Lutein and zeaxanthin measured separately in the living human retina with fundus reflectometry

Investigative Ophthalmology and Visual Science

Volumn 49, Issue 12, 2008, Pages 5568-5573

  Van De Kraats, Jan ^a   Kanis, Martijn J ^a   Genders, Stijn W ^a   Van Norren, Dirk ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

XANTHOPHYLL; ZEAXANTHIN; VISUAL PIGMENT;

ABSORPTION SPECTROSCOPY; ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; MEASUREMENT; NORMAL HUMAN; OPHTHALMOSCOPY; OPTICAL DENSITY; PRIORITY JOURNAL; REFLECTOMETRY; RETINA; RETINA DISEASE; RETINA FOVEA; SUPPLEMENTATION; CHEMISTRY; DIET SUPPLEMENTATION; MIDDLE AGED; SPECTROPHOTOMETRY;

ADULT; DIETARY SUPPLEMENTS; FEMALE; HUMANS; LUTEIN; MALE; MIDDLE AGED; RETINA; RETINAL PIGMENTS; SPECTROPHOTOMETRY; XANTHOPHYLLS; YOUNG ADULT;

EID: 58149250830     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.08-1939     Document Type: Article

References (44)

1. Hammond BR Jr, Wooten BR, Snodderly DM. Preservation of visual sensitivity of older subjects: association with macular pigment density. Invest Ophthalmol Vis Sci. 1998;39(2):397-406.
2. Beatty S, Boulton M, Henson D, Koh HH, Murray IJ. Macular pigment and age related macular degeneration. Br J Ophthalmol. 1999;83(7):867-877. (Pubitemid 29324801)
3. Weale RA. Notes on the macular pigment (editorial). Ophthalmic Physiol Opt. 2007;27(1):1-10.
4. Snodderly DM, Auran JD, Delori FC. The macular pigment. II. Spatial distribution in primate retinas. Invest Ophthalmol Vis Sci. 1984;25(6):674-685.
5. Snodderly DM, Brown PK, Delori FC, Auran JD. The macular pigment. I. Absorbance spectra, localization, and discrimination from other yellow pigments in primate retinas. Invest Ophthalmol Vis Sci. 1984;25(6):660-673.
6. Bone RA, Landrum JT, Fernandez L, Tarsis SL. Analysis of the macular pigment by HPLC: retinal distribution and age study. Invest Ophthalmol Vis Sci. 1988;29(6):843-849. (Pubitemid 18157993)
7. Snodderly DM, Handelman GJ, Adler AJ. Distribution of individual macular pigment carotenoids in central retina of macaque and squirrel monkeys. Invest Ophthalmol Vis Sci. 1991;32(2):268-279.
8. Rapp LM, Maple SS, Choi JH. Lutein and zeaxanthin concentrations in rod outer segment membranes from perifoveal and peripheral human retina. Invest Ophthalmol Vis Sci. 2000;41(5):1200-1209.
9. Sommerburg OG, Siems WG, Hurst JS, et al. Lutein and zeaxanthin are associated with photoreceptors in the human retina. Curr Eye Res. 1999;19(6):491-495.
10. Delori FC, Goger DG, Keilhauer C, Salvetti P, Staurenghi G. Bimodal spatial distribution of macular pigment: evidence of a gender relationship. J Opt Soc Am A Opt Image Sci Vis. 2006;23(3):521-538.
11. Berendschot TTJM, van Norren D. Macular pigment shows ringlike structures. Invest Ophthalmol Vis Sci. 2006;47(2):709-714.
12. Kim SR, Nakanishi K, Itagaki Y, Sparrow JR. Photooxidation of A2-PE, a photoreceptor outer segment fluorophore, and protection by lutein and zeaxanthin. Exp Eye Res. 2006;82(5):828-839. (Pubitemid 43170883)
13. Cantrell A, McGarvey DJ, Truscott TG, Rancan F, Bohm F. Singlet oxygen quenching by dietary carotenoids in a model membrane environment. Arch Biochem Biophys. 2003;412(1):47-54. (Pubitemid 36324364)
14. Handelman GJ, Snodderly DM, Krinsky NI, Russett MD, Adler AJ. Biological control of primate macular pigment: biochemical and densitometric studies. Invest Ophthalmol Vis Sci. 1991;32(2):257-267.
15. Hammond BR Jr, Johnson EJ, Russell RM, et al. Dietary modification of human macular pigment density. Invest Ophthalmol Vis Sci. 1997;38(9):1795-1801.
16. Johnson EJ, Neuringer M, Russell RM, Schalch W, Snodderly DM. Nutritional manipulation of primate retinas, III: Effects of lutein or zeaxanthin supplementation on adipose tissue and retina of xanthophyll-free monkeys. Invest Ophthalmol Vis Sci. 2005;46(2):692-702. (Pubitemid 40270354)
17. Berendschot TTJM, Goldbohm RA, Klöpping WA, et al. Influence of lutein supplementation on macular pigment, assessed with two objective techniques. Invest Ophthalmol Vis Sci. 2000;41(11):3322-3326.
18. Aleman TS, Duncan JL, Bieber ML, et al. Macular pigment and lutein supplementation in retinitis pigmentosa and Usher syndrome. Invest Ophthalmol Vis Sci. 2001;42(8):1873-1881.
19. Wenzel AJ, Sheehan JP, Gerweck C, et al. Macular pigment optical density at four retinal loci during 120 days of lutein supplementation. Ophthalmic Physiol Opt. 2007;27(4):329-335. (Pubitemid 46955432)
