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Volumn , Issue , 2008, Pages

Statins activate human PPARα promoter and increase PPARα mRNA expression and activation in HepG2 cells

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A OXIDASE; ATORVASTATIN; CERIVASTATIN; FLUINDOSTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PITAVASTATIN; PRAVASTATIN; ROSUVASTATIN; SIMVASTATIN;

EID: 58149460011     PISSN: 16874757     EISSN: 16874765     Source Type: Journal    
DOI: 10.1155/2008/316306     Document Type: Article
Times cited : (27)

References (35)
  • 2
    • 9144234810 scopus 로고    scopus 로고
    • Pitavastatin, a potent hydroxymethylglutaryl coenzyme a reductase inhibitor, increases cholesterol 7 α -hydroxylase gene expression in HepG2 cells
    • Fan P., Zhang B., Kuroki S., Saku K., Pitavastatin, a potent hydroxymethylglutaryl coenzyme a reductase inhibitor, increases cholesterol 7 α -hydroxylase gene expression in HepG2 cells Circulation Journal 2004 68 11 1061 1066
    • (2004) Circulation Journal , vol.68 , Issue.11 , pp. 1061-1066
    • Fan, P.1    Zhang, B.2    Kuroki, S.3    Saku, K.4
  • 4
    • 0029074865 scopus 로고
    • Design features and baseline characteristics of the LIPID (long-term intervention with pravastatin in ischemic disease) study: A randomized trial in patients with previous acute myocardial infarction and/or unstable angina pectoris
    • Tonkin A., Aylward P., Colquhoun D., Design features and baseline characteristics of the LIPID (long-term intervention with pravastatin in ischemic disease) study: a randomized trial in patients with previous acute myocardial infarction and/or unstable angina pectoris The American Journal of Cardiology 1995 76 7 474 479
    • (1995) The American Journal of Cardiology , vol.76 , Issue.7 , pp. 474-479
    • Tonkin, A.1    Aylward, P.2    Colquhoun, D.3
  • 5
    • 0035910051 scopus 로고    scopus 로고
    • Influence of low high-density lipoprotein cholesterol and elevated triglyceride on coronary heart disease events and response to simvastatin therapy in 4S
    • Ballantyne C. M., Olsson A. G., Cook T. J., Mercuri M. F., Pedersen T. R., Kjekshus J., Influence of low high-density lipoprotein cholesterol and elevated triglyceride on coronary heart disease events and response to simvastatin therapy in 4S Circulation 2001 104 25 3046 3051
    • (2001) Circulation , vol.104 , Issue.25 , pp. 3046-3051
    • Ballantyne, C.M.1    Olsson, A.G.2    Cook, T.J.3    Mercuri, M.F.4    Pedersen, T.R.5    Kjekshus, J.6
  • 6
    • 0036804450 scopus 로고    scopus 로고
    • Factors affecting low-density lipoprotein and high-density lipoprotein cholesterol response to pravastatin in the West of Scotland Coronary Prevention Study (WOSCOPS)
    • Streja L., Packard C. J., Shepherd J., Cobbe S., Ford I., Factors affecting low-density lipoprotein and high-density lipoprotein cholesterol response to pravastatin in the West of Scotland Coronary Prevention Study (WOSCOPS) The American Journal of Cardiology 2002 90 7 731 736
    • (2002) The American Journal of Cardiology , vol.90 , Issue.7 , pp. 731-736
    • Streja, L.1    Packard, C.J.2    Shepherd, J.3    Cobbe, S.4    Ford, I.5
  • 7
    • 0033618378 scopus 로고    scopus 로고
    • 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing Rho GTPase-induced down-regulation of p 27 K i p 1
    • Laufs U., Marra D., Node K., Liao J. K., 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing Rho GTPase-induced down-regulation of p 27 K i p 1 The Journal of Biological Chemistry 1999 274 31 21926 21931
    • (1999) The Journal of Biological Chemistry , vol.274 , Issue.31 , pp. 21926-21931
    • Laufs, U.1    Marra, D.2    Node, K.3    Liao, J.K.4
  • 8
    • 0034987274 scopus 로고    scopus 로고
