-
1
-
-
35748946948
-
Retinal and choroidal microangiopathies: Therapeutic opportunities
-
Afzal A, Shaw LC, Ljubimov AV, Boulton ME, Segal MS, Grant MB. 2007. Retinal and choroidal microangiopathies: Therapeutic opportunities. Microvasc Res 74:131-144.
-
(2007)
Microvasc Res
, vol.74
, pp. 131-144
-
-
Afzal, A.1
Shaw, L.C.2
Ljubimov, A.V.3
Boulton, M.E.4
Segal, M.S.5
Grant, M.B.6
-
2
-
-
0037448528
-
Genome-Wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
-
Ashrafi K, Chang FY, Watts JL, Fraser AG, Kamath RS, Ahringer J, Ruvkun G. 2003. Genome-Wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature 421:268-272.
-
(2003)
Nature
, vol.421
, pp. 268-272
-
-
Ashrafi, K.1
Chang, F.Y.2
Watts, J.L.3
Fraser, A.G.4
Kamath, R.S.5
Ahringer, J.6
Ruvkun, G.7
-
3
-
-
12144289681
-
A large-scale RNAi screen in human cells identifies new components of the p53 pathway
-
Berns K, Hijmans EM, Mullenders J, Brummelkamp TR, Velds A, Heimerikx M, Kerkhoven RM, Madiredjo M, Nijkamp W, Weigelt B, Agami R, Ge W, Cavet G, Linsley PS, Beijersbergen RL, Bernards R. 2004. A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Natrue 428:431-437.
-
(2004)
Natrue
, vol.428
, pp. 431-437
-
-
Berns, K.1
Hijmans, E.M.2
Mullenders, J.3
Brummelkamp, T.R.4
Velds, A.5
Heimerikx, M.6
Kerkhoven, R.M.7
Madiredjo, M.8
Nijkamp, W.9
Weigelt, B.10
Agami, R.11
Ge, W.12
Cavet, G.13
Linsley, P.S.14
Beijersbergen, R.L.15
Bernards, R.16
-
4
-
-
0242456167
-
Ocular neovascularization: A valuable model system
-
Campochiaro PA, Hackett SF. 2003. Ocular neovascularization: A valuable model system. Oncogene 22:6537-6548.
-
(2003)
Oncogene
, vol.22
, pp. 6537-6548
-
-
Campochiaro, P.A.1
Hackett, S.F.2
-
5
-
-
0035937715
-
Regulation of glutl mRNA by hypoxia-inducible factor-l. Interaction between H-ras and hypoxia
-
Chen C, Pore N, Behrooz A, Ismail-Beigi F, Maity A. 2001. Regulation of glutl mRNA by hypoxia-inducible factor-l. Interaction between H-ras and hypoxia. J Biol Chem 276:9519-9525.
-
(2001)
J Biol Chem
, vol.276
, pp. 9519-9525
-
-
Chen, C.1
Pore, N.2
Behrooz, A.3
Ismail-Beigi, F.4
Maity, A.5
-
6
-
-
0035942736
-
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
-
Elbashir SM, Harborth J, Lendeckel W,Yalcin A, Weber K,Tuschl T. 2001. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411:494-498.
-
(2001)
Nature
, vol.411
, pp. 494-498
-
-
Elbashir, S.M.1
Harborth, J.2
Lendeckel, W.3
Yalcin, A.4
Weber, K.5
Tuschl, T.6
-
7
-
-
0032545933
-
Potent and specific genetic interference by double-stranded RNAin Caenorhabditis elegans
-
Fire A,Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. 1998. Potent and specific genetic interference by double-stranded RNAin Caenorhabditis elegans. Nature 391:806-811.
-
(1998)
Nature
, vol.391
, pp. 806-811
-
-
Fire, A.1
Xu, S.2
Montgomery, M.K.3
Kostas, S.A.4
Driver, S.E.5
Mello, C.C.6
-
8
-
-
0029761644
-
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor l
-
Forsythe JA, Jiang BH, Iyer NV, Agani F, Leung SW, Koos RD, Semenza GL. 1996. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor l. Mol Cell Biol 16:4604-4613.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 4604-4613
-
-
Forsythe, J.A.1
Jiang, B.H.2
Iyer, N.V.3
Agani, F.4
Leung, S.W.5
Koos, R.D.6
Semenza, G.L.7
-
9
-
-
0348048874
-
Diabetic retinopathy
-
Frank RN. 2004. Diabetic retinopathy. N Engl J Med 350:48-58.
