The extracellular signal-regulated kinase pathway contributes to mitogenic and antiapoptotic effects of peroxisome proliferators in vitro

Toxicology and Applied Pharmacology

Volumn 159, Issue 2, 1999, Pages 125-133

  Mounho, Barbara J ^a   Thrall, Brian D ^a  

^a PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

Author keywords

Apoptosis; Extracellular signal regulated kinase; Hepatocarcinogenesis; Mitogenesis; Peroxisome proliferators

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; APIGENIN; CARCINOGEN; DNA; EPIDERMAL GROWTH FACTOR; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; PEROXISOME PROLIFERATOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PHORBOL ESTER; PIRINIXIC ACID; TRICHLOROACETIC ACID;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; LIVER CARCINOGENESIS; LIVER CELL; MITOGENESIS; MITOSIS; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS;

EID: 0033200395     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1999.8740     Document Type: Article

References (33)

1. Agullo G., Gamet-Payrastre L., Manenti S., Viala C., Remesy C., Chap H., Payrastre B. Relationship between flavonoid structure and inhibition of phosphatidylinositol 3-kinase: A comparison with tyrosine kinase and protein kinase C inhibition. Biochem. Pharmacol. 53:1997;1649-1657.
2. Alessi D. R., Cuenda A., Cohen P., Dudley D. T., Saltiel A. R. PD98059 is a specific inhibitor of the mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem. 70:1995;27489-27494.
3. Bayly A. C., Roberts R. A., Dive C. Suppression of liver cell apoptosis in vitro by the non-genotoxic hepatocarcinogen and peroxisome proliferator nafenopin. J. Cell Biol. 125:1994;197-203.
4. Camp H. S., Tafuri S. R. Regulation of peroxisome proliferator-activated receptor γ activity by mitogen-activated protein kinase. J. Biol. Chem. 272:1997;10811-10816.
5. Cross D. A. E., Alessi D. R., Vandenheede J. R., McDowell H. E., Hundal H. S., Cohen P. The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: Evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf. Biochem. J. 303:1994;21-26.
6. Farese R. V. Insulin-sensitive phospholipid signaling systems and glucose transport: An update. Proc. Soc. Exp. Biol. Med. 213:1996;1-12.
7. Grasl-Kraupp B., Huber W., Timmermann-Trosiener I., Schulte-Hermann R. Peroxisomal enzyme induction uncoupled from enhanced DNA synthesis in putative preneoplastic liver foci of rats treated with a single dose of the peroxisome proliferator nafenopin. Carcinogenesis. 14:1993;2435-2437.
8. Grasl-Kraupp B., Ruttkay-Nedecky B., Mullauer L., Taper H., Huber W., Bursch W., Schulte-Hermann R. Inherent increase of apoptosis in liver tumors: Implications for carcinogenesis and tumor regression. Hepatology. 25:1997;906-912.
9. Guyton K. Z., Gorospe M., Kensler T. W., Holbrook N. J. Mitogen-activated protein kinase (MAPK) activation by butylated hydroxytoluene hydroperoxide: Implications for cellular survival and tumor promotion. Cancer Res. 56:1996;3480-3485.
10. James N. H., Roberts R. A. The peroxisome proliferator class of non-genotoxic hepatocarcinogens synergize with epidermal growth factor to promote clonal expansion of initiated rat hepatocytes. Carcinogenesis. 15:1994;2687-2694.
11. James N. H., Roberts R. A. The peroxisome proliferator class of non-genotoxic hepatocarcinogens synergize with epidermal growth factor to promote clonal expansion of initiated rat hepatocytes. Carcinogenesis. 15:1996;2687-2694.
12. Kumar A., Chambers T. C., Cloud-Heflin B. A., Mehta K. D. Phorbol ester-induced low density lipoprotein receptor gene expression in HepG2 cells involves protein kinase C-mediated p42/44 MAP kinase activation. J. Lipid Res. 38:1997;2240-2248.
13. Kuo M.-L., Yang N.-C. Reversion of v-H-ras transformed NIH 3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogenes. Biochem. Biophys. Res. Commun. 212:1995;767-775.
14. Lee S. S.-T., Pineau T., Drago J., Lee E. J., Owens J. W., Kroetz D. L., Fernandez-Salguero P. M., Westphal H., Gonzalez F. J. Targeted disruption of the α-isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol. Cell. Biol. 15:1995;3012-3022.
