Retinoid antagonism of NF-IL6: Insight into the mechanism of antiproliferative effects of retinoids in Kaposi's sarcoma

Molecular and Cellular Biology

Volumn 17, Issue 7, 1997, Pages 4159-4168

  Nagpal, Sunil ^a   Cai, Jie ^b   Zheng, Tong ^b   Patel, Sheetal ^a   Masood, Rizwan ^b   Lin, George Y ^b   Priant, Sylvie ^a   Johnson, Alan ^c   Smith, D Lynne ^b   Chandraratna, Roshantha A S ^a,c   Gill, Parkash S ^b,d  

^a Department of Biology ^*  (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c ALLERGAN INC   (United States)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [2 (5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYL 2 NAPHTHYL) 1,3 DIOXOLAN 2 YL]BENZOIC ACID; 4 [2 METHYL 1 (5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYL 2 NAPHTHYL) 1 PROPENYL]BENZOIC ACID; ALITRETINOIN; INTERLEUKIN 6; LEUCINE ZIPPER PROTEIN; MESSENGER RNA; NUCLEAR FACTOR; RETINOIC ACID; RETINOIC ACID RECEPTOR; RETINOID; RETINOID X RECEPTOR; TAZAROTENE; TRANSCRIPTION FACTOR;

ARTICLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG MECHANISM; ENHANCER REGION; HELA CELL; HUMAN; HUMAN CELL; KAPOSI SARCOMA; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; SPINDLE CELL; TRANSACTIVATION;

EID: 0030978804     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.17.7.4159     Document Type: Article

References (57)

