메뉴 건너뛰기




Volumn 20, Issue 4, 2008, Pages 517-523

Pervasive and stochastic changes in the TCR repertoire of regulatory T-cell-deficient mice

Author keywords

Autoimmunity; Dual TCR; Repertoire; Scurfy; T cells

Indexed keywords

CD3 ANTIBODY; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; T LYMPHOCYTE RECEPTOR BETA CHAIN; TRANSCRIPTION FACTOR FOXP3;

EID: 41149095155     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxn017     Document Type: Article
Times cited : (10)

References (27)
  • 1
    • 0023663430 scopus 로고
    • T cell tolerance by clonal elimination in the thymus
    • Kappler, J. W., Roehm, N. and Marrack, P. 1987. T cell tolerance by clonal elimination in the thymus. Cell. 49:273.
    • (1987) Cell , vol.49 , pp. 273
    • Kappler, J.W.1    Roehm, N.2    Marrack, P.3
  • 2
    • 0033025703 scopus 로고    scopus 로고
    • Thymic selection by single MHC-peptide ligand: Autoreactive T cells are low-affinity cells
    • Lee, D.-S., Aim, C., Ernst, B., Sprent, J. and Surh, C. D. 1999. Thymic selection by single MHC-peptide ligand: Autoreactive T cells are low-affinity cells. Immunity. 10:83.
    • (1999) Immunity , vol.10 , pp. 83
    • Lee, D.-S.1    Aim, C.2    Ernst, B.3    Sprent, J.4    Surh, C.D.5
  • 4
    • 0034507693 scopus 로고    scopus 로고
    • Impact of negative selection on the T cell repertoire reactive to a self-peptide: A large fraction of T cell clones escapes clonal deletion
    • Bouneaud, C., Kourilsky, P. and Bousso, P. 2000. Impact of negative selection on the T cell repertoire reactive to a self-peptide: A large fraction of T cell clones escapes clonal deletion. Immunity. 13:829.
    • (2000) Immunity , vol.13 , pp. 829
    • Bouneaud, C.1    Kourilsky, P.2    Bousso, P.3
  • 7
    • 33645102841 scopus 로고    scopus 로고
    • An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires
    • Hsieh, C. S., Zheng, Y., Liang, Y., Fontenot, J. D. and Rudensky, A. Y. 2006. An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. Nat. Immunol. 7:401.
    • (2006) Nat. Immunol , vol.7 , pp. 401
    • Hsieh, C.S.1    Zheng, Y.2    Liang, Y.3    Fontenot, J.D.4    Rudensky, A.Y.5
  • 8
    • 33747099523 scopus 로고    scopus 로고
    • Origin and T cell receptor diversity of Foxp3+CD4+CD25+ T cells
    • Pacholczyk, R., Ignatowicz, H., Kraj, P. and Ignatowicz, L. 2006. Origin and T cell receptor diversity of Foxp3+CD4+CD25+ T cells. Immunity 25:249.
    • (2006) Immunity , vol.25 , pp. 249
    • Pacholczyk, R.1    Ignatowicz, H.2    Kraj, P.3    Ignatowicz, L.4
  • 9
    • 4143066714 scopus 로고    scopus 로고
    • Recognition of the peripheral self by naturally arising CD25+CD4+ T cell receptors
    • Hsieh, C.-S., Liang, Y., Tyznik, A. J., Self, S. G., Liggitt, D. and Rudensky, A. Y. 2004. Recognition of the peripheral self by naturally arising CD25+CD4+ T cell receptors. Immunity. 21:267.
    • (2004) Immunity , vol.21 , pp. 267
    • Hsieh, C.-S.1    Liang, Y.2    Tyznik, A.J.3    Self, S.G.4    Liggitt, D.5    Rudensky, A.Y.6
  • 10
    • 0033985780 scopus 로고    scopus 로고
    • Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific
    • Thornton, A. M. and Shevach, E. M. 2000 Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific. J. Immunol. 164:183.
    • (2000) J. Immunol , vol.164 , pp. 183
    • Thornton, A.M.1    Shevach, E.M.2
  • 11
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chain (CD25)
    • Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M. and Toda, M. 1995. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chain (CD25). J. Immunol. 155:1151.
    • (1995) J. Immunol , vol.155 , pp. 1151
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 12
    • 33846530214 scopus 로고    scopus 로고
