메뉴 건너뛰기




Volumn 30, Issue 6, 2009, Pages 1176-1183

Targeting and imaging cancer cells by Folate-decorated, quantum dots (QDs)- loaded nanoparticles of biodegradable polymers

Author keywords

Cancer diagnosis; Cancer nanotechnology; Confocal laser scanning microscopy; Molecular imaging; Nanomedicine; Vitamin E TPGS

Indexed keywords

BIODEGRADABLE POLYMERS; CELL CULTURE; CONFOCAL MICROSCOPY; COPOLYMERIZATION; LASER APPLICATIONS; LASERS; MEDICAL NANOTECHNOLOGY; NANOPARTICLES; NANOTECHNOLOGY; OPTICAL WAVEGUIDES; POLYMERS; QUANTUM ELECTRONICS; SCANNING;

EID: 57849090020     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2008.10.039     Document Type: Article
Times cited : (238)

References (52)
  • 1
    • 20144379798 scopus 로고    scopus 로고
    • Quantum dot bioconjugates for imaging, labelling and sensing
    • Medintz I.L., Uyeda H.T., Goldman E.R., and Mattoussi H. Quantum dot bioconjugates for imaging, labelling and sensing. Nature Materials 4 6 (2005 Jun) 435-446
    • (2005) Nature Materials , vol.4 , Issue.6 , pp. 435-446
    • Medintz, I.L.1    Uyeda, H.T.2    Goldman, E.R.3    Mattoussi, H.4
  • 3
    • 19944433260 scopus 로고    scopus 로고
    • Quantum dots for live cells, in vivo imaging, and diagnostics
    • Michalet X., Pinaud F.F., Bentolila L.A., Tsay J.M., Doose S., Li J.J., et al. Quantum dots for live cells, in vivo imaging, and diagnostics. Science 307 5709 (2005 Jan) 538-544
    • (2005) Science , vol.307 , Issue.5709 , pp. 538-544
    • Michalet, X.1    Pinaud, F.F.2    Bentolila, L.A.3    Tsay, J.M.4    Doose, S.5    Li, J.J.6
  • 4
    • 0842287342 scopus 로고    scopus 로고
    • Probing the cytotoxicity of semiconductor quantum dots
    • Derfus A.M., Chan W.C.W., and Bhatia S.N. Probing the cytotoxicity of semiconductor quantum dots. Nano Letters 4 1 (2004 Jan) 11-18
    • (2004) Nano Letters , vol.4 , Issue.1 , pp. 11-18
    • Derfus, A.M.1    Chan, W.C.W.2    Bhatia, S.N.3
  • 6
    • 0012392952 scopus 로고    scopus 로고
    • Semiconductor nanocrystals as fluorescent biological labels
    • Bruchez M., Moronne M., Gin P., Weiss S., and Alivisatos A.P. Semiconductor nanocrystals as fluorescent biological labels. Science 281 5385 (1998 Sep) 2013-2016
    • (1998) Science , vol.281 , Issue.5385 , pp. 2013-2016
    • Bruchez, M.1    Moronne, M.2    Gin, P.3    Weiss, S.4    Alivisatos, A.P.5
  • 7
    • 0037225979 scopus 로고    scopus 로고
    • Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots
    • Wu X.Y., Liu H.J., Liu J.Q., Haley K.N., Treadway J.A., Larson J.P., et al. Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots. Nature Biotechnology 21 1 (2003 Jan) 41-46
    • (2003) Nature Biotechnology , vol.21 , Issue.1 , pp. 41-46
    • Wu, X.Y.1    Liu, H.J.2    Liu, J.Q.3    Haley, K.N.4    Treadway, J.A.5    Larson, J.P.6
  • 9
    • 53549118598 scopus 로고    scopus 로고
    • Formulation, characterization and in vitro evaluation of quantum dots loaded in poly(lactide)-vitamin E TPGS nanoparticles for cellular and molecular imaging
    • Pan J., and Feng S.S. Formulation, characterization and in vitro evaluation of quantum dots loaded in poly(lactide)-vitamin E TPGS nanoparticles for cellular and molecular imaging. Biotechnology and Bioengineering 101 3 (2008) 622-633
    • (2008) Biotechnology and Bioengineering , vol.101 , Issue.3 , pp. 622-633
    • Pan, J.1    Feng, S.S.2
  • 10
    • 0033302303 scopus 로고    scopus 로고
