Rapid and selective expansion of nonclonotypic T cells in regulatory T cell-deficient, foreign antigen-specific TCR-transgenic scurfy mice: Antigen-dependent expansion and TCR analysis

Journal of Immunology

Volumn 181, Issue 10, 2008, Pages 6934-6941

  Sharma, Rahul ^a   Ju, Angela Chiao Ying ^a   Kung, John T ^b   Shu, Man Fu ^a   Ju, Shyr Te ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b INSTITUTE OF MOLECULAR BIOLOGY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CD4 ANTIGEN; OVALBUMIN; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; TRANSCRIPTION FACTOR FOXP3; LYMPHOCYTE ANTIGEN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; BLOOD; CD4+ FOXP3+ REGULATORY T LYMPHOCYTE; CONTROLLED STUDY; GENOTYPE; INFLAMMATION; LUNG; LYMPH NODE; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; TRANSGENIC MOUSE; ADOPTIVE TRANSFER; ANIMAL; FLOW CYTOMETRY; GENETICS; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

ADOPTIVE TRANSFER; ANIMALS; FLOW CYTOMETRY; IMMUNE TOLERANCE; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, TRANSGENIC; OVALBUMIN; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES; T-LYMPHOCYTES, REGULATORY;

EID: 58149181981     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.181.10.6934     Document Type: Article

References (37)

