Determining structure and function of steroid dehydrogenase enzymes by sequence analysis, homology modeling, and rational mutational analysis

Annals of the New York Academy of Sciences

Volumn 1061, Issue , 2005, Pages 135-148

  Duax, William L ^a,e   Thomas, James ^b   Pletnev, Vladimir ^c   Addlagatta, Anthony ^d   Huether, Robert ^a   Habegger, Lukas ^a   Weeks, Charles M ^a  

^a HAUPTMAN WOODWARD MEDICAL RESEARCH INSTITUTE   (United States)

^b MERCER UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c SHEMYAKIN OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY   (Russian Federation)

^d UNIVERSITY OF OREGON   (United States)

^e UNIVERSITY AT BUFFALO   (United States)

Author keywords

Breast cancer; Homology modeling; Prediction of ligand specificity; Prostate cancer; Rational mutational analysis; Steroid dehydrogenase; Testosterone 3 HSDII

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; OXIDOREDUCTASE; STEROID REDUCTASE; URIDINE DIPHOSPHATE GLUCOSE 4 EPIMERASE;

BREAST CANCER; CONFERENCE PAPER; CRYSTAL STRUCTURE; DIABETES MELLITUS; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; GENE MUTATION; HUMAN; HYPERTENSION; KIDNEY POLYCYSTIC DISEASE; PROSTATE CANCER; SEQUENCE HOMOLOGY; STEROID METABOLISM; TISSUE SPECIFICITY;

BACTERIA (MICROORGANISMS);

EID: 32244446846     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1336.015     Document Type: Conference Paper

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