In vitro and in vivo characterisation of anti-murine IL-13 antibodies recognising distinct functional epitopes

International Immunopharmacology

Volumn 9, Issue 2, 2009, Pages 201-206

  Berry, L M ^a   Adams, R ^a   Airey, M ^a   Bracher, M G ^a   Bourne, T ^a   Carrington, B ^a   Cross, A S ^a   Davies, G C G ^a   Finney, H M ^a   Foulkes, R ^a   Gozzard, N ^a   Griffin, R A ^a   Hailu, H ^a   Lamour, S D ^a   Lawson, A D ^a   Lightwood, D J ^a   McKnight, A J ^a   O'Dowd, V L ^a   Oxbrow, A K F ^a   Popplewell, A G ^a   Shaw, S ^a   Stephens, P E ^a   Sweeney, B ^a   Tomlinson, K L ^a   Uhe, C ^a   Palframan, R T ^a   more..

^a UCB   (United Kingdom)

Author keywords

IL 13; IL 13R 1; IL 13R 2; IL 4R ; STAT 6

Indexed keywords

EOTAXIN; EPITOPE; INTERLEUKIN 13 ANTIBODY; INTERLEUKIN 4 ANTIBODY; MESSENGER RNA; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY A; MONOCLONAL ANTIBODY B; MUCIN 5AC; RECOMBINANT INTERLEUKIN 13; STAT6 PROTEIN; UNCLASSIFIED DRUG;

ALLERGY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN BINDING; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL PROLIFERATION; CONCENTRATION RESPONSE; DRUG INHIBITION; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; IN VITRO STUDY; LUNG PARENCHYMA; MALE; MOUSE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; TRANSCRIPTION INITIATION; UPREGULATION;

EID: 58249126458     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2008.11.001     Document Type: Article

References (29)

