Ascorbic acid 6-palmitate suppresses gap-junctional intercellular communication through phosphorylation of connexin 43 via activation of the MEK-ERK pathway

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 660, Issue 1-2, 2009, Pages 51-56

  Lee, Kyung Mi ^a   Kwon, Jung Yeon ^a,b   Lee, Ki Won ^b   Lee, Hyong Joo ^a  

^a Seoul National University   (South Korea)

^b Konkuk University   (South Korea)

Author keywords

Ascorbic acid 6 palmitate; Gap junctional intercellular communication; Mitogen activated protein kinase extracellular signal regulated kinase kinase

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ALPHA TOCOPHEROL; ASCORBIC ACID; ASCORBIC ACID 6 PALMITATE; ASCORBIC ACID DERIVATIVE; CATALASE; CONNEXIN 43; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NADPH OXIDASE INHIBITOR; PALMITIC ACID; PRESERVATIVE; PROTEIN KINASE C INHIBITOR; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SCAVENGER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CARCINOGENICITY; CELL COMMUNICATION; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG POTENCY; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; GAP JUNCTION; INHIBITION KINETICS; LIVER; NONHUMAN; PARADOXICAL DRUG REACTION; PRIORITY JOURNAL; RAT; TREATMENT CONTRAINDICATION;

ANIMALS; ASCORBIC ACID; BUTADIENES; CELL COMMUNICATION; CELL LINE; CONNEXIN 43; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GAP JUNCTIONS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR STRUCTURE; NITRILES; PHOSPHORYLATION; RATS;

RATTUS;

EID: 58149476602     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2008.10.012     Document Type: Article

References (40)

