Increasing the number of 5-HT1A-receptors in cortex and hippocampus does not induce mnemonic deficits in mice

Pharmacology Biochemistry and Behavior

Volumn 92, Issue 1, 2009, Pages 76-81

  Bert, Bettina ^a   Voigt, Jörg Peter ^b   Kusserow, Heike ^c   Theuring, Franz ^c   Rex, André ^a   Fink, Heidrun ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

5 HT1A receptor; 8 OH DPAT; Cortex; Hippocampus; Inhibitory avoidance; Learning; Memory; Postsynaptic; Transgenic mice

Indexed keywords

SEROTONIN 1A RECEPTOR;

AMNESIA; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COGNITION; CONTROLLED STUDY; GENOTYPE; LEARNING DISORDER; MEMORY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; AVOIDANCE LEARNING; CEREBRAL CORTEX; CUES; HIPPOCAMPUS; MALE; MAZE LEARNING; MEMORY; MEMORY DISORDERS; MICE; MICE, TRANSGENIC; RECEPTOR, SEROTONIN, 5-HT1A; SEROTONIN AGONISTS; SPACE PERCEPTION;

MUS; MUS MUSCULUS;

EID: 58549115256     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2008.10.014     Document Type: Article

References (55)

1. Ago Y., Koyama Y., Baba A., and Matsuda T. Regulation by 5-HT1A receptors of the in vivo release of 5-HT and DA in mouse frontal cortex. Neuropharmacology 45 (2003) 1050-1056
2. Albert P.R., Zhou Q.Y., Van Tol H.H., Bunzow J.R., and Civelli O. Cloning, functional expression, and mRNA tissue distribution of the rat 5-hydroxytryptamine1A receptor gene. J Biol Chem 265 (1990) 5825-5832
3. Bert B., Fink H., Rothe J., Walstab J., and Bönisch H. Learning and memory in 5-HT1A-receptor mutant mice. Behav Brain Res 195 (2008) 78-85
4. Bert B., Dere E., Wilhelmi N., Kusserow H., Theuring F., Huston J.P., et al. Transient overexpression of the 5-HT(1A) receptor impairs water-maze but not hole-board performance. Neurobiol Learn Mem 84 (2005) 57-68
5. Bert B., Fink H., Hortnagl H., Veh R.W., Davies B., Theuring F., et al. Mice over-expressing the 5-HT(1A) receptor in cortex and dentate gyrus display exaggerated locomotor and hypothermic response to 8-OH-DPAT. Behav Brain Res 167 (2006) 328-341
6. Blanchard R.J., Griebel G., Guardiola-Lemaitre B., Brush M.M., Lee J., and Blanchard D.C. An ethopharmacological analysis of selective activation of 5-HT1A receptors: the mouse 5-HT1A syndrome. Pharmacol Biochem Behav 57 (1997) 897-908
7. Blier P., and de Montigny C. Electrophysiological investigation of the adaptive response of the 5-HT system to the administration of 5-HT1A receptor agonists. J Cardiovasc Pharmacol 15 Suppl 7 (1990) S42-S48
8. Borg J., Andree B., Lundberg J., Halldin C., and Farde L. Search for correlations between serotonin 5-HT1A receptor expression and cognitive functions-a strategy in translational psychopharmacology. Psychopharmacology (Berl) 185 (2006) 389-394
9. Buhot M.C., Martin S., and Segu L. Role of serotonin in memory impairment. Ann Med 32 (2000) 210-221
10. Carli M., and Samanin R. 8-Hydroxy-2-(di-n-propylamino)tetralin impairs spatial learning in a water maze: role of postsynaptic 5-HT1A receptors. Br J Pharmacol 105 (1992) 720-726
11. Carli M., Balducci C., and Samanin R. Stimulation of 5-HT(1A) receptors in the dorsal raphe ameliorates the impairment of spatial learning caused by intrahippocampal 7-chloro-kynurenic acid in naive and pretrained rats. Psychopharmacology (Berl) 158 (2001) 39-47
