Adjudin-mediated germ cell depletion alters the anti-oxidant status of adult rat testis

Molecular Reproduction and Development

Volumn 76, Issue 1, 2009, Pages 31-37

  Sarkar, Oli ^a   Mathur, P P ^a  

^a PONDICHERRY UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ADJUDIN; ANDROGEN; ANDROGEN BINDING PROTEIN; CATALASE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; HYDRAZIDE DERIVATIVE; HYDROGEN PEROXIDE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GERM CELL; HORMONE TRANSPORT; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; TESTIS;

AGING; ANDROGEN-BINDING PROTEIN; ANIMALS; ANTIOXIDANTS; CELL SURVIVAL; GERM CELLS; HYDRAZINES; INDAZOLES; MALE; ORGAN SIZE; RATS; RATS, WISTAR; TESTIS;

MAMMALIA; RATTUS;

EID: 58449088225     PISSN: 1040452X     EISSN: 10982795     Source Type: Journal    
DOI: 10.1002/mrd.20928     Document Type: Article

References (44)

1. Agarwal A, Saleh RA, Bedaiwy MA. 2003. Role of reactive oxygen species in the pathophysiology of human reproduction. Fert Steril 79:829-843.
2. Aitken RJ. 1995. Free radicals, lipid peroxidation and sperm function. Reprod Fert Dev 7:659-668.
3. Chapin RE, Harris MW, Davis BJ, Ward SM, Wilson RE, Mauney MA, Lockhart AC, Smialowicz RJ, Moser VC, Burka LT, Collins BJ. 1997. The effects of perinatal/juvenile methoxychlor exposure on adult rat nervous, immune, and reproductive system function. Fundam Appl Toxicol 40:138-157.
4. Cheng CY, Silvestrini B, Grima J, Mo MY, Zhu LJ, Johansson E, Saso L, Leone MG, Palmery M, Mruk DD. 2001. Two new male contraceptives exert their effects by depleting germ cells prematurely from the testis. Biol Reprod 65:449-461.
5. Chiarugi P, Pani G, Giannoni E, Taddei L, Colavitti R, Raugei G, Symons M, Borrello S, Galeotti T, Ramponi G. 2003. Reactive oxygen species as essential mediators of cell adhesion: The oxidative inhibition of a FAK tyrosine phosphatase is required for cell adhesion. J Cell Biol 161:933-944.
6. Claiborne A. 1985. Catalase activity. In: Greenwald R, editor. CRC handbook of methods for oxygen radical research.Boca Raton: CRC Press. p283.
7. CPCSEA. 2003. CPCSEA guidelines for laboratory animal facility. Indian J Pharmacol 35:257-274.
8. Ford WC. 2004. Regulation of sperm function by reactive oxygen species. Hum Reprod Update 10:387-399.
9. 2 at physiological concentrations modulates Leydig cell function inducing oxidative stress and apoptosis. Apoptosis 11:39-46.
10. Gil-Guzman E, Ollero M, Lopez MC, Sharma RK, Alvarez JG, Thomas AJ, Jr., Agarwal A. 2001. Differential production of reactive oxygen species by subsets of human spermatozoa at different stages of maturation. Hum Reprod 16:1922-1930.
11. Grima J, Silvestrini B, Cheng CY. 2001. Reversible inhibition of spermatogenesis in rats using a new male contraceptive, 1-(2,4-dichlorobenzyl)- indazole-3-carbohydrazide. Biol Reprod 64:1500-1508.
12. Guitton N, Touzalin AM, Sharpe RM, Cheng CY, Pinon-Lataillade G, Meritte H, Chenal C, Jegou B. 2000. Regulatory influence of germ cells on Sertoli cell function in the pre-pubertal rat after acute irradiation of the testis. Int J Androl 23:332-339.
13. Gunsalus GL, Larrea F, Musto NA, Becker RR, Mather JP, Bardin CW. 1981. Androgen binding protein as a marker for Sertoli cell function. J Steroid Biochem 15:99-106.
14. Habig WH, Pabst MJ, Jakoby WB. 1974. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 249:7130-7139.
15. Laemmli UK. 1970. Cleavage of structural proteins during assembly of the head if the Bacteriophage T4. Nature 227:680-685.
16. Latchoumycandane C, Mathur PP. 2002. Effect of methoxychlor on the antioxidant system in mitochondrial and microsome-rich fractions of rat testis. Toxicology 176:67-75.
17. Latchoumycandane C, Chitra KC, Mathur PP. 2002. Induction of oxidative stress in the rat epididymal sperm after exposure to 2,3,7,8-tetrachlorodibenzo- p-dioxin. Arch Toxicol 76:113-118.
18. Lee HS, Namkoong K, Kim DH, Kim KJ, Cheong YH, Kim SS, Lee WB, Kim KY. 2004. Hydrogen peroxide-induced alterations of tight junction proteins in bovine brain microvascular endothelial cells. Microvasc Res 68:231-238.
19. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275.
20. Marklund S, Marklund G. 1974. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 47:469-474.
