Vitamin C derivative ascorbyl palmitate promotes ultraviolet-B-induced lipid peroxidation and cytotoxicity in keratinocytes

Journal of Investigative Dermatology

Volumn 119, Issue 5, 2002, Pages 1103-1108

  Meves, Alexander ^b   Stock, Sibylle N ^a   Beyerle, Astrid ^a   Pittelkow, Mark R ^a   Peus, Dominik ^a,c  

^a MAYO CLINIC   (United States)

^b WORLD HEALTH ORGANIZATION   (Switzerland)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Antioxidants; Reactive oxygen species; Signaling; Skin

Indexed keywords

4 HYDROXYNONENAL; ANTIOXIDANT; ASCORBIC ACID DERIVATIVE; ASCORBYL PALMITATE; EPIDERMAL GROWTH FACTOR RECEPTOR; GLUTATHIONE; HYDROGEN PEROXIDE; PHOSPHOTRANSFERASE; REACTIVE OXYGEN METABOLITE; SCAVENGER; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN;

ARTICLE; CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; KERATINOCYTE; LIPID PEROXIDATION; LIPID SOLUBILITY; OXIDATION; PRIORITY JOURNAL; PROTEIN DEPLETION; RADIATION INJURY; SKIN DEFECT; SKIN PROTECTION; ULTRAVIOLET B RADIATION;

EID: 18744387967     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2002.19521.x     Document Type: Article

References (38)

