Specific JNK inhibition by D-JNKI1 protects Purkinje cells from cell death in Lurcher mutant mouse

Cerebellum

Volumn 7, Issue 4, 2008, Pages 534-538

  Repici, Mariaelena ^a,b   Zanjani, Hadi S ^a,b,d   Gautheron, Vanessa ^a,b   Borsello, Tiziana ^c   Dusart, Isabelle ^a,b   Mariani, Jean ^a,b,e  

^a CNRS   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^d MARYLAND PSYCHIATRIC RESEARCH CENTER   (United States)

^e HÔPITAL CHARLES FOIX   (France)

Author keywords

Cell death; Cell permeable peptide; JNK; Lurcher mutant mouse; Purkinje cells

Indexed keywords

STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR;

ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CELL DEATH; CELL MEMBRANE PERMEABILITY; CELL STRUCTURE; CONTROLLED STUDY; FEMALE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL; QUANTITATIVE ANALYSIS;

ALANINE; AMINO ACID SUBSTITUTION; ANIMALS; ANIMALS, NEWBORN; CELL DEATH; CELL MEMBRANE PERMEABILITY; CEREBELLUM; CROSSES, GENETIC; FEMALE; GENOTYPE; MALE; MAP KINASE KINASE 4; MICE; MICE, NEUROLOGIC MUTANTS; MUTATION; NEURONS; PEPTIDES; PURKINJE CELLS; RECEPTORS, GLUTAMATE; THREONINE;

EID: 58149086969     PISSN: 14734222     EISSN: 14734230     Source Type: Journal    
DOI: 10.1007/s12311-008-0070-8     Document Type: Article

References (36)

