A double blind, single centre, sub-chronic reperfusion trial evaluating FX06 following haemorrhagic shock in pigs

Resuscitation

Volumn 80, Issue 2, 2009, Pages 264-271

  Roesner, Jan P ^a   Petzelbauer, Peter ^b   Koch, Alexander ^c   Tran, Nguyen ^c   Iber, Thomas ^a   Mutz, Christian ^a   Vollmar, Brigitte ^d   Nöldge Schomburg, Gabriele E F ^a   Zacharowski, Kai ^c  

^a ROSTOCK UNIVERSITY MEDICAL CENTER   (Germany)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c UNIVERSITY HOSPITALS BRISTOL NHS FOUNDATION TRUST   (United Kingdom)

^d UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

Fibrin derived peptide; Haemorrhagic shock; Organ injury; Oxygen deficit; Trauma

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CREATININE; ELECTROLYTE; ENDOTOXIN; FIBRIN DERIVATIVE; FX 06; HEMOGLOBIN; PEPTIDE; PEPTIDE B BETA[15-42]; PROTEIN S100B; TROPONIN T; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BACTERIAL TRANSLOCATION; BLEEDING; BLOOD EXAMINATION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE MODEL; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG SCREENING; FLUID RESUSCITATION; HEART FUNCTION; HEART STROKE VOLUME; HEMATOCRIT; HEMODYNAMICS; HEMOGLOBIN BLOOD LEVEL; HEMORRHAGIC SHOCK; HYPOXIA; INTESTINE INJURY; KIDNEY DYSFUNCTION; KIDNEY INJURY; LIVER DYSFUNCTION; LIVER INJURY; MALE; MORTALITY; NEUROLOGIC DISEASE; NONHUMAN; ORGAN INJURY; OXYGEN TENSION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN SECRETION; REPERFUSION INJURY; SWINE; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; THERAPY EFFECT; UREA NITROGEN BLOOD LEVEL;

ANIMALS; ANTICOAGULANTS; ASPARTATE AMINOTRANSFERASES; BLOOD GLUCOSE; BLOOD UREA NITROGEN; CREATINE KINASE; DISEASE MODELS, ANIMAL; DOUBLE-BLIND METHOD; DRUG EVALUATION, PRECLINICAL; ENDOTOXINS; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; GLUTAMATE DEHYDROGENASE; INTERLEUKINS; L-LACTATE DEHYDROGENASE; LEUKOCYTE COUNT; MALE; NERVE GROWTH FACTORS; NEUROLOGIC EXAMINATION; OXYGEN; PEPTIDE FRAGMENTS; PULMONARY GAS EXCHANGE; RANDOM ALLOCATION; REPERFUSION; RESUSCITATION; S100 PROTEINS; SHOCK, HEMORRHAGIC; STROKE VOLUME; SWINE; TROPONIN T; TUMOR NECROSIS FACTOR-ALPHA;

EID: 58149349753     PISSN: 03009572     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resuscitation.2008.10.019     Document Type: Article

References (34)

