메뉴 건너뛰기




Volumn 6, Issue 2, 2008, Pages 73-78

Motexafin gadolinium for the treatment of metastatic renal cell carcinoma: Phase II study results

Author keywords

Hypoxia inducible factor; Moleculartargeted therapy; Simon 2 stage clinical trial; Thioredoxin reductase inhibitors

Indexed keywords

GADOLINIUM TEXAPHYRIN; METALLOPORPHYRIN;

EID: 58149200520     PISSN: 15587673     EISSN: None     Source Type: Journal    
DOI: 10.3816/CGC.2008.n.011     Document Type: Article
Times cited : (24)

References (48)
  • 1
    • 85031335934 scopus 로고    scopus 로고
    • Cancer facts & Figures 2008
    • Available at:, Accessed: September 11
    • Jemal A, Siegel R, Ward E, et al. Cancer Facts & Figures 2008. American Cancer Society [Web site]. Available at: http://www.cancer.org/ downloads/STT/2008CAFFfinalsecured.pdf]. Accessed: September 11, 2008.
    • (2008) American Cancer Society [Web site]
    • Jemal, A.1    Siegel, R.2    Ward, E.3
  • 2
    • 0034038518 scopus 로고    scopus 로고
    • Chemotherapy for renal cell carcinoma
    • Amato R. Chemotherapy for renal cell carcinoma. Semin Oncol 2000; 27: 177-86.
    • (2000) Semin Oncol. , vol.27 , pp. 177-186
    • Amato, R.1
  • 3
    • 0042342564 scopus 로고    scopus 로고
    • The von hippel-lindau protein, vascular endothelial growth factor, and kidney cancer
    • (Pubitemid 36910018) George D, Kaelin W. The von Hippel-Lindau protein, vascular endothelial growth factor, and kidney cancer. N Engl J Med 2003; 349: 419-21.
    • (2003) N. Engl. J. Med. , vol.349 , pp. 419-421
    • George, D.1    Kaelin, W.2
  • 6
    • 0034113335 scopus 로고    scopus 로고
    • Effect of cytokine therapy on survival for Patients with advanced renal cell carcinoma
    • (Pubitemid 30261931) Motzer RJ, Mazumdar M, Bacik J, et al. Effect of cytokine therapy on survival for patients with advanced renal cell carcinoma. J Clin Oncol 2000; 18: 1928-35.
    • (2000) J. Clin. Oncol. , vol.18 , pp. 1928-1935
    • Motzer, R.J.1    Mazumdar, M.2    Bacik, J.3
  • 7
    • 0032772880 scopus 로고    scopus 로고
    • Survival and prognostic stratification of 670 Patients with advanced renal cell carcinoma
    • (Pubitemid 29368255) Motzer RJ, Mazumdar M, Bacik J, et al. Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. J Clin Oncol 1999; 17: 2530-40.
    • (1999) J. Clin. Oncol. , vol.17 , pp. 2530-2540
    • Motzer, R.J.1    Mazumdar, M.2    Bacik, J.3
  • 8
    • 0002688203 scopus 로고    scopus 로고
    • Cancer of the kidney and ureter
    • DeVita V, Hellman S, Rosenberg S, eds, Philadelphia, PA: Lippincott Williams & Wilkins
    • Linehan W, Zbar B, Bates S, et al. Cancer of the kidney and ureter. In: DeVita V, Hellman S, Rosenberg S, eds. Cancer: Principles & Practice of Oncology. 6th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2001: 1362-96.
    • (2001) Cancer: Principles & Practice of Oncology. 6th Ed. , pp. 1362-1396
    • Linehan, W.1    Zbar, B.2    Bates, S.3
  • 9
    • 0033587146 scopus 로고    scopus 로고
    • The tumour suppressor protein vhl targets hypoxia-inducible factors for oxygen-dependent proteolysis
    • Maxwell PH, Wiesener MS, Chang GW, et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 1999; 399: 271-5.