    • NK-104, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, reduces osteopontin expression by rat aortic smooth muscle cells
    • Takemoto M., Kitahara M., Yokote K., NK-104, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, reduces osteopontin expression by rat aortic smooth muscle cells British Journal of Pharmacology 2001 133 1 83 88
    • (2001) British Journal of Pharmacology , vol.133 , Issue.1 , pp. 83-88
    • Takemoto, M.1    Kitahara, M.2    Yokote, K.3
  • 9
    • 5444226475 scopus 로고    scopus 로고
    • The effect of high glucose on NO and O2- through endothelial GTPCH1 and NADPH oxidase
    • Ding Q., Hayashi T., Packiasamy A. J., The effect of high glucose on NO and O2- through endothelial GTPCH1 and NADPH oxidase Life Sciences 2004 75 26 3185 3194
    • (2004) Life Sciences , vol.75 , Issue.26 , pp. 3185-3194
    • Ding, Q.1    Hayashi, T.2    Packiasamy, A.J.3
  • 10
    • 0036321078 scopus 로고    scopus 로고
    • Glucose increases endothelial-dependent superoxide formation in coronary arteries by NAD(P)H oxidase activation
    • Christ M., Bauersachs J., Liebetrau C., Heck M., Günther A., Wehling M., Glucose increases endothelial-dependent superoxide formation in coronary arteries by NAD(P)H oxidase activation Diabetes 2002 51 8 2648 2652
    • (2002) Diabetes , vol.51 , Issue.8 , pp. 2648-2652
    • Christ, M.1    Bauersachs, J.2    Liebetrau, C.3    Heck, M.4    Günther, A.5    Wehling, M.6
  • 11
    • 0034647595 scopus 로고    scopus 로고
    • Lipophilic HMG-CoA reductase inhibitor has an anti-inflammatory effect: Reduction of mRNA levels for interleukin-1 β, interleukin-6, cyclooxygenase-2, and p22phox by regulation of peroxisome proliferator-activated receptor α (PPAR α) in primary endothelial cells
    • Inoue I., Goto S.-I., Mizotani K., Lipophilic HMG-CoA reductase inhibitor has an anti-inflammatory effect: reduction of mRNA levels for interleukin-1 β, interleukin-6, cyclooxygenase-2, and p22phox by regulation of peroxisome proliferator-activated receptor α (PPAR α) in primary endothelial cells Life Sciences 2000 67 8 863 876
    • (2000) Life Sciences , vol.67 , Issue.8 , pp. 863-876
    • Inoue, I.1    Goto, S.-I.2    Mizotani, K.3
  • 12
    • 0030602866 scopus 로고    scopus 로고
    • The peroxisome proliferator activated receptors (PPARs) and their effects on lipid metabolism and adipocyte differentiation
    • Schoonjans K., Staels B., Auwerx J., The peroxisome proliferator activated receptors (PPARs) and their effects on lipid metabolism and adipocyte differentiation Biochimica et Biophysica Acta 1996 1302 2 93 109
    • (1996) Biochimica et Biophysica Acta , vol.1302 , Issue.2 , pp. 93-109
    • Schoonjans, K.1    Staels, B.2    Auwerx, J.3
  • 16
    • 36949009469 scopus 로고    scopus 로고
    • Peroxisome proliferator activated receptors and lipoprotein metabolism
    • Kersten S., Peroxisome proliferator activated receptors and lipoprotein metabolism PPAR Research 2008 2008 11
    • (2008) PPAR Research , vol.2008 , pp. 11
    • Kersten, S.1
  • 17
    • 0037165840 scopus 로고    scopus 로고
    • Triglyceride-lowering effect of pitvastatin in a rat model of postprandial lipemia
    • Aoki T., Yoshinaka Y., Yamazaki H., Triglyceride-lowering effect of pitvastatin in a rat model of postprandial lipemia European Journal of Pharmacology 2002 444 1-2 107 113
    • (2002) European Journal of Pharmacology , vol.444 , Issue.1-2 , pp. 107-113
    • Aoki, T.1    Yoshinaka, Y.2    Yamazaki, H.3
  • 18
    • 33646686191 scopus 로고    scopus 로고
    • Effects of obesity on lipid-lowering, anti-inflammatory, and antiatherosclerotic benefits of atorvastatin or pravastatin in patients with coronary artery disease (from the REVERSAL Study)
