PEGylated immunoliposomes directed against brain astrocytes

Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents

Volumn 12, Issue 1, 2005, Pages 1-6

  Chekhonin, V P ^a   Zhirkov, Yu A ^a   Gurina, O I ^a   Ryabukhin, I A ^a   Lebedev, S V ^a   Kashparov, I A ^a   Dmitriyeva, T B ^a  

^a Serbsky Natl Res Ctr Social F   (Russian Federation)

Author keywords

Astrocytes; GFAP; Immunoliposomes; Polyethylene Glycol (PEG)

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; IMMUNOLIPOSOME; MACROGOL; MALEIMIDE; MONOCLONAL ANTIBODY; PHOSPHATIDYLETHANOLAMINE; POLYCLONAL ANTIBODY;

ANIMAL CELL; ANTIBODY SPECIFICITY; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; BRAIN CIRCULATION; BRAIN TISSUE; CENTRAL NERVOUS SYSTEM; COMPETITIVE INHIBITION; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG ELIMINATION; DRUG TARGETING; EMBRYO DEVELOPMENT; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIBODIES, MONOCLONAL; ASTROCYTES; BLOOD-BRAIN BARRIER; BRAIN; DRUG CARRIERS; GLIAL FIBRILLARY ACIDIC PROTEIN; LIPOSOMES; POLYETHYLENE GLYCOLS; RATS; RATS, WISTAR;

EID: 11244264537     PISSN: 10717544     EISSN: None     Source Type: Journal    
DOI: 10.1080/10717540590889556     Document Type: Article

References (19)

1. Allen, T. M., Hansen, C. B., and Zalipsky, S. 1995. Antibody-targeted stealth liposomes. In Stealth Liposomes, ed. D. Lasic and F. Marin, 233-244. Boca Raton, FL: CRS Press.
2. Barnea, A., and Roberts, J. 1999. A method for dissociation and aggregate culture of human fetal brain cells in serum-free medium. Brain Res. Protocols 4:156-164.
3. Benzinger, P., Martiny-Baron, G., Reusch, P., Siemeister, G., Kley, J. T., Marme, D., Unger, C., and Massing, U. 2000. Targeting of endothelial KDR receptors with 3G2 immunoliposomes in vitro. Biochim. Biophys. Acta 1466:71-78.
4. Cerletti, A., Drewe, J., Fricker, G., Eberle, A. N., and Huwyler, J. 2000. Endocytosis and transcytosis of an immunoliposome-based brain drug delivery system. J. Drug Target. 8:435-446.
5. Chekhonin, V. P., Dmitriyeva, T. B., and Zhirkov, Yu. A. 2000. Immunochemical Analysis of Neurospecific Antigens, Moscow: Meditsina (in Russian; submitted for publication in English, Pergamon Press, 2002).
6. Chekhonin, V. P., Gurina, O. I., Dmitriyeva, T. B., Shepeleva, I. I., Ryabukhin, I. A., and Babich, G. N. 2001. Monoclonal antibodies against GFAP: preparation, characterization, and immunoenzyme assay. Byul. Eksp. Biol. Med. (Russian Bull. Exp. Biol. Med.) 132:188-191 (in Russian).
7. Chekhonin, V. P., Gurina, O. I., Ryabukhin, I. A., Shepeleva, I. I., Savchenko, EA., Semenova, A. V., Khaustova, M. Yu., Biktimirov, R. G., Kekelidze, Z. I., and Dmitriyeva, T. B. 2000a. An immunoenzyme assay for GFAP with monoclonal antibodies in the assessment of the blood brain barrier permeability in various neural and/or mental diseases. Ross. Psikhiatr. Zh. (Russ. Psych. J.) 1:14-18 (in Russian).
8. Chekhonin, V. P., Kabanov, A. V., Zhirkov, Yu. A., and Morozov, G. V. 1991. Fatty acid acylated F(ab)-fragments of antibodies to neurospecific proteins as carriers for neuroleptic targeted delivery in brain. FEBS Lett. 287:149-152.
9. Chekhonin, V. P., Ryabukhin, I. A., and Zhirkov, Yu. A. 1995. Transport of hydrophobized fragments of anitbodies through the blood-brain barrier. Neuroreport 7:129-132.
10. Froes, M. M., Correia, A. H. P., Garcia-Abreu, J., Spray, D. C., Campos de Carvalho, A., and Neto, V. M. 1999. Gap-junctional coupling between neurons and astrocytes in primary central nervous system cultures. Proc. Natl. Acad. Sci. USA 96:7541-7546.
11. Gutman, R. L., Peacock, G., and Lu, D. R. 2000. Targeted drug delivery for brain cancer treatment. J. Control. Rel. 65:31-41.
12. Huwyler, J., Wu, D., and Pardridge, W. M. 1996. Brain drug delivery of small molecules using immunoliposomes. Proc. Natl. Acad Sci. USA 93:14164-14169.
13. Kamps, J. A. A. M., Konig, G. A., Velinova, M. J., Morselt, H. W. M., Wilkens, M., Gorter, A., Donga, J., and Scherphof, G. L. 2000. Uptake of long-circulating immunoliposomes, directed against colon adenocarcinoma cells, by liver metastases of colon cancer. J. Drug Target. 8:235-245.
14. Nakanishi, K., Nakanishi, M., and Kukita, F. 1999. Dual intracellular recording of neocortical neurons in a neuron-glia coculture system. Brain Res. Protocols 4:105-114.
15. Shi, N., and Pardridge, W. M. 2000. Noninvasive gene targeting to the brain. Proc. Natl. Acad. Sci. USA 97:7567-7572.
16. Shi, N., Boado, R. J., and Pardridge, W. M. 2000. Antisense imaging of gene expression in the brain in vivo. Proc. Natl. Acad. Sci. USA 97:14709-14714.
17. Stewart, J. C. M. 1980. Colorimetric determination of phospholipids with ammonium ferrothiocyanate. Anal. Biochem. 104:10-14.
18. Wessel, D., and Flügge, U. I. 1984. A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. Anal. Biochem. 138:141-143.
19. Wu, D., and Pardridge, W. M. 1999. Neuroprotection with noninvasive neurotrophin delivery to the brain. Proc. Natl. Acad. Sci. USA 96:254-259.