A Conserved Postsynaptic Transmembrane Protein Affecting Neuromuscular Signaling in Caenorhabditis elegans

Journal of Neuroscience

Volumn 24, Issue 9, 2004, Pages 2191-2201

  Loria, Paula M ^a   Hodgkin, Jonathan ^b   Hobert, Oliver ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

C. elegans; Genetics; Motor axon; Neuromuscular junction; Neurotransmission; Transmembrane protein

Indexed keywords

COLLAGEN; COLMEDIN; CYSTEINE; MEMBRANE PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CAENORHABDITIS ELEGANS; CHOLINERGIC SYNAPSE; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DROSOPHILA; EXTRACELLULAR MATRIX; GABAERGIC SYSTEM; GABAERGIC TRANSMISSION; GENE; GENE FUNCTION; GENE MUTATION; LIFE; LOCOMOTION; MICROENVIRONMENT; MOLECULAR CLONING; MOTONEURON; MOTOR UNIT; NERVE FIBER; NEUROMUSCULAR TRANSMISSION; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PHYLOGENY; POSTSYNAPTIC MEMBRANE; PRESYNAPTIC NERVE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF; UNC 122 GENE; VERTEBRATE;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CHROMOSOME MAPPING; CONSERVED SEQUENCE; GENES, REPORTER; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MOTOR ACTIVITY; MOTOR NEURONS; MUSCLES; NEUROMUSCULAR JUNCTION; PHENOTYPE; PHYLOGENY; SYNAPSES; SYNAPTIC TRANSMISSION;

EID: 0442272486     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5462-03.2004     Document Type: Article

References (41)