12. Carli M., Balducci C., Millan M.J., Bonalumi P., and Samanin R. S 15535, a benzodioxopiperazine acting as presynaptic agonist and postsynaptic 5-HT1A receptor antagonist, prevents the impairment of spatial learning caused by intrahippocampal scopolamine. Br J Pharmacol 128 (1999) 1207-1214
13. Childers Jr. W.E., Abou-Gharbia M.A., Kelly M.G., Andree T.H., Harrison B.L., Ho D.M., et al. Synthesis and biological evaluation of benzodioxanylpiperazine derivatives as potent serotonin 5-HT(1A) antagonists: the discovery of Lecozotan. J Med Chem 48 (2005) 3467-3470
14. Dirks A., Pattij T., Bouwknecht J.A., Westphal T.T., Hijzen T.H., Groenink L., et al. 5-HT1B receptor knockout, but not 5-HT1A receptor knockout mice, show reduced startle reactivity and footshock-induced sensitization, as measured with the acoustic startle response. Behav Brain Res 118 (2001) 169-178
15. Dourish C.T., Hutson P.H., and Curzon G. Characteristics of feeding induced by the serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT). Brain Res Bull 15 (1985) 377-384
16. Dulawa S.C., Gross C., Stark K.L., Hen R., and Geyer M.A. Knockout mice reveal opposite roles for serotonin 1A and 1B receptors in prepulse inhibition. Neuropsychopharmacology 22 (2000) 650-659
17. Egashira N., Yano A., Ishigami N., Mishima K., Iwasaki K., Fujioka M., et al. Investigation of mechanisms mediating 8-OH-DPAT-induced impairment of spatial memory: involvement of 5-HT1A receptors in the dorsal hippocampus in rats. Brain Res 1069 (2006) 54-562
18. Heisler L.K., Chu H.M., Brennan T.J., Danao J.A., Bajwa P., Parsons L.H., et al. Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice. Proc Natl Acad Sci U S A 95 (1998) 15049-15054
19. Huguet F., Drieu K., and Piriou A. Decreased cerebral 5-HT1A receptors during ageing: reversal by Ginkgo biloba extract (EGb 761). J Pharm Pharmacol 46 (1994) 316-318
20. Joyce J.N., Shane A., Lexow N., Winokur A., Casanova M.F., and Kleinman J.E. Serotonin uptake sites and serotonin receptors are altered in the limbic system of schizophrenics. Neuropsychopharmacology 8 (1993) 315-336
21. Kasper S., Tauscher J., Willeit M., Stamenkovic M., Neumeister A., Kufferle B., et al. Receptor and transporter imaging studies in schizophrenia, depression, bulimia and Tourette's disorder-implications for psychopharmacology. World J Biol Psych 3 (2002) 133-146
22. Kepe V., Barrio J.R., Huang S.C., Ercoli L., Siddarth P., Shoghi-Jadid K., et al. Serotonin 1A receptors in the living brain of Alzheimer's disease patients. Proc Natl Acad Sci U S A 103 (2006) 702-707
23. Lai M.K., Tsang S.W., Francis P.T., Esiri M.M., Keene J., Hope T., et al. Reduced serotonin 5-HT1A receptor binding in the temporal cortex correlates with aggressive behavior in Alzheimer disease. Brain Res 974 (2003) 82-87
24. Lanctot K.L., Hussey D.F., Herrmann N., Black S.E., Rusjan P.M., Wilson A.A., et al. A positron emission tomography study of 5-Hydroxytryptamine-1A receptors in Alzheimer disease. Am J Geriatr Psychiatry (2007)
25. Luttgen M., Elvander E., Madjid N., and Ogren S.O. Analysis of the role of 5-HT1A receptors in spatial and aversive learning in the rat. Neuropharmacology 48 (2005) 830-852
