Identification and structural mechanism for a novel interaction between a ubiquitin ligase WWP1 and Nogo-A, a Key inhibitor for central nervous system regeneration

Biochemistry

Volumn 47, Issue 51, 2008, Pages 13647-13658

  Qin, Haina ^a   Pu, Helen X ^b   Li, Minfen ^a   Ahmed, Sohail ^b   Song, Jianxing ^a,c  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b Neural Stem Cell Laboratory   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

CENTRAL NERVOUS SYSTEMS; COMPLEX MODELS; DISSOCIATION CONSTANTS; DO-MAINS; ENDOPLASMIC RETICULUM; FREE STATES; HIGH AFFINITIES; IN VITRO; IN-VIVO; NEUROMUSCULAR JUNCTIONS; NMR DATUMS; PROTEIN LEVELS; SOLUTION STRUCTURES; STRUCTURAL MECHANISMS; UBIQUITIN LIGASE; UBIQUITINATION; WW DOMAINS;

AMINES; DISSOCIATION; FLOW INTERACTIONS; MATHEMATICAL MODELS; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEINS; VOLUMETRIC ANALYSIS;

ENZYMES;

PROTEIN NOGO A; UBIQUITIN PROTEIN LIGASE E3; UBIQUITIN PROTEIN LIGASE WWP1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CENTRAL NERVOUS SYSTEM; CIRCULAR DICHROISM; CONTROLLED STUDY; ISOTHERMAL TITRATION CALORIMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN ISOLATION; PROTEIN MOTIF; PROTEIN STRUCTURE; REGENERATION; THERMODYNAMICS;

AMINO ACID SEQUENCE; ANIMALS; CENTRAL NERVOUS SYSTEM; CIRCULAR DICHROISM; GLUTATHIONE TRANSFERASE; HUMANS; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; MYELIN PROTEINS; PROTEIN BINDING; SEQUENCE HOMOLOGY, AMINO ACID; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 58149166734     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi8017976     Document Type: Article

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