Experimental extracorporeal photopheresis inhibits the sensitization and effector phases of contact hypersensitivity via two mechanisms: Generation of IL-10 and induction of regulatory T cells

Journal of Immunology

Volumn 181, Issue 9, 2008, Pages 5956-5962

  Maeda, Akira ^a,b   Schwarz, Agatha ^a   Bullinger, Ann ^c   Morita, Akimichi ^b   Peritt, David ^c   Schwarz, Thomas ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^c Therakos Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; 1 FLUORO 2,4 DINITROBENZENE;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTACT ALLERGY; CONTROLLED STUDY; CYTOKINE PRODUCTION; EXTRACORPOREAL PHOTOPHERESIS; IMMUNITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROPHYLAXIS; PUVA; REGULATORY T LYMPHOCYTE; SENSITIZATION; ANIMAL; BIOSYNTHESIS; C3H MOUSE; C57BL MOUSE; CELL CULTURE; CELL DIFFERENTIATION; COCULTURE; COMPARATIVE STUDY; CYTOLOGY; DISEASE MODEL; GENETICS; IMMUNIZATION; IMMUNOLOGY; IMMUNOSUPPRESSIVE TREATMENT; METABOLISM; METHODOLOGY; PHYSIOLOGY; SKIN ALLERGY;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; COCULTURE TECHNIQUES; DERMATITIS, ALLERGIC CONTACT; DINITROFLUOROBENZENE; DISEASE MODELS, ANIMAL; IMMUNIZATION; IMMUNOSUPPRESSION; INTERLEUKIN-10; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; PHOTOPHERESIS; T-LYMPHOCYTES, REGULATORY;

EID: 58749084519     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.181.9.5956     Document Type: Article

References (41)