26. Madjid N., Tottie E.E., Luttgen M., Meister B., Sandin J., Kuzmin A., et al. 5-hydroxytryptamine 1A receptor blockade facilitates aversive learning in mice: interactions with cholinergic and glutamatergic mechanisms. J Pharmacol Exp Ther 316 (2006) 581-591
27. Mendelson S.D., Quartermain D., Francisco T., and Shemer A. 5-HT1A receptor agonists induce anterograde amnesia in mice through a postsynaptic mechanism. Eur J Pharmacol 236 (1993) 177-182
28. Meneses A., and Hong E. 5-HT1A receptors modulate the consolidation of learning in normal and cognitively impaired rats. Neurobiol Learn Mem 71 (1999) 207-218
29. Meneses A., and Perez-Garcia G. 5-HT(1A) receptors and memory. Neurosci Biobehav Rev 31 (2007) 705-727
30. Micheau J., and Van Marrewijk B. Stimulation of 5-HT1A receptors by systemic or medial septum injection induces anxiogenic-like effects and facilitates acquisition of a spatial discrimination task in mice. Prog Neuro-psychopharmacol Biol Psychiatry 23 (1999) 1113-1133
31. Millan M.J., Rivet J.M., Canton H., Lejeune F., Gobert A., Widdowson P., et al. S 15535: a highly selective benzodioxopiperazine 5-HT1A receptor ligand which acts as an agonist and an antagonist at presynaptic and postsynaptic sites respectively. Eur J Pharmacol 230 (1993) 99-102
32. Millan M.J., Gobert A., Roux S., Porsolt R., Meneses A., Carli M., et al. The serotonin1A receptor partial agonist S15535 [4-(benzodioxan-5-yl)1-(indan-2-yl)piperazine] enhances cholinergic transmission and cognitive function in rodents: a combined neurochemical and behavioral analysis. J Pharmacol Exp Ther 311 (2004) 190-203
33. Misane I., Johansson C., and Ogren S.O. Analysis of the 5-HT1A receptor involvement in passive avoidance in the rat. Br J Pharmacol 125 (1998) 499-509
34. Moller M., Jakobsen S., and Gjedde A. Parametric and regional maps of free serotonin 5HT1A receptor sites in human brain as function of age in healthy humans. Neuropsychopharmacology 32 (2007) 1707-1714
35. Nyakas C., Oosterink B.J., Keijser J., Felszeghy K., de Jong G.I., Korf J., et al. Selective decline of 5-HT1A receptor binding sites in rat cortex, hippocampus and cholinergic basal forebrain nuclei during aging. J Chem Neuroanat 13 (1997) 53-61
36. Parks C.L., Robinson P.S., Sibille E., Shenk T., and Toth M. Increased anxiety of mice lacking the serotonin1A receptor. Proc Natl Acad Sci U S A 95 (1998) 10734-10739
37. Parsey R.V., Oquendo M.A., Simpson N.R., Ogden R.T., Van Heertum R., Arango V., et al. Effects of sex, age, and aggressive traits in man on brain serotonin 5-HT1A receptor binding potential measured by PET using [C-11]WAY-100635. Brain Res 954 (2002) 173-182
38. Pattij T., Broersen L.M., van der Linde J., Groenink L., van der Gugten J., Maes R.A., et al. Operant learning and differential-reinforcement-of-low-rate 36-s responding in 5-HT1A and 5-HT1B receptor knockout mice. Behav Brain Res 141 (2003) 137-145
39. Pompeiano M., Palacios J.M., and Mengod G. Distribution and cellular localization of mRNA coding for 5-HT1A receptor in the rat brain: correlation with receptor binding. J Neurosci 12 (1992) 440-453
40. Raje S., Patat A.A., Parks V., Schechter L., Plotka A., Paul J., et al. A positron emission tomography study to assess binding of Lecozotan, a novel 5-hydroxytryptamine-1A silent antagonist, to brain 5-HT(1A) receptors in healthy young and elderly subjects, and in patients with Alzheimer's disease. Clin Pharmacol Ther (2007)