-
(2004)
N Engl J Med
, vol.350
, pp. 48-58
-
-
Frank, R.N.1
-
10
-
-
17644403503
-
A small interfering RNA targeting vascular endothelial growth factor inhibits Ewing's sarcoma growth in a xenograft mouse model
-
Guan H, Zhou Z, Wang H, Jia SF, Liu W, Kleinerman ES. 2005. A small interfering RNA targeting vascular endothelial growth factor inhibits Ewing's sarcoma growth in a xenograft mouse model. Clin Cancer Res 11:2662-2669.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 2662-2669
-
-
Guan, H.1
Zhou, Z.2
Wang, H.3
Jia, S.F.4
Liu, W.5
Kleinerman, E.S.6
-
11
-
-
9644275599
-
Inhibition of ocular angiogenesis by siRNA targeting vascular endothelial growth factor pathway genes: Therapeutic strategy for herpetic stromal keratitis
-
Kim B, Tang Q, Biswas PS, Xu J, Schiffelers RM, Xie FY, Ansari AM, Scaria PV, Woodle MC, Lu P, Rouse BT. 2004. Inhibition of ocular angiogenesis by siRNA targeting vascular endothelial growth factor pathway genes: Therapeutic strategy for herpetic stromal keratitis. Am J Pathol 165:2177-2185.
-
(2004)
Am J Pathol
, vol.165
, pp. 2177-2185
-
-
Kim, B.1
Tang, Q.2
Biswas, P.S.3
Xu, J.4
Schiffelers, R.M.5
Xie, F.Y.6
Ansari, A.M.7
Scaria, P.V.8
Woodle, M.C.9
Lu, P.10
Rouse, B.T.11
-
12
-
-
20444426889
-
A genetic screen identifies PITXl as a suppressor of RAS activity and tumorigenicity
-
Kolfschoten IG, Van Leenwen B, Berns K, Mullenders J, Beijersbergen RL, Bernards R, Voorhoeve PM, Agami R. 2005. A genetic screen identifies PITXl as a suppressor of RAS activity and tumorigenicity. Cell 121:849-858.
-
(2005)
Cell
, vol.121
, pp. 849-858
-
-
Kolfschoten, I.G.1
Van Leenwen, B.2
Berns, K.3
Mullenders, J.4
Beijersbergen, R.L.5
Bernards, R.6
Voorhoeve, P.M.7
Agami, R.8
-
13
-
-
0035969508
-
Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression
-
Makino Y, Cao R, Svensson K, Bertilsson G, Asman M, Tanaka H, Cao Y, Berkenstam A, Poellinger L. 2001. Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Nature 414:550-554.
-
(2001)
Nature
, vol.414
, pp. 550-554
-
-
Makino, Y.1
Cao, R.2
Svensson, K.3
Bertilsson, G.4
Asman, M.5
Tanaka, H.6
Cao, Y.7
Berkenstam, A.8
Poellinger, L.9
-
14
-
-
0037031808
-
Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3 alpha locus
-
Makino Y, Kanopka A, Wilson WJ, Tanaka H, Poellinger L. 2002. Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3 alpha locus. J Biol Chem 277:32405-32408.
-
(2002)
J Biol Chem
, vol.277
, pp. 32405-32408
-
-
Makino, Y.1
Kanopka, A.2
Wilson, W.J.3
Tanaka, H.4
Poellinger, L.5
-
15
-
-
0029811143
-
Gene transfer with liposomes to the intraocular tissues by different routes of administration
-
Masuda I, Matsuo T, Yasuda T, Matsuo N. 1996. Gene transfer with liposomes to the intraocular tissues by different routes of administration. Invest Ophthalmol Vis Sci 37:1914-1920.
-
(1996)
Invest Ophthalmol Vis Sci
, vol.37
, pp. 1914-1920
-
-
Masuda, I.1
Matsuo, T.2
Yasuda, T.3
Matsuo, N.4
-
16
-
-
33644621321
-
Inhibition of ocular angiogenesis by diced small interfering RNAs (siRNAs) specific to vascular endothelial growth factor (VEGF)
-
Murata M,Takanami T,Shimizu S, Kubota Y,Horiuchi S, Habano W,Ma JX,Sato S. 2006. Inhibition of ocular angiogenesis by diced small interfering RNAs (siRNAs) specific to vascular endothelial growth factor (VEGF). Curr Eye Res 31:171-180.
-
(2006)
Curr Eye Res
, vol.31
, pp. 171-180
-
-
Murata, M.1
Takanami, T.2
Shimizu, S.3
Kubota, Y.4
Horiuchi, S.5
Habano, W.6
Ma, J.X.7
Sato, S.8
-
17
-
-
0032932138
-
Hypoxia inducible factor-l alpha is increased in ischemic retina: Temporal and spatial correlation with VEGF expression
-
Ozaki H, Yu AY, Della N, Ozaki K, Luna JD, Yamada H, Hackett SF, Okamoto N, Zack DJ, Semenza GL, Campochiaro PA. 1999. Hypoxia inducible factor-l alpha is increased in ischemic retina: Temporal and spatial correlation with VEGF expression. Invest Ophthalmol Vis Sci 40:182-189.