    • Transport of molecules, particles, and cells in solid tumors
    • Jain R.K. Transport of molecules, particles, and cells in solid tumors. Annual Review of Biomedical Engineering 1 (1999) 241-263
    • (1999) Annual Review of Biomedical Engineering , vol.1 , pp. 241-263
    • Jain, R.K.1
  • 11
    • 0035816177 scopus 로고    scopus 로고
    • Delivery of molecular medicine to solid tumors: lessons from in vivo imaging of gene expression and function
    • Jain R.K. Delivery of molecular medicine to solid tumors: lessons from in vivo imaging of gene expression and function. Journal of Controlled Release 74 1-3 (2001 Jul) 7-25
    • (2001) Journal of Controlled Release , vol.74 , Issue.1-3 , pp. 7-25
    • Jain, R.K.1
  • 15
    • 3543022686 scopus 로고    scopus 로고
    • In vivo cancer targeting and imaging with semiconductor quantum dots
    • Gao X.H., Cui Y.Y., Levenson R.M., Chung L.W.K., and Nie S.M. In vivo cancer targeting and imaging with semiconductor quantum dots. Nature Biotechnology 22 8 (2004 Aug) 969-976
    • (2004) Nature Biotechnology , vol.22 , Issue.8 , pp. 969-976
    • Gao, X.H.1    Cui, Y.Y.2    Levenson, R.M.3    Chung, L.W.K.4    Nie, S.M.5
  • 17
    • 0027436790 scopus 로고
    • Endocytosis of folate-protein conjugates - ultrastructural-localization in Kb cells
    • Turek J.J., Leamon C.P., and Low P.S. Endocytosis of folate-protein conjugates - ultrastructural-localization in Kb cells. Journal of Cell Science 106 (1993 Sep) 423-430
    • (1993) Journal of Cell Science , vol.106 , pp. 423-430
    • Turek, J.J.1    Leamon, C.P.2    Low, P.S.3
  • 18
    • 27944455140 scopus 로고    scopus 로고
    • Folate receptor-mediated drug targeting: from therapeutics to diagnostics
    • Hilgenbrink A.R., and Low P.S. Folate receptor-mediated drug targeting: from therapeutics to diagnostics. Journal of Pharmaceutical Sciences 94 10 (2005 Oct) 2135-2146
    • (2005) Journal of Pharmaceutical Sciences , vol.94 , Issue.10 , pp. 2135-2146
    • Hilgenbrink, A.R.1    Low, P.S.2
  • 20
    • 0142074730 scopus 로고    scopus 로고
    • Folic acid-conjugated nanostructured materials designed for cancer cell targeting
    • Pan D., Turner J.L., and Wooley K.L. Folic acid-conjugated nanostructured materials designed for cancer cell targeting. Chemical Communications (2003 Oct(19)) 2400-2401
    • (2003) Chemical Communications , pp. 2400-2401
    • Pan, D.1    Turner, J.L.2    Wooley, K.L.3
  • 21
    • 33646920343 scopus 로고    scopus 로고
    • Synthesis and grafting of thioctic acid-PEG-folate conjugates onto Au nanoparticles for selective targeting of folate receptor-positive tumor cells
    • Dixit V., Van den Bossche J., Sherman D.M., Thompson D.H., and Andres R.P. Synthesis and grafting of thioctic acid-PEG-folate conjugates onto Au nanoparticles for selective targeting of folate receptor-positive tumor cells. Bioconjugate Chemistry 17 3 (2006 May) 603-609
    • (2006) Bioconjugate Chemistry , vol.17 , Issue.3 , pp. 603-609
    • Dixit, V.1    Van den Bossche, J.2    Sherman, D.M.3    Thompson, D.H.4    Andres, R.P.5
  • 22
    • 0343882023 scopus 로고    scopus 로고
    • Targeted drug delivery via the folate receptor
    • Sudimack J., and Lee R.J. Targeted drug delivery via the folate receptor. Advanced Drug Delivery Reviews 41 2 (2000 Mar) 147-162
    • (2000) Advanced Drug Delivery Reviews , vol.41 , Issue.2 , pp. 147-162
    • Sudimack, J.1    Lee, R.J.2
  • 23
