PET imaging and optical imaging with D-luciferin [11C]methyl ester and D-luciferin [11C]methyl ether of luciferase gene expression in tumor xenografts of living mice

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 2, 2006, Pages 331-337

  Wang, Ji Quan ^a   Pollok, Karen E ^b   Cai, Shanbao ^b   Stantz, Keith M ^a   Hutchins, Gary D ^a   Zheng, Qi Huang ^a  

^a INDIANA UNIVERSITY   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

D Luciferin 11C methyl ester ( 11C LMEster, 11C 1); d Luciferin 11C methyl ether ( 11C LMEther, 11C 2); Gene expression; Luciferase; Positron emission tomography (PET) imaging

Indexed keywords

ARTICLE; POSITRON EMISSION TOMOGRAPHY;

ANIMALS; CARBON ISOTOPES; ESTERS; FIREFLY LUCIFERIN; GENE EXPRESSION REGULATION, ENZYMOLOGIC; LUCIFERASES; METHYL ETHERS; MICE; MOLECULAR STRUCTURE; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; OPTICS; POSITRON-EMISSION TOMOGRAPHY; TIME FACTORS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 28044441148     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.09.082     Document Type: Article

References (30)

1. H.K. Boxhorn, and S.L. Eck Hematol. Oncol. Clin. North Am. 12 1998 665
2. M. Shalev, T.C. Thompson, D. Kadmon, G. Ayala, K. Kernen, and B.J. Miles Urology 57 2001 8
3. D.C. MacLaren, T. Toyokuni, S.R. Cherry, J.R. Barrio, M.E. Phelps, H.R. Herschman, and S.S. Gambhir Biol. Psychiatry 48 2000 337
4. Y. Wang, M. Iyer, A.J. Annala, S. Chappell, V. Mauro, and S.S. Gambhir J. Nucl. Med. 46 2005 667
5. K.H. Lee, S.S. Byun, J.Y. Paik, S.Y. Lee, S.H. Song, Y.S. Choe, and B.T. Kim Nucl. Med. Commun. 24 2003 1003
6. J.-Q. Wang, X. Fei, T.A. Gardner, G.D. Hutchins, and Q.-H. Zheng Bioorg. Med. Chem. 13 2005 549
7. J.-Q. Wang, Q.-H. Zheng, X. Fei, B.H. Mock, and G.D. Hutchins Bioorg. Med. Chem. Lett. 13 2003 3933
8. J.-Q. Wang, Q.-H. Zheng, X. Fei, X. Liu, T.A. Gardner, C. Kao, S.P. Raikwar, B.E. Glick-Wilson, M.L. Sullivan, B.H. Mock, and G.D. Hutchins Synth. Commun. 34 2004 917
9. Q.-H. Zheng, J.-Q. Wang, X. Liu, X. Fei, B.H. Mock, B.E. Glick-Wilson, M.L. Sullivan, S.P. Raikwar, T.A. Gardner, C. Kao, and G.D. Hutchins Synth. Commun. 34 2004 689
10. Q.-H. Zheng, J.-Q. Wang, X. Fei, and G.D. Hutchins Synthesis 2003 2785
11. B.R. Branchini, M.M. Hayward, S. Bamford, P.M. Brennan, and E.J. Lajiness Photochem. Photobiol. 49 1989 5
12. O. Gandelman, I. Allue, K. Bowers, and P. Cobbold J. Biolumin. Chemilumin. 9 1994 363
13. B.J. Gates, and M. DeLuca Arch. Biochem. Biophys. 169 1975 616
14. R. Fontes, A. Dukhovich, A. Sillero, and M.A. Sillero Biochem. Biophys. Res. Commun. 237 1997 445
15. E.H. White, M.G. Steinmetz, J.D. Miano, P.D. Wildes, and R. Morland J. Am. Chem. Soc. 102 1980 3199
16. S.Y. Lee, Y.S. Choe, K.H. Lee, J. Lee, Y. Choi, and B.T. Kim Bioorg. Med. Chem. Lett. 14 2004 1161
17. J.L. Denburg, R.T. Lee, and W.D. McElroy Arch. Biochem. Biophys. 134 1969 381
18. B.H. Mock, G.K. Mulholland, and M.T. Vavrek Nucl. Med. Biol. 26 1999 467
19. Q.-H. Zheng, and G.K. Mulholland Nucl. Med. Biol. 23 1996 981
20. Q.-H. Zheng, and G.K. Mulholland Synth. Commun. 30 2000 333
21. X. Fei, J.-Q. Wang, K.D. Miller, G.W. Sledge, G.D. Hutchins, and Q.-H. Zheng Nucl. Med. Biol. 31 2004 1033
22. K.E. Pollok, J.R. Hartwell, A. Braber, R.J. Cooper, M. Jansen, S. Ragg, B.J. Bailey, L.C. Erickson, E.L. Kreklau, and D.A. Williams Hum. Gene Ther. 14 2003 1703
23. J.-Q. Wang, M.A. Miller, X. Fei, K.L. Stone, J.C. Lopshire, W.J. Groh, D.P. Zipes, G.D. Hutchins, and Q.-H. Zheng Nucl. Med. Biol. 31 2004 957
24. N.C. Rouze, and G.D. Hutchins IEEE Trans. Nucl. Sci. 50 2003 1491
25. G.D. Hutchins, N. Rouze, K.L. Stone, G. Krishnamurthi, and Y. Liang J. Nucl. Med. 43 5 2002 59P
26. G. Luurtsema, C.F. Molthoff, R.C. Schuit, A.D. Windhorst, A.A. Lammertsma, and E.J. Franssen Nucl. Med. Biol. 32 2005 87
27. X. Fei, and Q.-H. Zheng J. Liq. Chromatogr. Rel. Technol. 28 2005 939
28. R. Paulmurugan, and S.S. Gambhir Anal. Chem. 77 2005 1295
29. 2, was 25-35%, and the radiochemical purity was >93% measured by analytical HPLC; (d) Tumor xenografts of living mice: all animal experiments were performed under a protocol approved by the Indiana University Institutional Animal Care and Use Committee. The LucSH cDNA was purchased from InvivoGen (San Diego, CA) and is a fusion between the luciferase and zeocin resistance genes. Both genes have been modified and contain no CpG. The SF91-LUC-EGFP vector co-expressed LucSH and EGFP was pseudotyped with the GALV envelope using the PG13 stable producer line. Tumor cells were transduced and either selected in zeocin or sorted for EGFP+ cells by flow cytometry.
30. M. Gao, B.H. Mock, G.D. Hutchins, and Q.-H. Zheng Nucl. Med. Biol. 32 2005 543