Myocardial ischemia induces interleukin-6 and tissue factor production in patients with coronary artery disease: A dobutamine stress echocardiography study

Circulation

Volumn 112, Issue 21, 2005, Pages 3272-3279

  Ikonomidis, Ignatios ^a   Athanassopoulos, George ^b   Lekakis, John ^a   Venetsanou, Kyriaki ^a   Marinou, Margarita ^b   Stamatelopoulos, Kimon ^a   Cokkinos, Dennis V ^b   Nihoyannopoulos, Petros ^c  

^a UNIVERSITY OF ATHENS   (Greece)

^b ONASSIS CARDIAC SURGERY CENTER   (Greece)

^c HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

Echocardiography; Hypoxia; Interleukins; Ischemia; Tissue factor

Indexed keywords

BIOLOGICAL MARKER; COLONY STIMULATING FACTOR 1; DOBUTAMINE; INTERLEUKIN 6; THROMBOPLASTIN;

ADULT; AGED; ANGIOGRAPHY; ARTICLE; ATHEROSCLEROTIC PLAQUE; BLOOD SAMPLING; CARDIAC PATIENT; CORONARY ARTERY DISEASE; CYTOKINE RELEASE; ENDOTHELIUM CELL; FEMALE; HEART LEFT VENTRICLE FAILURE; HEART MUSCLE ISCHEMIA; HUMAN; HYPOXIA; INOTROPISM; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; REPERFUSION INJURY; STRESS ECHOCARDIOGRAPHY; THROMBOGENESIS; BLOOD; CLINICAL TRIAL; CORONARY ARTERY ATHEROSCLEROSIS; ECHOGRAPHY; HEART LEFT VENTRICLE FUNCTION; HEART STROKE VOLUME; METABOLISM; MIDDLE AGED; PREDICTION AND FORECASTING;

ADULT; AGED; BIOLOGICAL MARKERS; CORONARY ARTERIOSCLEROSIS; ECHOCARDIOGRAPHY, STRESS; FEMALE; HUMANS; INTERLEUKIN-6; MALE; MIDDLE AGED; MYOCARDIAL ISCHEMIA; PREDICTIVE VALUE OF TESTS; STROKE VOLUME; THROMBOPLASTIN; VENTRICULAR DYSFUNCTION, LEFT;

EID: 33644873824     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.104.532259     Document Type: Article

References (46)

