All-trans retinoic acid suppresses interleukin-6 expression in interleukin-1-stimulated synovial fibroblasts by inhibition of ERK1/2 pathway independently of RAR activation

Arthritis Research and Therapy

Volumn 10, Issue 6, 2008, Pages

  Kirchmeyer, Mélanie ^a   Koufany, Meriem ^a   Sebillaud, Sylvie ^a   Netter, Patrick ^a   Jouzeau, Jean Yves ^a   Bianchi, Arnaud ^a  

^a Biopôle de l Université de Lorraine   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRHEUMATIC AGENT; BMS 649; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; RETINOIC ACID; RETINOIC ACID RECEPTOR; RETINOIC ACID RECEPTOR ALPHA; RETINOIC ACID RECEPTOR BETA; RETINOIC ACID RECEPTOR GAMMA; RETINOID X RECEPTOR; RETINOID X RECEPTOR ALPHA; RETINOID X RECEPTOR BETA; RETINOID X RECEPTOR GAMMA; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; INTERLEUKIN 1; MITOGEN ACTIVATED PROTEIN KINASE 3;

ANIMAL CELL; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; DNA FLANKING REGION; DRUG MECHANISM; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FIBROBLAST; IMMUNOASSAY; MALE; NONHUMAN; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SYNOVIOCYTE; SYNOVIUM; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; CELL CULTURE; COMPARATIVE STUDY; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; METABOLISM; PHYSIOLOGY; WISTAR RAT;

ANIMALS; CELLS, CULTURED; FIBROBLASTS; INTERLEUKIN-1; INTERLEUKIN-6; MALE; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; RATS; RATS, WISTAR; RECEPTORS, RETINOIC ACID; SYNOVIAL MEMBRANE; TRETINOIN;

EID: 58249106353     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar2569     Document Type: Article

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