    • Cutting edge: A regulatory T cell-dependent novel function of CD25 (IL-2Rα) controlling memoryCD8+Tcell homeostasis
    • Sharma, R., Zheng, L., Deshmukh, U. S. et al. 2007. Cutting edge: a regulatory T cell-dependent novel function of CD25 (IL-2Rα) controlling memoryCD8+Tcell homeostasis. J. Immunol. 178:1251.
    • (2007) J. Immunol , vol.178 , pp. 1251
    • Sharma, R.1    Zheng, L.2    Deshmukh, U.S.3
  • 13
    • 0026565245 scopus 로고
    • Preferential positive selection of Vα2+ CD8+ T cells in mouse strains expressing both H-2k and T cell receptor Vα haplotypes: Determination with a Vα2-specific monoclonal antibody
    • Pircher, H., Rebai, N., Groettrup, M. et al. 1992. Preferential positive selection of Vα2+ CD8+ T cells in mouse strains expressing both H-2k and T cell receptor Vα haplotypes: Determination with a Vα2-specific monoclonal antibody. Eur. J. Immunol. 22:399.
    • (1992) Eur. J. Immunol , vol.22 , pp. 399
    • Pircher, H.1    Rebai, N.2    Groettrup, M.3
  • 14
    • 0024455741 scopus 로고
    • Alnalysis of a monoclonal rat antibody directed to the alpha-chain variable region (Vα3) of the mouse T cell antigen receptor
    • Utsunomiya, Y., Bill, J., Palmer, E., Gollob, K., Takagaki, Y. and Kanagawa, O. 1989. Alnalysis of a monoclonal rat antibody directed to the alpha-chain variable region (Vα3) of the mouse T cell antigen receptor. J. Immunol. 143:2602.
    • (1989) J. Immunol , vol.143 , pp. 2602
    • Utsunomiya, Y.1    Bill, J.2    Palmer, E.3    Gollob, K.4    Takagaki, Y.5    Kanagawa, O.6
  • 15
    • 0024384261 scopus 로고
    • Two monoclonal antibodies specific for the T cell receptor Vα8
    • Tomonari, K., Lovering, E., Fairchild, S. and Spencer, S. 1989. Two monoclonal antibodies specific for the T cell receptor Vα8. Eur. J. Immunol. 19:1131.
    • (1989) Eur. J. Immunol , vol.19 , pp. 1131
    • Tomonari, K.1    Lovering, E.2    Fairchild, S.3    Spencer, S.4
  • 16
    • 0025952481 scopus 로고
    • The T cell receptor Vα11 gene family. Analysis of allelic sequence polymorphism and demonstration of Jα region-dependent recognition by allele-specific antibodies
    • Jameson, S. C., Nakajima, P. B., Brooks, J. L., Heath, W., Kanagawa, O. and Gascoigne, N. R. 1991. The T cell receptor Vα11 gene family. Analysis of allelic sequence polymorphism and demonstration of Jα region-dependent recognition by allele-specific antibodies. J. Immunol. 147:3185.
    • (1991) J. Immunol , vol.147 , pp. 3185
    • Jameson, S.C.1    Nakajima, P.B.2    Brooks, J.L.3    Heath, W.4    Kanagawa, O.5    Gascoigne, N.R.6
  • 17
    • 27744475035 scopus 로고    scopus 로고
    • CD1d-independent developmental acquisition of prompt IL-4 gene inducibility in thymus CD161(NK1)-CD44lowCD4+CD8- T cells is associated with complementarity determining region 3-diverse and biased Vβ2/Vβ7/Vβ8/Vα3.2 T cell receptor usage
    • Chen, Y. T. and Kung, J. T 2005. CD1d-independent developmental acquisition of prompt IL-4 gene inducibility in thymus CD161(NK1)-CD44lowCD4+CD8- T cells is associated with complementarity determining region 3-diverse and biased Vβ2/Vβ7/Vβ8/Vα3.2 T cell receptor usage. J. Immunol. 175:6537.
    • (2005) J. Immunol , vol.175 , pp. 6537
    • Chen, Y.T.1    Kung, J.T.2
  • 18
    • 0033958328 scopus 로고    scopus 로고
    • Oligoclonal T cell expansions in atherosclerotic lesions of apolipoprotein E-deficient mice
    • Paulsson, G., Zhou, X., Tornquist, E. and Hansson, G. K. 2000. Oligoclonal T cell expansions in atherosclerotic lesions of apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol. 20:10.
    • (2000) Arterioscler. Thromb. Vasc. Biol , vol.20 , pp. 10
    • Paulsson, G.1    Zhou, X.2    Tornquist, E.3    Hansson, G.K.4
  • 19
    • 0028220953 scopus 로고
    • Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping correlation with immune status