-
(1999)
Invest Ophthalmol Vis Sci
, vol.40
, pp. 182-189
-
-
Ozaki, H.1
Yu, A.Y.2
Della, N.3
Ozaki, K.4
Luna, J.D.5
Yamada, H.6
Hackett, S.F.7
Okamoto, N.8
Zack, D.J.9
Semenza, G.L.10
Campochiaro, P.A.11
-
18
-
-
0033882794
-
Blockade of vascular endothelial cell growth factor receptor signaling is sufficient to completely prevent retinal neovascularization
-
Ozaki H, Seo MS, Ozaki K, Yamada H, Yamada E, Okamoto N, Hofmann F, Wood JM, Campochiaro PA. 2000. Blockade of vascular endothelial cell growth factor receptor signaling is sufficient to completely prevent retinal neovascularization. Am J Pathol 156:697-707.
-
(2000)
Am J Pathol
, vol.156
, pp. 697-707
-
-
Ozaki, H.1
Seo, M.S.2
Ozaki, K.3
Yamada, H.4
Yamada, E.5
Okamoto, N.6
Hofmann, F.7
Wood, J.M.8
Campochiaro, P.A.9
-
19
-
-
0030668663
-
Development of the human retinal vasculature: Cellular relations and VEGF expression
-
Provis JM, Leech J, Diaz CM, Penfold PL, Stone J, Keshet E. 1997. Development of the human retinal vasculature: Cellular relations and VEGF expression. Exp Eye Res 65:555-568.
-
(1997)
Exp Eye Res
, vol.65
, pp. 555-568
-
-
Provis, J.M.1
Leech, J.2
Diaz, C.M.3
Penfold, P.L.4
Stone, J.5
Keshet, E.6
-
20
-
-
0038748037
-
Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model
-
Reich SJ, Fosnot J, Kuroki A, Tang W, Yang X, Maguire AM, Bennett J, Tolentino MJ.2003. Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model. Mol Vis 9:210-216.
-
(2003)
Mol Vis
, vol.9
, pp. 210-216
-
-
Reich, S.J.1
Fosnot, J.2
Kuroki, A.3
Tang, W.4
Yang, X.5
Maguire, A.M.6
Bennett, J.7
Tolentino, M.J.8
-
21
-
-
0033233243
-
Regulation of mammalian O2 homeostasis byhypoxia-inducible factor l
-
Semenza GL. 1999. Regulation of mammalian O2 homeostasis byhypoxia-inducible factor l. Annu RevCell Dev Biol 15:551-578.
-
(1999)
Annu RevCell Dev Biol
, vol.15
, pp. 551-578
-
-
Semenza, G.L.1
-
22
-
-
8044253996
-
Structural and functional analysis of hypoxia-inducible factor l
-
Semenza GL, Agani F, Booth G, Forsythe J, Iyer N, Jiang BH, Leung S, Roe R, Wiener C, Yu A. 1997. Structural and functional analysis of hypoxia-inducible factor l. Kidney Int 51:553-555.
-
(1997)
Kidney Int
, vol.51
, pp. 553-555
-
-
Semenza, G.L.1
Agani, F.2
Booth, G.3
Forsythe, J.4
Iyer, N.5
Jiang, B.H.6
Leung, S.7
Roe, R.8
Wiener, C.9
Yu, A.10
-
23
-
-
0842310832
-
Restriction enzyme-generated siRNA (REGS) vectors and libraries
-
Sen G, Wehrman TS, Myers JW, Blau HM. 2004. Restriction enzyme-generated siRNA (REGS) vectors and libraries. Nat Genet 36:183-189.
-
(2004)
Nat Genet
, vol.36
, pp. 183-189
-
-
Sen, G.1
Wehrman, T.S.2
Myers, J.W.3
Blau, H.M.4
-
24
-
-
31444440290
-
Suppression of ocular neovascularization with siRNA targeting VEGF receptor l
-
Shen J, Samul R, Silva RL, Akiyama H, Liu H, Saishin Y, Hackett SF, Zinnen S, Kossen K, Fosnaugh K, Vargeese C, Gomez A, Bouhana K, Aitchison R, Pavco P, Campochiaro PA. 2006a. Suppression of ocular neovascularization with siRNA targeting VEGF receptor l. Gene Ther 13:225-234.
-
(2006)
Gene Ther
, vol.13
, pp. 225-234
-
-
Shen, J.1
Samul, R.2
Silva, R.L.3
Akiyama, H.4
Liu, H.5
Saishin, Y.6
Hackett, S.F.7
Zinnen, S.8
Kossen, K.9
Fosnaugh, K.10
Vargeese, C.11
Gomez, A.12
Bouhana, K.13
Aitchison, R.14
Pavco, P.15
Campochiaro, P.A.16
-
25
-
-
33646235632
-
Vasohibin is up-regulated by VEGF in the retina and suppresses VEGF receptor 2 and retinal neovascularization
-
Shen J, Yang X, Xiao WH, Hackett SF, Sato Y, Campochiaro PA. 2006b. Vasohibin is up-regulated by VEGF in the retina and suppresses VEGF receptor 2 and retinal neovascularization. FASEB J 20:723-725.
