Visualization of advanced human prostate cancer lesions in living mice by a targeted gene transfer vector and optical imaging

Nature Medicine

Volumn 8, Issue 8, 2002, Pages 891-896

  Adams, Jason Y ^a   Johnson, Mai ^a   Sato, Makoto ^a   Berger, Frank ^b   Gambhir, Sanjiv S ^b   Carey, Michael ^b   Iruela Arispe, M Luisa ^a   Wu, Lily ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; LUCIFERASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER LOCALIZATION; CONTROLLED STUDY; DIAGNOSTIC IMAGING; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER; LUMINESCENCE; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE CANCER; SIGNAL TRANSDUCTION; TRANSGENE;

ANIMALS; DIAGNOSTIC IMAGING; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; LIVER; LUCIFERASES; MALE; MICE; MICE, SCID; MICE, TRANSGENIC; NEOPLASM TRANSPLANTATION; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; RECOMBINANT FUSION PROTEINS; SPINE;

ADENOVIRIDAE; ANIMALIA;

EID: 0036341381     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm743     Document Type: Article

References (20)

1. The role of prostate specific antigen measurement in the detection and management of prostate cancer
2. An update on prostate cancer
3. Economic evaluation of chemotherapy with mitoxantrone plus prednisone for symptomatic hormone-resistant prostate cancer: Based on a Canadian randomized trial with palliative end points
4. Gene therapy for prostate cancer: Current status and future prospects
5. Chimeric PSA enhancers exhibit augmented activity in prostate cancer gene therapy vectors
6. Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice
7. Evidence for clonal outgrowth of androgen-independent prostate cancer cells from androgen-dependent tumors through a two-step process
8. Rapid and quantitative assessment of cancer treatment response using in vivo bioluminescence imaging
9. Noninvasive optical imaging of firefly luciferase reporter gene expression in skeletal muscles of living mice
10. Sequestration of adenoviral vector by Kupffer cells leads to a nonlinear dose response of transduction in liver
11. Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy
12. Androgen receptor localisation and turnover in human prostate epithelium treated with the antiandrogen, casodex
13. Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor
14. Amplification and overexpression of androgen receptor gene in hormone-refractory prostate cancer
15. A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase
16. A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy
17. Molecular engineering of a two-step transcription amplification (TSTA) system for transgene delivery in prostate cancer
18. Direct correlation between positron emission tomographic images of two reporter genes delivered by two distinct adenoviral vectors
19. Comparative studies of the estrogen receptors β and α and the androgen receptor in normal human prostate glands, dysplasia, and in primary and metastatic carcinoma