    • Gorski, J., Yassai, M., Zhu, X., Kissella, B., Keever, C. and Flomenberg, N. 1994. Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping correlation with immune status. J. Immunol. 152:5109.
    • (1994) J. Immunol , vol.152 , pp. 5109
    • Gorski, J.1    Yassai, M.2    Zhu, X.3    Kissella, B.4    Keever, C.5    Flomenberg, N.6
  • 20
    • 0033546652 scopus 로고    scopus 로고
    • Does a shift in the T-cell receptor repertoire precede the onset of MS?
    • Haegert, D. G., Cowan, T, Murray, T. J., Gadag, V. and O'Connor, P. 1999. Does a shift in the T-cell receptor repertoire precede the onset of MS? Neurology 53:485.
    • (1999) Neurology , vol.53 , pp. 485
    • Haegert, D.G.1    Cowan, T.2    Murray, T.J.3    Gadag, V.4    O'Connor, P.5
  • 21
    • 41149090247 scopus 로고    scopus 로고
    • Pearson, K. 1896. Mathematical contributions to the theory of evolotion. III. Regression, heredity, and panmixia. Philos. Trans. R. Soc. Lond. A 187:253.
    • Pearson, K. 1896. Mathematical contributions to the theory of evolotion. III. Regression, heredity, and panmixia. Philos. Trans. R. Soc. Lond. A 187:253.
  • 22
    • 33947600584 scopus 로고    scopus 로고
    • Regulatory T cell development in the absence of functional Foxp3
    • Lin, W., Haribhai, D., Relland, L. M. et al. 2007. Regulatory T cell development in the absence of functional Foxp3. Nat Immunol. 8:359.
    • (2007) Nat Immunol , vol.8 , pp. 359
    • Lin, W.1    Haribhai, D.2    Relland, L.M.3
  • 23
    • 26844450449 scopus 로고    scopus 로고
    • How defects in central tolerance impinge on a deficiency in regulatory T cells
    • Chen, Z., Benoist, C. and Mathis, D. 2005. How defects in central tolerance impinge on a deficiency in regulatory T cells. Proc. Natl Acad. Sci. USA 102:14735.
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 14735
    • Chen, Z.1    Benoist, C.2    Mathis, D.3
  • 24
    • 34347364684 scopus 로고    scopus 로고
    • Large functional repertoire of regulatory T cell-suppressible autoimmune T cells in scurfy mice
    • Sharma, R., Jarjour, W. N., Zheng, L., Gaskin, F, Fu, S. M. and Ju, S.-T. 2007. Large functional repertoire of regulatory T cell-suppressible autoimmune T cells in scurfy mice. J. Autoimmun. 29:10.
    • (2007) J. Autoimmun , vol.29 , pp. 10
    • Sharma, R.1    Jarjour, W.N.2    Zheng, L.3    Gaskin, F.4    Fu, S.M.5    Ju, S.-T.6
  • 25
    • 0035136980 scopus 로고    scopus 로고
    • The murine mutation scurfy (sf) results in an antigen-dependent lymphoproliferative disease with altered T cell sensitivity
    • Zahorsky-Reeves, J. L. and Wilkinson, J. E. 2001. The murine mutation scurfy (sf) results in an antigen-dependent lymphoproliferative disease with altered T cell sensitivity. Eur. J. Immunol. 31:196.
    • (2001) Eur. J. Immunol , vol.31 , pp. 196
    • Zahorsky-Reeves, J.L.1    Wilkinson, J.E.2
  • 26
    • 0031907550 scopus 로고    scopus 로고
    • CDR3 size spectratyping and sequencing of spectratype-derived TCR of spinal cord T cells in autoimmune encephalomyelitis
    • Kim, G., Tanuma, N., Kojima, T. et al. 1998. CDR3 size spectratyping and sequencing of spectratype-derived TCR of spinal cord T cells in autoimmune encephalomyelitis. J. Immunol. 160:509.
    • (1998) J. Immunol , vol.160 , pp. 509
    • Kim, G.1    Tanuma, N.2    Kojima, T.3
  • 27
    • 33645759941 scopus 로고    scopus 로고
    • CDR3 spectratyping analysis of the TCR repertoire in myasthenia gravis
    • Matsumoto, Y., Matsuo, H., Sakuma, H. et al. 2006. CDR3 spectratyping analysis of the TCR repertoire in myasthenia gravis. J. Immunol. 176:5100.
    • (2006) J. Immunol , vol.176 , pp. 5100
    • Matsumoto, Y.1    Matsuo, H.2    Sakuma, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.