Ciglitazone induces apoptosis via activation of p38 MAPK and AIF nuclear translocation mediated by reactive oxygen species and Ca2+ in opossum kidney cells

Toxicology

Volumn 257, Issue 1-2, 2009, Pages 1-9

  Kwon, Chae Hwa ^a   Park, Ji Yeon ^a   Kim, Thae Hyun ^a   Woo, Jae Suk ^a   Kim, Yong Keun ^a  

^a Pusan National University School of Medicine   (South Korea)

Author keywords

AIF; Apoptosis; Ca2+; Ciglitazone; Mitochondrial membrane potential; p38 MAPK; Reactive oxygen species; Renal epithelial cells

Indexed keywords

APOPTOSIS INDUCING FACTOR; CALCIUM ION; CIGLITAZONE; EGTAZIC ACID; LANTHANUM CHLORIDE; MICRORNA; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TROLOX C;

ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL DEATH; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; ENZYME ACTIVATION; EPITHELIUM CELL; GENE TRANSLOCATION; GENETIC TRANSFECTION; KIDNEY CELL; KIDNEY EPITHELIUM; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; OPOSSUM; PRIORITY JOURNAL; PROTEIN FUNCTION; RNA VECTOR;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; ANTIOXIDANTS; APOPTOSIS; APOPTOSIS INDUCING FACTOR; CALCIUM; CALCIUM CHANNEL BLOCKERS; CELLS, CULTURED; CHELATING AGENTS; CHROMANS; DOSE-RESPONSE RELATIONSHIP, DRUG; EGTAZIC ACID; ENZYME ACTIVATION; EPITHELIAL CELLS; HYPOGLYCEMIC AGENTS; KIDNEY; LANTHANUM; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; OPOSSUMS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PPAR GAMMA; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; RNA, SMALL INTERFERING; THIAZOLIDINEDIONES; TIME FACTORS; TRANSFECTION;

DIDELPHIDAE;

EID: 58649094847     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2008.11.019     Document Type: Article

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