Acid trehalase is involved in intracellular trehalose mobilization during postdiauxic growth and severe saline stress in Saccharomyces cerevisiae

FEMS Yeast Research

Volumn 9, Issue 1, 2009, Pages 52-62

  Garre, Elena ^a,b   Pérez Torrado, Roberto ^b   Gimeno Alcañiz, José V ^b   Matallana, Emilia ^a,b  

^a UNIVERSITY OF VALENCIA   (Spain)

^b INSTITUTO DE AGROQUÍMICA Y TECNOLOGÍA DE ALIMENTOS CSIC   (Spain)

Author keywords

Acid trehalase; Saccharomyces cerevisiae; Stress resistance

Indexed keywords

GENE DELETION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, FUNGAL; MITOGEN-ACTIVATED PROTEIN KINASES; OSMOTIC PRESSURE; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SALINITY; TRANSCRIPTION, GENETIC; TREHALASE; TREHALOSE;

SACCHAROMYCES CEREVISIAE;

EID: 58149333407     PISSN: 15671356     EISSN: 15671364     Source Type: Journal    
DOI: 10.1111/j.1567-1364.2008.00453.x     Document Type: Article

References (40)

1. Alizadeh P Klionsky DJ (1996) Purification and biochemical characterization of the ATH1 gene product, vacuolar acid trehalase, from Saccharomyces cerevisiae. FEBS Lett 39 : 273 278.
2. Blomberg A (2000) Metabolic surprises in Saccharomyces cerevisiae during adaptation to saline conditions: questions, some answers and a model. FEMS Microbiol Lett 182 : 1 8.
3. Chopra R, Sharma VM Ganesan K (1999) Elevated growth of Saccharomyces cerevisiae ATH1 null mutants on glucose is an artefact of nonmatching auxotrophies of mutant and reference strains. Appl Environ Microb 62 : 1563 1569.
4. Crowe JH, Hoekstra FA Crowe LM (1992) Anhydrobiosis. Annu Rev Physiol 54 : 579 599.
5. De Mesquita JF, Panek AD de Araujo PS (2003) In silico and in vivo analysis reveal a novel gene in Saccharomyces cerevisiae trehalose metabolism. BMC Genomics 4 : 45.
6. Destruelle M, Holzer H Klionsky DJ (1995) Isolation and characterization of a novel yeast gene, ATH1, that is required for vacuolar acid trehalase activity. Yeast 11 : 1015 1025.
7. De Virgilio C, Hottiger T, Dominguez J, Boller T Wiemken A (1994) The role of trehalose synthesis for the acquisition of thermotolerance in yeast. I. Genetic evidence that trehalose is a thermoprotectant. Eur J Biochem 219 : 179 186.
8. Elbein AD, Pan YT, Pastuszak I Carroll D (2003) New insights on trehalose: a multifunctional molecule. Glycobiology 13 : 17R 27R.
9. François J Parrou JL (2001) Reserve carbohydrates metabolism in the yeast Saccharomyces cerevisiae. FEMS Microbiol Rev 25 : 125 145.
10. Gietz RD, Schiestl RH, Willems AR Woods RA (1995) Studies on the transformation of intact yeast cells by the LiAc/SS-DNA/PEG procedure. Yeast 11 : 355 360.
11. Güldener U, Heck S, Fielder T, Beinhauer J Hegemann JH (1996) A new efficient gene disruption cassette for repeated use in budding yeast. Nucleic Acids Res 24 : 2519 2524.
12. Harris SD Cotter DA (1988) Transport of the yeast vacuolar trehalase to the vacuole. Can J Microbiol 34 : 835 838.
13. Hohmann S Mager WH (2003) Yeast Stress Response. Topics in Currents Genetics. Springer Verlag, Berlin.
14. Huang J, Reggiori F Klionsky DJ (2007) The transmembrane domain of acid trehalase mediates ubiquitin-independent multivesicular body pathway sorting. Mol Biol Cell 18 : 2511 2524.
15. Jorge JA, Polizeli ML, Thevelein JM Terenzi HF (1997) Trehalase and trehalose hydrolysis in fungi. FEMS Microbiol Lett 154 : 165 171.
16. Jules M, Guillou V, François J Parrou JL (2004) Two distinct pathways for trehalose assimilation in the yeast Saccharomyces cerevisiae. Appl Environ Microb 70 : 2771 2778.
17. Jules M, Beltrán G, François J Parrou JL (2008) New insights in yeast trehalose metabolism: NTH2 encodes a functional cytosolic trehalase, and deletion of TPS1 reveals a Ath1p-dependent trehalose mobilization. Appl Environ Microb 74 : 605 614.
18. Kim J, Alizadeh P, Harding T, Hefner-Gravink A Klionsky DJ (1996) Disruption of the yeast ATH1 gene confers better survival after dehydration, freezing, and ethanol shock: potential commercial applications. Appl Environ Microb 62 : 1563 1569.
