Role of superoxide dismutase in survival of Leishmania within the macrophage

Biochemical Journal

Volumn 369, Issue 3, 2003, Pages 447-452

  Ghosh, Sanjay ^a   Goswami, Srikanta ^a   Adhya, Samit ^a  

^a INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

Author keywords

Antisense RNA; Leishmania; Macrophage; Superoxide dismutase

Indexed keywords

CLONING; ENZYMES; GENES; HYDROGEN PEROXIDE; PROTOZOA; RNA; TOXIC MATERIALS;

MACROPHAGE HOSTS;

BIOCHEMISTRY;

COMPLEMENTARY RNA; FREE RADICAL; HYDROGEN PEROXIDE; MENADIONE; SUPEROXIDE; SUPEROXIDE DISMUTASE;

ARTICLE; ENZYME ASSAY; ENZYME MECHANISM; EPISOME; GENETIC TRANSFECTION; LEISHMANIA TROPICA; MACROPHAGE; MOLECULAR CLONING; NONHUMAN; NUCLEIC ACID ANALYSIS; NUCLEOTIDE SEQUENCE; PARASITE SURVIVAL; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION;

AMINO ACID SEQUENCE; ANIMALS; CHROMOSOME MAPPING; CLONING, MOLECULAR; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HYDROGEN PEROXIDE; LEISHMANIA; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; MUTATION; OXIDANTS; SEQUENCE HOMOLOGY, AMINO ACID; SUPEROXIDE DISMUTASE; SURVIVAL RATE;

LEISHMANIA TROPICA; PROTOZOA;

EID: 0037328022     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20021684     Document Type: Article

References (16)

1. Zuckerman, A. and Lainson, R. (1979) Leishmania. In Parasitic Protozoa (Kreier, J. P., ed.), pp. 57-133, Academic Press, New York
2. Beaman, L. and Beaman, B. L. (1984) The role of oxygen and its derivatives in microbial pathogenesis and host defense. Annu. Rev. Microbiol. 38, 27-48
3. Shiloh, M. U., MacMicking, J. D., Nicholson, S., Brause, J. E., Potter, S., Marino, M., Fang, F., Dinauer, M. and Nathan, C. (1999) Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase. Immunity 10, 29-38
4. Meshnick, S. R. and Eaton, J. W. (1981) Leishmanial superoxide dismutase: a possible target for chemotherapy. Biochem. Biophys. Res. Commun. 102, 970-976
5. Paramchuk, W. J., Ismail, S. O., Bhatia, A. and Gedamu, L. (1997) Cloning, characterization and overexpression of two iron superoxide dismutase cDNAs from Leishmania chagasi: role in pathogenesis. Mol. Biochem. Parasitol. 90, 203-221
6. Levick, M. P., Tetaud, E., Fairlamb, A. H. and Blackwell, J. M. (1998) Identification and characterisation of a functional peroxidoxin from Leishrnania major. Mol. Biochem. Parasitol. 96, 125-137
7. Barr, S. D. and Gedamu, L. (2001) Cloning and characterization of three differentially expressed peroxidoxin genes from Leishrnania chagasi. Evidence for an enzymatic detoxification of hydroxyl radicals. J. Biol. Chem. 276, 34279-34287
8. Das, S. and Adhya, S. (1990) Organization and chromosomal localization of β-tubulin genes in Leishmania donovani. J. Biosci. 15, 239-248
9. Kapler, G. M., Coburn, C. M. and Beverley, M. (1990) Stable transfection of the human parasite Leishmania major delineates a 30-kilobase region sufficient for extrachromosomal replication and expression. Mol. Cell. Biol. 10, 1084-1094
10. Ghosh, S. S., Mukherjee, S. and Adhya, S. (1998) Chromosome profile of Leishmania donovani: Interstrain and interspecific variations. J. Biosci. 23, 247-254
11. Bhaumik, M., Das, S. and Adhya, S. (1991) Evidence for translational control of β-tubulin synthesis during differentiation of Leishmania donovani. Parasitology 103, 197-205
12. Mahapatra, S., Ghosh, T. and Adhya, S. (1994) Import of small RNAs into Leishmania mitochondria in vitro. Nucleic Acids Res. 22, 3381-3386
13. Beauchamp, C. and Fridovich, I. (1971) Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. Anal. Biochem. 44, 276-287
14. Wilson, M. E., Andersen, K. A. and Britigan, B. E. (1994) Response of Leishmania chagasi promastigotes to oxidant stress. Infect. Immun. 62, 5133-5141
15. Parker, M. W. and Blake, C. C. F. (1988) Iron- and manganese-containing superoxide dismutases can be distinguished by analysis of their primary structure. FEBS Lett. 229, 377-382
16. Heinzen, R. A., Frazier, M. E. and Mallavia, L. P. (1992) Coxiella burnetti superoxide dismutase gene: cloning, sequencing and expression in Escherichia coli. Infect. Immun. 60, 3814-3823