Development and characterization of a novel rat model of type 2 diabetes mellitus: The UC Davis type 2 diabetes mellitus UCD-T2DM rat

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 295, Issue 6, 2008, Pages

  Cummings, Bethany P ^a   Digitale, Erin K ^a   Stanhope, Kimber L ^a   Graham, James L ^a   Baskin, Denis G ^b   Reed, Benjamin J ^b   Sweet, Ian R ^b   Griffen, Steven C ^c   Havel, Peter J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

cell; Diabetic rodent model; Hyperglycemia; Insulin

Indexed keywords

GLUCOSE; INSULIN; LEPTIN; LIPID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GLUCOSE TOLERANCE; GLUCOSURIA; HYPERGLYCEMIA; HYPERINSULINEMIA; HYPERPHAGIA; IMMUNOHISTOCHEMISTRY; INCIDENCE; INSULIN RESISTANCE; INTRAVENOUS GLUCOSE TOLERANCE TEST; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ONSET AGE; PANCREAS INSUFFICIENCY; PANCREAS ISLET BETA CELL; PATHOPHYSIOLOGY; POLYURIA; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; ZUCKER DIABETIC FATTY RAT;

ADIPOKINES; ADIPOSITY; AGE FACTORS; AGING; ANIMALS; BLOOD GLUCOSE; CROSSES, GENETIC; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FEMALE; FERTILITY; GHRELIN; GLUCAGON; GLUCOSE INTOLERANCE; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; INTRA-ABDOMINAL FAT; LIPIDS; MALE; OBESITY; RATS; RATS, SPRAGUE-DAWLEY; RATS, ZUCKER; TRIGLYCERIDES;

EID: 57749116205     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.90635.2008     Document Type: Article

References (58)

