Poly(lactide-co-glycolide) microsphere formulations of darbepoetin alfa: Spray drying is an alternative to encapsulation by spray-freeze drying

Pharmaceutical Research

Volumn 21, Issue 3, 2004, Pages 500-506

  Burke, Paul A ^a   Klumb, Lisa A ^a   Herberger, John D ^a   Nguyen, Xichdao C ^a   Harrell, Roy A ^a   Zordich, Monica ^a  

^a AMGEN INC   (United States)

Author keywords

Controlled release; Microencapsulation; Novel erythropoiesis stimulating protein (NESP); Poly(lactide co glyocolide) (PLGA); Protein stability

Indexed keywords

HEMOGLOBIN; MICROSPHERE; NOVEL ERYTHROPOIESIS STIMULATING PROTEIN; POLYGLACTIN; LACTIC ACID; POLYGLYCOLIC ACID; POLYMER;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG RELEASE; EVALUATION; FREEZE DRYING; GEL PERMEATION CHROMATOGRAPHY; IN VITRO STUDY; MALE; MOLECULAR WEIGHT; NONHUMAN; PHYSICAL PARAMETERS; PILOT STUDY; PRIORITY JOURNAL; RAT; WESTERN BLOTTING; ANIMAL; CHEMISTRY; PARTICLE SIZE;

ANIMALS; DARBEPOETIN ALFA; DRUG COMPOUNDING; FREEZE DRYING; LACTIC ACID; MICROSPHERES; PARTICLE SIZE; POLYGLACTIN 910; POLYGLYCOLIC ACID; POLYMERS;

EID: 1542511345     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:PHAM.0000019305.79599.a5     Document Type: Article

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