Tocotrienol suppresses adipocyte differentiation and Akt phosphorylation in 3T3-L1 preadipocytes

Journal of Nutrition

Volumn 139, Issue 1, 2009, Pages 51-57

  Uto Kondo, Harumi ^a   Ohmori, Reiko ^b   Kiyose, Chikako ^c   Kishimoto, Yoshimi ^d   Saito, Hisako ^e   Igarashi, Osamu ^f   Kondo, Kazuo ^d  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^b UTSUNOMIYA UNIVERSITY   (Japan)

^c KANAGAWA INSTITUTE OF TECHNOLOGY   (Japan)

^d OCHANOMIZU UNIVERSITY   (Japan)

^e HIROSAKI UNIVERSITY   (Japan)

^f IBARAKI CHRISTIAN UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ALPHA TOCOTRIENOL; CCAAT ENHANCER BINDING PROTEIN ALPHA; FATTY ACID BINDING PROTEIN; GAMMA TOCOTRIENOL; INSULIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN KINASE B; TRIACYLGLYCEROL;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN 3T3; CONTROLLED STUDY; GENE EXPRESSION; LIPID STORAGE; MOUSE; NONHUMAN; PROADIPOCYTE; PROTEIN PHOSPHORYLATION;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; CELL DIFFERENTIATION; MICE; ONCOGENE PROTEIN V-AKT; PHOSPHORYLATION; PLANT OILS; TOCOTRIENOLS;

RATTUS;

EID: 58649087808     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.108.096131     Document Type: Article

References (43)

