Reversible inhibition of spermatogenesis in rats using a new male contraceptive, 1-(2,4-dichlorobenzyl)-indazole-3-carbohydrazide

Biology of Reproduction

Volumn 64, Issue 5, 2001, Pages 1500-1508

  Grima, J ^a   Silvestrini, B ^a   Yan Cheng, C ^a  

^a POPULATION COUNCIL   (United States)

Author keywords

Sertoli cells; Spermatogenesis; Testis

Indexed keywords

AF 2364; FOLLITROPIN; LONIDAMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN FUNCTION; CHEMISTRY; CONTRACEPTION; FERTILITY; HORMONE DETERMINATION; KIDNEY FUNCTION; LIVER FUNCTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROSTATE; RAT; SPERMATOGENESIS;

ANIMALIA;

EID: 0035027440     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod64.5.1500     Document Type: Article

References (22)

1. Status of male contraception: Hormonal approach
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3. Lonidamine and related compounds
4. Pharmacological investigations on lonidamine
5. The cytoskeleton as a target of the antineoplastic drug lonidamine
6. Morphological, histochemical and biochemical studies on germ cell mitochondria of normal rats
7. Effects of AF1312TS and lonidamine on mammalian testis. A morphological study
8. Testin is tightly associated with testicular cell membrane upon its secretion by Sertoli cells whose steady-state mRNA level in the testis correlates with the turnover and integrity of inter-testicular cell junctions
9. Two novel male contraceptives exert their effects by depleting germ cells prematurely from the testis
10. Testin secreted by Sertoli cells is associated with the cell surface, and its expression correlates with the disruption of Sertoli-germ cell junctions but not the inter-Sertoli tight junctions
11. Cyclic and postnatal developmental changes of testin in the rat seminiferous epithelium-an immunohistochemical study
12. Rat testin is a newly identified component of the junctional complexes in various tissues whose mRNA is predominately expressed in the testis and ovary
13. Germ cell control of testin production is inverse to that of other Sertoli cell products
14. Testins are structurally related to the mouse cysteine proteinase precursor proregion but devoid of any protease/anti-protease activity
15. Toxicology studies on 1-substituted-indazole-3-carboxylic acids
16. The structure and function of the epididymis. 1. The histology of the rat epididymis
17. Protein and cell membrane iodinations with a sparingly soluble chloramide 1,3,4,6-tetrachloro-3α, 6α-diphenyl-glycoluril
18. Effects of lonidamine (AF1890) and its analogues on follicle-stimulating hormone, luteinizing hormone, testosterone and rat androgen binding protein concentrations in the rat and rhesus monkey
19. Characterization of the exfoliative antispermatogenic agent 1-(2,4-dicholorbenzyl)-1H-indazole-3-carboxylic acid in the rhesus monkey
20. Endocrine control of the development and maintenance of sperm fertilizing ability in the epididymis
21. Effects of ligation, orchidectomy and hypophysectomy on expression of the Yf subunit of GST-P in prinicpal and basal cells of the adult rat epididymis and on basal cell shape and overall arrangement