    • (1999) Nature , vol.399 , pp. 271-275
    • Maxwell, P.H.1    Wiesener, M.S.2    Chang, G.W.3
  • 10
    • 0035477438 scopus 로고    scopus 로고
    • Effects of ras and von hippel-lindau (VHL) gene mutations on hypoxia-inducible factor (HIF) -1 alpha, HIF-2 alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3 '-kinase/Akt signaling pathway
    • (Pubitemid 32946535) Blancher C, Moore JW, Robertson N, et al. Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF) -1 alpha, HIF-2 alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3 '-kinase/Akt signaling pathway. Cancer Res 2001; 61: 7349-55.
    • (2001) Cancer Res. , vol.61 , pp. 7349-7355
    • Blancher, C.1    Moore, J.W.2    Robertson, N.3
  • 11
    • 33846181370 scopus 로고    scopus 로고
    • Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
    • (Pubitemid 46089672) Motzer RJ, Hutson TE, Tomczak P, et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 2007; 356: 115-24.
    • (2007) N. Engl. J. Med. , vol.356 , pp. 115-124
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3
  • 12
    • 33846148701 scopus 로고    scopus 로고
    • Sorafenib in advanced clear-cell renal-cell carcinoma
    • (Pubitemid 46089673) Escudier B, Eisen T, Stadler WM, et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007; 356: 125-34.
    • (2007) N. Engl. J. Med. , vol.356 , pp. 125-134
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3
  • 13
    • 13244284943 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 alpha is associated with angiogenesis, and expression of bfgf, pdgf-bb, and egfr in invasive breast cancer
    • Bos R, van Diest PJ, de Jong JS, et al. Hypoxia-inducible factor-1 alpha is associated with angiogenesis, and expression of bFGF, PDGF-BB, and EGFR in invasive breast cancer. Histopathology 2005; 46: 31-6.
    • (2005) Histopathology , vol.46 , pp. 31-36
    • Bos, R.1    Van Diest, P.J.2    De Jong, J.S.3
  • 14
    • 0035012605 scopus 로고    scopus 로고
    • HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1 alpha (HIF-1 alpha) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
    • (Pubitemid 32476461) Laughner E, Taghavi P, Chiles K, et al. HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1 alpha (HIF-1 alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Bio 2001; 21: 3995-4004.
    • (2001) Mol. Cell. Bio , vol.21 , pp. 3995-4004
    • Laughner, E.1    Taghavi, P.2    Chiles, K.3
  • 15
    • 1842426907 scopus 로고    scopus 로고
    • Up-regulation of hypoxia-inducible factor 1 alpha is an early event in prostate carcinogenesis
    • (Pubitemid 38448745) Zhong H, Semenza GL, Simons JW, et al. Up-regulation of hypoxia-inducible factor 1 alpha is an early event in prostate carcinogenesis. Cancer Detect Prev 2004; 28: 88-93.
    • (2004) Cancer Detect. Prev. , vol.28 , pp. 88-93
    • Zhong, H.1    Semenza, G.L.2    Simons, J.W.3
  • 16
    • 85031339828 scopus 로고    scopus 로고
    • Hypoxia inducible factor-1α Is over expressed in CLL B cells because of an impaired proteasome pathway associated with defective interaction with von hippel-landau protein
    • Abstract 2115
    • Lee YK, Strege AK, Bone ND, et al. Hypoxia inducible factor-1α is over expressed in CLL B cells because of an impaired proteasome pathway associated with defective interaction with von Hippel-Landau protein. Blood 2005; 106: 598a (Abstract 2115).
    • (2005) Blood , vol.106
    • Lee, Y.K.1    Strege, A.K.2    Bone, N.D.3
  • 17
    • 34249779568 scopus 로고    scopus 로고
    • Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
    • (Pubitemid 46849157) Hudes G, Carducci M, Tomczak P, et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 2007; 3356: 2271-81.
    • (2007) N. Engl. J. Med. , vol.3356 , pp. 2271-2281
    • Hudes, G.1    Carducci, M.2    Tomczak, P.3
  • 18
    • 0036735392 scopus 로고    scopus 로고
    • The redox protein thioredoxin-1 (Trx-1) increases hypoxia-inducible factor 1 alpha protein expression: Trx-1 overexpression results in increased vascular endothelial growth factor production and enhanced tumor angiogenesis
    • (Pubitemid 34984438) Welsh S, Bellamy W, Briehl N, et al. The redox protein thioredoxin-1 (Trx-1) increases hypoxia-inducible factor 1 alpha protein expression: Trx-1 overexpression results in increased vascular endothelial growth factor production and enhanced tumor angiogenesis. Cancer Res. 2002; 2: 5089-95.
