Molecular or pharmacologic inhibition of the CD14 signaling pathway protects against burn-related myocardial inflammation and dysfunction

Shock

Volumn 30, Issue 6, 2008, Pages 705-713

  Barber, Robert C ^a,b   Maass, David L ^a   White, D Jean ^a   Chang, Ling Yu E ^a   Horton, Jureta W ^a  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Burn; Calcium; Cardiac function; Cardiomyocyte; CD14; Cytokines; Dysfunction; Geldanamycin; Inflammation; Knockout; Myocardial; Sodium; TLR4 signaling

Indexed keywords

CALCIUM; CD14 ANTIGEN; GELDANAMYCIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; NITRIC OXIDE; SODIUM; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; BODY SURFACE; BURN; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CONTROLLED STUDY; CYTOKINE RELEASE; GENE DELETION; HEART CONTRACTION; HEART FUNCTION; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE CELL; HEART MUSCLE CONDUCTION DISTURBANCE; HEART PROTECTION; ISOLATED HEART; KNOCKOUT MOUSE; MOUSE; MYOCARDITIS; NONHUMAN; SHAM PROCEDURE; SIGNAL TRANSDUCTION; SODIUM CELL LEVEL; WILD TYPE;

ANIMALS; ANTIGENS, CD14; BENZOQUINONES; BURNS; CALCIUM; CYTOKINES; INTERLEUKIN-1BETA; INTERLEUKIN-6; LACTAMS, MACROCYCLIC; MICE; MICE, KNOCKOUT; MYOCARDITIS; MYOCARDIUM; MYOCYTES, CARDIAC; SIGNAL TRANSDUCTION; SODIUM; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA; VENTRICULAR FUNCTION, LEFT;

EID: 58149269009     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/SHK.0b013e31816f6caa     Document Type: Article

References (47)