1. Uematsu, Y., S. Ryser, Z. Dembic, P. Borgulya, P. Krimpenfort, A. Berns, H. von Boehmer, and M. Steinmetz. 1988. In transgenic mice the introduced functional T cell receptor β gene prevents expression of endogenous β genes. Cell 52: 831-841. (Pubitemid 18095349)
2. Aifantis, I., J. Buer, H. von Boehmer, and O. Azogui. 1997. Essential role of the pre-T cell receptor in allelic exclusion of the T cell receptor β locus. Immunity 7: 60I-607.
3. Malissen, M., J. Trucy, E. Jouvin-Marche, P.-A. Cazenave, R. Scollay, and B. Malissen. 1992. Regulation of TCR α and β gene allelic exclusion during T-cell development. Immunol. Today 13: 315-322.
4. Zhou, P., R. Borojevic, C. Streutker, D. Snider, H. Liang, and K. Croitoru. 2004. Expression of dual TCR on DO11.10 T cells allows for ovalbumin-induced oral tolerance to prevent T cell-mediated colitis directed against unrelated enteric bacterial antigens. J. Immunol. 172: 1515-1523. (Pubitemid 38116795)
5. Schittek, B., E. Unkelbach, and K. Rajewsky. 1989. Violation of allelic exclusion of the T cell receptor β genes in a helper T cell clone. Int. Immunol. 1: 273-280. (Pubitemid 19263685)
6. Davodeau, F., M.-A. Peyrat, F. Romagne, A. Necker, M.-M. Haller, H. Vie, and M. Bonneville. 1995. Dual T cell receptor β chain expression on human T lymphocytes. J. Exp. Med. 181: 1391-1398.
7. Padovan, E., C. Giachino, M. Cella, S. Valitutti, O. Acuto, and A. Lanzavecchia. 1995. Normal T lymphocytes can express two different T cell receptor β chains: Implications for the mechanism of allelic exclusion. J. Exp. Med. 181: 1587-1591.
8. Malissen, M., J. Trucy, F. Letourneur, N. Rebai, D. E. Dunn, F. W. Fitch, L. Hood, and B. Malissen. 1988. A T cell clone expresses two T cell receptor α genes but uses one αβ heterodimer for allorecognition and self MHC-restricted antigen recognition. Cell 55: 49-59.
9. Heath, W. R., F. R. Carbone, P. Bertolino, J. Kelly, S. Cose, and J. F. A. P. Miller. 1995. Expression of two T cell receptor α chains on the surface of normal murine T cells. Eur. J. Immunol. 25: 1617-1623.
10. Mason, D. 1994. Allelic exclusion of α chains in TCR. Int. Immunol. 6: 881-885.
11. + T cell defects. J. Immunol. 180: 4465-4475.
12. + T cells. J. Exp. Med. 176: 1733-1738.
13. McMahan, C. J., and P. J. Fink. 2000. Receptor revision in peripheral T cells creates a diverse Vβ repertoire. J. Immunol. 165: 6902-6907.
14. Lohr, J., B. Knoechel, E. C. Kahn, and A. K. Abbas. 2004. Role of B7 in T cell tolerance. J. Immunol. 173: 5028-5035.
15. Knoechel, B., J. Lohr, E. Kahn, J. A. Bluestone, and A. K. Abbas. 2005. Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen. J. Exp. Med. 202: 1375-1386. (Pubitemid 41668740)
16. Zahorsky-Reeves, J. L., and J. E. Wilkinson. 2001. The murine mutation scurfy (sf) results in an antigen-dependent lymphoproliferative disease with altered T cell sensitivity. Eur. J. Immunol. 31: 196-204.
17. Chen, Z., Benoist, C., and D. Mathis. 2005. How defects in central tolerance impinge on a deficiency in regulatory T cells. Proc. Natl. Acad. Sci. USA 102: 14735-14740. (Pubitemid 41457125)
18. Robertson, J. M., P. E. Jensen, and B. D. Evavold. 2000. DO11.10 and OT-II T cells recognize a C-terminal ovalbumin 323-329 epitope. J. Immunol. 164: 4706-4712.
19. Sharma, R., H. Bagavant, W. N. Jarjour, S.-S. Sung, and S.-T. Ju. 2005. The role of Fas in the immune system biology of IL-2Rα knockout mice: interplay among regulatory T cells, inflammation, hemopoiesis, and apoptosis. J. Immunol. 175: 1965-1973.
20. + T cell homeostasis. J. Immunol. 178: 1251-1255.
21. Zheng, L., R. Sharma, J. T. Kung, U. S. Deshmukh, W. N. Jarjour, S. M. Fu, and S.-T. Ju. 2008. Pervasive and stochastic changes in the TCR repertoire of regulatory T-cell-deficient mice. Int. Immunol. 20: 517-523.
22. Sharma, R., W. N. Jarjour, L. Zheng, F. Gaskin, S. M. Fu, and S.-T. Ju. 2007. Large functional repertoire of regulatory T cell suppressible autoimmune T cells in scurfy mice. J. Autoimm. 29: 10-19.
23. He, X., C. A. Janeway, Jr., M. Levine, E. Robinson, P. Preston-Hurlburt, C. Viret, and K. Bottomly. 2002. Dual receptor T cells extend the immune repertoire for foreign antigens. Nat. Immunol. 3: 127-134. (Pubitemid 34141442)
24. Dittel, B. N., I. Stefanova, R. N. Germain, and C. A. Janeway, Jr. 1999. Cross-antagonism of a T cell clone expressing two distinct T cell receptors. Immunity 11: 289-298.
25. + regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2: 301-306.
26. Ribot, J., G. Enault, S. Pilipenko, A. Huchenq, M. Calise, D. Hudrisier, P. Romagnoli, and J. P. van Meerwijk. 2007. Shaping of the autoreactive regulatory T cell repertoire by thymic cortical positive selection. J. Immunol. 179: 6741-6748.
27. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J. Immunol. 162: 5317-5326.
28. + T-cell development is regulated by at least 2 distinct mechanisms. Blood 99: 555-560.
29. + regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice. Proc. Natl. Acad. Sci. USA 99: 8213-8218.
30. + regulatory T cell repertoire formation shaped by differential presentation of peptides from a self-antigen. J. Immunol. 180: 2149-2157.
31. + regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression. J. Immunol. 168: 4399-4405.
32. + naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int. Immunol. 10: 1969-1980.
33. + immunoregulatory T cells is antigen nonspecific. J. Immunol. 164: 183-190.
34. Sha, W. C., C. A. Nelson, R. D. Newberry, D. M. Kranz, J. H. Russell, and D. Y. Loh. 1988. Positive and negative selection of an antigen receptor on T cells in transgenic mice. Nature 336: 73-76. (Pubitemid 18262137)
35. Barnden, M. J., W. R. Heath, S. Rodda, and F. R. Carbone. 1994. Peptide antagonists that promote positive selection are inefficient at T cell activation and thymocyte deletion. Eur. J. Immunol. 24: 2452-2456.
36. Kappler, J. W., N. Roehm, and P. Marrack. 1987. T cell tolerance by clonal elimination in the thymus. Cell 49: 273-280.
37. Lee, D.-S., C. Aim, B. Ernst, J. Sprent, and C. D. Surh. 1999. Thymic selection by single MHC-peptide ligand: autoreactive T cells are low-affinity cells. Immunity 10: 83-92.