    • (2002) Cancer Res. , vol.2 , pp. 5089-5095
    • Welsh, S.1    Bellamy, W.2    Briehl, N.3
  • 19
    • 0142144338 scopus 로고    scopus 로고
    • The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1 alpha and vascular endothelial growth factor formation
    • Welsh S, Williams R, Birmingham A, et al. The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1 alpha and vascular endothelial growth factor formation. Mol Cancer Ther 2003; 2: 235-43.
    • (2003) Mol. Cancer Ther. , vol.2 , pp. 235-243
    • Welsh, S.1    Williams, R.2    Birmingham, A.3
  • 20
    • 33744956073 scopus 로고    scopus 로고
    • Motexafin gadolinium, a tumor-selective drug targeting thioredoxin reductase and ribonucleotide reductase
    • Hashemy SI, Ungerstedt JS, Avval FZ, et al. Motexafin gadolinium, a tumor-selective drug targeting thioredoxin reductase and ribonucleotide reductase. J Biol Chem 2006; 281: 10691-7.
    • (2006) J. Biol. Chem. , vol.281 , pp. 10691-10697
    • Hashemy, S.I.1    Ungerstedt, J.S.2    Avval, F.Z.3
  • 21
    • 70349343252 scopus 로고    scopus 로고
    • Motexafin gadolinium mobilizes zinc and inhibits thioredoxin reductase in human lymphoma cell lines
    • Abstract 4316
    • Magda D, Lecane P , Cheryl L, et al. Motexafin gadolinium mobilizes zinc and inhibits thioredoxin reductase in human lymphoma cell lines. Blood 2004; 104: 164bm (Abstract 4316).
    • (2004) Blood , vol.104
    • Magda, D.1    Lecane, P.2    Cheryl, L.3
  • 22
    • 20944432604 scopus 로고    scopus 로고
    • Motexafin gadolinium disrupts zinc metabolism in human cancer cell lines
    • (Pubitemid 40616364) Magda D, Lecane P, Miller RA, et al. Motexafin gadolinium disrupts zinc metabolism in human cancer cell lines. Cancer Res 2005; 65: 3837-45.
    • (2005) Cancer Res. , vol.65 , pp. 3837-3845
    • Magda, D.1    Lecane, P.2    Miller, R.A.3
  • 23
    • 0035312794 scopus 로고    scopus 로고
    • Effects of motexafin gadolinium on tumor metabolism and radiation sensitivity
    • (Pubitemid 32294318) Xu S, Zakian K, Thaler H, et al. Effects of motexafin gadolinium on tumor metabolism and radiation sensitivity. Int J Radiat Oncol Biol Phys 2001; 49: 1381-90.
    • (2001) Int. J. Radiat. Oncol. Biol. Phys. , vol.49 , pp. 1381-1390
    • Xu, S.1    Zakian, K.2    Thaler, H.3
  • 24
    • 8344276555 scopus 로고    scopus 로고
    • Motexafin gadolinium (MGd) increases tumor response to chemotherapy in lewis lung cancer (LLC) animal model
    • Abstract 466
    • Miller R, Fan Q, Lee I, et al. Motexafin gadolinium (MGd) increases tumor response to chemotherapy in Lewis lung cancer (LLC) animal model. Proc Am Soc Clin Oncol 2002; 21: 117a (Abstract 466).
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21
    • Miller, R.1    Fan, Q.2    Lee, I.3
  • 25
    • 0034797931 scopus 로고    scopus 로고
    • Motexafin gadolinium: A redox active drug that enhances the efficacy of bleomycin and doxorubicin
    • (Pubitemid 32963846) Miller RA, Woodburn KW, Fan Q, et al. Motexafin gadolinium: a redox active drug that enhances the efficacy of bleomycin and doxorubicin. Clin Cancer Res 2001; 7: 3215-21.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 3215-3221
    • Miller, R.A.1    Woodburn, K.W.2    Fan, Q.3
  • 26
    • 70349346186 scopus 로고    scopus 로고
    • Motexafin gadolinium (MGd) enhances the activity of cisplatin, carboplatin, and docetaxel
    • Lepp C, Qing F, Lecane P, et al. Motexafin gadolinium (MGd) enhances the activity of cisplatin, carboplatin, and docetaxel. AACR 2003; 44: 623-4.