1. Antal-Szalmas P: Evaluation of CD14 in host defence. Eur J Clin Invest 30: 167-179, 2000.
2. Kielian TL, Blecha F: Cdl4 and other recognition molecules for lipopolysaccharide-a review. Immunopharmacology 29:187-205. 1995.
3. Finberg RW, Re F, Popova L, Golenbock DT. Kurt-Jones EA: Cell activation by toll-like receptors: role of LBP and CD14. J Endotoxin Res 10:413-418, 2004.
4. Gangloff SC, Zahringer U, Blondin C, Guenounou M, Silver J. Goyert SM: Influence of CD14 on ligand interactions between lipopolysaccharide and its receptor complex. J Immunol 175:3940-3945, 2005.
5. Miller SI, Ernst RK. Bader MW: LPS. TLR4 and infectious disease diversity. Nat Rev Microbiol 3:36-46. 2005.
6. Wright SD, Ramos RA. Tobias PS. Ulevitch RJ. Mathison JC: CD14. a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249:1431-1433. 1990.
7. Schwacha MG: Macrophages and post-burn immune dysfunction. Bums 29: 1-14. 2003.
8. Akira S. Hemmi H: Recognition of pathogen-associated molecular patterns by TLR family. Immunol Lett 85:85-95. 2003.
9. Poltorak A. He X. Smirnova I. Liu MY. Van Huffel C. Du X. Birdwell D. Alejos E, Silva M. Galanos C. et al.: Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282:2085-2088. 1998.
10. Landmann R. Muller B. Zimmerli W: CD14. new aspects of ligand and signal diversity. Microbes Infect 2:295-304. 2000.
11. Bazil V. Baudys M. Hilgert I. Stefanova I. Low MG. Zbrozek J. Horejsi V: Structural relationship between the soluble and membrane-bound forms of human monocyte surface glycoprotein-CD14. Mol Immunol 26:657-662, 1989.
12. Zieglerheitbrock HWL. Ulevitch RJ: CD14-cell-surface receptor and differentiation marker. Immunol Today 14:121-125. 1993.
13. Guha M. Mackman N: LPS induction of gene expression in human monocytes. Cell Signal 13:85-94, 2001.
14. Thomas JA. Tsen MF. White DJ, Horton JW: TLR4 inactivation and rBP[(21) block burn-induced myocardial contractile dysfunction. Am. J Physiol Heart Circ Physiol 283:H1645-H1655. 2002.
15. Baumgarten G. Knuefermann P. Nozaki N. Sivasubramanian N. Mann DL, Vallejo JG: In vivo expression of proinflammatory mediators in the adult heart after endotoxin administration: the role of toll-like receptor-4. J Infect Dis 183: 1617-1624. 2001.
16. Chong AJ, Shimamoto A. Hampton CR. Takayama H. Spring DJ. Rothnie CL. Yada M. Pohlman TH. Verrier ED: Toll-like receptor 4 mediates ischemia/reperfusion injury of the heart. J Thorac Cardan asc Surg 128:170-179. 2004.
17. Arroyo-Espliguero R. Avanzas P. Jeffery S. Kaski JC: CDI4 and toll-like receptor 4: a link between infection and acute coronary events? Heart 90: 983-988, 2004.
18. Fang CWH, Yao YM, Shi ZG. Yu Y. Wu Y. Lu LR. Sheng ZY: Lipopolysaccharide-binding protein and lipopolysaccharide receptor CDI4 gene expression after thermal injury and its potential mechanism(s). J Trauma In Infect Crit Care 53:957-967. 2002.
19. Fang CWH. Yao YM. Zhai HX. Yu Y. Wu Y. Lu LR. Sheng ZY. Sheng CY: Tissue lipopolysaccharide-binding protein expression in rats after thermal injury: potential role of TNF-alpha. Burns 30:225-231. 2004.
20. Maass DL. White DJ. Thomas JA. Horton JW: TLR4 mutation/deletion prevents postburn myocardial inflammation. Shock 21:18. 2004.
21. Asea A, Rehli M. Kabingu E. Boch JA. Bare O. Auron PE. Stevenson MA. Calderwood SK: Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4. J Biol Client 277: 15028-15034, 2002.
22. Moroi Y. Mayhew M. Trcka J. Hoe MH. Takechi Y. Hartl FU, Rolhman JE. Houghton AN: Induction of cellular immunity by immunization with novel hybrid peptides complexed to heat shock protein 70. Proc Sail Acad Sci U S A 97:3485-3490. 2000.
23. Dybdahl B, Wahba A. Lien E. Flo TH. Waage A. Qureshi N. Sellevold OF. Espevik T. Sundan A: Inflammatory response after open heart surgery: release of heat-shock protein 70 and signaling through toll-like receptor-4. Circulation 105:685-690. 2002.
24. Zhou J, An HZ. Xu HM, Liu SX, Cao XT: Heat shock up-regulates expression of toll-like receptor-2 and toll-like receptor-4 in human monocytes via p38 kinase signal pathway. Immunology 114:522-530, 2005.
25. Vabulas RM, Ahmad-Nejad P. Ghose S, Kirschning CJ. Issels RD. Wagner H: HSP70 as endogenous stimulus of the toll/interleukin-1 receptor signal pathway. J Biol Chem 277:15107-15112. 2002.