-
(2006)
FASEB J
, vol.20
, pp. 723-725
-
-
Shen, J.1
Yang, X.2
Xiao, W.H.3
Hackett, S.F.4
Sato, Y.5
Campochiaro, P.A.6
-
26
-
-
0027982899
-
Oxygen-induced retinopathy in the mouse
-
Smith LE, Wesolowski E, McLellan A, Kostyk SK, D'Amato R, Sullivan R, D'Amore PA. 1994. Oxygen-induced retinopathy in the mouse. Invest Ophthalmol Vis Sci 35:101-110.
-
(1994)
Invest Ophthalmol Vis Sci
, vol.35
, pp. 101-110
-
-
Smith, L.E.1
Wesolowski, E.2
McLellan, A.3
Kostyk, S.K.4
D'Amato, R.5
Sullivan, R.6
D'Amore, P.A.7
-
27
-
-
0029074024
-
Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia
-
Stone J, Itin A, Alon T, Pe'er J, Gnessin H, Chan-Ling T, Keshet E. 1995. Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia. J Neurosci 15:4738-4747.
-
(1995)
J Neurosci
, vol.15
, pp. 4738-4747
-
-
Stone, J.1
Itin, A.2
Alon, T.3
Pe'er, J.4
Gnessin, H.5
Chan-Ling, T.6
Keshet, E.7
-
28
-
-
1642486652
-
Subcellular localization and regulation of hypoxia-inducible factor-2a in vascular endothelial cells
-
Takahashi R, Kobayashi C, Kondo Y, Nakatani Y, Kudo I, Kunimoto M, Imura N, Hara S. 2004. Subcellular localization and regulation of hypoxia-inducible factor-2a in vascular endothelial cells. Biochem Biophys Res Commun 317:84-91.
-
(2004)
Biochem Biophys Res Commun
, vol.317
, pp. 84-91
-
-
Takahashi, R.1
Kobayashi, C.2
Kondo, Y.3
Nakatani, Y.4
Kudo, I.5
Kunimoto, M.6
Imura, N.7
Hara, S.8
-
29
-
-
0033870281
-
The expression and distribution of the hypoxia-inducible factors HIF-l alpha and HIF-2 alpha in normal human tissues, cancers, and tumor-associated macrophages
-
Talks KL, Turley H, Gatter KC, Maxwell PH, Pugh CW, Ratcliffe PJ, Harris AL. 2000. The expression and distribution of the hypoxia-inducible factors HIF-l alpha and HIF-2 alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 157:411-421.
-
(2000)
Am J Pathol
, vol.157
, pp. 411-421
-
-
Talks, K.L.1
Turley, H.2
Gatter, K.C.3
Maxwell, P.H.4
Pugh, C.W.5
Ratcliffe, P.J.6
Harris, A.L.7
-
30
-
-
20444376939
-
A genetic screen for candidate tumor suppressors identifies REST
-
Westbrook TF, Martin ES, Schlabach MR, Leng Y, Liang AC, Feng B, Zhao JJ, Roberts TM, Mandel G, Hannon GL, Depinho RA, Chin L, Elledge SJ. 2005. A genetic screen for candidate tumor suppressors identifies REST. Cell 121:837-848.
-
(2005)
Cell
, vol.121
, pp. 837-848
-
-
Westbrook, T.F.1
Martin, E.S.2
Schlabach, M.R.3
Leng, Y.4
Liang, A.C.5
Feng, B.6
Zhao, J.J.7
Roberts, T.M.8
Mandel, G.9
Hannon, G.L.10
Depinho, R.A.11
Chin, L.12
Elledge, S.J.13
-
31
-
-
0034737298
-
RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals
-
Zamore PD, Tuschl T, Sharp PA, Bartel DP. 2000. RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell 101:25-33.
-
(2000)
Cell
, vol.101
, pp. 25-33
-
-
Zamore, P.D.1
Tuschl, T.2
Sharp, P.A.3
Bartel, D.P.4
-
32
-
-
33845536782
-
Ocular neovascularization: Implication of endogenous angiogenic inhibitors and potential therapy
-
Zhang SX, Ma JX. 2007. Ocular neovascularization: Implication of endogenous angiogenic inhibitors and potential therapy. Prog Retin Eye Res 26:1-37.
-
(2007)
Prog Retin Eye Res
, vol.26
, pp. 1-37
-
-
Zhang, S.X.1
Ma, J.X.2
|