Context-dependent modulation of αβγ and αβδ GABAA receptors by penicillin: Implications for phasic and tonic inhibition

Neuropharmacology

Volumn 56, Issue 1, 2009, Pages 161-173

  Feng, Hua Jun ^a   Botzolakis, Emmanuel J ^a   Macdonald, Robert L ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cys loop; Deactivation; Desensitization; Ion channel; Kinetics; Ligand gated; Markov; Modeling; Open channel block; Rebound

Indexed keywords

4 AMINOBUTYRIC ACID; ION CHANNEL; PENICILLIN G;

ARTICLE; CELL STRAIN HEK293; CHANNEL GATING; CONTROLLED STUDY; DRUG SELECTIVITY; GABAERGIC SYSTEM; HUMAN; HUMAN CELL; ION CURRENT; MOLECULAR MODEL; NEUROMODULATION; PATCH CLAMP; PRIORITY JOURNAL; PROBABILITY; SYNAPTIC MEMBRANE;

CELL LINE, TRANSFORMED; GAMMA-AMINOBUTYRIC ACID; HUMANS; ION CHANNEL GATING; MEMBRANE POTENTIALS; MODELS, BIOLOGICAL; PATCH-CLAMP TECHNIQUES; PENICILLINS; POTASSIUM; PROTEIN SUBUNITS; RECEPTORS, GABA-A; TRANSFECTION;

EID: 58049112691     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2008.08.010     Document Type: Article

References (66)