20. Bone RA, Landrum JT, Cao Y, Howard AN, Varez-Calderon F. Macular pigment response to a supplement containing meso-zeaxanthin, lutein and zeaxanthin. Nutr Metab (Lond). 2007;4:12. (Pubitemid 46789402)
21. Johnson EJ, Hammond BR, Yeum KJ, et al. Relation among serum and tissue concentrations of lutein and zeaxanthin and macular pigment density. Am J Clin Nutr. 2000;71(6):1555-1562.
22. van Norren D, Tiemeijer LF. Spectral reflectance of the human eye. Vision Res. 1986;26:313-320.
23. Delori FC, Pflibsen KP. Spectral reflectance of the human ocular fundus. Appl Opt. 1989;28:1061-1077.
24. van de Kraats J, Berendschot TTJM, van Norren D. The pathways of light measured in fundus reflectometry. Vision Res. 1996;36(15):2229-2247.
25. van de Kraats J, van Norren D. Directional and non-directional spectral reflection from the human fovea. J Biomed Opt. 2008;13(2):024010.
26. Handelman GJ, Dratz EA, Reay CC, van Kuijk JG. Carotenoids in the human macula and whole retina. Invest Ophthalmol Vis Sci. 1988;29(6):850-855.
27. van de Kraats J, Berendschot TT, Valen S, van Norren D. Fast assessment of the central macular pigment density with natural pupil using the macular pigment reflectometer. J Biomed Opt. 2006;11(6):064031. (Pubitemid 46331210)
28. van de Kraats J, van Norren D. Optical density of the aging human ocular media in the visible and the UV. J Opt Soc Am A Opt Image Sci Vis. 2007;24(7):1842-1857. (Pubitemid 47342610)
29. Press WH, Flannery BP, Teukolsky SA, Vetterling WT. Numerical Recipes in Pascal: the Art of Scientific Computing. Cambridge, UK: Cambridge University Press; 1989.
30. Knighton RW, Qian C. An optical model of the human retinal nerve fiber layer: implications of directional reflectance for variability of clinical measurements. J Glaucoma. 2000;9(1):56-62. (Pubitemid 32440552)
31. Snodderly DM, Mares JA, Wooten BR, et al. Macular pigment measurement by heterochromatic flicker photometry in older subjects: the carotenoids and age-related eye disease Study. Invest Ophthalmol Vis Sci. 2004;45(2):531-538.
32. Mellerio J, Ahmadi-Lari S, van Kuijk F, et al. A portable instrument for measuring macular pigment with central fixation. Curr Eye Res. 2002;25(1):37-47. (Pubitemid 36120913)
33. Delori FC, Goger DG, Hammond BR, Snodderly DM, Burns SA. Macular pigment density measured by autofluorescence spectrometry: comparison with reflectometry and heterochromatic flicker photometry. J Opt Soc Am A Opt Image Sci Vis. 2001;18(6):1212-1230.
34. Richer S, Devenport J, Lang JC. LAST II: Differential temporal responses of macular pigment optical density in patients with atrophic age-related macular degeneration to dietary supplementation with xanthophylls. Optometry. 2007;78(5):213-219.
35. Bernstein PS, Yoshida MD, Katz NB, McClane RW, Gellermann W. Raman detection of macular carotenoid pigments in intact human retina. Invest Ophthalmol Vis Sci. 1998;39(11):2003-2011. (Pubitemid 28455069)
36. Bone RA, Landrum JT, Friedes LM, et al. Distribution of lutein and zeaxanthin stereoisomers in the human retina. Exp Eye Res. 1997;64(2):211-218. (Pubitemid 27139567)
37. Sujak A, Okulski W, Gruszecki WI. Organisation of xanthophyll pigments lutein and zeaxanthin in lipid membranes formed with dipalmitoylphosphatidylcholine. Biochim Biophys Acta. 2000;1509(1-2):255-263.
38. Sujak A, Mazurek P, Gruszecki WI. Xanthophyll pigments lutein and zeaxanthin in lipid multibilayers formed with dimyristoylphosphatidylcholine. J Photochem Photobiol B. 2002;68(1):39-44.
39. Bernstein PS, Balashov NA, Tsong ED, Rando RR. Retinal tubulin binds macular carotenoids. Invest Ophthalmol Vis Sci. 1997;38:167-175.
40. Billsten HH, Bhosale P, Yemelyanov A, Bernstein PS, Polivka T. Photophysical properties of xanthophylls in carotenoproteins from human retinas. Photochem Photobiol. 2003;78(2):138-145.
41. Yemelyanov AY, Katz NB, Bernstein PS. Ligand-binding characterization of xanthophyll carotenoids to solubilized membrane proteins derived from human retina. Exp Eye Res. 2001;72(4):381-392.
42. Elsner AE, Burns SA, Beausencourt E, Weiter JJ. Foveal cone photopigment distribution: small alterations associated with macular pigment distribution. Invest Ophthalmol Vis Sci. 1998;39(12):2394-2404. (Pubitemid 28485651)
43. Bone RA, Landrum JT, Hime GW, Cains A, Zamor J. Stereochemistry of the human macular carotenoids. Invest Ophthalmol Vis Sci. 1993;34(6):2033-2040.
44. Zimmer JP, Hammond BR. Possible influences of lutein and zeaxanthin on the developing retina. Clin Ophthalmol. 2007;1(1):1-11.