1. Alfonso A, Grundahl K, Duerr JS, Han HP, Rand JB (1993) The Caenorhabditis elegans unc-17 gene: a putative vesicular acetylcholine transporter. Science 261:617-619.
2. Avery L, Thomas JH (1997) Feeding and defecation. In: C. elegans II (Riddle DL, Blumenthal T, Meyer BJ, Priess JR, eds), pp 679-716. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
3. Bamber BA, Beg AA, Twyman RE, Jorgensen EM (1999) The Caenorhabditis elegans unc-49 locus encodes multiple subunits of a heteromultimeric GABA receptor. J Neurosci 19:5348-5359.
4. Brenner S (1974) The genetics of Caenorhabditis elegans. Genetics 77:71-94.
5. Brown MC, Holland RL, Hopkins WG (1981) Motor nerve sprouting. Annu Rev Neurosci 4:17-42.
6. Duerr JS, Frisby DL, Gaskin J, Duke A, Asermely K, Huddleston D, Eiden LE, Rand JB (1999) The cat-1 gene of Caenorhabditis elegans encodes a vesicular monoamine transporter required for specific monoamine-dependent behaviors. J Neurosci 19:72-84.
7. Fares H, Greenwald I (2001) Genetic analysis of endocytosis in Caenorhabditis elegans: coelomocyte uptake defective mutants. Genetics 159:133-145.
8. Feng G, Krejci E, Molgo J, Cunningham JM, Massoulie J, Sanes JR (1999) Genetic analysis of collagen Q: roles in acetylcholinesterase and butyrylcholinesterase assembly and in synaptic structure and function. J Cell Biol 144:1349-1360.
9. Filla MS, Liu X, Nguyen TD, Polansky JR, Brandt CR, Kaufman PL, Peters DM (2002) In vitro localization of TIGR/MYOC in trabecular mesh-work extracellular matrix and binding to fibronectin. Invest Ophthalmol Vis Sci 43:151-161.
10. Fleming JT, Squire MD, Barnes TM, Tornoe C, Matsuda K, Ahnn J, Fire A, Sulston JE, Barnard EA, Sattelle DB, Lewis JA (1997) Caenorhabditis elegans levamisole resistance genes lev-1, unc-29, and unc-38 encode functional nicotinic acetylcholine receptor subunits. J Neurosci 17:5843-5857.
11. Hallam SJ, Jin Y (1998) lin-14 regulates the timing of synaptic remodeling in Caenorhabditis elegans. Nature 395:78-82.
12. Hedgecock EM, Culotti JG, Hall DH (1990) The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans. Neuron 4:61-85.
13. Hillier BJ, Vacquier VD (2003) Amassin, an olfactomedin protein, mediates the massive intercellular adhesion of sea urchin coelomocytes. J Cell Biol 160:597-604.
14. Hobert O, Westphal H (2000) Function of LIM homeobox genes. Trends Genet 16:75-83.
15. Hobert O, Tessmar K, Ruvkun G (1999a) The Caenorhabditis elegans lim-6 LIM homeobox gene regulates neurite outgrowth and function of particular GABAergic neurons. Development 126:1547-1562.
16. Hobert O, Moerman DG, Clark KA, Beckerle MC, Ruvkun G (1999b) A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans. J Cell Biol 144:45-57.
17. Hosono R, Kamiya Y (1991) Additional genes which result in an elevation of acetylcholine levels by mutations in Caenorhabditis elegans. Neurosci Lett 128:243-244.
18. Jessell TM (2000) Neuronal specification in the spinal cord: inductive signals and transcriptional codes. Nat Rev Genet 1:20-29.
19. Jin Y, Jorgensen E, Hartwieg E, Horvitz HR (1999) The Caenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase and is required for synaptic transmission but not synaptic development. J Neurosci 19:539-548.
20. Kent JW, Zahler AM (2000) The Intronerator: exploring introns and alternative splicing in C. elegans. Nucleic Acids Res 28:91-93.
21. Lackner MR, Nurrish SJ, Kaplan JM (1999) Facilitation of synaptic transmission by EGL-30 Gqalpha and EGL-8 PLCbeta: DAG binding to UNC-13 is required to stimulate acetylcholine release. Neuron 24:335-346.
22. Lelianova VG, Davletov BA, Sterling A, Rahman MA, Grishin EV, Totty NF, Ushkaryov YA (1997) Alpha-latrotoxin receptor, latrophilin, is a novel member of the secretin family of G protein-coupled receptors. J Biol Chem 272:21504-21508.
23. Loria PM, Duke A, Rand JB, Hobert O (2003) Two neuronal, nuclear-localized RNA binding proteins involved in synaptic transmission. Curr Biol 13:1317-1323.
24. Mayne R, Brewton RG (1993) New members of the collagen superfamily. Curr Opin Cell Biol 5:883-890.
25. McIntire SL, Reimer RJ, Schuske K, Edwards RH, Jorgensen EM (1997) Identification and characterization of the vesicular GABA transporter. Nature 389:870-876.
26. Mehta N, Loria PM, Hobert O (2004) A genetic screen for neurite out-growth mutants in C. elegans reveals a new function for the F-box ubiquitin ligase component LIN-23. Genetics, in press.
27. Mello CC, Kramer JM, Stinchcomb D, Ambros V (1991) Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences. EMBO J 10:3959-3970.
28. Miller KG, Alfonso A, Nguyen M, Crowell JA, Johnson CD, Rand JB (1996) A genetic selection for Caenorhabditis elegans synaptic transmission mutants. Proc Natl Acad Sci USA 93:12593-12598.
29. Patton BL (2000) Laminins of the neuromuscular system. Microsc Res Tech 51:247-261.
30. Richmond JE, Jorgensen EM (1999) One GABA and two acetylcholine receptors function at the C. elegans neuromuscular junction. Nat Neurosci 2:791-797.
31. Sanes JR, Lichtman JW (1999) Development of the vertebrate neuromuscular junction. Annu Rev Neurosci 22:389-442.
32. Shirasaki R, Pfaff SL (2002) Transcriptional codes and the control of neuronal identity. Annu Rev Neurosci 25:251-281.
33. Snyder DA, Rivers AM, Yokoe H, Menco BP, Anholt RR (1991) Olfactomedin: purification, characterization, and localization of a novel olfactory glycoprotein. Biochemistry 30:9143-9153.
34. Stone EM, Fingert JH, Alward WLM, Nguyen TD, Polansky JR, Sunden SLF, Nishimura D, Clark AF, Nystuen A, Nichols BE, Mackey DA, Ritch R, Kalenak JW, Craven ER, Sheffield VC (1997) Identification of a gene that causes primary open angle glaucoma. Science 275:668-670.
35. Swofford DL (2000) PAUP: phylogenetic analysis using parsimony and other methods. Sunderland, MA: Sinauer.
36. Thompson JD, Gibson TJ, Plewniak F, Jeanmougin F, Higgins DG (1997) The CLUSTAL X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res 25:4876-4882.
37. Thor S, Thomas J (2002) Motor neuron specification in worms, flies and mice: conserved and "lost" mechanisms. Curr Opin Genet Dev 12:558-564.
38. Tsalik EL, Hobert O (2003) Functional mapping of neurons that control locomotory behavior in Caenorhabditis elegans. J Neurobiol 56:178-197.
39. Tsuchida T, Ensini M, Morton SB, Baldassare M, Edlund T, Jessell TM, Pfaff SL (1994) Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes. Cell 79:957-970.
40. Yokoe H, Anholt RR (1993) Molecular cloning of olfactomedin, an extracellular matrix protein specific to olfactory neuroepithelium. Proc Natl Acad Sci USA 90:4655-4659.
41. Zhao H, Nonet ML (2000) A retrograde signal is involved in activity-dependent remodeling at a C. elegans neuromuscular junction. Development 127:1253-1266.