Uptake kinetics and biodistribution of 14C-d-luciferin-a radiolabeled substrate for the firefly luciferase catalyzed bioluminescence reaction: Impact on bioluminescence based reporter gene imaging

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 35, Issue 12, 2008, Pages 2275-2285

  Berger, Frank ^a   Paulmurugan, Ramasamy ^c   Bhaumik, Srabani ^b   Gambhir, Sanjiv Sam ^c  

^a UNIVERSITY OF MUNICH   (Germany)

^b GE GLOBAL RESEARCH   (United States)

^c STANFORD UNIVERSITY   (United States)

Author keywords

Biodistribution; D Luciferin; Luciferase; Optical imaging; Reporter Genes

Indexed keywords

BENZENE DERIVATIVE; BUFFER; CARBON 14; DEXTRO LUCIFERIN CARBON 14 CONJUGATE; FIREFLY LUCIFERASE; LUCIFERIN; UNCLASSIFIED DRUG;

ADENOVIRUS; ANIMAL EXPERIMENT; ARTICLE; AUTORADIOGRAPHY; BIOLUMINESCENCE; BLADDER; CATALYSIS; CELL CULTURE; CONTROLLED STUDY; DECARBOXYLATION; DRUG DISTRIBUTION; DRUG STRUCTURE; ENZYME SUBSTRATE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VIVO STUDY; INFRARED RADIATION; INTESTINE; ISOTOPE LABELING; MOLECULAR IMAGING; MOUSE; NONHUMAN; NUDE MOUSE; OXIDATION; PLAQUE FORMING CELL; POSITRON EMISSION TOMOGRAPHY; PROTEIN EXPRESSION; REPORTER GENE; WHOLE BODY AUTORADIOGRAPHY;

ADENOVIRIDAE; ANIMALS; AUTORADIOGRAPHY; BENZOTHIAZOLES; BIOCATALYSIS; BIOLOGICAL TRANSPORT; BUFFERS; CARBON RADIOISOTOPES; CATTLE; CELL LINE; COLD TEMPERATURE; CULTURE MEDIA; GENE EXPRESSION; GENES, REPORTER; HUMANS; INJECTIONS; INTRACELLULAR SPACE; KIDNEY; KINETICS; LUCIFERASES, FIREFLY; LUMINESCENT MEASUREMENTS; TISSUE DISTRIBUTION;

EID: 58149279051     PISSN: 16197070     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-008-0870-6     Document Type: Article

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