41. Ramboz S., Oosting R., Amara D.A., Kung H.F., Blier P., Mendelsohn M., et al. Serotonin receptor 1A knockout: an animal model of anxiety-related disorder. Proc Natl Acad Sci U S A 95 (1998) 14476-14481
42. Sanger D.J., and Joly D. Performance of a passive avoidance response is disrupted by compounds acting at 5HT(1A) receptors. Behav Pharmacol 1 (1989) 235-240
43. Sarnyai Z., Sibille E.L., Pavlides C., Fenster R.J., McEwen B.S., and Toth M. Impaired hippocampal-dependent learning and functional abnormalities in the hippocampus in mice lacking serotonin(1A) receptors. Proc Natl Acad Sci U S A 97 (2000) 14731-14736
44. Schechter L.E., Smith D.L., Rosenzweig-Lipson S., Sukoff S.J., Dawson L.A., Marquis K., et al. Lecozotan (SRA-333): a selective serotonin 1A receptor antagonist that enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties. J Pharmacol Exp Ther 314 (2005) 1274-1289
45. Simpson M.D., Lubman D.I., Slater P., and Deakin J.F. Autoradiography with [3H]8-OH-DPAT reveals increases in 5-HT(1A) receptors in ventral prefrontal cortex in schizophrenia. Biol Psychiatry 39 (1996) 919-928
46. Sirvio J., Riekkinen Jr. P., Jakala P., and Riekkinen P.J. Experimental studies on the role of serotonin in cognition. Prog Neurobiol 43 (1994) 363-379
47. Sprouse J.S., and Aghajanian G.K. Responses of hippocampal pyramidal cells to putative serotonin 5-HT1A and 5-HT1B agonists: a comparative study with dorsal raphe neurons. Neuropharmacology 27 (1988) 707-715
48. Tauscher J., Verhoeff N.P., Christensen B.K., Hussey D., Meyer J.H., Kecojevic A., et al. Serotonin 5-HT1A receptor binding potential declines with age as measured by [11C]WAY-100635 and PET. Neuropsychopharmacology 24 (2001) 522-530
49. Tauscher J., Kapur S., Verhoeff N.P., Hussey D.F., Daskalakis Z.J., Tauscher-Wisniewski S., et al. Brain serotonin 5-HT(1A) receptor binding in schizophrenia measured by positron emission tomography and [11C]WAY-100635. Arch Gen Psychiatry 59 (2002) 514-520
50. Topic B., Willuhn I., Palomero-Gallagher N., Zilles K., Huston J.P., and Hasenohrl R.U. Impaired maze performance in aged rats is accompanied by increased density of NMDA, 5-HT1A, and alpha-adrenoceptor binding in hippocampus. Hippocampus 17 (2007) 68-77
51. Truchot L., Costes S.N., Zimmer L., Laurent B., Le Bars D., Thomas-Anterion C., et al. Up-regulation of hippocampal serotonin metabolism in mild cognitive impairment. Neurology 69 (2007) 1012-1017
52. Van den Hooff P., and Galvan M. Actions of 5-hydroxytryptamine and 5-HT1A receptor ligands on rat dorso-lateral septal neurones in vitro. Br J Pharmacol 106 (1992) 893-899
53. Voigt J.P., Morgenstern E., and Fink H. Memory-enhancing effects of benzodiazepines in mice. Eur Neuropsychopharmacology 6 (1996) 253-255
54. Voits M., Fink H., Gerhardt P., and Huston J.P. Application of 'nose-poke habituation' validation with post-trial diazepam- and cholecystokinin-induced hypo- and hypermnesia. J Neurosci Methods 57 (1995) 101-105
55. Yamada J., Sugimoto Y., and Horisaka K. The behavioural effects of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in mice. Eur J Pharmacol 154 (1988) 299-304