1. Bartsch, D., B. Boye, C. Baust, H. Zur Hausen, and E. Schwarze. 1992. Retinoic acid-mediated repression of human papillomavirus 18 transcription and different ligand regulation of the retinoic acid receptor β gone in non-tumorigenic and tumorigenic and tumorigenic HeLa hybrid cell. EMBO J. 11:2283-2291.
2. Becherel, P. A., M. D. Mossalayi, L. LeGeoff, C. Frances, O. Chosidow, P. Debris, and M. Arock. 1994. Mechanism of anti-inflammatory action of retinoids on keratinocytes. Lancet ii:1570-1574.
3. Bonhomme, L., G. Fredj, S. Averous, A. M. Szekely, E. Ecstein, B. Trumbic, P. Meyer, J. M. Lang, L. K. Misset, and C. Jasmin. 1991. Topical treatment of epidemic Kaposi's sarcoma with all-trans retinoic acid. Ann. Oncol. 2:234-235.
4. Brasier, A. R., and A. Kumar. 1994. Identification of a novel determinant for basic domain-leucine zipper DNA binding activity in the acute-phase inducible nuclear factor-interleukin-6 transcription factor. J. Biol. Chem. 269: 10341-10351.
5. Breathnach, S. M. 1993. The skin immune system and psoriasis. Clin. Exp. Immunol. 91:343-345.
6. Brinkerhoff, C. E., J. W. Coeffey, and A. C. Sullivan. 1983. Inflammation and collagenase production in rats with adjuvant arthritis reduced with 13-cis retinoic acid. Science 221:756-758.
7. Bugge, T. H., J. Polhl, O. Lonnoy, and H. G. Stunnenberg. 1992. RXRα, a promiscuous partner of retinoic acid and thyroid hormone receptors. EMBO J. 11:1409-1418.
8. Chambon, P. 1994. The retinoid signaling pathway: molecular and genetic analysis. Semin. Cell Biol. 5:115-125.
9. Corbeil, J., E. Rappaport, D. D. Richman, and D. J. Looney. 1994. Antiproliferative effect of retinoid compounds on Kaposi's sarcoma cells. J. Clin. Invest. 93:1981-1986.
10. Durand, B., M. Saunders, P. Leroy, M. Leid, and P. Chambon. 1992. Alltrans and 9-cis retinoic acid induction of CRABP II transcription is mediated by RAR-RxR heterodimers bound to DR1 and DR2 repeated motifs. Cell 71:73-85.
11. Ensoli, B., S. Nakamura, S. Z. Salahuddin, P. Biberfeld, L. Larsson, B. Beaver, F. Wong-Staal, and R. C. Gallo. 1989. AIDS-Kaposi's sarcomaderived cells express cytokines and autocrine and paracrine growth effects. Science 243:223-226.
12. Ensoli, B., G. Barillari, S. Z. Salahuddin, R. C. Gallo, and F. Wong-Staal. 1989. Tat protein of HIV-I stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients. Nature 345:84-86.
13. Esgleyes-Ribot, T., R. A. Chandraratna, D. A. Lew-Kaya, J. Seflon, and M. Duvic. 1994. Response of psoriasis to a new topical retinoid, AGN 190168. J. Am. Acad. Dermatol. 30:581-590.
14. Fanjul, A., M. I. Dawson, P. D. Hobbs, L. Jong, J. F. Cameron, E. Harlev, G. Graupner, X.-P. Lu, and M. Pfahl. 1994. A new class of retinoids with selective inhibition of AP-1 inhibits proliferation. Nature 372:107-111.
15. Gill, P. S., C. Loureiro, M. Bernstein-Singer, M. U. Rarick, F. Sattler, and A. M. Levine. 1989. Clinical effect of glucocorticoids on Kaposi's sarcoma related to the acquired immunodeficiency syndrome (AIDS). Ann. Intern. Med. 110:937-940.
16. Gill, P. S., M. U. Rarick, J. A. McCutchan, L. Slater, B. Parker, E. Much-more, M. Berstein-Singer, B. Akil, B. M. Espina, M. Krailo, and A. M. Levine. 1991. Systemic treatment of AIDS-related Kaposi's sarcoma: results of a randomized trial. Am. J. Med. 90:427-433.
17. Gill, P. S., A. Hamilton, and Y. Naidu. 1994. Epidemic (AIDS-related) Kaposi's sarcoma: Epidemiology, pathogenesis, and treatment, p. 1-11. In V. T. Devita, S. Hellman, and S. A. Rosenberg (ed.), AIDS, vol. 7. J. B. Lippincott Co., Philadelphia, Pa.
18. Gill, P. S., B. M. Espina, T. Moudgil, S. Kidane, J. A. Esplin, A. Tulpule, and A. M. Levine. 1994. All-trans retinoic acid for the treatment of AIDS-related Kaposi's sarcoma: results of a pilot phase II study. Leukemia 8(Suppl. 3): S26-32.
19. 18a.Gill, P. S., and R. Masood. Unpublished results.
20. Grossman, R. M., J. Krueger, D. Yourish, A. Granelli-Piperno, D. P. Murphy, L. T. May, T. S. Kupper, P. B. Sehgal, and A. B. Gottlieb. 1989. Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes. Proc. Natl. Acad. Sci. USA 86:6367-6371.
