Mechanisms of cytoprotective effect of amino acids on local toxicity caused by sodium laurate, a drug absorption enhancer, in intestinal epithelium

Journal of Pharmaceutical Sciences

Volumn 91, Issue 3, 2002, Pages 730-743

  Endo, Yoko ^a   Hanada, Kiyonori ^a   Miyake, Masateru ^a   Ogawara, Ken Ichi ^a   Higaki, Kazutaka ^a   Kimura, Toshikiro ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

Absorption enhancer; Amino acids; Cytoprotection; Heat shock protein 70; Histamine; Intracellular calcium; Local toxicity

Indexed keywords

AMINO ACID; ARGININE; CALCIUM; GLUTAMINE; HEAT SHOCK PROTEIN 70; LAURATE SODIUM; LAURIC ACID DERIVATIVE; METHIONINE; QUERCETIN; TAURINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL PROTECTION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG FORMULATION; ELECTRIC RESISTANCE; HISTAMINE RELEASE; INTESTINE ABSORPTION; INTESTINE EPITHELIUM; MALE; NONHUMAN; PROTEIN INDUCTION; RAT; TRANSPORT KINETICS; WESTERN BLOTTING;

EID: 0036281181     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10049     Document Type: Article

References (44)

1. Absorption enhancing agents for the GI system
2. Intestinal permeability enhancement for proteins, peptides, and other polar drugs: Mechanisms and potential toxicity
3. Effect of medium-chain glycerides on physiological properties of rabbit intestinal epithelium in vitro
4. Intestinal permeability enhancement: Efficacy, acute local toxicity, and reversibility
5. Absorption enhancement through intracellular regulation of tight junction permeability by medium chain fatty acids in Caco-2 cells
6. Characteristics and therapeutic application of MCT
7. Present situation of nutrition via tubing for patients
8. Studies on the promoting effects of carboxylic acid derivatives on the rectal absorption of β-lactam antibiotics in rats
9. Absorption-enhancing mechanism of sodium caprate and decanoylcarnitine in Caco-2 cells
10. Effect of medium-chain glycerides on the intestinal absorption of phenol red: Studies on the mechanisms of the promoting effect
11. Amino acids protect epithelial cells from local toxicity by absorption enhancer, sodium laurate
12. Effects of permeation enhancers on the transport of a peptidomimetic thrombin inhibitor (CRC 220) in a human intestinal cell line (Caco-2)
13. Glutamine is a powerful effector of heat shock protein expression in Drosophila Kc cells
14. Glutamine protects intestinal epithelial cells: Role of inducible HSP70
15. 2+
16. Reversible oxidant-induced increases in albumin transfer across cultured endothelium: Alterations in cell shape and calcium homeostasis
17. 4-[4-[(2-Hydroxybenzoyl)amino]phenyl]butyric acid as a novel oral delivery agent for recombinant human growth hormone
18. Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond
19. A new enzymatic method for determination of serum choline-containing phospholipids
20. Protein measurement with the Folin phenol reagent
21. Procedures for immunochemical study of histamine release from leukocytes with small volume of blood
22. Enhancement of membrane permeability to a poorly absorbed drugs by medium-chain glycerides: Effect of medium-chain glycerides on the release of phenol red from egg phosphatidylcholine liposomes
23. Enhancement of colonic drug absorption by the transcellular permeation route
24. Quercetin, an inhibitor of heat shock protein synthesis, inhibits the acquisition of thermotolerance in a human colon carcinoma cell line
25. Inhibition of the activation of heat shock factor in vivo and in vitro by flavonoids
26. Mitochondrial metabolism of glutamine and glutamate and its physiologic significance
27. Glutamine is essential for epidermal growth factor-stimulated intestinal cell proliferation
28. Glutamine metabolism by the intestinal tract
29. Glutamine-mediated regulation of heat shock protein expression in intestinal cells
30. Heat shock protein 70 kDa: Molecular biology, biochemistry, and physiology
31. Heat-shock proteins, molecular chaperones, and the stress response: Evolutionary and ecological physiology
32. Reduced thermotolerance in aged cells results from a loss of an hsp72-mediated control of JNK signaling pathway
33. Cellular calcium in health and disease
34. Intracellular calcium homeostasis
35. Calcium-associated cytoprotective effect of taurine on the calcium and oxygen paradoxes in isolated rat hepatocytes
36. Protection against cell damage due to hypoxia and reoxygenation: The role of taurine and the involved mechanisms
37. 2+ sequestration by taurine
38. 2+ exchange current: Lack of effect of taurine
39. Role of increased cytosolic free calcium in the pathogenesis of rabbit proximal tubule cell injury and protection by glycine or acidosis
40. Calcium channel blockers and prostaglandin generation by gastric surface epithelial cells
41. Early ultrastructural changes of surface epithelial cells isolated from rat gastric mucosa after exposure to ethanol with or without 16, 16-dimethylprostaglandin E2
42. Regulation of heat shock protein 72 kDa and 90 kDa in human breast cancer MDA-MB-231 cells
43. Peripheral regulation of gastric acid secretion
44. Histamine, bradykinin and their antagonists