Molecular determinants for the stereospecific reduction of 3-ketosteroids and reactivity towards all-trans-retinal of a short-chain dehydrogenase/reductase (DHRS4)

Archives of Biochemistry and Biophysics

Volumn 481, Issue 2, 2009, Pages 183-190

  Endo, Satoshi ^a   Maeda, Satoshi ^a   Matsunaga, Toshiyuki ^a   Dhagat, Urmi ^b   El Kabbani, Ossama ^b   Tanaka, Nobutada ^c   Nakamura, Kazuo T ^c   Tajima, Kazuo ^d   Hara, Akira ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

^b MONASH UNIVERSITY   (Australia)

^c SHOWA UNIVERSITY   (Japan)

^d HOKURIKU UNIVERSITY   (Japan)

Author keywords

3 Ketosteroid reductase; All trans retinal; Carbonyl reductase; DHRS4; Short chain dehydrogenase reductase; Stereospecificity

Indexed keywords

3 KETOSTEROID DERIVATIVE; BENZOIN; ISATIN; OXIDOREDUCTASE; OXOSTEROID; PHENYLALANINE; PROTEIN DHRS4; RETINAL; SERINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DOG; ENZYME BINDING; ENZYME SUBSTRATE; GENE MUTATION; HUMAN; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; RABBIT; REDUCTION; STEREOSPECIFICITY; SWINE;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CONSERVED SEQUENCE; DOGS; ESCHERICHIA COLI; FATTY ACID SYNTHETASE COMPLEX; HYDROXYBUTYRATE DEHYDROGENASE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NADH, NADPH OXIDOREDUCTASES; RABBITS; RECOMBINANT PROTEINS; RETINALDEHYDE; SEQUENCE ALIGNMENT; SWINE; TRANSFECTION;

ANIMALIA; CANIS FAMILIARIS; ORYCTOLAGUS CUNICULUS; SUIDAE;

EID: 58049113486     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2008.11.014     Document Type: Article

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