1. Knobler, R. 2000. Extracorporeal photochemotherapy-present and future. Vox Sang. 78(Suppl. 2): 197-201.
2. Edelson, R., C. Berger, F. Gasparro, B. Jegasoth, P. Heald, B. Wintroub, E. Vonderheid, R. Knobler, K. Wolff, G. Plewig, et al. 1987. Treatment of cutaneous T-cell lymphoma by extracorporeal photochemotherapy: preliminary results. N. Engl. J. Med. 316: 297-303. (Pubitemid 17036377)
3. Heald, P., A. Rook, M. Perez, B. Wintroub, R. Knobler, B. Jegasothy, F. Gasparro, C. Berger, and R. Edelson. 1992. Treatment of erythrodermic cutaneous T-cell lymphoma with extracorporeal photochemotherapy. J. Am. Acad. Dermatol. 27: 427-433.
4. Maccherin, M., F. Diciolla, F. Laghi Pasini, G. Lisi, P. Tanganelli, G. D'Ascenzo, S. Mondillo, E. Carone, L. Oricchio, C. Baraldi, et al. 2001. Photopheresis immunomodulation after heart transplantation. Transplant. Proc. 33: 1591-1594.
5. Barr, M. L., B. M. Meise, H. J. Eisen, R. F. Roberts, U. Livi, R. Dall'Amico, R. Dorent, J. G. Rogers, B. Radovancevic, D. O. Taylor, et al. 1998. Photopheresis for the prevention of rejection in cardiac transplantation: Photopheresis Transplantation Study Group. N. Engl. J. Med. 339: 1744-1751.
6. Gorgun, G., K. B. Miller, and F. M. Foss. 2002. Immunologic mechanisms of extracorporeal photochemotherapy in chronic graft-versus-host disease. Blood 100: 941-947. (Pubitemid 34832621)
7. Greinix, H. T., B. Volc-Platzer, P. Kalhs, G. Fischer, A. Rosenmayr, F. Keil, H. Hönigsmann, and R. M. Knobler. 2000. Extracorporeal photochemotherapy in the treatment of severe steroid-refractory acute graft-versus-host disease: a pilot study. Blood 96: 2426-2431.
8. Greinix, H. T., B. Volc-Platzer, W. Rabitsch, B. Gmeinhart, C. Guevara-Pineda, P. Kalhs, J. Krutmann, H. Hönigsmann, M. Ciovica, and R. M. Knobler. 1998. Successful use of extracorporeal photochemotherapy in the treatment of severe acute and chronic graft-versus-host disease. Blood 92: 3098-3104.
9. Reinisch, W., H. Nahavandi, R. Santella, Y. Zhang, C. Gasch, G. Moser, T. Waldhor, A. Gangl, H. Vogelsang, and R. Knobler. 2001. Extracorporeal photochemotherapy in patients with steroid-dependent Crohn's disease: a prospective pilot study. Aliment. Pharmacol. Ther. 15: 1313-1322. (Pubitemid 32835537)
10. Malawista, S. E., D. Trock, and R. L. Edelson. 1991. Photopheresis for rheumatoid arthritis. Ann. NY Acad. Sci. 636: 217-226.
11. Ludvigsson, J., U. Samuelsson, J. Ernerudh, C. Johansson, L. Stenhammar, and G. Berlin. 2001. Photopheresis at onset of type 1 diabetes: a randomized, double blind, placebo controlled trial. Arch. Dis. Child. 85: 149-154. (Pubitemid 32701684)
12. Oliven, A., and Y. Shechter. 2001. Extracorporeal photopheresis: a review. Blood Rev. 15: 103-108.
13. Lim, H. W., and R. L. Edelson. 1995. Photopheresis for the treatment of cutaneous T-cell lymphoma. Hematol. Oncol. Clin. North Am. 9: 1117-1126.
14. Suchin, K. R., M. Cassin, R. Washko, G. Nahas, M. Berkson, B. Stouch, B. R. Vowels, and A. H. Rook. 1999. Extracorporeal photochemotherapy does not suppress T- or B-cell responses to novel or recall antigens. J. Am. Acad. Dermatol. 41: 980-986.
15. Lamioni, A., F. Parisi, G. Isacchi, E. Giorda, S. Di Cesare, A. Landolfo, F. Cenci, G. F. Bottazzo, and R. Carsetti. 2005. The immunological effects of extracorporeal photopheresis unraveled: induction of tolerogenic dendritic cells in vitro and regulatory T cells in vivo. Transplantation 79: 846-850. (Pubitemid 40546206)
16. Aubin, F., and C. Mousson. 2004. Ultraviolet light-induced regulatory (suppressor) T cells: an approach for promoting induction of operational allograft tolerance? Transplantation 77: S29-S31. (Pubitemid 38114416)
17. + regulatory T cells are numerically deficient in acute and chronic GvHD. Blood 107: 1717-1723.
18. Hertl, M., R. Eming, and C. Veldman. 2006. T cell control in autoimmune bullous skin disorders. J. Clin. Invest. 116: 1159-1166.
19. + TREG cell counts and the response to extracorporeal photopheresis in lung transplant recipients. Transplant. Proc. 39: 213-217.
20. + regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol. Rev. 182: 18-32.
21. Chatenoud, L., B. Salomon, and J. A. Bluestone. 2001. Suppressor T cells - they're back and critical for regulation of autoimmunity! Immunol. Rev. 2182: 149-163.