1. Biasucci LM, Vitelli A, Liuzzo D, Altamura S, Caliguri G, Monaco C, Rebuzzi AG, Ciliberto G, Maseri A. Elevated levels of interleukin-6 in unstable angina. Circulation. 1996;94:874-877.
2. Miyao Y, Yasue H, Ogawa H, Misumi I, Masuda T, Sakamoto T, Morita E. Elevated plasma interleukin-6 levels ill patients with acute myocardial infarction. Am Heart J. 1993;126:1299-1304.
3. Tashiro H, Simokawa H, Yamamoto K, Nagano M, Momomar M, Muramatu K, Taheshita A. Monocyte-related cytokines in acute myocardial infarction. Am Heart J. 1995;130:446-452.
4. Saitoh T, Kishiba H, Tsukada Y, Fukuma Y, Sano J, Yasutake M, Fukuma N, Kusama Y. Clinical significance of increased plasma concentration of MCSF in patients with angina pectoris. J Am Coll Cardiol. 2000;35: 655-665.
5. Ikonomidis I, Andreotti F, Economou E, Stefanadis C, Toutouzas P, Nihoyannopoulos P. Increased proinflammatory cytokines in patients with chronic stable angina and their reduction by aspirin. Circulation. 1999;100: 793-798.
6. Ikonomidis I, Andreotti F, Nihoyannopoulos P. Reduction of daily-life ischaemia by aspirin in patients with angina: underlying link between thromboxane A2 and macrophage colony stimulating factor. Heart. 2004;90: 389-393.
7. Roth P, Stanley ER. The biology of CSF-1 and its receptor. Curr Top Microbiol Immunol. 1992;181:141-158.
8. Oster W, Brach MA, Grass HJ, Mertelsmann R, Herrmann F. Interleukin-1β (IL-1β) expression in human blood mononuclear phagocytes is differentially regulated by granulocyte-macrophage colony stimulating factor (GM-CSF), M-CSF and IL-3. Blood. 1992;79:1260-1265.
9. Bauer J, Ganter U, Geiger T, Jacobshagen U, Gilberto G. Regulation of interleukin 6 expression in cultured human blood monocytes and monocyte derived macrophages. Blood. 1988;72:1134-1140.
10. Narahara N, Enden T, Wiiger M, Prydz H. Polar expression of tissue factor in human umbilical vein endothelial cell. Arteriorscler Thromb. 1994;14: 1815-1820.
11. Yesner LM, Huh HY, Pearce SF, Silverstein RL. Regulation of monocyte CD36 and thrombospondin expression by soluble mediators. Arterioscler Thromb Vasc Biol. 1996;16:1019-1025.
12. Lyberg T, Stanley ER, Prydz H. Colony stimulating factor -1 induces thromboplastin activity in murine macrophages and human monocytes. J Cell Physiol. 1987;132:367-370.
13. Tremoli E, Camera M, Toschi V, Colli S. Tissue factor in atherosclerosis. Atherosclerosis. 1999;144:273-283.
14. Misumi K, Ogawa H, Yasue H, Soejima H, Suefuji H, Nishiyama K, Takazoe K, Kugiyama K, Tsuji I, Kumeda K, Nakamura S. Comparison of plasma tissue factor levels in unstable and stable angina pectoris. Am J Cardiol. 1998;81:22-26.
15. Falciani M, Gori AM, Fedi S, Chiarugi L, Simonetti I, Dabizzi RP, Prisco D, Pepe G, Abbate R, Gensini GF, Neri Serneri GG. Elevated tissue factor and tissue factor pathway inhibitor circulating levels in ischaemic heart disease patients. Thromb Haemost. 1998;79:495-499.
16. Kukielka GL, Smith CW, Manning AM, Youker KA, Michael LH, Entman ML. Induction of interleukin-6 synthesis in the myocardium: potential role in post-perfusion inflammatory injury. Circulation. 1995;92:1866-1875.
17. Chong AJ, Pohlman T, Hampton CR, Shimamoto A, Mackman N, Verrier ED. Tissue factor and thrombin mediate myocardial ischaemia-reperfusion injury. Ann Thorac Surg. 2003;75:S649-S655.
18. Febbraio MA, Steensberg A, Starkie RL, McConell GK, Kingwell BA. Skeletal muscle interleukin-6 and tumor necrosis factor-α release in healthy subjects and patients with type 2 diabetes at rest and during exercise. Metabolism. 2003;52:939-944.
19. Sawada SG, Segar DS, Ryan T, Brown S, Dohan B, Williams R, Fineberg N, Armstrong N, Feigenbaum H. Echocardiographic detection of coronary artery disease during dobutamine infusion. Circulation. 1991;83:1605-1614.
20. Hoffmann R, Lethen H, Kühl H, Lepper W, Hanrath P. Extent and severity of test positivity during dobutamine stress echocardiography: influence on the predictive value for coronary artery disease. Eur Heart J. 1999;20: 1485-1492.
21. Tsoukas A, Ikonomidis I, Cokkinos P, Nihoyannopoulos P. Significance of persistent left ventricular dysfunction during recovery after dobutamine stress echocardiography. J Am Coll Cardiol. 1997;30:621-626.
22. Finkel MS, Hoffman RA, Shen L, Oddis CV, Simmons RL, Hattler BG. Interleukin 6 as a mediator of stunned myocardium. Am J Cardiol. 1993;71: 1231-1232.
23. Deng MC, Erren M, Lutgen A, Zimmermann P, Brisse B, Schmitz W, Assmann G, Breithardt G, Scheld H. Interleukin 6 correlates with hemodynamic impairment during dobutamine administration in chronic heart failure. Int J Cardiol. 1996;57:129-134.
24. Neumann F, Ott I, Cawaz M, Richardt G, Holzapfel H, Jochum M, Schomig A. Cardiac release of cytokines and inflammatory responses in acute myocardial infarction. Circulation. 1995;92:748-755.
