Conformationally constrained analogues of N′-(4-tert-butylbenzyl)-N-(4-methylsulfonylaminobenzyl)thiourea as TRPV1 antagonists

European Journal of Medicinal Chemistry

Volumn 44, Issue 1, 2009, Pages 322-331

  Lim, Ju Ok ^a   Jin, Mi Kyoung ^a   Ryu, HyungChul ^a   Kang, Dong Wook ^a   Lee, Jeewoo ^a   Pearce, Larry V ^b   Tran, Richard ^b   Toth, Attila ^b   Blumberg, Peter M ^b  

^a Tumor Microenvironment Global Core Research Center   (South Korea)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Analgesic; Conformationally constrained analogues; TRPV1 antagonists

Indexed keywords

N' (4 TERT BUTYLBENZYL) N (4 METHYLSULFONYLAMINOBENZYL)THIOUREA; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 1 BLOCKING AGENT;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CONFORMATION; DRUG SYNTHESIS; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; REACTION ANALYSIS; RECEPTOR AFFINITY; RECEPTOR BLOCKING; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; INDANS; MOLECULAR CONFORMATION; NAPHTHALENES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; THIOUREA; TRPV CATION CHANNELS;

EID: 57949109642     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.02.026     Document Type: Article

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19. {A figure is presented}