Expression of hepatocyte nuclear factor 4α in developing mice

Journal of Veterinary Medicine Series C: Anatomia Histologia Embryologia

Volumn 38, Issue 1, 2009, Pages 34-41

  Kanazawa, T ^a   Konno, A ^a   Hashimoto, Y ^a   Kon, Y ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HEPATOCYTE NUCLEAR FACTOR 4; MESSENGER RNA;

ANIMAL; ARTICLE; C57BL MOUSE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOHISTOCHEMISTRY; KIDNEY; METABOLISM; MOUSE; NEWBORN; PRENATAL DEVELOPMENT; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; ANIMALS, NEWBORN; GENE EXPRESSION REGULATION; HEPATOCYTE NUCLEAR FACTOR 4; IMMUNOHISTOCHEMISTRY; KIDNEY; MICE; MICE, INBRED C57BL; PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; UP-REGULATION;

MUS;

EID: 58449110584     PISSN: 03402096     EISSN: 14390264     Source Type: Journal    
DOI: 10.1111/j.1439-0264.2008.00889.x     Document Type: Article

References (27)

1. Bard, J. B., 2002 : Growth and death in the developing mammalian kidney: signals, receptors and conversations. Bioessays 24, 72 82.
2. Chen, W. S., K. Manova, D. C. Weinstein, S. A. Duncan, A. S. Plump, V. R. Prezioso, R. F. Bachvarova J. E. Jr., Darnell, 1994 : Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. Genes Dev. 8, 2466 2477.
3. Chiba, H., N. Sakai, M. Murata, M. Osanai, T. Ninomiya, T. Kajima N. Sawada, 2006 : The nuclear receptor hepatocyte nuclear factor 4α acts as a morphogen to induce the formation of microvilli. J. Cell Biol. 175, 971 980.
4. Davies, J. A. C. E. Fisher, 2002 : Genes and proteins in renal development. Exp. Nephrol. 10, 102 113.
5. Duncan, S. A., K. Manova, W. C. Chen, P. Hoodless, D. C. Weinstein, R. F. Bachvarova J. E. Jr., Darnell, 1994 : Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst. Proc. Natl Acad. Sci. USA 91, 7598 7602.
6. Duncan, S. A., A. Nagy W. Chan, 1997 : Murine gastrulation requires HNF-4 regulated gene expression in the visceral endoderm: tetraploid rescue of Hnf-4(-/-) embryos. Development 124, 279 287.
7. Eeckhoute, J., E. Moerman, T. Bouckenooghe, B. Lukoviak, F. Pattou, P. Formstecher, J. Kerr-Conte, B. Vandewalle B. Laine, 2003 : Hepatocyte nuclear factor 4α isoforms originated from the P1 promoter are expressed in human pancreatic β-cells and exhibit stronger transcriptional potentials than P2 promoter-driven isoforms. Endocrinology 144, 1686 1694.
8. Furuta, H., N. Iwasaki, Y. Hinokio, Y. Horikawa, K. Yamagata, N. Yano, J. Sugahiro, M. Ogata, H. Ohgawara, Y. Omori, Y. Iwamoto G. I. Bell, 1997 : Organization and partial sequence of the hepatocyte nuclear factor-4α/ MODY1 gene and identification of a missense mutation, R127W, in a Japanese family with MODY. Diabetes 46, 1652 1657.
9. Hadzopoulou-Cladaras, M., E. Kistanova, C. Evagelopoulou, S. Zeng, C. Cladaras J. A. Ladias, 1997 : Functional domains of the nuclear receptor hepatocyte nuclear factor 4. J. Biol. Chem. 272, 539 550.
10. Hayhurst, G. P., Y. H. Lee, G. Lambert, J. M. Ward F. J. Gonzalez, 2001 : Hepatocyte nuclear factor 4α (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol. Cell. Biol. 21, 1393 1403.
11. Jiang, S., T. Tanaka, H. Iwanari, H. Hotta, H. Yamashita, J. Kumakura, Y. Watanabe, Y. Uchiyama, H. Aburatani, T. Hamakubo, T. Kodama M. Naito, 2003 : Expression and localization of P1 promoter-driven hepatocyte nuclear factor-4α (HNF4α) isoforms in human and rats. Nucl. Recept. 1, 5 Available at: http://www.nuculear-receptor.com/content/1/1/5.