21. Mruk DD, Cheng CY. 2004a. Sertoli-Sertoli and Sertoli-germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis. Endocr Rev 25:747-806.
22. Mruk DD, Cheng CY. 2004b. Cell-cell interactions at the ectoplasmic specialization in the testis. Trends Endocrinol Metab 15:439-447.
23. Mruk DD, Wong CH, Silvestrini B, Cheng CY. 2006. A male contraceptive targeting germ cell adhesion. Nat Med 12:1323-1328.
24. Murugesan P, Muthusamy T, Balasubramanian K, Arunakaran J. 2007. Effects of vitamins C and E on steroidogenic enzymes mRNA expression in polychlorinated biphenyl (Aroclor 1254) exposed adult rat Leydig cells. Toxicology 232:170-182.
25. Ochsendorf FR. 1999. Infections in the male genital tract and reactive oxygen species. Hum Reprod Update 5:399-420.
26. Ohkawa H, Ohishi N, Yagi K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351-358.
27. Pick E, Keisari Y. 1981. Superoxide anion and hydrogen peroxide production by chemically elicited peritoneal macrophages - Induction by multiple nonphagocytic stimuli. Cell Immunol 59:301-318.
28. Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG. 1973. Selenium: Biochemical role as a component of glutathione peroxidase. Science 179:588-590.
29. Saenz-Morales D, Escribese MM, Stamatakis K, Garcia-Martos M, Alegre L, Conde E, Perez-Sala D, Mampaso F, Garcia-Bermejo ML. 2006. Requirements for proximal tubule epithelial cell detachment in response to ischemia: Role of oxidative stress. Exp Cell Res 312:3711-3727.
30. Saradha B, Vaithinathan S, Mathur PP. 2008. Single exposure to low dose of lindane causes transient decrease in testicular steroidogenesis in adult male Wistar rats. Toxicology 244:190-197.
31. Sarkar O, Xia W, Mruk DD. 2006. Adjudin-mediated junction restructuring in the seminiferous epithelium leads to displacement of soluble guanylate cyclase from adherens junctions. J Cell Phys 208:175-187.
32. Sarkar O, Mathur PP, Mruk DD. 2008. Nitric Oxide-cGMP signaling: its role in cell junction dynamics during spermatogenesis. Immunol Endocr Metab Agents Med Chem 8:28-35.
33. Senthil Kumar J, Banudevi S, Sharmila M, Murugesan P, Srinivasan N, Balasubramanian K, Aruldhas MM, Arunakaran J. 2004. Effects of Vitamin C and E on PCB (Aroclor 1254) induced oxidative stress, androgen binding protein and lactate in rat Sertoli cells. Reprod Toxicol 19:201-208.
34. Sikka SC. 1996. Oxidative stress and role of antioxidants in normal and abnormal sperm function. Front Biosci 1:e78-e86.
35. Sikka SC, Rajasekaran M, Hellstrom WJ. 1995. Role of oxidative stress and antioxidants in male infertility. J Androl 16:464-468.
36. Siu MK, Mruk DD, Lee WM, Cheng CY. 2003. Adhering junction dynamics in the testis are regulated by an interplay of β1-integrin and focal adhesion complex-associated proteins. Endocrinology 144:2141-2163.
37. Spitz IM, Gunsalus GL, Mather JP, Thau R, Bardin CW. 1985. The effects of the indazole carboxylic acid derivative, tolnidamine, on testicular function. I. Early changes in androgen binding protein secretion in the rat. J Androl 6:171-178.
38. Steinberger A, Steinberger E. 1971. Replication pattern of Sertoli cells in maturing rat testis in vivo and in organ culture. Biol Reprod 4:84-87.
39. Sujatha R, Chitra KC, Latchoumycandane C, Mathur PP. 2001. Effect of lindane on testicular antioxidant system and steroidogenic enzymes in adult rats. Asian J Androl 3:135-138.
40. Vogl AW, Pfeiffer DC, Mulholland D, Kimel G, Guttman J. 2000. Unique and multifunctional adhesion junctions in the testis: Ectoplasmic specializations. Arch Histol Cytol 63:1-15.
41. Wolski KM, Perrault C, Tran-Son-Tay R, Cameron DF. 2005. Strength measurement of the Sertoli-spermatid junctional complex. J Androl 26:354-359.
42. Wolski KM, Mruk DD, Cameron DF. 2006. The Sertoli-spermatid junctional complex adhesion strength is affected in vitro by Adjudin. J Androl 27:790-794.
43. Xia W, Mruk DD, LeeWM, Cheng CY. 2005. Cytokines and junction restructuring during spermatogenesis - A lesson to learn from the testis. Cytokine Growth Factor Rev 16:469-493.
44. Yan HH, Cheng CY. 2005. Blood-testis barrier dynamics are regulated by an engagement/disengagement mechanism between tight and adherens junctions via peripheral adaptors. Proc Natl Acad Sci USA 102:11722-11727.