26. Kol A, Lichtman AH, Finberg RW, Libby P, Kurt-Jones EA: Cutting edge: heat shock protein (HSP) 60 activates the innate immune response: CD14 is an essential receptor for HSP60 activation of mononuclear cells. J Immunol 164: 13-17, 2000.
27. White DJ, Carlson D, Ordway GA, Horton JW: Protective role of heat stress in burn trauma. Crit Care Med 32:1338-1345, 2004.
28. Triantafilou K, Triantafilou M, Ladha S, Mackie A, Fernandez N, Dedrick RL, Cherry R: Fluorescence recovery after photobleaching reveals that LPS rapidly transfers from CD14 to HSP70 and HSP90 on the cell membrane. J Cell Sci 114:2535-2545,2001.
29. Triantafilou K, Triantafilou M, Dedrick RL: A CD14-independent LPS receptor cluster. Nat Immunol 2:338-345, 2001.
30. Vega VL, De Maio A: Geldanamycin treatment ameliorates the response to LPS in murine macrophages by decreasing CD14 surface expression. Mol Biol Cell 14:764-773, 2003.
31. Malhotra V, Shanley TP, Pittet JF, Welch WJ, Wong HR: Geldanamycin inhibits NF-kappa B activation and interleukin-8 gene expression in cultured human respiratory epithelium. Am J Respir Cell Mol Biol 25:92-97, 2001.
32. White J, Maass DL, Giroir B, Horton JW: Development of an acute burn model in adult mice for studies of cardiac function and cardiomyocyte cellular function. Shock 16:122-129, 2001.
33. Knuefermann P, Nemoto S, Baumgarten G, Misra A, Sivasubramanian N, Carabello BA, Vallejo JG: Cardiac inflammation and innate immunity in septic shock: is there a role for toll-like receptors? Chest 121:1329-1336, 2002.
34. Comstock KL, Krown KA, Page MT, Martin D, Ho P, Pedraza M, Castro EN, Nakajima N, Glembotski CC, Quintana PJ, et al.: LPS-induced TNF-alpha release from and apoptosis in rat cardiomyocytes: obligatory role for CD14 in mediating the LPS response. J Mol Cell Cardiol 30:2761-2775, 1998.
35. Tobias PS, Soldau K, Gegner JA, Mintz D, Ulevitch RJ: Lipopolysaccharide binding protein-mediated complexation of lipopolysaccharide with soluble CD14. J Biol Chem 270:10482-10488, 1995.
36. Opal SM, Palardy JE, Parejo N, Jasman RL: Effect of anti-CD14 monoclonal antibody on clearance of Escherichia coli bacteremia and endotoxemia. Crit Care Med 31:929-932, 2003.
37. Jersmann HPA, Hii CST, Hodge GL, Ferrante A: Synthesis and surface expression of CD14 by human endothelial cells. Infect Immunol 69:479-485, 2001.
38. Knuefermann P, Nemoto S, Misra A, Nozaki N, Defreitas G, Goyert SM, Carabello BA, Mann DL, Vallejo JG: CD14-deficient mice are protected against lipopolysaccharide-induced cardiac inflammation and left ventricular dysfunction. Circulation 106:2608-2615, 2002.
39. Meldrum DR: Tumor necrosis factor in the heart. Am J Physiol 274: R577-R595, 1998.
40. Kapadia S, Lee J, TorreAmione G, Birdsall HH, Ma TS, Mann DL: Tumornecrosis-factor-alpha gene and protein expression in adult feline myocardium after endotoxin administration. J Clin Invest 96:1042-1052, 1995.
41. Bryant D, Becker L, Richardson J, Shelton J, Franco F, Peshock R, Thompson M, Giroir B: Cardiac failure in transgenic mice with myocardial expression of tumor necrosis factor-alpha. Circulation 97:1375-1381, 1998.
42. Maass DL, White J, Horton JW: IL-1 beta and IL-6 act synergistically with TNF-alpha to alter cardiac contractile function after burn trauma. Shock 18: 360-366, 2002.
43. Horton JW, Maass DL, White DJ: Hypertonic saline dextran after burn injury decreases inflammatory cytokine responses to subsequent pneumonia-related sepsis. Am J Physiol Heart Circ Physiol 290:H1642-H1650, 2006.
44. Kiang JG, Bowman PD, Wu BW, Hampton N, Kiang AG, Zhao BT, Juang YT, Atkins JL, Tsokos GC: Geldanamycin treatment inhibits hemorrhage-induced increases in KLF6 and iNOS expression in unresuscitated mouse organs: role of inducible HSP70. J App Physiol 97:564-569, 2004.
45. Kiang JG, Tsokos GC: Heat shock protein 70 kDa: molecular biology, biochemistry, and physiology. Pharmacol Ther 80:183-201, 1998.
46. Shiono Y, Fujita Y, Oka S, Yamazaki Y: ATPase inhibitors suppress actinomycin D-induced apoptosis in leukemia cells. Anticancer Res 22: 2907-2911,2002.
47. Weiss YG, Maloyan A, Tazelaar J, Raj N, Deutschman CS: Adenoviral transfer of HSP-70 into pulmonary epithelium ameliorates experimental acute respiratory distress syndrome. J Clin Invest 110:801-806, 2002.