    • 0029360414 scopus 로고
    • The controlled intravenous delivery of drugs using peg-coated sterically stabilized nanospheres
    • Gref R., Domb A., Quellec P., Blunk T., Muller R.H., Verbavatz J.M., et al. The controlled intravenous delivery of drugs using peg-coated sterically stabilized nanospheres. Advanced Drug Delivery Reviews 16 2-3 (1995 Sep) 215-233
    • (1995) Advanced Drug Delivery Reviews , vol.16 , Issue.2-3 , pp. 215-233
    • Gref, R.1    Domb, A.2    Quellec, P.3    Blunk, T.4    Muller, R.H.5    Verbavatz, J.M.6
  • 25
    • 1842638560 scopus 로고    scopus 로고
    • Folate receptor targeted biodegradable polymeric doxorubicin micelles
    • Yoo H.S., and Park T.G. Folate receptor targeted biodegradable polymeric doxorubicin micelles. Journal of Controlled Release 96 2 (2004 Apr) 273-283
    • (2004) Journal of Controlled Release , vol.96 , Issue.2 , pp. 273-283
    • Yoo, H.S.1    Park, T.G.2
  • 26
    • 33646894333 scopus 로고    scopus 로고
    • A folate receptor-targeted liposomal formulation for paclitaxel
    • Wu J., Liu Q., and Lee R.J. A folate receptor-targeted liposomal formulation for paclitaxel. International Journal of Pharmaceutics 316 1-2 (2006 Jun) 148-153
    • (2006) International Journal of Pharmaceutics , vol.316 , Issue.1-2 , pp. 148-153
    • Wu, J.1    Liu, Q.2    Lee, R.J.3
  • 27
    • 28444473061 scopus 로고    scopus 로고
    • Folate-conjugated methoxy poly(ethylene glycol)/poly(epsilon-caprolactone) amphiphilic block copolymeric micelles for tumor-targeted drug delivery
    • Park E.K., Kim S.Y., Lee S.B., and Lee Y.M. Folate-conjugated methoxy poly(ethylene glycol)/poly(epsilon-caprolactone) amphiphilic block copolymeric micelles for tumor-targeted drug delivery. Journal of Controlled Release 109 1-3 (2005 Dec) 158-168
    • (2005) Journal of Controlled Release , vol.109 , Issue.1-3 , pp. 158-168
    • Park, E.K.1    Kim, S.Y.2    Lee, S.B.3    Lee, Y.M.4
  • 28
    • 33646578120 scopus 로고    scopus 로고
    • Intracellular uptake and intracavitary targeting of folate-conjugated liposomes in a mouse lymphoma model with up-regulated folate receptors
    • Shmeeda H., Mak L., Tzemach D., Astrahan P., Tarshish M., and Gabizon A. Intracellular uptake and intracavitary targeting of folate-conjugated liposomes in a mouse lymphoma model with up-regulated folate receptors. Molecular Cancer Therapeutics 5 4 (2006 Apr) 818-824
    • (2006) Molecular Cancer Therapeutics , vol.5 , Issue.4 , pp. 818-824
    • Shmeeda, H.1    Mak, L.2    Tzemach, D.3    Astrahan, P.4    Tarshish, M.5    Gabizon, A.6
  • 29
    • 33745819580 scopus 로고    scopus 로고
    • Preparation and characterization of folic acid linked poly(l-glutamate) nanoparticles for cancer targeting
    • Lee Y.K. Preparation and characterization of folic acid linked poly(l-glutamate) nanoparticles for cancer targeting. Macromolecular Research 14 3 (2006 Jun) 387-393
    • (2006) Macromolecular Research , vol.14 , Issue.3 , pp. 387-393
    • Lee, Y.K.1
  • 30
    • 41949133558 scopus 로고    scopus 로고
    • Targeted delivery of paclitaxel using folate-decorated poly(lactide)evitamin E TPGS nanoparticles
    • Pan J., and Feng S.S. Targeted delivery of paclitaxel using folate-decorated poly(lactide)evitamin E TPGS nanoparticles. Biomaterials 29 (2008) 2663-2672
    • (2008) Biomaterials , vol.29 , pp. 2663-2672
    • Pan, J.1    Feng, S.S.2
  • 31
    • 36048931761 scopus 로고    scopus 로고