12. Jung, J., M. Zheng, M. Goldfarb K. S. Zaret, 1999 : Initiation of mammalian liver development from endoderm by fibroblast growth factors. Science 284, 1998 2003.
13. Kaufman, M. H., 1992 : The Atlas of Mouse Development. Tokyo : Academic Press.
14. Li, J., G. Ning S. A. Duncan, 2000 : Mammalian hepatocyte differentiation requires the transcription factor HNF4α. Genes Dev. 14, 464 474.
15. Lucas, B., K. Grigo, S. Erdmann, J. Lausen, L. Klein-Hitpass G. U. Ryffel, 2005 : HNF4α reduces proliferation of kidney cells and affects genes deregulated in renal cell carcinoma. Oncogene 24, 6418 6431.
16. Nakhei, H., A. Lingott, I. Lemm G. U. Ryffel, 1998 : An alternative splice variant of the tissue specific transcription factor HNF4α predominates in undifferentiated murine cell types. Nucleic Acid Res. 26, 497 504.
17. Ninomiya, T., Y. Hayashi, K. Saijoh, K. Ohta, S. Yoon, H. Nakabayashi, T. Tamaoki, M. Kasuga H. Itoh, 1996 : Expression ratio of hepatocyte nuclear factor-1 to variant hepatocyte nuclear factor-1 in differentiation of hepatocellular carcinoma and hepatoblastoma. J. Hepatol. 25, 445 453.
18. Parviz, F., C. Matullo, W. D. Garrison, L. Savatski, J. W. Adamson, G. Ning, K. H. Kaestner, J. M. Rossi, K. S. Zaret S. A. Duncan, 2003 : Hepatocyte nuclear factor 4α controls the development of a hepatic epithelium and liver morphogenesis. Nat. Genet. 34, 292 296.
19. Sel, S., T. Ebert, G. U. Ryffel T. Drewes, 1996 : Human renal cell carcinogenesis is accompanied by a coordinate loss of the tissue specific transcription factors HNF4α and HNF1α. Cancer Lett. 101, 205 210.
20. Sladek, F. M., W. M. Zhong, E. Lai I. E. Darnel, 1990 : Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes Dev. 4, 2353 2365.
21. Taraviras, S., A. P. Monaghan, G. Schütz G. Kelsey, 1994 : Characterization of the mouse HNF-4 gene and its expression during mouse embryogenesis. Mech. Dev. 48, 67 79.
22. Thomas, H., K. Jaschkowitz, M. Bulman, T. M. Frayling, S. M. S. Mitchell, S. Roosen, A. Lingott-Frieg, C. J. Tack, S. Ellard, G. U. Ryffel A. T. Hattersley, 2001 : A distinct upstream promoter of the HNF4α gene connects the transcription factors involved in maturity-onset diabetes of the young. Human Mol. Genet. 10, 2089 2097.
23. Tirona, R. G., W. Lee, B. F. Leake, L. B. Lan, C. B. Cline, V. Lamda, F. Parviz, S. A. Duncan, Y. Inoue, F. J. Gonzalez, E. G. Schütz R. B. Kim, 2003 : The orphan nuclear receptor EEεNεF4α determines PXR- and CAR-mediated xenobiotic induction of CYP3A4. Nat. Med. 9, 220 224.
24. Torres-Padilla, M. E., F. M. Sladek M. C. Weiss, 2002 : Developmentally regulated N-terminal variants of the nuclear receptor hepatocyte nuclear factor 4α mediate multiple interactions through coactivator and corepressor-histone deacetylase complexes. J. Biol. Chem. 277, 44677 44687.
25. Watt, A. J., W. D. Garrison S. A. Duncan, 2003 : HNF4: a central regulator of hepatocyte differentiation and function. Hepatology 37, 1249 1253.
26. Winter, W. E. J. H. Silverstein, 2000 : Molecular and genetic bases for maturity onset diabetes of youth. Curr. Opin. Pediatr. 12, 388 393.
27. Yamagata, K., H. Furuta, N. Oda, P. J. Kaisaki, S. Menzel, N. J. Cox, S. S. Fajans, S. Signorini, M. Stoffel G. I. Bell, 1996 : Mutations in the hepatic nuclear factor-4α gene in maturity-onset diabetes of the young (MODY1). Nature 384, 458 460.