Probes for narcotic receptor mediated phenomena. 37.1 Synthesis and opioid binding affinity of the final pair of oxide-bridged phenylmorphans, the ortho- and para-b-isomers and their N-phenethyl analogues, and the synthesis of the N-phenethyl analogues of the ortho- and para-d-isomers

Journal of Medicinal Chemistry

Volumn 51, Issue 24, 2008, Pages 7866-7881

  Kurimura, Muneaki ^a,b   Liu, Hehua ^a   Sulima, Agnieszka ^a,c   Hashimoto, Akihiro ^a,d   Przybyl, Anna K ^a,e   Ohshima, Etsuo ^a,f   Kodato, Shinichi ^a,g   Deschamps, Jeffrey R ^h   Dersch, Christina M ⁱ   Rothman, Richard B ⁱ   Yong, Sok Lee ^c   Jacobson, Arthur E ^a   Rice, Kenner C ^a  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^b OTSUKA PHARMACEUTICAL CO LTD   (Japan)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d Achillion Pharmaceuticals   (United States)

^e ADAM MICKIEWICZ UNIVERSITY   (Poland)

^f KYOWA HAKKO KOGYO CO LTD   (Japan)

^g Bushu Pharmaceuticals Ltd   (Japan)

^h NAVAL RESEARCH LABORATORY   (United States)

ⁱ NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,3,4,5,6,11A HEXAHYDRO 2 METHYL 2H 3,6A METHANOBENZOFURO[2,3 C]AZOCIN 10 OL; 1,3,4,5,6,11A HEXAHYDRO 2 METHYL 2H 3,6A METHANOBENZOFURO[2,3 C]AZOCIN 8 OL; 1,3,4,5,6,11A HEXAHYDRO 2 PHENETHYL 2H 3,6A METHANOBENZOFURO[2,3 C]AZOCIN 10 OL; 2,3,4,5,6,6A HEXAHYDRO 3 PHENETHYL 1H 4,11B METHANOBENZOFURO[3,2 D]AZOCIN 10 OL; 2,3,4,5,6,6A HEXAHYDRO 3 PHENETHYL 1H 4,11B METHANOBENZOFURO[3,2 D]AZOCIN 8 OL; AROMATIC COMPOUND; FLUORINE DERIVATIVE; FUNCTIONAL GROUP; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); KAPPA OPIATE RECEPTOR ANTAGONIST; MORPHINE DERIVATIVE; MU OPIATE RECEPTOR; NITRO DERIVATIVE; OPIATE; PHENYL GROUP; SULFUR 35; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG SYNTHESIS; ISOMERISM; RACEMIC MIXTURE; RECEPTOR BINDING; THIN LAYER CHROMATOGRAPHY; X RAY CRYSTALLOGRAPHY;

ANALGESICS, OPIOID; CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ELECTRONS; FLUORINE; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); KINETICS; LIGANDS; MODELS, CHEMICAL; MODELS, MOLECULAR; NITROGEN; OXIDES; PROTEIN BINDING; RECEPTORS, OPIOID;

EID: 58149086981     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm800913d     Document Type: Article

References (21)

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