    • (2003) AACR , vol.44 , pp. 623-624
    • Lepp, C.1    Qing, F.2    Lecane, P.3
  • 27
    • 85031344590 scopus 로고    scopus 로고
    • Motexafin gadolinium, a redox mediator, induces apoptosis in chronic lymphocytic leukemia B cells and is additive or synergistic with fludarabine
    • Naumovski L, Bone N, Sirisawad M, et al. Motexafin gadolinium, a redox mediator, induces apoptosis in chronic lymphocytic leukemia B cells and is additive or synergistic with fludarabine. J Investig Med 2005; 53: S365.
    • (2005) J. Investig Med. , vol.53
    • Naumovski, L.1    Bone, N.2    Sirisawad, M.3
  • 28
    • 10644275717 scopus 로고    scopus 로고
    • Inhibition of growth and induction of apoptosis by motexafin gadolinium (Xcytrin (R)) alone and in combination with other therapeutic agents in lymphoma and myeloma tumor cell lines
    • Abstract 4573
    • Naumovski L, Chen J, Ramos J, et al. Inhibition of growth and induction of apoptosis by Motexafin gadolinium (Xcytrin (R)) alone and in combination with other therapeutic agents in lymphoma and myeloma tumor cell lines. Blood 2003; 102: 213b (Abstract 4573).
    • (2003) Blood , vol.102
    • Naumovski, L.1    Chen, J.2    Ramos, J.3
  • 29
    • 33751200395 scopus 로고    scopus 로고
    • Potentiation of motexafin gadolinium cytotoxicity by celecoxib but not other cyclooxygenase-2 inhibitors
    • Naumovski L, Ramos J, Sirisawad M, et al. Potentiation of motexafin gadolinium cytotoxicity by celecoxib but not other cyclooxygenase-2 inhibitors. AACR 2005; 46: 1165.
    • (2005) AACR , vol.46 , pp. 1165
    • Naumovski, L.1    Ramos, J.2    Sirisawad, M.3
  • 30
    • 85031334962 scopus 로고    scopus 로고
    • Motexafin gadolinium enhances rituximab-induced cytotoxicity against b-cell lymphoma cell lines: Role of elevated intracellular calcium
    • Abstract 4829
    • Chen J, Ramos J, Sirisawad M, et al. Motexafin gadolinium enhances rituximab-induced cytotoxicity against B-cell lymphoma cell lines: role of elevated intracellular calcium. Blood 2005; 106: 287b (Abstract 4829).
    • (2005) Blood , vol.106
    • Chen, J.1    Ramos, J.2    Sirisawad, M.3
  • 31
    • 0032907689 scopus 로고    scopus 로고
    • A phase I single-dose trial of gadolinium texaphyrin (Gd-Tex), a tumor selective radiation sensitizer detectable by magnetic resonance imaging
    • (Pubitemid 29180823) Rosenthal DI, Nurenberg P, Becerra CR, et al. A phase I single-dose trial of gadolinium texaphyrin (Gd-Tex), a tumor selective radiation sensitizer detectable by magnetic resonance imaging. Clin Cancer Res 1999; 5: 739-45.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 739-745
    • Rosenthal, D.I.1    Nurenberg, P.2    Becerra, C.R.3
  • 32
    • 0035300617 scopus 로고    scopus 로고
    • Multicenter phase IB/II trial of the radiation enhancer motexafin gadolinium in patients with brain metastases
    • (Pubitemid 32702553) Carde P, Timmerman R, Mehta M P, et al. Multicenter phase Ib/II trial of the radiation enhancer motexafin gadolinium in patients with brain metastases. J Clin Oncol 2000; 19: 2074-83.