    • Folate-mediated tumor cell uptake of quantum dots entrapped in lipid nanoparticles
    • Schroeder J.E., Shwek I., Shmeeda H., Banin U., and Gabizon A. Folate-mediated tumor cell uptake of quantum dots entrapped in lipid nanoparticles. Journal of Controlled Release 124 1-2 (2007 Dec) 28-34
    • (2007) Journal of Controlled Release , vol.124 , Issue.1-2 , pp. 28-34
    • Schroeder, J.E.1    Shwek, I.2    Shmeeda, H.3    Banin, U.4    Gabizon, A.5
  • 32
    • 23844477204 scopus 로고    scopus 로고
    • Folate-receptor-mediated delivery of InP quantum dots for bioimaging using confocal and two-photon microscopy
    • Bharali D.J., Lucey D.W., Jayakumar H., Pudavar H.E., and Prasad P.N. Folate-receptor-mediated delivery of InP quantum dots for bioimaging using confocal and two-photon microscopy. Journal of the American Chemical Society 127 32 (2005 Aug) 11364-11371
    • (2005) Journal of the American Chemical Society , vol.127 , Issue.32 , pp. 11364-11371
    • Bharali, D.J.1    Lucey, D.W.2    Jayakumar, H.3    Pudavar, H.E.4    Prasad, P.N.5
  • 33
    • 33846410672 scopus 로고    scopus 로고
    • Folate-decorated poly(lactide-co-glycolide)-vitamin E TPGS nanoparticles for targeted drug delivery
    • Zhang Z.P., Sh L., and Feng S.S. Folate-decorated poly(lactide-co-glycolide)-vitamin E TPGS nanoparticles for targeted drug delivery. Biomaterials 28 10 (2007) 1889-1899
    • (2007) Biomaterials , vol.28 , Issue.10 , pp. 1889-1899
    • Zhang, Z.P.1    Sh, L.2    Feng, S.S.3
  • 34
    • 0141921483 scopus 로고    scopus 로고
    • Polymeric micelle for tumor pH and folate-mediated targeting
    • Lee E.S., Na K., and Bae Y.H. Polymeric micelle for tumor pH and folate-mediated targeting. Journal of Controlled Release 91 1-2 (2003 Aug) 103-113
    • (2003) Journal of Controlled Release , vol.91 , Issue.1-2 , pp. 103-113
    • Lee, E.S.1    Na, K.2    Bae, Y.H.3
  • 35
    • 0032566763 scopus 로고    scopus 로고
    • Quantum dot bioconjugates for ultrasensitive nonisotopic detection
    • Chan W.C.W., and Nie S.M. Quantum dot bioconjugates for ultrasensitive nonisotopic detection. Science 281 5385 (1998 Sep) 2016-2018
    • (1998) Science , vol.281 , Issue.5385 , pp. 2016-2018
    • Chan, W.C.W.1    Nie, S.M.2
  • 36
    • 0035850521 scopus 로고    scopus 로고
    • Photochemical instability of CdSe nanocrystals coated by hydrophilic thiols
    • Aldana J., Wang Y.A., and Peng X.G. Photochemical instability of CdSe nanocrystals coated by hydrophilic thiols. Journal of the American Chemical Society 123 36 (2001 Sep) 8844-8850
    • (2001) Journal of the American Chemical Society , vol.123 , Issue.36 , pp. 8844-8850
    • Aldana, J.1    Wang, Y.A.2    Peng, X.G.3
  • 37
    • 10044225776 scopus 로고    scopus 로고
    • Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs
    • Khin Y.W., and Feng S.S. Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs. Biomaterials 26 (2005) 2713-2722
    • (2005) Biomaterials , vol.26 , pp. 2713-2722
    • Khin, Y.W.1    Feng, S.S.2
  • 38
    • 0037161315 scopus 로고    scopus 로고
    • Vitamin E TPGS used as emulsifier in the solvent evaporation/extraction technique for fabrication of polymeric nanospheres for controlled release of paclitaxel (Taxol (R))
    • Mu L., and Feng S.S. Vitamin E TPGS used as emulsifier in the solvent evaporation/extraction technique for fabrication of polymeric nanospheres for controlled release of paclitaxel (Taxol (R)). Journal of Controlled Release 80 1-3 (2002 Apr) 129-144