25. Hulley SB, Cummings SR. Estimating sample size and power In: Designing Clinical Research. Baltimore, Md: Williams and Wilkins; 1988:148, Appendix 13.A, 215.
26. Tanda N, Ohyama H, Yamakawa M, Ericsson M, Tsuji T, Mc Bride J, Elovic A, Wong DT, Login GR. IL-1 and IL-6 in mouse parotid acinar cells: characterization of synthesis, storage and release. Am J Physiol. 1998;274: G147-G156.
27. Conti P Kempuraj D, Di Gioacchino M, Boucher W, Letourneau R, Kandere K, Barbacane RC, Reale M, Felaco M, Frydas S, Theoharides TC. Interleukin 6 and mast cells. Allergy Asthma Proc. 2002;23:331-335.
28. Kandere-Grzybowska K, Letourneau R, Kempruraj D, Donela J, Poplawski S, Bouche W, Athanassiou A, Theocharides TC. IL-1 induces vesicular secretion of IL-6 without degranulation from human mast cells. J Immunol. 2003;171:4830-4836.
29. Zhu FG, Gomi K, Marshall JS. Short-term cytokine release by mouse bone marrow mast cells and the differentiated KU-812 cell line are inhibited by brefeldin A. J Immunol. 1998;161:2541-2551.
30. Lacy P, Levi-Schaffer F, Mahmudi-Azer S, Babitz B, Hagen SC, Velasquez J, Kay AB, Moqbel R. Intracellular localization of interleukin 6 in eosinophils from atopic asthmatics and effects of interferon gamma. Blood. 1998;91: 2508-2516.
31. Rhind SG, Castellani JW, Brenner IK, Shephard RJ, Zamecnik J, Montain SJ, Young AJ, Shek PN. Intracellular monocyte and serum cytokine expression by exhausting exercise and cold exposure. Am J Physiol Regul Integr Comp Physiol. 2001;281:R66-R75.
32. Gaertner R, Lepailleur-Enouf D, Gonzalez W, Nocoletti A, Mandet C, Philippe M, Mercadier JJ, Michel JB. Pulmonary endothelium as a site of synthesis and storage of interleukin 6 in experimental congestive heart failure. Eur J Heart Fail. 2003;5:435-442.
33. Chi L, Sthno-Bittel L, Smirnova I, Stechschulte DJ, Dileepan KN. Signal transduction pathways in mast cell granule-mediated endothelial cell activation. Mediators Inflamm. 2003;12:79-87.
34. Frangogiannis NG, Lindsey ML, Michael LH, Youker KA, Bressler RB, Mendoza LH, Spengler RN, Smith CW, Entman ML. Resident mast cells degranulate and release preformed TNF-α initiating the cytokine cascade in experimental canine myocardial ischemia reperfusion. Circulation. 1998;98: 699-710.
35. Engler RL. Free radical and granulocyte mediated injury during myocardial ischemia and reperfusion. Am J Cardiol. 1989;63:19E-23E.
36. Sawa Y, Ichikawa H, Kagisaki K, Ohata T, Matsuda H. Interleukin-6 derived from hypoxic myocytes promotes neutrophil-mediated reperfusion injury in myocardium. J Thorac Cardiovasc Surg. 1998;116:511-515.
37. Kinugawa T, Kato M, Ogino K, Osaki S, Tomikura Y, Igawa O, Hisatome I, Shigemasa C. Interleukin-6 and tumor necrosis factor-α levels increase in response to maximal exercise in patients with chronic heart failure. Int J Cardiol. 2003;87:83-90.
38. Deliargyris E, Raymond RJ, Theoharides TC, Boucher WS, Tate DA, Dehmer GJ. Sites of interleukin 6 in patients with acute coronary syndromes and in patients with congestive heart failure. Am J Cardiol. 2000;86:913-918.
39. Kaplan DL, Eielson CM, Horowitz MC, Insogna KL, Weir EC. Tumor necrosis factor-α induces transcription of the colony-stimulating factor-1 gene in murine osteoclasts. J Cell Physiol. 1996;168:199-208.
40. Sadamatsu K, Shimokawa H, Tashiro H, Yamamoto K. Long term treatment with enalapril reduces plasma concentrations of macrophage colony stimulating factor in patients with coronary artery disease. Heart. 2001;86: 457-458.
41. Huang KC, Chen CW, Chen JC, Lin WW. Statins induce suppressor of cytokine signaling-3 in macrophages. FEBS Lett. 2003;555:385-389.
42. Golino P, Ragni M, Cirillo P, Avvedimento VE, Feliciello A, Esposito N, Scognamiglio A, Trimarco B, Iaccarino G, Condorelli M, Chiariello M, Ambrosio G. Effects of tissue factor induced by oxygen free radicals on coronary flow during reperfusion. Nat Med. 1996;2:35-40.
43. Otto I. Tissue factor in acute coronary syndromes. Semin Vasc Med. 2003; 3:185-192.
44. Shyy J, Wickham LL, Hagan JP, Hsieh H, Hu Y, Telian S, Valente AJ, Sung KLP, Chien S. Human monocyte colony-stimulating factor stimulates gene expression of monocyte chemotactic protein 1 and increases the adhesion of monocytes to endothelial monolayers. J Clin Invest. 1993;92:1745-1751.
45. Frangogiannis NG, Mendoza LH, Ren G, Akrivakis S, Jackson PL, Michael LH, Smith CW, Entman ML. MCSF expression is induced in healing myocardial infarcts and may regulate monocyte and endothelial cell phenotype. Am J Physiol Heart Circ Physiol. 2003;285:H483-H492.
46. Nishiyama K, Ogawa H, Yasue H, Soejima H, Misumi K, Takazoe K, Yoshimura M, Kugiyama K, Tsuji I, Kumeda K. Simultaneous elevation of the levels of circulating monocyte chemoattractant protein-1 and tissue factor in acute coronary syndromes. Jpn Circ J. 1998;62:710-712.