1. Bissett DL, Hannon DP, Orr TV: An animal model of solar-aged skin: Histological, physical and visible changes in UV-irradiated hairless mouse skin. Photochem Photobiol 46:367-378, 1987
2. Bissett DL, Chatterjee R, Hannon DP: Photoprotective effect of superoxide-scavenging antioxidants against ultraviolet radiation-induced chronic skin damage in the hairless mouse. Photodermatol Photoimmunol Photomed 7:56-62, 1990
3. Black HS: Potential involvement of free radical reactions in ultraviolet light-mediated cutaneous damage. Photochem Photobiol 46:213-221, 1987
4. 2. J Biol Chem 273:32554-32560, 1998
5. Cerutti PA: Prooxidant states and tumor promotion. Science 227:375-381, 1985
6. Comporti M: Lipid peroxidation and biogenic aldehydes: From the identification of 4-hydroxynonenal to further achievements in biopathology. Free Radic Res 28:623-635, 1998
7. Darr D, Fridovich I: Free radicals in cutaneous biology. J Invest Dermatol 102:671-675, 1994
8. Darr D, Combs S, Dunston S, Manning T, Pinnell S: Topical vitamin C protects porcine skin from ultraviolet radiation-induced damage. Br J Dermatol 127:247-253, 1992
9. Darr DJ, Colven RM, Pinnell SR: Topical vitamin C. In: Packer L Fuchs J, eds. Vitamin C in Health and Disease. New York: Marcel Dekker, 1997 pp 517-524
10. DeRitter E: Physiologic availability of dehydro-L-ascorbic acid and palmitoyl-L-ascorbic acid. Science 113:628-631, 1951
11. Eberlein-Konig B, Placzek M, Przybilla B: Protective effect against sunburn of combined systemic ascorbic acid (vitamin C) and d-alpha-tocopherol (vitamin E). J Am Acad Dermatol 38:45-48, 1998
12. Fryer MJ: Evidence for the photoprotective effects of vitamin E. Photochem Photobiol 58:304-312, 1993
13. Fukuda A, Osawa T, Hitomi K, Uchida K: 4-Hydroxy-2-nonenal cytotoxicity in renal proximal tubular cells: Protein modification and redox alteration. Arch Biochem Biophys 333:419-426, 1996
14. Gross S, Knebel A, Tenev T, Neininger A, Gaestel M, Herrlich P, Bohmer FD: Inactivation of protein-tyrosine phosphatases as mechanism of UV-induced signal transduction. J Biol Chem 274:26378-26386, 1999
15. Haneda M, Sugimoto T, Kikkawa R: Mitogen-activated protein kinase phosphatase: A negative regulator of the mitogen-activated protein kinase cascade. Eur J Pharmacol 365:1-7, 1999
16. Hedley D, Chow S: Flow cytometric measurement of lipid peroxidation in vital cells using parinaric acid. Cytometry 13:686-692, 1992
17. Hibi M, Lin A, Smeal T, Minden A, Karin M: Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev 7:2135-2148, 1993
18. Huang RP, Wu JX, Fan Y, Adamson ED: UV activates growth factor receptors via reactive oxygen intermediates. J Cell Biol 133:211-220, 1996
19. Ischiropoulos H, Gow A, Thom SR, Kooy NW, Royall JA, Crow JP: Detection of reactive nitrogen species using 2,7-dichlorodihydrofluorescein and dihydrorhodamine 123. Meth Enzymol 301:367-373, 1999
20. Jurkiewicz BA, Bissett DL, Buettner GR: Effect of topically applied tocopherol on ultraviolet radiation-mediated free radical damage in skin. J Invest Dermatol 104:484-488, 1995
21. Karin M: The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem 270:16483-16486, 1995
22. May JM, Qu ZC, Cobb CE: Accessibility and reactivity of ascorbate 6-palmitate bound to erythrocyte membranes. Free Radic Biol Med 21:471-480, 1996
23. Meister A: Glutathione, ascorbate, and cellular protection. Cancer Res 54:1969s-1975s, 1994
24. 2 mediates oxidative stress-induced epidermal growth factor receptor phosphorylation. Toxicol Lett 122:205-214, 2001
25. Packer L: Ultraviolet radiation (UVA, UVB) and skin antioxidants. In: Rice-Evans CA Burdon RH, eds. Free Radical Damage and its Control. Amsterdam: Elsevier, 1994: pp 239-255
26. Pap EH, Drummen GP, Winter VJ, et al: Ratio-fluorescence microscopy of lipid oxidation in living cells using C11-BODIPY (581/591). FEBS Lett 25:278-282, 1999
27. Pathak MA, Nghiem P, Fitzpatrick TB: Acute and chronic effects of the sun. In: Freedberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI, eds. Fitzpatrick's Dermatology in General Medicine, 5th edn. New York: McGraw-Hill, 1999 pp 1598-1607
28. Peus D, Hamacher L, Pittelkow MR: EGF-receptor tyrosine kinase inhibition induces keratinocyte growth arrest and terminal differentiation. J Invest Dermatol 109:751-756, 1997
29. 2 is an important mediator of UVB-induced EGF-receptor phosphorylation in cultured keratinocytes. J Invest Dermatol 110:966-971, 1998
30. 2 is required for UVB-induced EGF receptor and downstream signaling pathway activation. Free Radic Biol Med 27:1197-1202, 1999a
31. Peus D, Vasa RA, Beyerle A, Meves A, Krautmacher C, Pittelkow MR: UVB activates ERK1/2 and p38 signaling pathways via reactive oxygen species in cultured keratinocytes. J Invest Dermatol 112:751-756, 1999b
32. Peus D, Beyerle A, Rittner HL, Pott M, Meves A, Weyand C, Pittelkow MR: Antipsoriatic drug anthralin activates JNK via lipid peroxidation: Mononuclear cells are more sensitive than keratinocytes. J Invest Dermatol 114:688-692, 2000a
33. Peus D, Vasa RA, Meves A, Beyerle A, Pittlekow MR: UVB-induced epidermal growth factor receptor phosphorylation is critical for downstream signaling and keratinocyte survival. Photochem Photobiol 72:135-140, 2000b
34. Schreiber M, Baumann B, Cotton M, Angel P, Wagner EF: Fos is an essential component of the mammalian UV response. Embo J 14:5338-5349, 1995
35. Shindo Y, Witt E, Packer L: Antioxidant defense mechanisms in murine epidermis and dermis and their responses to ultraviolet light. J Invest Dermatol 100:260-265, 1993
36. Suzuki S, Miyachi Y, Niwa Y, Isshiki N: Significance of reactive oxygen species in distal flap necrosis and its salvage with liposomal SOD. Br J Plast Surg 42:559-564, 1989
37. Tebbe B, Wu S, Geilen CC, Eberle J, Kodelja V, Orfanos CE: 1-Ascorbic acid inhibits UVA-induced lipid peroxidation and secretion of IL-1alpha and IL-6 in cultured human keratinocytes in vitro. J Invest Dermatol 108:302-306, 1997
38. Uchida K, Shiraishi M, Naito Y, Torii Y, Nakamura Y, Osawa T: Activation of stress signaling pathways by the end product of lipid peroxidation: 4-hydroxy-2-nonenal is a potential inducer of intracellular peroxide production. J Biol Chem 274:2234-2242, 1999