15. Marsman D. S., Cattley R. C., Conway J. G., Popp J. A. Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenecity of the peroxisome proliferators di(2-ethylhexyl)phthalate and [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (Wy-14,643) in rats. Cancer Res. 48:1988;6739-6744.
16. Oberhammer F. A., Qin H.-M. Effect of three tumour promoters on the stability of hepatocyte cultures and apoptosis after transforming growth factor-β1. Carcinogenesis. 16:1995;1363-1371.
17. Oka H., Chatani Y., Hoshino R., Ogawa O., Kakehi Y., Terachi T., Okada Y., Kawaichi M., Kohno M., Yoshida O. Constitutive activation of mitogen-activated protein (MAP) kinases in human renal cell carcinoma. Cancer Res. 55:1995;4182-4187.
18. Orellana A., Holuigue L., Hidalgo P. C., Faúndez V., González A., Bronfman M. Ciprofibrate, a carcinogenic peroxisome proliferator, increases the phosphorylation of epidermal-growth-factor receptor in isolated rat hepatocytes. Eur. J. Biochem. 215:1993;903-906.
19. Peters J. M., Cattley R. C., Gonzalez F. J. Role of PPARα in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643. Carcinogenesis. 18:1997;2029-2033.
20. Rao M. S., Reddy J. K. Hepatocarcinogenesis of peroxisome proliferators. Ann. NY Acad. Sci. 804:1996;573-587.
21. Roberts R. A., James N. H., Woodyatt N. J., Macdonald N., Tugwood J. D. Evidence for the suppression of apoptosis by the peroxisome proliferator activated receptor alpha (PPARα). Carcinogenesis. 19:1998;43-48.
22. Roberts R. A., Soames A. R., Gill J. H., Wheeldon E. B. Non-genotoxic hepatocarcinogens stimulate DNA synthesis and their withdrawal induces apoptosis, but in different hepatocyte populations. Carcinogenesis. 16:1995;1693-1698.
23. Robinson M. J., Cobb M. H. Mitogen-activated protein kinase pathways. Curr. Opin. Cell. Biol. 9:1997;180-186.
24. Rokos C. L., Ledwith B. J. Peroxisome proliferators activate extracellular signal-regulated kinases in immortalized mouse liver cells. J. Biol. Chem. 272:1997;13452-13457.
25. Schulte-Hermann R., Bursch W., Löw-Baselli A., Wagner A., Grasl-Kraupp B. Apoptosis in the liver and its role in hepatocarcinogenesis. Cell Biol. Toxicol. 13:1997;339-348.
26. Shalev A., Siegrist-Kaiser C. A., Yen P. M., Wahli W., Burger A. G., Chin W. W., Meier C. A. The peroxisome proliferator-activated receptor α is a phosphoprotein: Regulation by insulin. Endocrinology. 137:1996;4499-4502.
27. Standaert M. L., Bandyopadhyay G., Farese R. V. Studies with wortmannin suggest a role for phosphatidylinositol 3-kinase in the activation of glycogen synthase and mitogen-activated protein kinase by insulin in rat adipocytes: Comparison of insulin and protein kinase C modulators. Biochem. Biophys. Res. Commun. 209:1995;1082-1088.
28. Stauber A. J., Bull R. J., Thrall B. D. Dichloroacetate and trichloroacetate promote clonal expansion of anchorage-independent hepatocytes in vivo and in vitro. Toxicol. Appl. Pharmacol. 150:1998;287-294.
29. Tanaka K., Smith P. F., Stromberg P. C., Eydelloth R. S., Herold E. G., Grossman S. J., Frank J. D., Hertzog P. R., Soper K. A., Keenan K. P. Studies of early hepatocellular proliferation and peroxisomal proliferation in Sprague-Dawley rats treated with tumorigenic doses of clofibrate. Toxicol. Appl. Pharmacol. 116:1992;71-77.
30. Vlahos C. J., Matter W. F., Hui K. Y., Brown R. F. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one (LY294002). J. Biol. Chem. 269:1993;5241-5248.
31. Wada N., Marsman D. S., Popp J. A. Dose-related effects of the hepato-carcinogen, Wy-14,643, on peroxisomes and cell replication. Fundam. Appl. Toxicol. 18:1992;149-154.
32. Xia Z., Dickens M., Raingeaud J., Davis R. J., Greenberg M. E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science. 270:1995;1326-1330.
33. Zhang S., Hirai S.-I., Mizuno K., Suzuki A., Akimoto K., Izumi Y., Yamashita A., Ohno S. Involvement of protein kinase C in the activation of extracellular signal-regulated kinase 1/2 by UVC irradiation. Biochem. Biophys. Res. Commun. 240:1997;273-278.