19. Lewis JG, Learmonth RP, Attfield PV Watson K (1997) Stress co-tolerance and trehalose content in baking strains of Saccharomyces cerevisiae. J Ind Microbiol Biot 18 : 30 36.
20. Nwaka S Holzer H (1998) Molecular biology of trehalose and the trehalases in the yeast Saccharomyces cerevisiae. Prog Nucleic Acid Re 58 : 197 237.
21. Nwaka S, Kopp M Holzer H (1995a) Expression and function of the trehalase genes NTH1 and YBR0106 in Saccharomyces cerevisiae. J Biol Chem 270 : 10193 10198.
22. Nwaka S, Mechler B, Destruelle M Holzer H (1995b) Phenotypic features of trehalase mutants in Saccharomyces cerevisiae. FEBS Lett 360 : 286 290.
23. Nwaka S, Mechler B Holzer H (1996) Deletion of the ATH1 gene in Saccharomyces cerevisiae prevents growth on trehalose. FEBS Lett 386 : 235 238.
24. Panni S, Landgraf C, Volkmer-Engert R, Cesareni G Castagnoli L (2008) Role of 14-3-3 proteins in the regulation of neutral trehalase in the yeast Saccharomyces cerevisiae. FEMS Yeast Res 8 : 53 56.
25. Parrou JL François J (1997) A simplified procedure for a rapid and reliable assay of both glycogen and trehalose in whole yeast cells. Anal Biochem 248 : 186 188.
26. Parrou JL, Teste MA François J (1997) Effects of various types of stress on the metabolism of reserve carbohydrates in Saccharomyces cerevisiae: genetic evidence for a stress-induced recycling of glycogen and trehalose. Microbiology 143 : 1891 1900.
27. Parrou JL, Enjalbert B, Plourde L, Bauche A, Gonzalez B Francois J (1999) Dynamic responses of reserve carbohydrate metabolism under carbon and nitrogen limitations in Saccharomyces cerevisiae. Yeast 15 : 191 203.
28. Parrou JL, Jules M, Beltran G François J (2005) Acid trehalase in yeasts ands filamentous fungi: localization, regulation and physiological function. FEMS Yeast Res 5 : 503 511.
29. 2 in Saccharomyces cerevisiae mutants deficient in trehalase genes. Arch Microbiol 177 : 494 499.
30. Sambrook J Rusell DW (2001) Molecular Cloning. A Laboratory Manual. Cold Spring Harbor Laboratory Press, New York.
31. San Miguel PF Argüelles JC (1994) Differential changes in the activity of cytosolic and vacuolar trehalases along the growth cycle of Saccharomyces cerevisiae. Biochim Biophys Acta 1200 : 155 160.
32. Sharma SC (1997) A possible role of trehalose in osmotolerance and ethanol tolerance in Saccharomyces cerevisiae. FEMS Microbiol Lett 152 : 11 15.
33. Singer MA Lindquist S (1998a) Multiple effects of trehalose on protein folding in vitro and in vivo. Mol Cell 1 : 639 648.
34. Singer MA Lindquist S (1998b) Thermotolerance in Saccharomyces cerevisiae: the Yin and Yang of trehalose. Trends Biotechnol 16 : 460 468.
35. Thevelein JM Hohmann S (1995) Trehalose synthase: guard to the gate of glycolysis in yeast? Trends Biochem Sci 20 : 3 10.
36. Van Wuytswinkel O, Reiser V, Siderius M, Kelders MC, Ammerer G, Ruis H Mager WH (2000) Responses of Saccharomyces cerevisiae to severe osmotic stress: evidence for a novel activation mechanism of the HOG MAP kinase pathway? Mol Microbiol 37 : 382 397.
37. Winderickx J, de Winde JH, Crauwels M, Hino A, Hohmann S, Van Dijck P Thevelein JM (1996) Regulation of genes encoding subunits of the trehalose synthase complex in Saccharomyces cerevisiae: novel variations of STRE-mediated transcription control. Mol Gen Genet 252 : 470 482.
38. Zahringer H, Burgert M, Holzer H Nwaka S (1997) Neutral trehalase Nth1p of Saccharomyces cerevisiae encoded by the NTH1 gene is a multiple stress responsive protein. FEBS Lett 412 : 615 620.
39. Zahringer H, Holzer H Nwaka S (1998) Stability of neutral trehalase during heat stress in Saccharomyces cerevisiae is dependent on the activity of the catalytic subunits of cAMP-dependent protein kinase, Tpk1 and Tpk2. Eur J Biochem 255 : 544 551.
40. Zahringer H, Thevelein JM Nwaka S (2000) Induction of neutral trehalase Nth1 by heat and osmotic stress is controlled by STRE elements and Msn2/Msn4 transcription factors: variations of PKA effect during stress and growth. Mol Microbiol 35 : 397 406.