1. J Zuo PL De Jager KA Takahashi W Jiang DJ Linden N Heintz 1997 Neurodegeneration in Lurcher mice caused by mutation in d2 glutamate receptor Nature 388 769 773
2. KW Caddy TJ Biscoe 1975 Preliminary observations on the cerebellum in the mutant mouse Lurcher Brain Res 91 2 276 280
3. KW Caddy TJ Biscoe 1979 Structural and quantitative studies on the normal C3H and Lurcher mutant mouse Philos Trans R Soc Lond 287 1020 167 201
4. N Dumesnil-Bousez C Sotelo 1992 Early development of the Lurcher cerebellum: Purkinje cell alterations and impairment of synaptogenesis J Neurocytol 21 7 506 529
5. K Herrup K Sunter 1986 Cell lineage dependent and independent control of Purkinje cell number in the mammalian CNS: further quantitative studies of Lurcher chimeric mice Dev Biol 117 2 417 427
6. MW Vogel J Caston M Yuzaki J Mariani 2007 The Lurcher mouse: fresh insights from an old mutant Brain Res 1140 4 18
7. R McFarland A Blokhin J Sydnor J Mariani MW Vogel 2007 Oxidative stress, nitric oxide, and the mechanisms of cell death in Lurcher Purkinje cells Developmental Neurobiology 67 8 1032 1046
8. KE Larsen D Sulzer 2002 Autophagy in neurons: a review Histol Histopathol 17 3 897 908
9. DC Rubinsztein M DiFiglia N Heintz RA Nixon ZH Qin B Ravikumar 2005 Autophagy and its possible roles in nervous system diseases, damage and repair Autophagy 1 1 11 22
10. H Zanjani L Rondi-Reig M Vogel JC Martinou N Delhaye-Bouchaud J Mariani 1998 Overexpression of a Hu-bcl-2 transgene in Lurcher mutant mice delays Purkinje cell death C R de Acad Sci 321 8 633 640
11. HS Zanjani MW Vogel JC Martinou N Delhaye-Bouchaud J Mariani 1998 Postnatal expression of Hu-bcl-2 gene in Lurcher mutant mice fails to rescue Purkinje cells but protects inferior olivary neurons from target-related cell death J Neurosci 18 1 319 327
12. F Selimi MW Vogel J Mariani 2000 Bax inactivation in Lurcher mutants rescues cerebellar granule cells but not Purkinje cells or inferior olivary neurons J Neurosci 20 14 5339 5345
13. CR Weston RJ Davis 2007 The JNK signal transduction pathway Curr Opin Cell Biol 19 2 142 149
14. D Bozyczko-Coyne MS Saporito RL Hudkins 2002 Targeting the JNK pathway for therapeutic benefit in CNS disease Curr Drug Targets CNS Neurol Disord 1 1 31 49
15. T Borsello PG Clarke L Hirt A Vercelli M Repici DF Schorderet 2003 A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia Nat Med 9 9 1180 1186
16. M Repici C Centeno S Tomasi G Forloni C Bonny A Vercelli 2007 Time-course of c-Jun N-terminal kinase activation after cerebral ischemia and effect of D-JNKI1 on c-Jun and caspase-3 activation Neuroscience 150 1 40 49
17. W Wang C Ma Z Mao M Li 2004 JNK inhibition as a potential strategy in treating Parkinson's disease Drug News Perspect 17 10 646 654
18. SJ Harper N Wilkie 2003 MAPKs: new targets for neurodegeneration Expert Opin Ther Targets 7 2 187 200
19. W Lu SE Tsirka 2002 Partial rescue of neural apoptosis in the Lurcher mutant mouse through elimination of tissue plasminogen activator Development 129 8 2043 2050
20. C Bonny A Oberson S Negri C Sauser DF Schorderet 2001 Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death Diabetes 50 1 77 82
21. J Marin-Teva I Dusart C Colin A Gervais N van Rooijen M Mallat 2004 Microglia promote the death of developing Purkinje cells Neuron 41 4 535 547
22. I Dusart MS Airaksinen C Sotelo 1997 Purkinje cell survival and axonal regeneration are age dependent: an in vitro study J Neurosci 17 10 3710 3726
23. L Stoppini PA Buchs D Muller 1991 A simple method for organotypic cultures of nervous tissue J Neurosci Methods 37 2 173 182
24. F Selimi AM Lohof S Heitz A Lalouette CI Jarvis Y Bailly 2003 Lurcher GRID2-induced death and depolarization can be dissociated in cerebellar Purkinje cells Neuron 37 5 813 819
25. AM Ghoumari R Wehrle O Bernard C Sotelo I Dusart 2000 Implication of Bcl-2 and Caspase-3 in age-related Purkinje cell death in murine organotypic culture: an in vitro model to study apoptosis Eur J Neurosci 12 8 2935 2949
26. Zanjani H, Dusart I, Vogel MW, Mariani J (2006) Inhibition of c-Jun N-terminal kinase (JNK) activity in cerebellar slice cultures rescues Lurcher Purkinje cells from pathological cell death. Neurosci Abst 286.7
27. I Dusart JL Guenet C Sotelo 2006 Purkinje cell death: differences between developmental cell death and neurodegenerative death in mutant mice Cerebellum 5 2 163 173
28. J Baurle K Kranda S Frischmuth 2006 On the variety of cell death pathways in the Lurcher mutant mouse Acta Neuropathol 112 6 691 702
29. C Centeno M Repici JY Chatton BM Riederer C Bonny P Nicod 2007 Role of the JNK pathway in NMDA-mediated excitotoxicity of cortical neurons Cell Death Differ 14 2 240 253
30. S Rodriguez-Enriquez I Kim RT Currin JJ Lemasters 2006 Tracker dyes to probe mitochondrial autophagy (mitophagy) in rat hepatocytes Autophagy 2 1 39 46
31. L Yu A Alva H Su P Dutt E Freundt S Welsh 2004 Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8 Science 304 5676 1500 1502
32. T Borsello K Croquelois JP Hornung PG Clarke 2003 N-methyl-d-aspartate- triggered neuronal death in organotypic hippocampal cultures is endocytic, autophagic and mediated by the c-Jun N-terminal kinase pathway Eur J Neurosci 18 3 473 485
33. QJ Wang Y Ding DS Kohtz N Mizushima IM Cristea MP Rout 2006 Induction of autophagy in axonal dystrophy and degeneration J Neurosci 26 31 8057 8068
34. L Chang Y Jones MH Ellisman LS Goldstein M Karin 2003 JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins Dev Cell 4 4 521 533
35. T Kawauchi K Chihama YV Nishimura Y Nabeshima M Hoshino 2005 MAP1B phosphorylation is differentially regulated by Cdk5/p35, Cdk5/p25, and JNK Biochem Biophys Res Commun 331 1 50 55
36. S Soares M Barnat C Salim Y von Boxberg M Ravaille-Veron F Nothias 2007 Extensive structural remodeling of the injured spinal cord revealed by phosphorylated MAP1B in sprouting axons and degenerating neurons Eur J Neurosci 26 6 1446 1461