    • Nicholls S. J., Tuzcu E. M., Sipahi I., Effects of obesity on lipid-lowering, anti-inflammatory, and antiatherosclerotic benefits of atorvastatin or pravastatin in patients with coronary artery disease (from the REVERSAL Study) The American Journal of Cardiology 2006 97 11 1553 1557
    • (2006) The American Journal of Cardiology , vol.97 , Issue.11 , pp. 1553-1557
    • Nicholls, S.J.1    Tuzcu, E.M.2    Sipahi, I.3
  • 19
    • 48049109174 scopus 로고    scopus 로고
    • Baseline triglyceride levels and insulin sensitivity are major determinants of the increase of LDL particle size and buoyancy induced by rosuvastatin treatment in patients with primary hyperlipidemia
    • Kostapanos M. S., Milionis H. J., Lagos K. G., Rizos C. B., Tselepis A. D., Elisaf M. S., Baseline triglyceride levels and insulin sensitivity are major determinants of the increase of LDL particle size and buoyancy induced by rosuvastatin treatment in patients with primary hyperlipidemia European Journal of Pharmacology 2008 590 1-3 327 332
    • (2008) European Journal of Pharmacology , vol.590 , Issue.1-3 , pp. 327-332
    • Kostapanos, M.S.1    Milionis, H.J.2    Lagos, K.G.3    Rizos, C.B.4    Tselepis, A.D.5    Elisaf, M.S.6
  • 20
    • 13644255995 scopus 로고    scopus 로고
    • Atorvastatin improves peroxisome proliferator-activated receptor signaling in cardiac hypertrophy by preventing nuclear factor- κ B activation
    • Planavila A., Laguna J. C., Vazquez-Carrera M., Atorvastatin improves peroxisome proliferator-activated receptor signaling in cardiac hypertrophy by preventing nuclear factor- κ B activation Biochimica et Biophysica Acta 2005 1687 1-3 76 83
    • (2005) Biochimica et Biophysica Acta , vol.1687 , Issue.1-3 , pp. 76-83
    • Planavila, A.1    Laguna, J.C.2    Vazquez-Carrera, M.3
  • 21
    • 3042638413 scopus 로고    scopus 로고
    • Simvastatin modulates TNF α -induced adhesion molecules expression in human endothelial cells
    • Zapolska-Downar D., Siennicka A., Kaczmarczyk M., Kołodziej B., Naruszewicz M., Simvastatin modulates TNF α -induced adhesion molecules expression in human endothelial cells Life Sciences 2004 75 11 1287 1302
    • (2004) Life Sciences , vol.75 , Issue.11 , pp. 1287-1302
    • Zapolska-Downar, D.1    Siennicka, A.2    Kaczmarczyk, M.3    Kołodziej, B.4    Naruszewicz, M.5
  • 22
    • 8544237037 scopus 로고    scopus 로고
    • Statin induction of liver fatty acid-binding protein (L-FABP) gene expression is peroxisome proliferator-activated receptor- α -dependent
    • Landrier J.-F., Thomas C., Grober J., Statin induction of liver fatty acid-binding protein (L-FABP) gene expression is peroxisome proliferator- activated receptor- α -dependent The Journal of Biological Chemistry 2004 279 44 45512 45518
    • (2004) The Journal of Biological Chemistry , vol.279 , Issue.44 , pp. 45512-45518
    • Landrier, J.-F.1    Thomas, C.2    Grober, J.3
  • 23
    • 0036013438 scopus 로고    scopus 로고
    • Characterization of the human PPAR α promoter: Identification of a functional nuclear receptor response element
    • Torra I. P., Jamshidi Y., Flavell D. M., Fruchart J.-C., Staels B., Characterization of the human PPAR α promoter: identification of a functional nuclear receptor response element Molecular Endocrinology 2002 16 5 1013 1028
    • (2002) Molecular Endocrinology , vol.16 , Issue.5 , pp. 1013-1028
    • Torra, I.P.1    Jamshidi, Y.2    Flavell, D.M.3    Fruchart, J.-C.4    Staels, B.5
  • 24
    • 0042009938 scopus 로고    scopus 로고
    • Apoptosis of endothelial cells may be mediated by genes of peroxisome proliferator-activated receptor γ 1 (PPAR γ 1) and PPAR α genes
    • Inoue I., Hayashi K., Yagasaki F., Apoptosis of endothelial cells may be mediated by genes of peroxisome proliferator-activated receptor γ 1 (PPAR γ 1) and PPAR α genes Journal of Atherosclerosis and Thrombosis 2003 10 2 99 108