1. Krug E.G., Sharma G.K., and Lozano R. The global burden of injuries. Am J Public Health 90 4 (2000) 523-526
2. Moore F.A., Sauaia A., Moore E.E., Haenel J.B., Burch J.M., and Lezotte D.C. Postinjury multiple organ failure: a bimodal phenomenon. J Trauma 40 4 (1996) 501-510
3. Angele M.K., Schneider C.P., and Chaudry I.H. Bench-to-bedside review: latest results in hemorrhagic shock. Crit Care 12 4 (2008) 218
4. Bailey R.W., Brengman M.L., Fuh K.C., Hamilton S.R., Herlong H.F., and Bulkley G.B. Hemodynamic pathogenesis of ischemic hepatic injury following cardiogenic shock/resuscitation. Shock 14 4 (2000) 451-459
5. de Perrot M., Liu M., Waddell T.K., and Keshavjee S. Ischemia-reperfusion-induced lung injury. Am J Respir Crit Care Med 167 4 (2003) 490-511
6. Malone D.L., Dunne J., Tracy J.K., Putnam A.T., Scalea T.M., and Napolitano L.M. Blood transfusion, independent of shock severity, is associated with worse outcome in trauma. J Trauma 54 5 (2003) 898-905
7. Roesner J.P., Petzelbauer P., Koch A., et al. The fibrin-derived peptide Bbeta15-42 is cardioprotective in a pig model of myocardial ischemia-reperfusion injury. Crit Care Med 35 7 (2007) 1730-1735
8. Yellon D.M., and Hausenloy D.J. Mechanisms of disease: myocardial reperfusion injury. N Engl J Med 357 11 (2007) 1121-1135
9. Zakaria e., Spain D.A., Harris P.D., and Garrison R.N. Resuscitation regimens for hemorrhagic shock must contain blood. Shock 18 6 (2002) 567-573
10. 15-42 (FX06) reduces pulmonary, myocardial, liver and small intestine damage in a pig model of hemorrhagic shock and reperfusion. Crit Care Med; in press.
11. Petzelbauer P., Zacharowski P.A., Miyazaki Y., et al. The fibrin-derived peptide Bbeta15-42 protects the myocardium against ischemia-reperfusion injury. Nat Med 11 3 (2005) 298-304
12. Zacharowski K., Zacharowski P., Reingruber S., and Petzelbauer P. Fibrin(ogen) and its fragments in the pathophysiology and treatment of myocardial infarction. J Mol Med 84 6 (2006) 469-477
13. Zacharowski K., Zacharowski P.A., Friedl P., et al. The effects of the fibrin-derived peptide Bbeta15-42 in acute and chronic rodent models of myocardial ischemia-reperfusion. Shock 27 6 (2007) 631-637
14. Rixen D., Raum M., Holzgraefe B., Sauerland S., Nagelschmidt M., and Neugebauer E.A.M. A pig hemorrhagic shock model: oxygen debt and metabolic acidemia as indicators of severity. Shock 16 3 (2001) 239-244
15. Berg R.A., Otto C.W., Kern K.B., et al. High-dose epinephrine results in greater early mortality after resuscitation from prolonged cardiac-arrest in pigs-a prospective. Randomized study. Crit Care Med 22 2 (1994) 282-290
16. Fink M.P. Reactive oxygen species as mediators of organ dysfunction caused by sepsis, acute respiratory distress syndrome, or hemorrhagic shock: potential benefits of resuscitation with Ringer's ethyl pyruvate solution. Curr Opin Clin Nutr Metab Care 5 2 (2002) 167-174
17. Frangogiannis N.G., Smith C.W., and Entman M.L. The inflammatory response in myocardial infarction. Cardiovasc Res 53 1 (2002) 31-47
18. Harlan J.M., and Winn R.K. Leukocyte-endothelial interactions: clinical trials of anti-adhesion therapy. Crit Care Med 30 5 Suppl. (2002) S214-S219
19. Shenkar R., and Abraham E. Mechanisms of lung neutrophil activation after hemorrhage or endotoxemia: roles of reactive oxygen intermediates, NF-kappa B, and cyclic AMP response element binding protein. J Immunol 163 2 (1999) 954-962
20. Ware L.B., Golden J.A., Finkbeiner W.E., and Matthay M.A. Alveolar epithelial fluid transport capacity in reperfusion lung injury after lung transplantation. Am J Respir Crit Care Med 159 3 (1999) 980-988
21. Ikonomidis I., Athanassopoulos G., Lekakis J., et al. Myocardial ischemia induces interleukin-6 and tissue factor production in patients with coronary artery disease: a dobutamine stress echocardiography study. Circulation 112 21 (2005) 3272-3279
22. Matsushita K., Iwanaga S., Oda T., et al. Interleukin-6/soluble interleukin-6 receptor complex reduces infarct size via inhibiting myocardial apoptosis. Lab Invest 85 10 (2005) 1210-1223
23. Romano M., Sironi M., Toniatti C., et al. Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment. Immunity 6 3 (1997) 315-325
24. Yang R.K., Han X.N., Uchiyama T., et al. IL-6 is essential for development of gut barrier dysfunction after hemorrhagic shock and resuscitation in mice. Am J Physiol-Gastrointest Liver Physiol 285 3 (2003) G621-G629
25. Sperry J.L., Friese R.S., Frankel H.L., et al. Male gender is associated with excessive IL-6 expression following severe injury. J Trauma-Injury Infect Crit Care 64 3 (2008) 572-578
26. Roumen R.M.H., Hendriks T., Vandervenjongekrijg J., et al. Cytokine patterns in patients after major vascular-surgery, hemorrhagic-shock, and severe blunt trauma-relation with subsequent adult-respiratory-distress-syndrome and multiple organ failure. Ann. Surg 218 6 (1993) 769-776
27. Kauvar D.S., and Wade C.E. The epidemiology and modern management of traumatic hemorrhage: US and international perspectives. Crit Care 9 Suppl 5 (2005) S1-S9
28. Kwan I, Bunn F, Roberts I, on behalf of the WHO Pre-Hospital Trauma Care Steering Committee. Timing and volume of fluid administration for patients with bleeding. Cochrane Database of Systematic Reviews 2003, Issue 3. Art. No.: CD002245. DOI: 10.1002/14651858.CD002245.
29. Alam H.B., Chen Z., Ahuja N., et al. Profound hypothermia protects neurons and astrocytes, and preserves cognitive functions in a Swine model of lethal hemorrhage. J Surg Res 126 2 (2005) 172-181
30. Greenburg A.G., and Kim H.W. Hemoglobin-based oxygen carriers. Crit Care 8 Suppl. 2 (2004) S61-S64
31. Honma K., Koles N.L., Alam H.B., et al. Administration of recombinant interleukin-11 improves the hemodynamic functions and decreases third space fluid loss in a porcine model of hemorrhagic shock and resuscitation. Shock 23 6 (2005) 539-542
32. Johnson T., Arnaud F., Dong F., et al. Bovine polymerized hemoglobin (hemoglobin-based oxygen carrier-201) resuscitation in three swine models of hemorrhagic shock with militarily relevant delayed evacuation-effects on histopathology and organ function. Crit Care Med 34 5 (2006) 1464-1474
33. Proctor K.G. Blood substitutes and experimental models of trauma. J Trauma 54 5 Suppl. (2003) S106-S109
34. Sloan E.P., Koenigsberg M., Gens D., et al. Diaspirin cross-linked hemoglobin (DCLHb) in the treatment of severe traumatic hemorrhagic shock: a randomized controlled efficacy trial. JAMA 282 19 (1999) 1857-1864