P-glycoprotein expression in mouse brain increases with maturation

Biology of the Neonate

Volumn 81, Issue 1, 2002, Pages 58-64

  Tsai, Catherine E ^a   Daood, Monica J ^a   Lane, Robert H ^a   Hansen, Thor W R ^b   Gruetzmacher, Elisa M ^a   Watchko, Jon F ^a,c  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF OSLO   (Norway)

^c UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Bilirubin; Blood brain barrier; Development

Indexed keywords

GLYCOPROTEIN P; MESSENGER RNA; PROTEIN; PROTEIN MDR1A; RHODOPSIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN TISSUE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; IMMUNOHISTOCHEMISTRY; MATURATION; MOUSE; NEWBORN PERIOD; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AGING; ANIMALS; BLOOD-BRAIN BARRIER; BLOTTING, WESTERN; BRAIN; BRAIN CHEMISTRY; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; MICE; P-GLYCOPROTEIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

STAPHYLOCOCCUS PHAGE 187;

EID: 0036154996     PISSN: 00063126     EISSN: None     Source Type: Journal    
DOI: 10.1159/000047185     Document Type: Article

References (22)

1. ABC transporters - From microorganisms to man
2. Function and regulation of the human multidrug resistance gene
3. Biochemistry of multidrug resistance mediated by the multidrug transporter
4. P-glycoproteins and multidrug resistance
5. Cloning and characterization of mouse mdr genes
6. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in blood-brain barrier and to increased sensitivity to drugs
7. Isoform I (mdr 1a) is a major form of P-glycoprotein expressed in mouse brain capillaries: Evidence for cross-reactivity of antibody C219 with an unrelated protein
8. Absence of the mdr1a P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A
9. Brain microvascular and astrocyte localization of P-glycoprotein
10. Interaction of drugs with P-glycroprotein in brain capillaries
11. P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacologic activity of many drugs
12. Brain bilirubin content is increased in P-glycoprotein-deficient transgenic null mutant mice
13. Mouse Multidrug resistance 1a/3 gene is the earliest known endothelial cell differentiation marker during blood brain barrier development
14. The multidrug-resistance P-glycoprotein (pgp, MDR1) is an early marker of blood-brain barrier development in the microvessels of the developing human brain
15. Developmental expression of P-glycoprotein (multidrug resistance gene product) in the rat brain
16. Isolation of brain capillaries: A simplified technique
17. Protein measurement with the Folin phenol reagent
18. Detection of P-glycoprotein isoforms by gene-specific monoclonal antibodies
19. Measurement of GLUT mRNA in liver of fetal and neonatal rats using a novel method of quantitative polymerase chain reaction
20. New immunohistochemical 'sandwich' staining method for mdr1 P-glycoprotein detection with JSB-1 monoclonal antibody in formalin-fixed, paraffin-embeded human tissues
21. Bilirubin: A physiologic substrate for the multidrug transporter