Negative regulation of class IA phosphoinositide 3-kinase by protein kinase Cδ limits Fcγ receptor-mediated phagocytosis in macrophages

Journal of Biochemistry

Volumn 145, Issue 1, 2009, Pages 87-94

  Hazeki, Kaoru ^a   Inoue, Kazumi ^a   Nigorikawa, Kiyomi ^a   Hazeki, Osamu ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Akt; Fc receptor; Phagocytosis; Phosphoinositide 3 kinase; PKC

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B BETA; PROTEIN KINASE C DELTA; SHORT HAIRPIN RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; FEMALE; MACROPHAGE; MOUSE; NONHUMAN; PHAGOCYTOSIS; PROTEIN FUNCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELLS, CULTURED; FEMALE; MACROPHAGES; MICE; MICE, INBRED C57BL; PHAGOCYTOSIS; PHOSPHORYLATION; PROTEIN KINASE C-DELTA; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, IGG; TETRADECANOYLPHORBOL ACETATE;

MUS;

EID: 58149127388     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvn142     Document Type: Article

References (34)

1. Engelman, J.A., Luo, J., and Cantley, L.C. (2006) The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat. Rev. Genet. 7, 606-619
2. Ninomiya, N., Hazeki, K., Fukui, Y., Seya, T., Okada, T., Hazeki, O., and Ui, M. (1994) Involvement of phosphatidylinositol 3-kinase in Fc gamma receptor signaling. J. Biol. Chem. 269, 22732-22737
3. Tsukamoto, K., Hazeki, K., Hoshi, M., Nigorikawa, K., Inoue, N., Sasaki, T., and Hazeki, O. (2008) Critical roles of the p110 beta subtype of phosphoinositide 3-kinase in lipopolysaccharide-induced Akt activation and negative regulation of nitrite production in RAW 264.7 cells. J. Immunol. 180, 2054-2061
4. Hazeki, K., Nigorikawa, K., and Hazeki, O. (2007) Role of phosphoinositide 3-kinase in innate immunity. Biol. Pharm. Bull. 30, 1617-1623
5. Wymann, M.P. and Pirola, L. (1998) Structure and function of phosphoinositide 3-kinases. Biochim. Biophys. Acta. 1436, 127-150
6. Bondeva, T., Pirola, L., Bulgarelli-Leva, G., Rubio, I., Wetzker, R., and Wymann, M.P. (1998) Bifurcation of lipid and protein kinase signals of PI3Kgamma to the protein kinases PKB and MAPK. Science. 282, 293-296
7. Hirsch, E., Katanaev, V.L., Garlanda, C., Azzolino, O., Pirola, L., Silengo, L., Sozzani, S., Mantovani, A., Altruda, F., and Wymann, M.P. (2000) Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation. Science. 287, 1049-1053
8. Sasaki, T., Irie-Sasaki, J., Jones, R.G., Oliveira-dos-Santos, A.J., Stanford, W.L., Bolon, B., Wakeham, A., Itie, A., Bouchard, D., Kozieradzki, I., Joza, N., Mak, T.W., Ohashi, P.S., Suzuki, A., and Penninger, J.M. (2000) Function of PI3Kgamma in thymocyte development, T cell activation and neutrophil migration. Science. 287, 1040-1046
9. Mellor, H. and Parker, P.J. (1998) The extended protein kinase C superfamily. Biochem. J. 332 (Pt 2 ), 281-292
10. Hazeki, K., Hazeki, O., Matsuo, T., Seya, T., Yamashita, T., Nagasawa, S., Band, H., and Ui, M. (1999) Role of Syk in Fc gamma receptor-coupled tyrosine phosphorylation of Cbl in a manner susceptible to inhibition by protein kinase C. Eur. J. Immunol. 29, 3302-3312
11. Liu, H., Qiu, Y., Xiao, L., and Dong, F. (2006) Involvement of protein kinase Cepsilon in the negative regulation of Akt activation stimulated by granulocyte colony-stimulating factor. J. Immunol. 176, 2407-2413
12. Doornbos, R.P., Theelen, M., van der Hoeven, P.C., van Blitterswijk, W.J., Verkleij, A.J., and van Bergen en Henegouwen, P.M. (1999) Protein kinase Czeta is a negative regulator of protein kinase B activity. J. Biol. Chem. 274, 8589-8596
13. Li, L., Sampat, K., Hu, N., Zakari, J., and Yuspa, S.H. (2006) Protein kinase C negatively regulates Akt activity and modifies UVC-induced apoptosis in mouse keratinocytes. J. Biol. Chem. 281, 3237-3243
14. Matsumoto, M., Ogawa, W., Hino, Y., Furukawa, K., Ono, Y., Takahashi, M., Ohba, M., Kuroki, T., and Kasuga, M. (2001) Inhibition of insulin-induced activation of Akt by a kinase-deficient mutant of the epsilon isozyme of protein kinase C. J. Biol. Chem. 276, 14400-14406
15. al-Shami, A., Bourgoin, S.G., and Naccache, P.H. (1997) Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils. I. Tyrosine phosphorylation-dependent stimulation of phosphatidylinositol 3-kinase and inhibition by phorbol esters. Blood. 89, 1035-1044