22. + regulatory T cells generated ex vivo with IL-2 and TGF-β suppress a stimulatory graft-versus-host disease with a lupus-like syndrome. J. Immunol. 172: 1531-1539.
23. Wood, K. J., and S. Sakaguchi. 2003. Regulatory T cells in transplantation tolerance. Nat. Rev. Immunol. 3: 199-210.
24. + regulatory T cells. Immunol. Rev. 212: 60-73.
25. Ullrich, S. E. 2005. Mechanisms underlying UV-induced immune suppression. Mutat. Res. 571: 185-205.
26. Schwarz, T. 2005. Regulatory T cells induced by ultraviolet radiation. Int. Arch. Allergy Immunol. 137: 187-193.
27. Glass, M. J., P. R. Bergstresser, R. E. Tigelaar, and J. W. Streilein. 1990. UVB radiation and DNFB skin painting induce suppressor cells universally in mice. J. Invest. Dermatol. 94: 273-278.
28. Schwarz, A., A. Maeda, M. K. Wild, K. Kernebeck, N. Gross, Y. Aragane, S. Beissert, D. Vestweber, and T. Schwarz. 2004. Ultraviolet radiation-induced regulatory T cells not only inhibit the induction but can suppress the effector phase of contact hypersensitivity. J. Immunol. 172: 1036-1043.
29. Maeda, A., A. Schwarz, K. Kernebeck, N. Gross, Y. Aragane, D. Peritt, and T. Schwarz. 2005. Intravenous infusion of syngeneic apoptotic cells by photopheresis induces antigen-specific regulatory T cells. J. Immunol. 174: 5968-5976. (Pubitemid 40663783)
30. Gatza, E., C. E. Rogers, S. G. Clouthier, K. P. Lowler, I. Tawara, C. Liu, P. Reddy, and J. L. Ferrara. 2008. Extracorporeal photopheresis reverses experimental graft-versus-host disease through regulatory T cells. Blood 112: 1515-1521.
31. Ferguson, T. A., P. Dube, and T. S. Griffith. 1994. Regulation of contact hypersensitivity by interleukin 10. J. Exp. Med. 179: 1597-1604.
32. Schwarz, A., S. Grabbe, H. Riemann, Y. Aragane, M. Simon, S. Manon, S. Andrade, T. A. Luger, A. Zlotnik, and T. Schwarz. 1994. In vivo effects of interleukin-10 on contact hypersensitivity and delayed-type hypersensitivity reactions. J. Invest. Dermatol. 103: 211-216. (Pubitemid 24234610)
33. Schwarz, A., S. Beissert, K. Grosse-Heitmeyer, M. Gunzer, J. A. Bluestone, S. Grabbe, and T. Schwarz. 2000. Evidence for functional relevance of CTLA-4 in ultraviolet-radiation-induced tolerance. J. Immunol. 165: 1824-1831. (Pubitemid 30643132)
34. Aragane, Y., A. Maeda, A. Schwarz, T. Tezuka, K. Ariizumi, and T. Schwarz. 2003. Involvement of dectin-2 in ultraviolet radiation-induced tolerance. J. Immunol. 171: 3801-3807. (Pubitemid 37254586)
35. Schwarz, A., S. Grabbe, K. Grosse-Heitmeyer, B. Roters, H. Riemann, T. A. Luger, G. Trinchieri, and T. Schwarz. 1998. Ultraviolet light-induced immune tolerance is mediated via the Fas/Fas ligand system. J. Immunol. 160: 4262-4270. (Pubitemid 28217281)
36. Voll, R. E., M. Herrman, E. A. Roth, C. Stach, J. R. Kalden, and I. Girkontaite. 1997. Immunosuppressive effects of apoptotic cells. Nature 390: 350-351.
37. Craciun, L. I., P. Stordeur, L. Schandene, H. Duvillier, D. Bron, M. Lambermont, M. Goldman, and E. Dupont. 2002. Increased production of interleukin-10 and interleukin-1 receptor antagonist after extracorporeal photochemotherapy in chronic graft-versus-host disease. Transplantation 74: 995-1000.
38. Beissert, S., J. Hosoi, R. Kuhn, K. Rajewsky, W. Muller, and R. D. Granstein. 1996. Impaired immunosuppressive response to ultraviolet radiation in interleukin- 10-deficient mice. J. Invest. Dermatol. 107: 553-557. (Pubitemid 26338578)
39. Siewe, L., M. Bollati-Fogolin, C. Wickenhauser, T. Krieg, W. Müller, and A. Roers. 2006. Interleukin-10 derived from macrophages and/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA. Eur. J. Immunol. 36: 3248-3255.
40. Schwarz, A., A. Maeda, K. Kernebeck, H. van Steeg, S. Beissert, and T. Schwarz. 2005. Prevention of UV radiation-induced immunosuppression by IL-12 is dependent on DNA repair. J. Exp. Med. 201: 173-179. (Pubitemid 40189425)
41. Miller, K. B., T. F. Roberts, G. Chan, D. P. Schenkein, D. Lawrence, K. Sprague, G. Gorgun, V. Relias, H. Grodman, A. Mahajan, and F. M. Foss. 2004. A novel reduced intensity regimen for allogeneic hematopoietic stem cell transplantation associated with a reduced incidence of graft-versus-host disease. Bone Marrow Transplant. 33: 881-889. (Pubitemid 38660120)