    • (2003) Journal of Atherosclerosis and Thrombosis , vol.10 , Issue.2 , pp. 99-108
    • Inoue, I.1    Hayashi, K.2    Yagasaki, F.3
  • 25
    • 26944446214 scopus 로고    scopus 로고
    • CLOCK/BMAL1 is involved in lipid metabolism via transactivation of the peroxisome proliferator-activated receptor (PPAR) response element
    • Inoue I., Shinoda Y., Ikeda M., CLOCK/BMAL1 is involved in lipid metabolism via transactivation of the peroxisome proliferator-activated receptor (PPAR) response element Journal of Atherosclerosis and Thrombosis 2005 12 3 169 174
    • (2005) Journal of Atherosclerosis and Thrombosis , vol.12 , Issue.3 , pp. 169-174
    • Inoue, I.1    Shinoda, Y.2    Ikeda, M.3
  • 27
    • 0035174867 scopus 로고    scopus 로고
    • New evidence for beneficial effects of statins unrelated to lipid lowering
    • Palinski W., New evidence for beneficial effects of statins unrelated to lipid lowering Arteriosclerosis, Thrombosis, and Vascular Biology 2001 21 1 3 5
    • (2001) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.21 , Issue.1 , pp. 3-5
    • Palinski, W.1
  • 28
    • 0141430989 scopus 로고    scopus 로고
    • Rosuvastatin reduces atherosclerosis development beyond and independent of its plasma cholesterol-lowering effect in APOE * 3 -Leiden transgenic mice: Evidence for antiinflammatory effects of rosuvastatin
    • Kleemann R., Princen H. M. G., Emeis J. J., Rosuvastatin reduces atherosclerosis development beyond and independent of its plasma cholesterol-lowering effect in APOE * 3 -Leiden transgenic mice: evidence for antiinflammatory effects of rosuvastatin Circulation 2003 108 11 1368 1374
    • (2003) Circulation , vol.108 , Issue.11 , pp. 1368-1374
    • Kleemann, R.1    Princen, H.M.G.2    Emeis, J.J.3
  • 29
    • 0036186165 scopus 로고    scopus 로고
    • Atorvastatin activates PPAR- γ and attenuates the inflammatory response in human monocytes
    • Grip O., Janciauskiene S., Lindgren S., Atorvastatin activates PPAR- γ and attenuates the inflammatory response in human monocytes Inflammation Research 2002 51 2 58 62
    • (2002) Inflammation Research , vol.51 , Issue.2 , pp. 58-62
    • Grip, O.1    Janciauskiene, S.2    Lindgren, S.3
  • 31
    • 0028987876 scopus 로고
    • Mechanisms of hepatocarcinogenicity of peroxisome-proliferating drugs and chemicals
    • Lake B. G., Mechanisms of hepatocarcinogenicity of peroxisome- proliferating drugs and chemicals Annual Review of Pharmacology and Toxicology 1995 35 483 507
    • (1995) Annual Review of Pharmacology and Toxicology , vol.35 , pp. 483-507
    • Lake, B.G.1
  • 33
    • 0030771856 scopus 로고    scopus 로고
    • Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor
    • Zhu Y., Qi C., Jain S., Rao M. S., Reddy J. K., Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor The Journal of Biological Chemistry 1997 272 41 25500 25506
    • (1997) The Journal of Biological Chemistry , vol.272 , Issue.41 , pp. 25500-25506
    • Zhu, Y.1    Qi, C.2    Jain, S.3    Rao, M.S.4    Reddy, J.K.5
  • 34
    • 0032549811 scopus 로고    scopus 로고
    • A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
    • Puigserver P., Wu Z., Park C. W., Graves R., Wright M., Spiegelman B. M., A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis Cell 1998 92 6 829 839
    • (1998) Cell , vol.92 , Issue.6 , pp. 829-839
    • Puigserver, P.1    Wu, Z.2    Park, C.W.3    Graves, R.4    Wright, M.5    Spiegelman, B.M.6
  • 35
    • 33644636344 scopus 로고    scopus 로고
    • Going nuclear in metabolic and cardiovascular disease
    • Glass C. K., Going nuclear in metabolic and cardiovascular disease Journal of Clinical Investigation 2006 116 3 556 560
    • (2006) Journal of Clinical Investigation , vol.116 , Issue.3 , pp. 556-560
    • Glass, C.K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.