1. National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). (2002) Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 2002;106:3143-241.
2. Reaven GM. Role of insulin resistance in human disease (syndrome X): an expanded definition. Annu Rev Med. 1993;44:121-31.
3. Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO III, Criqui M, Fadl YY, Fortmann SP, Hong Y, et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation. 2003;107:499-511.
4. Fasshauer M, Paschke R. Regulation of adipocytokines and insulin resistance. Diabetologia. 2003;46:1594-603.
5. Furuyashiki T, Nagayasu H, Aoki Y, Bessho H, Hashimoto T, Kanazawa K, Ashida H. Tea catechin suppresses adipocyte differentiation accompanied by down-regulation of PPAR gamma2 and C/EBP alpha in 3T3-L1 cells. Biosci Biotechnol Biochem. 2004;68:2353-9.
6. Harmon AW, Harp JB. Differential effects of flavonoids on 3T3-L1 adipogenesis and lipolysis. Am J Physiol Cell Physiol. 2001;280:C807-13.
7. Chawla A, Lazar MA. Peroxisome proliferator and retinoid signaling pathways co-regulate preadipocyte phenotype and survival. Proc Natl Acad Sci USA. 1994;91:1786-90.
8. Xue JC, Schwarz EJ, Chawla A, Lazar MA. Distinct stages in adipogenesis revealed by retinoid inhibition of differentiation after induction of PPAR gamma. Mol Cell Biol. 1996;16:1567-75.
9. Kawada T, Kamei Y, Fujita A, Hida Y, Takahashi N, Sugimoto E, Fushiki T. Carotenoids and retinoids as suppressors on adipocyte differentiation via nuclear receptors. Biofactors. 2000;13:103-9.
10. Suryawan A, Hu CY. Effect of retinoic acid on differentiation of cultured pig preadipocytes. J Anim Sci. 1997;75:112-7.
11. Kamal-Eldin A, Appelqvist LA. The chemistry and antioxidant properties of tocopherols and tocotrienols. Lipids. 1996;31:671-701.
12. Parker RA, Pearce BC, Clark RW, Gordon DA, Wright JJ. Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J Biol Chem. 1993;268:11230-8.
13. Qureshi AA, Sami SA, Salser WA, Khan FA. Dose-dependent suppression of serum cholesterol by tocotrienol-rich fraction (TRF25) of rice bran in hypercholesterolemic humans. Atherosclerosis. 2002;161:199-207.
14. Saito H, Kiyose C, Yoshimura H, Ueda T, Kondo K, Igarashi O. Gamma-tocotrienol, a vitamin E homolog, is a natrmgretic hormone precursor. J Lipid Res. 2003;44:1530-5.
15. Ima-Nirwana S, Suhaniza S. Effects of tocopherols and tocotrienols on body composition and bone calcmgm content in adrenalectomized rats replaced with dexamethasone. J Med Food. 2004;7:45-51.
16. Ikeda S, Niwa T, Yamashita K. Selective uptake of dietary tocotrienols into rat skin. J Nutr Sci Vitaminol (Tokyo). 2000;46:141-3.
17. Ikeda S, Toyoshima K, Yamashita K. Dietary sesame seeds elevate alpha- and gamma-tocotrienol concentrations in skin and adipose tissue of rats fed the tocotrienol-rich fraction extracted from palm oil. J Nutr. 2001;131:2892-7.
18. Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ, et al. Measurement of protein using bicinchoninic acid. Anal Biochem. 1985;150:76-85.
19. Zhang B, Berger J, Hu E, Szalkowski D, White-Carrington S, Spiegelman BM, Moller DE. Negative regulation of peroxisome proliferator-activated receptor-gamma gene expression contributes to the antiadipogenic effects of tumor necrosis factor-alpha. Mol Endocrinol. 1996;10:1457-66.
20. Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell. 1994;79:1147-56.
21. Kliewer SA, UmesonoK, NoonanDJ, HeymanRA, EvansRM. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways throughheterodimerformationoftheirreceptors.Nature.1992;358:771-4.
22. Tontonoz P, Hu E, Graves RA, Budavari AI, Spiegelman BM. mPPARγ2: tissue-specific regulator of an adipocyte enhancer. Genes Dev. 1994;8:1224-34.
23. Tontonoz P, Graves RA, Budavari AI, Erdjument-Bromage H, Lui M, Hu E, Tempst P, Spiegelman BM. Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPARγ and RXRα. Nucleic Acids Res. 1994;22:5628-34.
24. Sears IB, Mac Ginnitie MA, Kovacs LG, Graves RA. Differentiation- dependent expression of the brown adipocyte uncoupling protein gene: regulation by peroxisome proliferator-activated receptor γ. Mol Cell Biol. 1996;16:3410-8.
25. Rubin CS, Hirsch A, Fung C, Rosen OM. Development of hormone receptors and hormonal responsiveness in vitro. Insulin receptors and insulin sensitivity in the preadipocyte and adipocyte forms of 3T3-L1 cells. J Biol Chem. 1978;253:7570-8.
26. Cornelius P, MacDougald OA, Lane MD. Regulation of adipocyte development. Annu Rev Nutr. 1994;14:99-129.
27. White MF, Kahn CR. The insulin signaling system. J Biol Chem. 1994;269:1-4.
28. Xu J, Liao K. Protein kinase B/AKT 1 plays a pivotal role in insulin-like growth factor-1 receptor signaling induced 3T3-L1 adipocyte differentiation. J Biol Chem. 2004;279:35914-22.
29. Tang QQ, Otto TC, Lane MD. Mitotic clonal expansion: a synchronous process required for adipogenesis. Proc Natl Acad Sci USA. 2003; 100:44-9.
30. Font de Mora J, Porras A, Ahn N, Santos E. Mitogen-activated protein kinase activation is not necessary for, but antagonizes, 3T3-L1 adipocytic differentiation. Mol Cell Biol. 1997;17:6068-75.
31. Qiu Z, Wei Y, Chen N, Jiang M, Wu J, Liao K. DNA synthesis and mitotic clonal expansion is not a required step for 3T3-L1 preadipocyte differentiation into adipocytes. J Biol Chem. 2001;276:11988-95.
32. Hu E, Kim JB, Sarraf P, Spiegelman BM. Inhibition of adipogenesis through Erkinase-mediated phosphorylation of PPAR gamma. Science. 1996;274:2100-3.
33. Bost F, Caron L, Marchetti I, Dani C, Le Marchand-Brustel Y, Binetruy B. Retinoic acid activation of the ERK pathway is required for embryonic stem cell commitment into the adipocyte lineage. Biochem J. 2002;361:621-7.
34. Sen P, Mukherjee S, Ray D, Raha S. Involvement of the Akt/PKB signaling pathway with disease processes. Mol Cell Biochem. 2003;253:241-6.
35. Ikeda I, Hamamoto R, Uzu K, Imaizumi K, Nagao K, Yanagita T, Suzuki Y, Kobayashi M, Kakuda T. Dietary gallate esters of tea catechins reduce deposition of visceral fat, hepatic triacylglycerol, and
36. activities of hepatic enzymes related to fatty acid synthesis in rats. Biosci Biotechnol Biochem. 2005;69:1049-53.
37. Nagao T, Hase T, Tokimitsu I. A green tea extract high in catechins reduces body fat and cardiovascular risks in humans. Obesity (Silver Spring). 2007;15:1473-83.
38. Waltner-Law ME, Wang XL, Law BK, Hall RK, Nawano M, Granner DK. Epigallocatechin gallate, a constituent of green tea, represses hepatic glucose production. J Biol Chem. 2002;277:34933-40.
39. Liu HS, Chen YH, Hung PF, Kao YH. Inhibitory effect of green tea (-)-epigallocatechin gallate on resistin gene expression in 3T3-L1 adipocytes depends on the ERK pathway. Am J Physiol Endocrinol Metab. 2006;290:E273-81.
40. Nakagawa K, Shibata A, Yamashita S, Tsuzuki T, Kariya J, Oikawa S, Miyazawa T. In vivo angiogenesis is suppressed by unsaturated vitamin E, tocotrienol. J Nutr. 2007;137:1938-43.
41. Samant GV, Sylvester PW. Gamma-tocotrienol inhibits ErbB3-dependent PI3K/Akt mitogenic signalling in neoplastic mammary epithelial cells. Cell Prolif. 2006;39:563-74.
42. Haidara MA, Ibrahim IM, Al-Tuwaijri AS, Awadalla, SA, Yaseen H. Effect of alpha-tocopherol on glucose uptake and contractility in rat skeletal muscle. Med Sci Monit. 2003;9:BR174-7.
43. Wechter WJ, Kantoci D, Murray ED Jr, D'Amico DC, Jung ME, Wang WH. A new endogenous natrmgretic factor: LLU-alpha. Proc Natl Acad Sci USA. 1996;93:6002-7.