1. Nishi M., Kumar N.M., and Gilula N.B. Developmental regulation of gap junction gene expression during mouse embryonic development. Dev. Biol. 146 (1991) 117-130
2. Houghton F.D. Role of gap junctions during early embryo development. Reproduction 129 (2005) 129-135
3. Vinken M., Vanhaecke T., Papeleu P., Snykers S., Henkens T., and Rogiers V. Connexins and their channels in cell growth and cell death. Cell Signal. 18 (2006) 592-600
4. Alexander D.B., and Goldberg G.S. Transfer of biologically important molecules between cells through gap junction channels. Curr. Med. Chem. 10 (2003) 2045-2058
5. Trosko J.E., and Chang C.C. Modulation of cell-cell communication in the cause and chemoprevention/chemotherapy of cancer. Biofactors 12 (2000) 259-263
6. Trosko J.E., and Ruch R.J. Cell-cell communication in carcinogenesis. Front. Biosci. 3 (1998) d208-236
7. Lee K.W., Chun K.S., Lee J.S., Kang K.S., Surh Y.J., and Lee H.J. Inhibition of cyclooxygenase-2 expression and restoration of gap junction intercellular communication in H-ras-transformed rat liver epithelial cells by caffeic acid phenethyl ester. Ann. N. Y. Acad. Sci. 1030 (2004) 501-507
8. Lampe P.D., and Lau A.F. Regulation of gap junctions by phosphorylation of connexins. Arch. Biochem. Biophys. 384 (2000) 205-215
9. Rivedal E., and Opsahl H. Role of PKC and MAP kinase in EGF- and TPA-induced connexin43 phosphorylation and inhibition of gap junction intercellular communication in rat liver epithelial cells. Carcinogenesis 22 (2001) 1543-1550
10. Cho J.H., Cho S.D., Hu H., Kim S.H., Lee S.K., Lee Y.S., and Kang K.S. The roles of ERK1/2 and p38 MAP kinases in the preventive mechanisms of mushroom Phellinus linteus against the inhibition of gap junctional intercellular communication by hydrogen peroxide. Carcinogenesis 23 (2002) 1163-1169
11. Ruch R.J., Trosko J.E., and Madhukar B.V. Inhibition of connexin43 gap junctional intercellular communication by TPA requires ERK activation. J. Cell. Biochem. 83 (2001) 163-169
12. Southorn P.A., and Powis G. Free radicals in medicine. II. Involvement in human disease. Mayo Clin. Proc. 63 (1988) 390-408
13. Khaw K.T., Bingham S., Welch A., Luben R., Wareham N., Oakes S., and Day N. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition. Lancet 357 (2001) 657-663
14. Duffy S.J., Gokce N., Holbrook M., Huang A., Frei B., Keaney J.F., and Vita Jr. J.A. Treatment of hypertension with ascorbic acid. Lancet 354 (1999) 2048-2049
15. Kurl S., Tuomainen T.P., Laukkanen J.A., Nyyssonen K., Lakka T., Sivenius J., and Salonen J.T. Plasma vitamin C modifies the association between hypertension and risk of stroke. Stroke 33 (2002) 1568-1573
16. Engelhart M.J., Geerlings M.I., Ruitenberg A., van Swieten J.C., Hofman A., Witteman J.C., and Breteler M.M. Dietary intake of antioxidants and risk of Alzheimer disease. J. Am. Med. Assoc. 287 (2002) 3223-3229
17. Cameron E., Pauling L., and Leibovitz B. Ascorbic acid and cancer: a review. Cancer Res. 39 (1979) 663-681
18. Lee K.W., Lee S.J., Kang N.J., Lee C.Y., and Lee H.J. Effects of phenolics in Empire apples on hydrogen peroxide-induced inhibition of gap-junctional intercellular communication. Biofactors 21 (2004) 361-365
19. Kim J.H., Kang N.J., Lee B.K., Lee K.W., and Lee H.J. Gallic acid, a metabolite of the antioxidant propyl gallate, inhibits gap junctional intercellular communication via phosphorylation of connexin 43 and extracellular-signal-regulated kinase1/2 in rat liver epithelial cells. Mutat. Res. 638 (2008) 175-183
20. Meves A., Stock S.N., Beyerle A., Pittelkow M.R., and Peus D. Vitamin C derivative ascorbyl palmitate promotes ultraviolet-B-induced lipid peroxidation and cytotoxicity in keratinocytes. J. Invest. Dermatol. 119 (2002) 1103-1108
21. Lee K.W., Kim Y.J., Lee H.J., and Lee C.Y. Cocoa has more phenolic phytochemicals and a higher antioxidant capacity than teas and red wine. J. Agric. Food Chem. 51 (2003) 7292-7295
22. van den Berg R., Haenen G.R.M.M., van den Berg H., and Bast A. Applicability of an improved Trolox equivalent antioxidant capacity (TEAC) assay for evaluation of antioxidant capacity measurements of mixtures. Food Chem. 66 (1999) 511-517
23. Kim D.O., Lee K.W., Lee H.J., and Lee C.Y. Vitamin C equivalent antioxidant capacity (VCEAC) of phenolic phytochemicals. J. Agric. Food Chem. 50 (2002) 3713-3717
24. Meves A., Stock S.N., Beyerle A., Pittelkow M.R., and Peus D. H(2)O(2) mediates oxidative stress-induced epidermal growth factor receptor phosphorylation. Toxicol. Lett. 122 (2001) 205-214
25. Trosko J.E., and Chang C.C. Mechanism of up-regulated gap junctional intercellular communication during chemoprevention and chemotherapy of cancer. Mutat. Res. 480-481 (2001) 219-229
26. Saez J.C., Berthoud V.M., Moreno A.P., and Spray D.C. Gap junctions. Multiplicity of controls in differentiated and undifferentiated cells and possible functional implications. Adv. Second Messenger Phosphoprotein Res. 27 (1993) 163-198
27. Kang K.S., Wilson M.R., Hayashi T., Chang C.C., and Trosko J.E. Inhibition of gap junctional intercellular communication in normal human breast epithelial cells after treatment with pesticides, PCBs, and PBBs, alone or in mixtures. Environ. Health Perspect. 104 (1996) 192-200
28. Matesic D.F., Rupp H.L., Bonney W.J., Ruch R.J., and Trosko J.E. Changes in gap-junction permeability, phosphorylation, and number mediated by phorbol ester and non-phorbol-ester tumor promoters in rat liver epithelial cells. Mol. Carcinog. 10 (1994) 226-236
29. Rummel A.M., Trosko J.E., Wilson M.R., and Upham B.L. Polycyclic aromatic hydrocarbons with bay-like regions inhibited gap junctional intercellular communication and stimulated MAPK activity. Toxicol. Sci. 49 (1999) 232-240
30. Warn-Cramer B.J., Cottrell G.T., Burt J.M., and Lau A.F. Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase. J. Biol. Chem. 273 (1998) 9188-9196
31. Klotz L.O., Patak P., Ale-Agha N., Buchczyk D.P., Abdelmohsen K., Gerber P.A., von Montfort C., and Sies H. 2-Methyl-1,4-naphthoquinone, vitamin K(3), decreases gap-junctional intercellular communication via activation of the epidermal growth factor receptor/extracellular signal-regulated kinase cascade. Cancer Res. 62 (2002) 4922-4928
32. Ueda Y., Hirai S., Osada S., Suzuki A., Mizuno K., and Ohno S. Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf. J. Biol. Chem. 271 (1996) 23512-23519
33. Mounho B.J., and Thrall B.D. The extracellular signal-regulated kinase pathway contributes to mitogenic and antiapoptotic effects of peroxisome proliferators in vitro. Toxicol. Appl. Pharmacol. 159 (1999) 125-133
34. Fischer L.J., Wagner M.A., and Madhukar B.V. Potential involvement of calcium, CaM kinase II, and MAP kinases in PCB-stimulated insulin release from RINm5F cells. Toxicol. Appl. Pharmacol. 159 (1999) 194-203
35. Shen K., and Novak R.F. DDT stimulates c-erbB2, c-met, and STATS tyrosine phosphorylation, Grb2-Sos association, MAPK phosphorylation, and proliferation of human breast epithelial cells. Biochem. Biophys. Res. Commun. 231 (1997) 17-21
36. Kang K.S., Kang B.C., Lee B.J., Che J.H., Li G.X., Trosko J.E., and Lee Y.S. Preventive effect of epicatechin and ginsenoside Rb(2) on the inhibition of gap junctional intercellular communication by TPA and H(2)O(2). Cancer Lett. 152 (2000) 97-106
37. Lee K.W., Lee H.J., Kang K.S., and Lee C.Y. Preventive effects of vitamin C on carcinogenesis. Lancet 359 (2002) 172
38. Guan X., Hardenbrook J., Fernstrom M.J., Chaudhuri R., Malkinson A.M., and Ruch R.J. Down-regulation by butylated hydroxytoluene of the number and function of gap junctions in epithelial cell lines derived from mouse lung and rat liver. Carcinogenesis 16 (1995) 2575-2582
39. Krutovskikh V., Asamoto M., Takasuka N., Murakoshi M., Nishino H., and Tsuda H. Differential dose-dependent effects of alpha-, beta-carotenes and lycopene on gap-junctional intercellular communication in rat liver in vivo. Jpn. J. Cancer Res. 88 (1997) 1121-1124
40. Chaumontet C., Bex V., Veran F., and Martel P. The vitamin E analog tocopherol succinate strongly inhibits gap junctional intercellular communication in rat liver epithelial cells (IAR203). J. Nutr. Biochem. 19 (2008) 263-268