Stimulation of 5-HT1A receptors in the dorsal raphe ameliorates the impairment of spatial learning caused by intrahippocampal 7-chloro-kynurenic acid in naive and pretrained rats

Psychopharmacology

Volumn 158, Issue 1, 2001, Pages 39-47

  Carli, M ^a   Balducci, C ^a   Samanin, R ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

7 Chloro kynurenic acid; Dorsal raphe; Hippocampus; Non spatial pretraining; Presynaptic 5 HT1A receptor; Rat; Spatial learning

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 7 CHLOROKYNURENIC ACID; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; N METHYL DEXTRO ASPARTIC ACID; SEROTONIN 1A AGONIST; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; WATER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CONTROLLED STUDY; DECISION MAKING; DORSAL RAPHE NUCLEUS; DRUG EFFECT; MALE; MAZE TEST; NONHUMAN; PARAMETER; PRIORITY JOURNAL; RAT; SPATIAL DISCRIMINATION; SWIMMING; TASK PERFORMANCE; TRAINING; AMNESIA; ANIMAL MODEL; BEHAVIOR DISORDER; CANNULATION; DISCRIMINATION LEARNING; HIPPOCAMPUS; LEARNING; PYRAMIDAL NERVE CELL;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; CONDITIONING, OPERANT; EXCITATORY AMINO ACID ANTAGONISTS; HIPPOCAMPUS; KYNURENIC ACID; MALE; MAZE LEARNING; PIPERAZINES; PYRIDINES; RAPHE NUCLEI; RATS; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SPACE PERCEPTION;

EID: 0034794409     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130100837     Document Type: Article

References (46)

1. A novel NMDA antagonist, MK-801, impairs performance in a hippocampal-dependent spatial learning task
2. Testing the NMDA, long-term potentiation, and cholinergic hypotheses of spatial learning
3. 1A receptors
4. 1A receptor antagonist, prevents the impairment of spatial learning caused by intrahippocampal administration of scopolamine or 7-chloro-kynurenic acid
5. 1A receptors in the dorsal raphe reverses the impairment of spatial learning caused by intrahippocampal scopolamine in rats
6. 1A receptor antagonist, prevent the impairment of spatial learning caused by blockade of hippocampal NMDA receptors
7. 1A receptors in the dorsal raphe
8. 1A receptors control 5-HT release in the rat medial prefrontal cortex
9. 1A receptor agonists improve the performance of normal and scopolamine-impaired rats in an operant delayed matching to position task
10. Spatial memory, habituation, and reaction to spatial and nonspatial changes in rats with selective lesions of the hippocampus, the entorhinal cortex or the subiculum
11. 1A receptor antagonist and an SSRI in vivo: Effects on 5-HT cell firing and extracellular 5-HT
12. Density and distribution of NMDA receptors in the human hippocampus in Alzheimer's disease
13. Circuitry of the frontal cortex and the regulation of behaviour by representational knowledge
14. Role of 5-HT in stress, anxiety, and depression
15. Effects of acute and chronic treatment with the selective receptor antagonist WAY-100635 on hippocampal 5-HT1A 5-HT release in vivo
16. Therapeutic effect of THA on hemicolinium-3-induced learning impairment is independent of serotonergic and noradrenergic system
17. 5-Hydroxytryptamine pathways in anxiety and its treatment
18. 1-like and GABA receptors in the dorsal raphe nucleus of the rat
19. Quinolinic acid lesion of the rat entorhinal cortex pars medialis produces selective amnesia in allocentric working memory (WM), but not in egocentric WM
20. Entorhinal-hippocampal interactions revealed by real-time imaging
21. Administration of 8-hydroxy-2-(di-n-propylamino)tetralin in raphe nuclei dorsalis and medianus reduces serotonin synthesis in the rat brain: Differences in potency and regional sensitivity
22. 1A receptors in the effects of acute and chronic fluoxetine on extra-cellular serotonin in the frontal cortex
23. 1A receptor enhances acetylcholine release in conscious rats
24. Structure and function of the brain serotonin system
25. The serotonergic innervation of cerebral cortex: Different classes of axon terminals arise from dorsal and median raphe nuclei
26. 1A autoreceptors of the dorsal and median raphe nuclei
27. Chlordiazepoxide, an anxiolytic benzodiazepine impairs place navigation in rats
28. Central cholinergic pathways in the rat: An overview based on an alternative nomenclature (Ch1-Ch6)
29. D-Cycloserine, a positive modulator of the N-methyl-D-aspartate receptor, enhances performance of learning task in rats
30. Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5
31. D-Cycloserine, a glycine site agonist, reverses working memory failure by hippocampal muscarinic receptor blockade in rats
32. Effects of intrahippocampal injections of N-methyl-D-aspartate receptor antagonists and scopolamine on working and reference memory assessed in rats by a three-panel runway
33. Intrahippocampal administration of a glycine site antagonist impairs working memory performance of rats
34. The effects of NMDA-induced retrohippocampal lesions on performance of four spatial memory tasks known to be sensitive to hippocampal damage in the rat
35. 3H)MK-801 binding in Alzheimer's disease
36. From arousal to cognition: The integrative position of the prefrontal cortex
37. Spatial learning without NMDA receptor-dependent long-term potentiation
38. Serotonin reduces synaptic excitation of principal cells in the superficial layers of rat hippocampal-entorhinal cortex combined slices
39. Dissociation between cognitive and motor/motivational deficits in the delayed matching to position test: Effects of scopolamine, 8-OH-DPAT and EAA antagonists
40. Antagonism of NMDA receptors impairs acquisition but not retention of olfactory memory
41. Differential effect of NMDA on extracellular serotonin in rat midbrain raphe and forebrain sites
42. The role of central 5-HT in spatial delayed non-matching to sample performance
43. Involvement of glycine site associate with the NMDA receptor in hippocampal long-term potentiation and acquisition of spatial memory in rats
44. Human amnesia and the medial temporal region: Enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus