Partial rescue of neural apoptosis in the Lurcher mutant mouse through elimination of tissue plasminogen activator

Development

Volumn 129, Issue 8, 2002, Pages 2043-2050

  Lu, Weiquan ^a   Tsirka, Stella E ^a  

^a STONY BROOK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Cerebellum; Lurcher; Mouse; Neurodegeneration; Purkinje; tPA

Indexed keywords

CASPASE 8; EXCITOTOXIN; GLUTAMATE RECEPTOR; SERINE PROTEINASE; TISSUE PLASMINOGEN ACTIVATOR;

APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; MOUSE; MOUSE MUTANT; NERVE CELL DEGENERATION; NONHUMAN; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PURKINJE CELL;

ANIMALS; APOPTOSIS; CASPASE 8; CASPASE 9; CASPASES; CEREBELLUM; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MICE, NEUROLOGIC MUTANTS; MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; PHOSPHORYLATION; PURKINJE CELLS; RECEPTORS, GLUTAMATE; TISSUE PLASMINOGEN ACTIVATOR;

EID: 0036336853     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Interaction of heparin with plasminogen activators and plasminogen: Effects on the activation of plasminogen
2. Plasminogen expression in the neonatal and adult mouse brain
3. Biochemical pathways of caspase activation during apoptosis
4. Physiological consequences of loss of plasminogen activator gene function in mice
5. The mouse tissue plasminogen activator gene 5′ flanking region directs appropriate expression in development and a seizure-enhanced response in the CNS
6. Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin
7. Neurodegeneration in Lurcher mice occurs via multiple cell death pathways
8. Tissue plasminogen activator mRNA expression in granule neurons coincides with their migration in the developing cerebellum
9. 2+-dependent release of tissue plasminogen activator
10. Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinase after neuronal injury
11. DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappa B and AP-1
12. Plasminogen activator release at the neuronal growth cone
13. The stress-activated protein kinase subfamily of c-Jun kinases
14. The lurcher gene induces apostolic cell death in cerebellar Purkinje cells
15. Tissue plasminogen activator (t-PA). is targeted to the regulated secretory pathway
16. 'Lurcher', a new gene in linkage group XI of the house mouse
17. Tissue-plasminogen activator is induced as an immediate-early gene during seizure, kindling and long-term potentiation
18. Tissue plasminogen activator induction in Purkinje neurons after cerebellar motor learning
19. Neuronal migration is retarded in mice lacking the tissue plasminogen activator gene
20. Target-related and intrinsic neuronal death in lurcher mutant mice are both mediated by caspase-3 activation
21. Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73
22. tPA and neuronal death
23. Excitotoxin induced neuronal degeneration and seizure are mediated by tissue-type plasminogen activator
24. An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus
25. The plasminogen activator/plasmin system
26. Phosphorylation of c-Jun is necessary for apoptosis induced by survival signal withdrawal in cerebellar granule neurons
27. Interaction of granule, Purkinje and inferior olivary neurons in lurcher chimeric mice. II. Granule cell death
28. Interaction of granule, Purkinje and inferior olivary neurons in lurcher chimaeric mice. I. Qualitative studies
29. 2+
30. The tPA/plasmin extracellular proteolytic system regulates seizure-induced hippocampal mossy fiber outgrowth through a proteoglycan substrate
31. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
32. Neurodegeneration in Lurcher mice caused by mutation in d2 glutamate receptor gene