The β-lactam antibiotics, penicillin-G and cefoselis have different mechanisms and sites of action at GABAA receptors

British Journal of Pharmacology

Volumn 135, Issue 2, 2002, Pages 427-432

  Sugimoto, Masahiro ^a   Fukami, Sakae ^a   Kayakiri, Hiroshi ^b   Yamazaki, Shunji ^b   Matsuoka, Nobuya ^b   Uchida, Ichiro ^a   Mashimo, Takashi ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b ASTELLAS PHARMA INC   (Japan)

Author keywords

Antibiotics; Convulsion; Electrophysiology; Mutation; Picrotoxin; Xenopus oocytes

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BETA LACTAM ANTIBIOTIC; BICUCULLINE; CEFOSELIS; PENICILLIN G; PICROTOXIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING SITE; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SEQUENCE; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; ELECTROPHYSIOLOGY; IC 50; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SITE DIRECTED MUTAGENESIS; VOLTAGE CLAMP; XENOPUS;

ANIMALS; ANTI-BACTERIAL AGENTS; BINDING SITES; CEFTIZOXIME; CEPHALOSPORINS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MICE; MUTAGENESIS, SITE-DIRECTED; OOCYTES; PENICILLIN G; PENICILLINS; RECEPTORS, GABA-A; RECOMBINANT PROTEINS; XENOPUS;

EID: 0036178570     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704496     Document Type: Article

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