    • (2000) J. Clin. Oncol. , vol.19 , pp. 2074-2083
    • Carde, P.1    Timmerman, R.2    Mehta, M.P.3
  • 33
    • 0037676125 scopus 로고    scopus 로고
    • Survival and neurologic outcomes in a randomized trial of motexafin gadolinium and whole-brain radiation therapy in brain metastases
    • (Pubitemid 46606335) Mehta M P, Rodrigus P, Terhaard CH, et al. Survival and neurologic outcomes in a randomized trial of motexafin gadolinium and whole-brain radiation therapy in brain metastases. J Clin Oncol 2003; 21: 2529-36.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 2529-2536
    • Mehta, M.P.1    Rodrigus, P.2    Terhaard, C.H.3
  • 34
    • 33746566212 scopus 로고    scopus 로고
    • Motexafin gadolinium (MGd) combined with prompt whole brain radiation therapy (RT) prolongs time to neurologic progression in non-small cell lung cancer (NSCLC) Patients with brain metastases: Results of a phase III trial
    • Abstract 7014
    • Mehta M P, Gervais R, Chabot P, et al. Motexafin gadolinium (MGd) combined with prompt whole brain radiation therapy (RT) prolongs time to neurologic progression in non-small cell lung cancer (NSCLC) patients with brain metastases: results of a phase III trial. J Clin Oncol 2006; 24 (18 suppl) : 367s (Abstract 7014).
    • (2006) J. Clin. Oncol. , vol.24 , Issue.18 SUPPL.
    • Mehta, M.P.1    Gervais, R.2    Chabot, P.3
  • 35
    • 0034594628 scopus 로고    scopus 로고
    • New guidelines to evaluate the response to treatment in solid tumors
    • (Pubitemid 30099779) Therasse P, Arbuck S, Eisenhauer E, et al. New guidelines to evaluate the response to treatment in solid tumors. J Natl Cancer Inst 2000; 92: 205-16.
    • (2000) J. Natl. Cancer Inst. , vol.92 , pp. 205-216
    • Therasse, P.1    Arbuck, S.2    Eisenhauer, E.3
  • 36
    • 0020396015 scopus 로고
    • Toxicity and response criteria of the eastern cooperative oncology group
    • Oken MM, Creech RH, Tormey DC, et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol 1982; 5: 649-55.
    • (1982) Am. J. Clin. Oncol. , vol.5 , pp. 649-655
    • Oken, M.M.1    Creech, R.H.2    Tormey, D.C.3
  • 37
  • 38
    • 0024536437 scopus 로고
    • Optimal two-stage design for phase II clinical trials
    • (Pubitemid 19099520) Simon R. Optimal two-stage design for phase II clinical trials. Control Clin Trials 1989; 10: 1-10.
    • (1989) Control Clin. Trials , vol.10 , pp. 1-10
    • Simon, R.1
  • 39
    • 35548945707 scopus 로고    scopus 로고
    • Phase I trial of bevacizumab plus sunitinib in patients (pts) with metastatic renal cell carcinoma (mRCC)
    • Abstract 5099
    • Feldman DR, Kondagunta GV, Ronnen EA, et al. Phase I trial of bevacizumab plus sunitinib in patients (pts) with metastatic renal cell carcinoma (mRCC). J Clin Oncol 2007; 25 (18 suppl) : 259s (Abstract 5099).
    • (2007) J. Clin. Oncol. , vol.25 , Issue.18 SUPPL.
    • Feldman, D.R.1    Kondagunta, G.V.2    Ronnen, E.A.3
  • 40
    • 33751181914 scopus 로고    scopus 로고
    • Motexafin gadolinium: A novel redux active drug for cancer therapy
    • (Pubitemid 44780135) Magda D, Miller R. Motexafin gadolinium: a novel redux active drug for cancer therapy. Semin Can Bio 2006; 16: 466-76.
    • (2006) Semin. Can. Bio. , vol.16 , pp. 466-476
    • Magda, D.1    Miller, R.2
  • 41
    • 37349080670 scopus 로고    scopus 로고
    • Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomized, double-blind phase III trial
    • (Pubitemid 350296300) Escudier B, Pluzanska A, Koralewski P, et al. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomized, double-blind phase III trial. Lancet 2007; 370: 2103-11.