16. Wen, H.C., Huang, W.C., Ali, A., Woodgett, J.R., and Lin, W.W. (2003) Negative regulation of phosphatidylinositol 3-kinase and Akt signalling pathway by PKC. Cell Signal. 15, 37-45
17. Kubo, H., Hazeki, K., Takasuga, S., and Hazeki, O. (2005) Specific role for p85/p110beta in GTP-binding-protein-mediated activation of Akt. Biochem. J. 392, 607-614
18. Kubo-Murai, M., Hazeki, K., Sukenobu, N., Yoshikawa, K., Nigorikawa, K., Inoue, K., Yamamoto, T., Matsumoto, M., Seya, T., Inoue, N., and Hazeki, O. (2007) Protein kinase Cdelta binds TIRAP/Mal to participate in TLR signaling. Mol. Immunol. 44, 2257-2264
19. Matsuo, T., Hazeki, K., Hazeki, O., Katada, T., and Ui, M. (1996) Activation of phosphatidylinositol 3-kinase by concanavalin A through dual signaling pathways, G-protein-coupled and phosphotyrosine-related and an essential role of the G-protein-coupled signals for the lectin-induced respiratory burst in human monocytic THP-1 cells. Biochem. J. 315 (Pt 2 ), 505-512
20. Liu, W.S. and Heckman, C.A. (1998) The sevenfold way of PKC regulation. Cell Signal. 10, 529-542
21. Srivastava, J., Procyk, K.J., Iturrioz, X., and Parker, P.J. (2002) Phosphorylation is required for PMA- and cell-cycle-induced degradation of protein kinase Cdelta. Biochem. J. 368, 349-355
22. Kroner, C., Eybrechts, K., and Akkerman, J.W. (2000) Dual regulation of platelet protein kinase B. J. Biol. Chem. 275, 27790-27798
23. Motley, E.D., Eguchi, K., Gardner, C., Hicks, A.L., Reynolds, C.M., Frank, G.D., Mifune, M., Ohba, M., and Eguchi, S. (2003) Insulin-induced Akt activation is inhibited by angiotensin II in the vasculature through protein kinase C-alpha. Hypertension 41, 775-780
24. Zheng, W.H., Kar, S., and Quirion, R. (2000) Stimulation of protein kinase C modulates insulin-like growth factor-1-induced akt activation in PC12 cells. J. Biol. Chem. 275, 13377-13385
25. Gschwendt, M., Muller, H.J., Kielbassa, K., Zang, R., Kittstein, W., Rincke, G., and Marks, F. (1994) Rottlerin, a novel protein kinase inhibitor. Biochem. Biophys. Res. Commun. 199, 93-98
26. Davies, S.P., Reddy, H., Caivano, M., and Cohen, P. (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 351, 95-105
27. Sidorenko, S.P., Law, C.L., Klaus, S.J., Chandran, K.A., Takata, M., Kurosaki, T., and Clark, E.A. (1996) Protein kinase C mu (PKC mu) associates with the B cell antigen receptor complex and regulates lymphocyte signaling. Immunity. 5, 353-363
28. Newman, S.L., Mikus, L.K., and Tucci, M.A. (1991) Differential requirements for cellular cytoskeleton in human macrophage complement receptor- and Fc receptor-mediated phagocytosis. J. Immunol. 146, 967-974
29. Gresham, H.D., Zheleznyak, A., Mormol, J.S., and Brown, E.J. (1990) Studies on the molecular mechanisms of human neutrophil Fc receptor-mediated phagocytosis. Evidence that a distinct pathway for activation of the respiratory burst results in reactive oxygen metabolite-dependent amplification of ingestion. J. Biol. Chem. 265, 7819-7826
30. Aksoy, E., Amraoui, Z., Goriely, S., Goldman, M., and Willems, F. (2002) Critical role of protein kinase C epsilon for lipopolysaccharide-induced IL-12 synthesis in monocyte-derived dendritic cells. Eur. J. Immunol. 32, 3040-3049
31. Chen, C.C., Wang, J.K., Chen, W.C., and Lin, S.B. (1998) Protein kinase C eta mediates lipopolysaccharide-induced nitric-oxide synthase expression in primary astrocytes. J. Biol. Chem. 273, 19424-19430
32. Castrillo, A., Pennington, D.J., Otto, F., Parker, P.J., Owen, M.J., and Bosca, L. (2001) Protein kinase Cepsilon is required for macrophage activation and defense against bacterial infection. J. Exp. Med. 194, 1231-1242
33. Monick, M.M., Carter, A.B., Flaherty, D.M., Peterson, M.W., and Hunninghake, G.W. (2000) Protein kinase C zeta plays a central role in activation of the p42/44 mitogen-activated protein kinase by endotoxin in alveolar macrophages. J. Immunol. 165, 4632-4639
34. Platten, M., Eitel, K., Wischhusen, J., Dichgans, J., and Weller, M. (2003) Involvement of protein kinase Cdelta and extracellular signal-regulated kinase-2 in the suppression of microglial inducible nitric oxide synthase expression by N-[3,4-dimethoxycinnamoyl]-anthranilic acid (tranilast). Biochem. Pharmacol. 66, 1263-1270