21. Kamei, Y., L. Xu, T. Heinzel, J. Torchia, R. Kurokawa, B. Glass, S.-C. Lin, R. A. Heyman, D. W. Rose, C. K. Glass, and M. G. Rosenfeld. 1996. A CBP integration complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85:403-414.
22. Kishimolo, T., S. Akira, and T. Taga. 1992. Interleukin-6 and its receptor: a paradigm for science. Cytokines 258:593-597.
23. Kliewer, S. A., K. Umesono, D. J. Mangelsdorf, and R. M. Evans. 1992. Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D, signalling. Nature 355:446-449.
24. Lehmann, J. M., L. Jong, A. Fanjul, J. F. Cameron, X. P. Lu, P. Haefner, D. I. Dawson, and M. Pfahl. 1992. Retinoids selective for retinoid x receptor response pathways. Science 258:1944-1946.
25. Leid, M., P. Kastner, R. Lyons, H. Nakshatri, M. Saunders, T. Zacharewski, J. Y. Chen, A. Staub, J. M. Garnier, S. Mader, and P. Chambon. 1992. Purification, cloning, and RXR identity of the HeLa cell factor with which RAR and TR heterodimerizes to bind target sequences efficiently. Cell 68:377-395.
26. Mangelsdorf, D. J., K. Umesono, and R. M. Evans. 1994. The retinoid receptors, p. 319-349. In M. B. Sporn, A. B. Roberts, and D. S. Goodman (ed.), The retinoids: biology, chemistry and medicine, 2nd ed. Raven Press, Ltd., New York, N.Y.
27. Marks, M. S., P. L. Hallenbeck, T. Nagata, J. H. Segars, E. Appella, W. M. Nikodem, and K. Ozato. 1992. H-2RIIBP (RXRβ) heterdimerization provides a mechanism for combinatorial diversity in the regulation of retinoic acid and thyroid responsive genes. EMBO J. 11:1419-1435.
28. Masood, R-, J. Cai, T. Zheng, D. L. Smith, Y. Naidu, and P. S. Gill. 1997. Vascular endothelial growth factor/vascular permeability factor (VEGF/ VPF) is an autocrine growth factor for AIDS-KS. Proc. Natl. Acad. Sci. USA 94:979-984.
29. Mehta, K., T. McQueen, S. Tucker, R. Pandita, and B. B. Aggarwal. 1994. Inhibition by all-trans-retinoic acid of tumor necrosis factor and nitric oxide production by peritoneal macrophages. J. Leukocyte Biol. 55:336-342.
30. Miles, S. A., A. R. Rezai, J. F. Salazar-Gonzales, M. V. Meyden, R. H. Stevens, D. M. Logan, K. T. Mitsuyasu, T. Taga, T. Hirano, T. Kishimoto, and O. Martinez-Maza. 1990. AIDS Kaposi's sarcoma-derived cells produce and respond to interleukin-6. Proc. Natl. Acad. Sci. USA 98:4068-2072.
31. Minucci, S., M. Leid, R. Toyama, J.-P. Saint-Jeannet, V. J. Peterson, V. Horn, J. E. Ishmael, N. Bhattacharyya, A. Dey, I. B. Dawid, and K. Ozato. 1997. Retinoid X receptor (RXR) within the RXR-retinoid acid receptor heterodimer binds its ligand and enhances retinoid-dependent gene expression. Mol. Cell. Biol. 17:644-655.
32. 30a.Nagpal, S. Unpublished observation.
33. Nagpal, S., J. Athanikar, and R. A. S. Chandraratna. 1995. Separation of transactivation and AP1 antagonism functions of retinoic acid receptorα. J. Biol. Chem. 270:923-927.
34. 31a.Nagpal, S., and R. A. S. Chandraratna. Unpublished observations.
35. Nagpal, S., S. Friant, H. Nakshatri, and P. Chambon. 1993. RARs and RXRs: evidence for two autonomous transactivation functions (AF-1 and AF-2) and heterodimerization in vivo. EMBO J. 12:2349-2360.
36. Nagpal, S., S. Patel, A. T. Asano, A. T. Johnson, M. Duvic, and R. A. S. Chandraratna. 1996. Tazarotene-induced gene 1 (TIG1), a novel retinoic acid receptor-responsive gene in skin. J. Invest. Dermatol. 106:269-274.
37. Nagpal, S., S. M. Thacher, S. Patel, S. Friant, M. Malhotra, J. Shafer, G. Krasinski, A. T, Asano, M. Teng, M. Duvic, and R. A, S. Chandraratna. 1996. Negative regulation of two hyperproliferative keratinocyte differentiation markers by a retinoid acid receptor specific retinoid: insight into the mechanism of retinoid action in psoriasis. Cell Growth Differ. 7:1783-1791.
38. Nagpal, S., M. Saunders, P. Kastner, B. Durand, H. Nakshatri, and P. Chambon. 1992. Promoter context- and response element-dependent specificity of the transcriptional activation and modulating functions of retinoic acid receptors. Cell 70:1007-1019.
39. Nair, B. C., A. L. DeVico, S. Nakamura, T. D. Copeland, Y. Chen, A. Patel, T. O'Neill, S. Oroszlan, R. C. Gallo, and M. G. Sarngadharan. 1992. Identification of major growth factor for AIDS-KS cells as oncostatin-M. Science 255:1430-1432.