    • (2002) Journal of Controlled Release , vol.80 , Issue.1-3 , pp. 129-144
    • Mu, L.1    Feng, S.S.2
  • 39
    • 11844255659 scopus 로고    scopus 로고
    • Physical characterizations of microemulsion systems using tocopheryl polyethylene glycol 1000 succinate (TPGS) as a surfactant for the oral delivery of protein drugs
    • Ke W.T., Lin S.Y., Ho H.O., and Sheu M.T. Physical characterizations of microemulsion systems using tocopheryl polyethylene glycol 1000 succinate (TPGS) as a surfactant for the oral delivery of protein drugs. Journal of Controlled Release 102 2 (2005 Feb) 489-507
    • (2005) Journal of Controlled Release , vol.102 , Issue.2 , pp. 489-507
    • Ke, W.T.1    Lin, S.Y.2    Ho, H.O.3    Sheu, M.T.4
  • 40
    • 0037426719 scopus 로고    scopus 로고
    • A novel controlled release formulation for the anticancer drug paclitaxel (Taxol (R)): PLGA nanoparticles containing vitamin E TPGS
    • Mu L., and Feng S.S. A novel controlled release formulation for the anticancer drug paclitaxel (Taxol (R)): PLGA nanoparticles containing vitamin E TPGS. Journal of Controlled Release 86 1 (2003 Jan) 33-48
    • (2003) Journal of Controlled Release , vol.86 , Issue.1 , pp. 33-48
    • Mu, L.1    Feng, S.S.2
  • 41
    • 16344363980 scopus 로고    scopus 로고
    • Novel powder formulations for controlled delivery of poorly soluble anticancer drug: application and investigation of TPGS and PEG in spray-dried particulate system
    • Mu L., Teo M.M., Ning H.Z., Tan C.S., and Feng S.S. Novel powder formulations for controlled delivery of poorly soluble anticancer drug: application and investigation of TPGS and PEG in spray-dried particulate system. Journal of Controlled Release 103 3 (2005 Apr) 565-575
    • (2005) Journal of Controlled Release , vol.103 , Issue.3 , pp. 565-575
    • Mu, L.1    Teo, M.M.2    Ning, H.Z.3    Tan, C.S.4    Feng, S.S.5
  • 42
    • 21344448183 scopus 로고    scopus 로고
    • Effect of vitamin E TPGS on immune response to nasally delivered diphtheria toxoid loaded poly(caprolactone) microparticles
    • Somavarapul S., Pandit S., Gradassi G., Bandera A., Ravichandran E., and Alpar O.H. Effect of vitamin E TPGS on immune response to nasally delivered diphtheria toxoid loaded poly(caprolactone) microparticles. International Journal of Pharmaceutics 298 2 (2005 Jul) 344-347
    • (2005) International Journal of Pharmaceutics , vol.298 , Issue.2 , pp. 344-347
    • Somavarapul, S.1    Pandit, S.2    Gradassi, G.3    Bandera, A.4    Ravichandran, E.5    Alpar, O.H.6
  • 43
    • 0346725932 scopus 로고    scopus 로고
    • The use of nanocrystals in biological detection
    • Alivisatos P. The use of nanocrystals in biological detection. Nature Biotechnology 22 1 (2004 Jan) 47-52
    • (2004) Nature Biotechnology , vol.22 , Issue.1 , pp. 47-52
    • Alivisatos, P.1
  • 44
    • 0035690028 scopus 로고    scopus 로고
    • Properties of fluorescent semiconductor nanocrystals and their application to biological labeling
    • Michalet X., Pinaud F., Lacoste T.D., Dahan M., Bruchez M.P., Alivisatos A.P., et al. Properties of fluorescent semiconductor nanocrystals and their application to biological labeling. Single Molecules 2 4 (2001) 261-276
    • (2001) Single Molecules , vol.2 , Issue.4 , pp. 261-276
    • Michalet, X.1    Pinaud, F.2    Lacoste, T.D.3    Dahan, M.4    Bruchez, M.P.5    Alivisatos, A.P.6