1. Wills-Karp M. Interleukin-13 in asthma pathogenesis. Immunol Rev 202 (2004) 175-190
2. Grunig G., Warnock M., Wakil A.E., Venkayya R., Brombacher F., and Rennick D.M. Requirement for IL-13 independently of IL-4 in experimental asthma. Science 282 5397 (1998) 2261-2263
3. van der Pouw Kraan T.C., van der Zee J.S., Boeije L.C., de Groot E.R., Stapel S.O., and Aarden L.A. The role of IL-13 in IgE synthesis by allergic asthma patients. Clin Exp Immunol 111 1 (1998) 129-135
4. Kolodsick J.E., Toews G.B., Jakubzick C., Hogaboam C., Moore T.A., and McKenzie A. Protection from fluorescein isothiocyanate-induced fibrosis in IL-13-deficient, but not IL-4-deficient, mice results from impaired collagen synthesis by fibroblasts. J Immunol 172 7 (2004) 4068-4076
5. Tliba O., Deshpande D., Chen H., Van Besien C., Kannan M., and Panettieri Jr. R.A. IL-13 enhances agonist-evoked calcium signals and contractile responses in airway smooth muscle. Br J Pharmacol 140 7 (2003) 1159-1162
6. Walter D.M., McIntire J.J., Berry G., McKenzie A.N., Donaldson D.D., DeKruyff R.H., et al. Critical role for IL-13 in the development of allergen-induced airway hyperreactivity. J Immunol 167 8 (2001) 4668-4675
7. Yang G., Volk A., Petley T., Emmell E., Giles-Komar J., Shang X., et al. Anti-IL-13 monoclonal antibody inhibits airway hyperresponsiveness, inflammation and airway remodeling. Cytokine 28 6 (2004) 224-232
8. Kasaian M.T., Donaldson D.D., Tchistiakova L., Marquette K., Tan X.Y., Ahmed A., et al. Efficacy of IL-13 neutralization in a sheep model of experimental asthma. Am J Respir Cell Mol Biol 36 3 (2007) 368-376
9. Bree A., Schlerman F.J., Wadanoli M., Tchistiakova L., Marquette K., Tan X.Y., et al. IL-13 blockade reduces lung inflammation after Ascaris suum challenge in cynomolgus monkeys. J Allergy Clin Immunol 119 5 (2007) 1251-1257
10. Andrews A.L., Holloway J.W., Holgate S.T., and Davies D.E. IL-4 receptor alpha is an important modulator of IL-4 and IL-13 receptor binding: implications for the development of therapeutic targets. J Immunol 176 12 (2006) 7456-7461
11. Arima K., Sato K., Tanaka G., Kanaji S., Terada T., Honjo E., et al. Characterization of the Interaction between interleukin-13 and interleukin-13 receptors. J Biol Chem 280 26 (2005) 24915-24922
12. Wood N., Whitters M.J., Jacobson B.A., Witek J., Sypek J.P., Kasaian M., et al. Enhanced interleukin (IL)-13 responses in mice lacking IL-13 receptor alpha 2. J Exp Med 197 6 (2003) 703-709
13. Fichtner-Feigl S., Strober W., Kawakami K., Puri R.K., and Kitani A. IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis. Nat Med 12 1 (2006) 99-106
14. Kasaian M.T., Tan X.Y., Jin M., Fitz L., Marquette K., Wood N., et al. Interleukin-13 neutralization by two distinct receptor blocking mechanisms reduces immunoglobulin E responses and lung inflammation in cynomolgus monkeys. J Pharmacol Exp Ther 325 3 (2008) 882-892
15. Babcook J.S., Leslie K.B., Olsen O.A., Salmon R.A., and Schrader J.W. A novel strategy for generating monoclonal antibodies from single, isolated lymphocytes producing antibodies of defined specificities. Proc Natl Acad Sci 93 15 (1996) 7843-7848
16. Tony H.P., Shen B.J., Reusch P., and Sebald W. Design of human interleukin-4 antagonists inhibiting interleukin-4-dependent and interleukin-13-dependent responses in T-cells and B-cells with high efficiency. Eur J Biochem 225 2 (1994) 659-665
17. Malmqvist M., and Karlsson R. Biomolecular interaction analysis: affinity biosensor technologies for functional analysis of proteins. Curr Opin Chem Biol 1 3 (1997) 378-383
18. Wenzel S.E., Trudeau J.B., Barnes S., Zhou X., Cundall M., Westcott J.Y., et al. TGF-beta and IL-13 synergistically increase eotaxin-1 production in human airway fibroblasts. J Immunol 169 8 (2002) 4613-4619
19. Liu J.B., Zhang Z.X., Xu Y.J., Xing L.H., and Zhang H.L. [Effects of interleukin-13 on the gob-5 and MUC5AC expression in lungs of a murine asthmatic model]. Zhonghua Jie He He Hu Xi Za Zhi 27 12 (2004) 837-340
20. Andrews A.L., Holloway J.W., Puddicombe S.M., Holgate S.T., and Davies D.E. Kinetic analysis of the interleukin-13 receptor complex. J Biol Chem 277 48 (2002) 46073-46078
21. Shim J.J., Dabbagh K., Ueki I.F., Dao-Pick T., Burgel P.R., Takeyama K., et al. IL-13 induces mucin production by stimulating epidermal growth factor receptors and by activating neutrophils. Am J Physiol Lung Cell Mol Physiol 280 1 (2001) L134-L140
22. Laoukili J., Perret E., Willems T., Minty A., Parthoens E., Houcine O., et al. IL-13 alters mucociliary differentiation and ciliary beating of human respiratory epithelial cells. J Clin Invest 108 12 (2001) 1817-1824
23. Zheng T., Liu W., Oh S.Y., Zhu Z., Hu B., Homer R.J., et al. IL-13 receptor alpha2 selectively inhibits IL-13-induced responses in the murine lung. J Immunol 180 1 (2008) 522-529
24. Tabata Y., Chen W., Warrier M.R., Gibson A.M., Daines M.O., and Hershey G.K. Allergy-driven alternative splicing of IL-13 receptor alpha2 yields distinct membrane and soluble forms. J Immunol 177 11 (2006) 7905-7912
25. O'Toole M., Legault H., Ramsey R., Wynn T.A., and Kasaian M.T. A novel and sensitive ELISA reveals that the soluble form of IL-13R-alpha2 is not expressed in plasma of healthy or asthmatic subjects. Clin Exp Allergy 38 4 (2008) 594-601
26. Andrews A.L., Nasir T., Bucchieri F., Holloway J.W., Holgate S.T., and Davies D.E. IL-13 receptor alpha 2: a regulator of IL-13 and IL-4 signal transduction in primary human fibroblasts. J Allergy Clin Immunol 118 4 (2006) 858-865
27. Munitz A., Brandt E., Mingler M., Finkelman F.D., and Rothenberg M.E. IL-13 mediated lung effects are exclusively dependent on IL-13Ralpha1 (CD213a). J Allergy Clin Immunol 121 2 (2008) S274
28. Daines M.O., Chen W., Tabata Y., Walker B.A., Gibson A.M., and Masino J.A. Allergen-dependent solubilization of IL-13 receptor alpha2 reveals a novel mechanism to regulate allergy. J Allergy Clin Immunol 119 2 (2007) 375-383
29. Ahn J.H., Kim C.H., Kim Y.H., Kim S.J., Lee S.Y., Kim Y.K., et al. Inflammatory and remodeling events in asthma with chronic exposure to house dust mites: a murine model. J Korean Med Sci 22 6 (2007) 1026-1033