Res. , vol.33 , pp. 579-583
    • Uzoukwu, M.1    Sleight, S.D.2
  • 77
    • 0026680263 scopus 로고
    • The chromogranins A and B: the first 25 years and future perspectives
    • Winkler H., and Fischer-Colbrie R. The chromogranins A and B: the first 25 years and future perspectives. Neuroscience 49 (1992) 497-528
    • (1992) Neuroscience , vol.49 , pp. 497-528
    • Winkler, H.1    Fischer-Colbrie, R.2
  • 78
    • 40849142446 scopus 로고    scopus 로고
    • Chlorpyrifos and chlorpyrifos-oxon inhibit axonal growth by interfering with the morphogenic activity of acetylcholinesterase
    • Yang D., Howard A., Bruun D., Ajua-Alemanj M., Pickart C., and Lein P.J. Chlorpyrifos and chlorpyrifos-oxon inhibit axonal growth by interfering with the morphogenic activity of acetylcholinesterase. Toxicol. Appl. Pharmacol. 228 (2008) 32-41
    • (2008) Toxicol. Appl. Pharmacol. , vol.228 , pp. 32-41
    • Yang, D.1    Howard, A.2    Bruun, D.3    Ajua-Alemanj, M.4    Pickart, C.5    Lein, P.J.6


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