  • 45
    • 0041837561 scopus 로고    scopus 로고
    • Lighting up cells: labelling proteins with fluorophores
    • Miyawaki A., Sawano A., and Kogure T. Lighting up cells: labelling proteins with fluorophores. Nature Cell Biology (2003 Sep) S1-S7
    • (2003) Nature Cell Biology
    • Miyawaki, A.1    Sawano, A.2    Kogure, T.3
  • 46
    • 0035915124 scopus 로고    scopus 로고
    • Nanoparticles, proteins, and nucleic acids: biotechnology meets materials science
    • Niemeyer C.M. Nanoparticles, proteins, and nucleic acids: biotechnology meets materials science. Angewandte Chemie - International Edition 40 22 (2001) 4128-4158
    • (2001) Angewandte Chemie - International Edition , vol.40 , Issue.22 , pp. 4128-4158
    • Niemeyer, C.M.1
  • 47
    • 30644480089 scopus 로고    scopus 로고
    • A study on the investigation of cadmium chloride genotoxicity in rat bone marrow using micronucleus test and chromosome aberration analysis
    • Celik A., Comelekoglu U., and Yalin S. A study on the investigation of cadmium chloride genotoxicity in rat bone marrow using micronucleus test and chromosome aberration analysis. Toxicology and Industrial Health 21 10 (2005 Nov) 243-248
    • (2005) Toxicology and Industrial Health , vol.21 , Issue.10 , pp. 243-248
    • Celik, A.1    Comelekoglu, U.2    Yalin, S.3
  • 48
    • 4644237609 scopus 로고    scopus 로고
    • Tracking metastatic tumor cell extravasation with quantum dot nanocrystals and fluorescence emission-scanning microscopy
    • Voura E.B., Jaiswal J.K., Mattoussi H., and Simon S.M. Tracking metastatic tumor cell extravasation with quantum dot nanocrystals and fluorescence emission-scanning microscopy. Nature Medicine 10 9 (2004 Sep) 993-998
    • (2004) Nature Medicine , vol.10 , Issue.9 , pp. 993-998
    • Voura, E.B.1    Jaiswal, J.K.2    Mattoussi, H.3    Simon, S.M.4
  • 50
    • 33751245917 scopus 로고    scopus 로고
    • Evaluation of quantum dot cytotoxicity based on intracellular uptake
    • Chang E., Thekkek N., Yu W.W., Colvin V.L., and Drezek R. Evaluation of quantum dot cytotoxicity based on intracellular uptake. Small 2 12 (2006 Dec) 1412-1417
    • (2006) Small , vol.2 , Issue.12 , pp. 1412-1417
    • Chang, E.1    Thekkek, N.2    Yu, W.W.3    Colvin, V.L.4    Drezek, R.5
  • 51
    • 9644268826 scopus 로고    scopus 로고
    • Physicochemical properties and cellular toxicity of nanocrystal quantum dots depend on their surface modification
    • Hoshino A., Fujioka K., Oku T., Suga M., Sasaki Y.F., Ohta T., et al. Physicochemical properties and cellular toxicity of nanocrystal quantum dots depend on their surface modification. Nano Letters 4 11 (2004 Nov) 2163-2169
    • (2004) Nano Letters , vol.4 , Issue.11 , pp. 2163-2169
    • Hoshino, A.1    Fujioka, K.2    Oku, T.3    Suga, M.4    Sasaki, Y.F.5    Ohta, T.6
  • 52
    • 33749667441 scopus 로고    scopus 로고
    • A systematic examination of surface coatings on the optical and chemical properties of semiconductor quantum dots
    • Smith A.M., Duan H.W., Rhyner M.N., Ruan G., and Nie S.M. A systematic examination of surface coatings on the optical and chemical properties of semiconductor quantum dots. Physical Chemistry Chemical Physics 8 33 (2006) 3895-3903
    • (2006) Physical Chemistry Chemical Physics , vol.8 , Issue.33 , pp. 3895-3903
    • Smith, A.M.1    Duan, H.W.2    Rhyner, M.N.3    Ruan, G.4    Nie, S.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.