40. Nakamura, S., S. Z. Salahuddin, P. Biberfeld, B. Ensoli, P. D. Markham, F. Wong-Staal, and R. C. Gallo. 1988. Kaposi's sarcoma cells: long term culture with growth factor from retrovirus-infected CD4+ T cells. Science 242:426-430.
41. Nicholson, R. C., S. Mader, S. Nagpal, M. Lied, C. Rochette-Egly, and P. Chambon. 1990. Negative regulations of the rat stromelysin gene promoter by retinoic acid is mediated by an AP1 binding site. EMBO J. 9:4443-4454.
42. Ogata, A., N. Nishimoto, Y. Shima, K. Yoshizaki, and T. Kishimoto. 1994. Inhibitory effect of all-trans retinoic acid on the growth of freshly isolated myeloma cells via interference with Interleukin-6 signal transduction. Blood 84:3040-3046.
43. Pottralz, S. T., T. Bellido, H. Mocharia, D. Crabb, and S. C. Manolagas. 1994. 17β-Estradiol inhibits expression of human interleukin-6 promoter-reporter constructs by a receptor-dependent mechanism. J. Clin. Invest. 93:944-950.
44. Ray, A., K. S. LaForge, and P. B. Sehgal. 1990. On the mechanism for efficient repression of the interleukin-6 promoter by glucocorticoids: enhancer, TATA box, and RNA start site (Inr motif) occlusion. Mol. Cell. Biol. 10:5736-5746.
45. Ray, A., K. E. Prefontaine, and P. Ray. 1994. Down modulation of interleukin-6 gene expression by 17β-estradiol in the absence of high affinity DNA binding by the estrogen receptor. J. Biol. Chem. 269:12940-12946.
46. Real, F. X., S. E. Krown, and B. Koziner. 1986. Steroid-related development of Kaposi's sarcoma in a homosexual man with Burkitt's lymphoma. Am. J. Med. 80:119-122.
47. Salahuddin, S. Z., S. Nakamura, P. Biberfeld, M. H. Kaplan, P. D. Markham, L. Larsson, and R. C. Gallo. 1988. Angiogenic properties of Kaposi's sarcoma derived cells after long-term culture in vitro. Science 242: 430-433.
48. Salbert, G., A. Fanjul, J. F. Piedrafita, X. P. Lu, S. J. Kim, P. Tran, and M. Pfahl. 1993. Retinoic acid receptors and retinoic x receptor-α down regulate the transforming growth factor-β, promoter by antagonizing AP-1 activity. Mol. Endocrinol. 7:1347-1356.
49. Saunders, N. A., S. H. Bernacki, T. M. Volberg, and A. M. Jetten. 1993. Regulation of transglutaminase type 1 expression in squamous differentiating rabbit tracheal epithelial cells and human epidermal keratinocytes: effects of retinoic acid and phorbal esters. Mol. Endocrinol. 7:387-398.
50. Schule, R., P. Rangarajan, N. Yang, S. Kliewer, L. J. Ransone, J. Bolando, I. M. Verma, and R. M. Evans. 1991. Retinoic acid is a negative regulator of AP-1-responsive genes. Proc. Natl. Acad. Sci. USA 88:6092-6096.
51. Schulhafer, E. P., M. E. Grossman, G. Fagin, and M. Bell. 1987. Steroid-induced Kaposi's sarcoma in a patient with pre-AIDS. Am. J. Med. 82:313-317.
52. 48a.Thatcher, S., and S. Friant. Personal communication.
53. Weindel, K., D. Marme, and H. A. Weich. 1992. AIDS-associated Kaposi's sarcoma cells in culture express vascular endothelial growth factor. Biochem. Biochys. Res. Commun. 183:1167-1174.
54. Weinstein, G., E. Jefes, M. Duvic, D. Friedman, B. Jegasothy, M. Tharp, J. Jorizzo, G. Kreiger, N. Lowe, E. Shmunez, E. Tschen, A. Monroe, J. Sefton, D. Leukaza, J. Lue, R. Chandraratna, and J. Gibson. 1995. Tazarotene gel for the treatment of plaque psoriasis: a double-blind clinical study, abstr. 638, p. 661. In Abstracts of the 56th Annual Meeting of the Society for Investigative Dermatology 1995. Society for Investigative Dermatology, Chicago, III.
55. Xia, C., J. B. Taylor, S. R. Spencer, and B. Ketterer. 1993. The human glutathione S-transferase Pl-1 gene: modulation of expression by retinoic acid and insulin. Biochem. J. 292:845-850.
56. Yang-Yen, H. F., X. K. Zhang, G. Graupner, M. Tzukerman, B. Sakamoto, M. Karin, and M. Pfahl. 1991. Antagonism between retinoic acid receptor and AP-1: implications for tumor promotion and inflammation. New Biol. 3:1206-1219.
57. Yu, V. C., C. Delsert, B. Anderson, J. M. Holloway, O. V. Devary, A. M. Naar, S. Y. Kim, J. M. Boutin, C. K. Glass, and M. G. Rasenfeld. 1991. RXR-β: a coregulator that enhances binding of retinoic acid, thyroid hormone and vitamin D receptors to their cognate response elements. Cell 67:1251-1266.