    • (2007) Lancet , vol.370 , pp. 2103-2111
    • Escudier, B.1    Pluzanska, A.2    Koralewski, P.3
  • 42
    • 33749251592 scopus 로고    scopus 로고
    • Increased efficacy and toxicity with combination anti-VEGF therapy using sorafenib and bevacizumab
    • Abstract 3004
    • Azad NS, Posadas EM, Kwitkowski VE, et al. Increased efficacy and toxicity with combination anti-VEGF therapy using sorafenib and bevacizumab. J Clin Oncol 2006; 24 (18 suppl) : 121s (Abstract 3004).
    • (2006) J. Clin. Oncol. , vol.24 , Issue.18 SUPPL.
    • Azad, N.S.1    Posadas, E.M.2    Kwitkowski, V.E.3
  • 43
    • 37349125184 scopus 로고    scopus 로고
    • The advanced renal cell carcinoma sorafenib (ARCCS) expanded access trial: Safety and efficacy in patients (pts) with prior bevacizumab (BEV) treatment
    • Abstract 5041
    • Drabkin HA, Figlin RA, Stadler WM, et al. The advanced renal cell carcinoma sorafenib (ARCCS) expanded access trial: safety and efficacy in patients (pts) with prior bevacizumab (BEV) treatment. J Clin Oncol 2007; 25 (18 suppl) : 245s (Abstract 5041).
    • (2007) J. Clin. Oncol. , vol.25 , Issue.18 SUPPL.
    • Drabkin, H.A.1    Figlin, R.A.2    Stadler, W.M.3
  • 44
    • 36749098248 scopus 로고    scopus 로고
    • Phase i/ii trial of cci-779 and bevacizumab in stage iv renal cell carcinoma: Phase I safety and activity results
    • Abstract 5034
    • Merchan JR, Liu G, Fitch T, et al. Phase I/II trial of CCI-779 and bevacizumab in stage IV renal cell carcinoma: phase I safety and activity results. J Clin Oncol 2007; 25 (18 suppl) : 243s (Abstract 5034).
    • (2007) J. Clin. Oncol. , vol.25 , Issue.18 SUPPL.
    • Merchan, J.R.1    Liu, G.2    Fitch, T.3
  • 45
    • 34247350610 scopus 로고    scopus 로고
    • Phase II study of sunitinib malate (SU11248) in bevacizumab-refractory metastatic renal cell carcinoma (MRCC)
    • Rini BI, George DJ, Michaelson MD, et al. Phase II study of sunitinib malate (SU11248) in bevacizumab-refractory metastatic renal cell carcinoma (MRCC). Ann Oncol 2006; 17: 144.
    • (2006) Ann. Oncol. , vol.17 , pp. 144
    • Rini, B.I.1    George, D.J.2    Michaelson, M.D.3
  • 46
    • 35549008792 scopus 로고    scopus 로고
    • Sequential use of sorafenib and sunitinib in renal cancer: Retrospective analysis in 90 patients
    • Abstract 5038
    • Sablin M P, Bouaita L, Balleyguier C, et al. Sequential use of sorafenib and sunitinib in renal cancer: retrospective analysis in 90 patients. J Clin Oncol 2007; 25 (18 suppl) : 244s (Abstract 5038).
    • (2007) J. Clin. Oncol. , vol.25 , Issue.18 SUPPL.
    • Sablin, M.P.1    Bouaita, L.2    Balleyguier, C.3
  • 47
    • 34047222738 scopus 로고    scopus 로고
    • Recent progress in the management of advanced renal cell carcinoma
    • (Pubitemid 46535711) Garcia J, Rini B. Recent progress in the management of advanced renal cell carcinoma. CA Cancer J Clin 2007; 57: 112-25.
    • (2007) CA Cancer J. Clin. , vol.57 , pp. 112-125
    • Garcia, J.1    Rini, B.2
  • 48
    • 37349092104 scopus 로고    scopus 로고
    • Targeted drugs for metastatic renal cell carcinoma
    • (Pubitemid 350296281) Motzer RJ, Basch E. Targeted drugs for metastatic renal cell carcinoma. Lancet 2007; 370: 2071-3.
    • (2007) Lancet , vol.370 , pp. 2071-2073
    • Motzer, R.J.1    Basch, E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.