1. Adams P.R. Voltage jump analysis of procaine action at frog end-plate. J. Physiol. 268 (1977) 291-318
2. Ascher P., Marty A., and Neild T.O. The mode of action of antagonists of the excitatory response to acetylcholine in Aplysia neurons. J. Physiol. 278 (1978) 177-206
3. Ascher P., Large W.A., and Rang H.P. Studies on the mechanism of action of acetylcholine antagonists on rat parasympathetic ganglion cells. J. Physiol. 295 (1979) 139-170
4. --current responses in rat striatal neurones. Br. J. Pharmacol. 129 (2000) 402-408
5. A receptor desensitization: structural determinants and possible relevance for synaptic function. J. Physiol. 544 (2002) 3-18
6. A receptor desensitization and deactivation. J. Physiol. 584 (2007) 769-787
7. Brunig I., Scotti E., Sidler C., and Fritschy J.M. Intact sorting, targeting, and clustering of γ-aminobutyric acid A receptor subtypes in hippocampal neurons in vitro. J. Comp. Neurol. 443 (2002) 43-55
8. Caraiscos V.B., Newell J.G., You-Ten K.E., Elliott E.M., Rosahl T.W., Wafford K.A., MacDonald J.F., and Orser B.A. Selective enhancement of tonic GABAergic inhibition in murine hippocampal neurons by low concentrations of the volatile anesthetic isoflurane. J. Neurosci. 24 (2004) 8454-8458
9. A receptor α4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 15230-15235
10. Chow P., and Mathers D. Convulsant doses of penicillin shorten the lifetime of GABA-induced channels in cultured central neurones. Br. J. Pharmacol. 88 (1986) 541-547
11. A receptor subtypes requires the γ2 subunit and gephyrin. Nat. Neurosci. 1 (1998) 563-571
12. A receptors. Nat. Rev. Neurosci. 6 (2005) 215-229
13. A receptors. Mol. Pharmacol. 66 (2004) 1517-1524
14. A receptor currents. Mol. Pharmacol. 66 (2004) 988-1003
15. Glykys J., and Mody I. The main source of ambient GABA responsible for tonic inhibition in the mouse hippocampus. J. Physiol. 582 (2007) 1163-1178
16. A receptor subunit partnership with high sensitivity to ethanol. Nat. Neurosci. 10 (2007) 40-48
17. A receptors in transfected L929 cells isolated by immunomagnetic bead separation. Neuropharmacology 36 (1997) 63-73
18. A receptor currents in mouse fibroblasts. J. Physiol. 514 (1999) 27-45
19. A receptors containing bovine α1, β1, γ2L subunits stably transfected into mouse fibroblast L-cells. Br. J. Pharmacol. 107 (1992) 732-737
20. Hsu F., Waldeck R., Faber D., and Smith S.S. Neurosteroid effects of GABAergic synaptic plasticity in hippocampus. J. Neurophysiol. 89 (2003) 1929-1940
21. Jimenez F., Velasco F., Carrillo-Ruiz J., Villanueva F.E., Velasco M., and Ponce H. Seizures induced by penicillin microinjections in the mesencephalic tegmentum. Epilepsy Res. 38 (2000) 33-44
22. A channel responses to brief agonist pulses. Neuron 15 (1995) 181-191
23. Jones M.V., and Westbrook G.L. The impact of receptor desensitization on fast synaptic transmission. Trends Neurosci. 19 (1996) 96-101
24. A receptor-operated chloride current in frog sensory neuron. Brain Res. 595 (1992) 249-255
25. Katz B., and Thesleff S. A study of the desensitization produced by acetylcholine at the motor end-plate. J. Physiol. 138 (1957) 63-80
26. Krishek B.J., Moss S.J., and Smart T.G. Homomeric β1 γ-aminobutyric acid A receptor-ion channels: evaluation of pharmacological and physiological properties. Mol. Pharmacol. 49 (1996) 494-504
27. A receptors to synaptic and extrasynaptic GABA. J. Physiol. 578 (2007) 655-676
28. A receptor gating. J. Physiol. 572 (2006) 183-200
29. A receptors. J. Neurosci. 26 (2006) 1749-1758
30. A channels that open spontaneously. Eur. J. Pharmacol. 496 (2004) 23-32
31. Lipton S.A. Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond. Nat. Rev. Drug Discov. 5 (2006) 160-170
32. A receptor trafficking, channel activity, and functional plasticity of inhibitory synapses. Pharmacol. Ther. 102 (2004) 195-221
33. Macdonald R.L., and Barker J.L. Pentylenetetrazol and penicillin are selective antagonists of GABA-mediated post-synaptic inhibition in cultured mammalian neurons. Nature 267 (1977) 720-721
34. A receptor mutations associated with generalized epilepsies. Adv. Pharmacol. 54 (2006) 147-169
35. Marty A. Nose and relaxation studies of acetylcholine induced currents in the presence of procaine. J. Physiol. 278 (1978) 237-250
36. A-receptor subtypes really occur in the brain?. Trends Neurosci. 19 (1996) 139-143
37. A receptors. Trends Neurosci. 27 (2004) 569-575
38. Mozrzymas J.W., Barberis A., Mercik K., and Zarnowska E.D. Binding sites, singly bound states, and conformation coupling shape GABA-evoked currents. J. Neurophysiol. 89 (2003) 871-883
39. A receptor activation shapes the "personality" of inhibitory synapses. Neuropharmacology 47 (2004) 945-960
40. A receptors mediate tonic inhibition in hippocampal dentate granule cells. Mol. Pharmacol. 69 (2005) 564-575
41. Neher E., and Steinbach J.H. Local anesthetics transiently block currents through single acetylcholine-receptor channels. J. Physiol. 277 (1978) 153-176
42. A receptors to synaptic and extrasynaptic membranes of cerebellar granule cells. J. Neurosci. 18 (1998) 1693-1703
43. Nusser Z., and Mody I. Selective modulation of tonic and phasic inhibitions in dentate gyrus granule cells. J. Neurophysiol. 87 (2002) 2624-2628
44. A receptor complex: structure and function. In: Egebjerg J., Schousboe A., and Krogsgaard-Larsen P. (Eds). Glutamate and GABA Receptors and Transporters: Structure, Function and Pharmacology (2002), Taylor and Francis, London 202-235
45. A receptor in a mouse model of temporal lobe epilepsy. J. Neurosci. 24 (2004) 8629-8639
46. A receptor subtypes in the cerebellum of mouse and rat. J. Neurochem. 87 (2003) 1444-1455
47. A receptor kinetics in the cerebellar nuclei: evidence for detection of transmitter from distant release sites. Biophys. J. 88 (2005) 1740-1754
48. Ruff R.L. A quantitative analysis of local anesthetic alteration of miniature end-plate currents and end-plate current fluctuations. J. Physiol. 264 (1977) 89-124
49. A receptor subunits: role of the δ subunit. J. Neurosci. 14 (1994) 7077-7086
50. A antagonists. Neuroscience 59 (1994) 259-273
51. A receptor blockade. Neuroscience 81 (1997) 1111-1122
52. A receptors: modulating gain and maintaining the tone. Trends Neurosci. 27 (2004) 262-269
53. Shen E.Y., and Lai Y.J. In vivo microdialysis study of excitatory and inhibitory amino acid levels in the hippocampus following penicillin-induced seizures in mature rats. Acta Paediatr. Taiwan. 43 (2002) 313-318
54. A conductances in hippocampal neurons. J. Neurosci. 22 (2002) 1-5
55. A receptors. Br. J. Pharmacol. 135 (2002) 427-432
56. A receptors in hippocampal granule cells. Brain Res. 1029 (2004) 207-216
57. A receptor in rat thalamus. Mol. Pharmacol. 56 (1999) 110-115
58. A α1β1 receptors. J. Membr. Biol. 154 (1996) 11-21
59. Tsuda A., Ito M., Kishi K., Shiraishi H., Tsuda H., and Mori C. Effect of penicillin on GABA-gated chloride ion influx. Neurochem. Res. 19 (1994) 1-4
60. A receptor channels from mouse spinal cord neurones in culture. J. Physiol. 445 (1992) 97-127
61. Uysal H., Kuli P., Caglar S., Inan L.E., Akarsu E.S., Palaoglu O., and Ayhan I.H. Antiseizure activity of insulin: insulin inhibits pentylenetetrazole, penicillin and kainic acid-induced seizures in rats. Epilepsy Res. 25 (1996) 185-190
62. A receptors and their activation by GABA spillover in the mouse dentate gyrus. J. Neurosci. 23 (2003) 10650-10661
63. A receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon. J. Neurosci. 12 (1992) 1040-1062
64. A receptors containing the δ subunit. J. Neurosci. 22 (2002) 1541-1549
65. A receptors in hippocampal neurons are high-affinity, low-conductance sensors for extracellular GABA. Mol. Pharmacol. 63 (2003) 2-8
66. A receptor subunits on dentate granule cell dendrites influences tonic and phasic inhibition in a mouse model of epilepsy. J. Neurosci. 27 (2007) 7520-7531