Involvement of intracellular Ca2+ dynamics in cytoprotective action by amino acids and cytotoxicity by sodium laurate, an absorption enhancer

Journal of Pharmaceutical Sciences

Volumn 95, Issue 10, 2006, Pages 2256-2265

  Okuda, Tomoyuki ^a   Kadotsuji, Kenta ^a   Takayama, Chie ^a   Hanada, Kiyonori ^a   Mukaizawa, Fuyuki ^a   Ogawara, Ken Ichi ^a   Higaki, Kazutaka ^a   Kimura, Toshikiro ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

Absorption enhancer; Amino acid; Caco 2 cells; Calcium; L glutamine; Permeability; Safety; Sodium laurate; Taurine; Toxicity

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); AMINO ACID; ARGININE; COMPOUND 48-80; GLUTAMINE; LAURATE SODIUM; LAURIC ACID DERIVATIVE; PHOSPHOLIPASE C INHIBITOR; TAURINE; UNCLASSIFIED DRUG; VANADATE SODIUM; VANADIC ACID; VERAPAMIL; 1,2 BIS(2 AMINOPHENOXY)ETHANE N,N,N',N' TETRAACETIC ACID ACETOXYMETHYL ESTER; 1,2-BIS(2-AMINOPHENOXY)ETHANE N,N,N',N'-TETRAACETIC ACID ACETOXYMETHYL ESTER; 4 METHOXY N METHYLPHENETHYLAMINE; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; CHELATING AGENT; DRUG DERIVATIVE; EGTAZIC ACID; LAURIC ACID;

ARTICLE; BIOAVAILABILITY; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL PROTECTION; CELL STRAIN CACO 2; CONTROLLED STUDY; CYTOTOXICITY; DRUG BIOAVAILABILITY; DRUG EFFECT; DRUG MECHANISM; DYNAMICS; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; INTESTINE EPITHELIUM CELL; HOMEOSTASIS; INTESTINE ABSORPTION; INTESTINE MUCOSA; METABOLISM;

ARGININE; CACO-2 CELLS; CALCIUM; CALCIUM CHANNEL BLOCKERS; CHELATING AGENTS; EGTAZIC ACID; GLUTAMINE; HOMEOSTASIS; HUMANS; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; LAURIC ACIDS; P-METHOXY-N-METHYLPHENETHYLAMINE; TAURINE; VERAPAMIL;

EID: 33749987761     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.20712     Document Type: Article

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