The 3′UTR of HIC mRNA improves the production of recombinant proteins in Chinese hamster ovary cells

Journal of Biotechnology

Volumn 139, Issue 2, 2009, Pages 152-155

  Liu, Jaron ^a,b   Ku, Sebastian C Y ^a   Lee, Jialing ^a   Young, Tara M ^c   Pe'ery, Tsafi ^c   Mathews, Michael B ^c   Chao, Sheng Hao ^a  

^a AGENCY FOR SCIENCE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

3 UTR; Erythropoietin; Human I mfa domain containing protein; Interferon ; P TEFb; RNA polymerase II

Indexed keywords

BIOPHARMACEUTICAL PROTEINS; CHINESE HAMSTERS; CHO CELLS; CODING REGIONS; ERYTHROPOIETIN; HUMAN ERYTHROPOIETINS; HUMAN I-MFA DOMAIN-CONTAINING PROTEIN; MAMMALIAN CELL LINES; MAMMALIAN CELLS; OVEREXPRESSION; P-TEFB; POSITIVE TRANSCRIPTION ELONGATION FACTOR B; RECOMBINANT PROTEIN EXPRESSIONS; RECOMBINANT PROTEINS; RNA POLYMERASE II; TRANSCRIPTIONAL REGULATORS; TRANSCRIPTIONAL STIMULATIONS; TRANSGENE EXPRESSIONS; TRANSIENT TRANSFECTIONS; UNTRANSLATED REGIONS;

ANIMAL CELL CULTURE; ANTIBIOTICS; CELL CULTURE; GLYCOPROTEINS; MAMMALS; POLYMERS; PROGRAMMING THEORY; PROTEINS; RNA; TRANSCRIPTION;

NUCLEIC ACIDS;

ERYTHROPOIETIN; GAMMA INTERFERON; MESSENGER RNA; MYOD PROTEIN; RECOMBINANT PROTEIN; HIC PROTEIN, HUMAN; MYOGENIC FACTOR; POSITIVE TRANSCRIPTION ELONGATION FACTOR B; RECOMBINANT ERYTHROPOIETIN;

3' UNTRANSLATED REGION; ANIMAL CELL; ARTICLE; CELL CULTURE; CHO CELL; CONTROLLED STUDY; GENE OVEREXPRESSION; GENETIC CODE; GENETIC TRANSFECTION; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; TRANSGENE; ANIMAL; BIOLOGICAL MODEL; BIOSYNTHESIS; CRICETULUS; GENE EXPRESSION; GENETICS; HAMSTER; HUMAN; METABOLISM;

CRICETULUS GRISEUS; MAMMALIA;

3' UNTRANSLATED REGIONS; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; ERYTHROPOIETIN, RECOMBINANT; GENE EXPRESSION; HUMANS; INTERFERON-GAMMA; MODELS, BIOLOGICAL; MYOGENIC REGULATORY FACTORS; POSITIVE TRANSCRIPTIONAL ELONGATION FACTOR B; RECOMBINANT PROTEINS; RNA, MESSENGER; TRANSGENES;

EID: 58049211789     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2008.10.008     Document Type: Article

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