Bovine polymerized hemoglobin (hemoglobin-based oxygen carrier-201) resuscitation in three swine models of hemorrhagic shock with militarily relevant delayed evacuation - Effects on histopathology and organ function

Critical Care Medicine

Volumn 34, Issue 5, 2006, Pages 1464-1474

  Johnson, Todd ^a   Arnaud, Francoise ^b   Dong, Feng ^b   Philbin, Nora ^b   Rice, Jennifer ^b   Asher, Ludmila ^c   Arrisueno, Martin ^b   Warndorf, Matthew ^b   Gurney, Jennifer ^e   McGwin, Gerald ^f   Kaplan, Lewis ^g   Flournoy, W Shannon ^d   Apple, Fred S ^h   Pearce, L B ⁱ   Ahlers, Stephen ^b   McCarron, Richard ^b   Freilich, Daniel ^b  

^a NAVAL MEDICAL RESEARCH CENTER   (United States)

^b Operational and Undersea Medicine   (United States)

^c WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^d Department of Veterinary Surgery ^*  (United States)

^e WALTER REED ARMY MEDICAL CENTER   (United States)

^f UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^g YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

ⁱ Biopure Corporation   (United States)

Author keywords

HBOC 201; Hemoglobin based oxygen carrier; Hemorrhagic shock; Histopathology; Organ function; Resuscitation

Indexed keywords

3 NITROTYROSINE; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CREATINE KINASE MB; CREATININE; EOSIN; HEMATOXYLIN; HETASTARCH; LACTATE DEHYDROGENASE; POLYMERIZED HEMOGLOBIN; SODIUM CHLORIDE; BLOOD SUBSTITUTE; HEMOGLOBIN;

ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; BLOOD TRANSFUSION; CONTROLLED STUDY; ELECTRON MICROSCOPY; HEART MUSCLE FIBROSIS; HEART MUSCLE NECROSIS; HEART OUTPUT; HEMODYNAMIC MONITORING; HEMORRHAGIC SHOCK; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; KIDNEY INJURY; KIDNEY PAPILLA; KRUSKAL WALLIS TEST; LIVER INJURY; LIVER NECROSIS; LUNG EDEMA; NONHUMAN; OXIDATION REDUCTION POTENTIAL; OXYGEN TENSION; OXYGEN TRANSPORT; PRIORITY JOURNAL; RESUSCITATION; SWINE; UREA NITROGEN BLOOD LEVEL; URINE VOLUME; ANIMAL; COMPARATIVE STUDY; DISEASE MODEL; DRUG EFFECT; EMERGENCY HEALTH SERVICE; EVALUATION; HEART MUSCLE; HEMODYNAMICS; LUNG; METABOLISM; METHODOLOGY; MILITARY MEDICINE; MORTALITY; NONPARAMETRIC TEST; PATHOLOGY; SURVIVAL; TIME; VISCERA;

ANALYSIS OF VARIANCE; ANIMALS; BLOOD SUBSTITUTES; DISEASE MODELS, ANIMAL; EMERGENCY MEDICAL SERVICES; HEMODYNAMIC PROCESSES; HEMOGLOBINS; HETASTARCH; LUNG; MILITARY MEDICINE; MYOCARDIUM; RESUSCITATION; SHOCK, HEMORRHAGIC; STATISTICS, NONPARAMETRIC; SURVIVAL ANALYSIS; SWINE; TIME FACTORS; VISCERA;

EID: 33646584487     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000215824.85190.89     Document Type: Article

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