1. Anderwald C, Brabant G, Bernroider E, Horn R, Brehm A, Waldhausl W, Roden M. Insulin-dependent modulation of plasma ghrelin and leptin concentrations is less pronounced in type 2 diabetic patients. Diabetes 52: 1792-1798, 2003.
2. Bhargava SK, Sachdev HS, Fall CH, Osmond C, Lakshmy R, Barker DJ, Biswas SK, Ramji S, Prabhakaran D, Reddy KS. Relation of serial changes in childhood body-mass index to impaired glucose tolerance in young adulthood. N Engl J Med 350: 865-875, 2004.
3. Caluwaerts S, Holemans K, van Bree R, Verhaeqhe J, Van Assche F. Is low-dose streptozotocin in rats an adequate model for gestational diabetes? J Soc Gynecol Investig 10: 216-221, 2003.
4. Carmena R. Type 2 diabetes, dyslipidemia, and vascular risk: rationale and evidence for correcting the lipid imbalance. Am Heart J 150: 859-870, 2005.
5. Chang AY. Spontaneous diabetes in animals. Gen Pharmac 9: 447-450, 1978.
6. Dezaki K, Kakei M, Yada T. Ghrelin uses Galphai2 and activates voltage-dependent K+ channels to attenuate glucose-induced Ca2+ signaling and insulin release in islet beta-cells: novel signal transduction of ghrelin. Diabetes 56: 2319-2327, 2007.
7. Dunning BE, Gerich JE. The role of alpha-cell dysregulation in fasting and postprandial hyperglycemia in type 2 diabetes and therapeutic implications. Endocr Rev 28: 253-283, 2007.
8. Ferrari B, Arnold M, Carr RD, Langhans W, Pacini G, Bodvarsdottir TB, Gram DX. Subdiaphragmatic vagal deafferentation affects body weight gain and glucose metabolism in obese male Zucker (fa/fa) rats. Am J Physiol Regul Integr Comp Physiol 289: R1027-R1034, 2005.
9. Folch J, Lees M, Sloane G, Stanley H. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226: 497-509, 1957.
10. Frayn KN, Arner P, Yki-Jarvinen H. Fatty acid metabolism in adipose tissue, muscle and liver in health and disease. Essays Biochem 42: 89-103, 2006.
11. Fu W, Haynes T, Kohli R, Hu J, Shi W, Spencer T, Carroll R, Meininger C, Wu G. Dietary L-arginine supplementation reduces fat mass in Zucker diabetic fatty rats. J Nutr 134: 714-721, 2005.
12. Funakoshi A, Miyasaka K, Kanai S, Masuda M, Yasunami Y, Nagai T, Ikeda S, Jimi A, Kawanami T, Kono A. Pancreatic endocrine dysfunction in rats not expressing the cholecystokinin-A receptor. Pancreas 12: 230-236, 1996.
13. Funakoshi A, Miyasaka K, Shinozaki H, Masuda M, Kawanami T, Takata Y, Kono A. An animal model of congenital defect of gene expression of cholecystokinin (CCK)-A receptor. Biochem Biophys Res Commun 210: 787-796, 1995.
14. Griffen SC, Oostema K, Stanhope KL, Graham J, Styne DM, Glaser N, Cummings DE, Connors MH, Havel PJ. Administration of Lispro insulin with meals improves glycemic control, increases circulating leptin, and suppresses ghrelin, compared with regular/NPH insulin in female patients with type 1 diabetes. J Clin Endocrinol Metab 91: 485-491, 2006.
15. Griffen SC, Wang J, German MS. A genetic defect in beta-cell gene expression segregates independently from the fa locus in the ZDF rat. Diabetes 50: 63-68, 2001.
16. Havel PJ. Update on adipocyte hormones: regulation of energy balance and carbohydrate/lipid metabolism. Diabetes 53: S143-S148, 2004.
17. Herberg L, Leiter EH. Obesity/diabetes in mice with mutations in the leptin or leptin receptor genes. In: Animal Models of Diabetes: A Primer, edited by Sima AAF and Shafrir E. Amsterdam, The Netherlands: Harwood Academic, 2001, p. 63-107.
18. Hogikyan RV, Halter JB. Aging and diabetes. In: Diabete Mellitus (5th ed.), edited by Porte D and Sherwin RS. Stamford, CT: Appleton and Lange, 1997, p. 565-580.
19. Kadowaki T, Yamauchi T. Adiponectin and adiponectin receptors. Endocr Rev 26: 439-451, 2005.
20. Kahn BB, Alquier T, Carling D, Hardie DG. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 1: 15-25, 2005.
21. Kahn SE, Porte D. The pathophysiology of type II (non-insulin dependent) diabetes mellitus: implications for treatment. In: Diabetes Mellitus (5th ed.), edited by Porte D and Sherwin RS. Stamford, CT: Appleton and Lange, 1997, p. 487-512.
22. Kahn SE, Prigeon RL, Schwartz RS, Fujimoto WY, Knopp RH, Brunzell JD, Porte D. Obesity, body fat distribution, insulin sensitivity and islet beta-cell function as explanations for metabolic diversity. J Nutr 131: 354S-360S, 2001.
23. Kalman R, Ziv E, Shafrir E, Bar-On H, Perez R. Psammomys obesus and the albino rat-two different models of nutritional insulin resistance, representing two different types of human populations. Lab Anim 35: 346-352, 2001.
24. Kawano K, Hirashima T, Mori S, Man ZW, Natori T. The OLETF rat. In: Animal Models of Diabetes: A Primer, edited by Sima AAF and Shafrir E. Amsterdam, The Netherlands: Harwood Academic, 2001, p. 213-225.
25. Kawano K, Hirashima T, Mori S, Natori T. OLETF (Otsuka Long-Evans Tokushima fatty) rat: a new NIDDM rat strain. Diabetes Res Clin Pract 24 Suppl: S317-S320, 1994.
26. Kessler MA, Meinitzer A, Petek W, Wolfbeis OS. Microalbuminuria and borderline-increased albumin excretion determined with a centrifugal analyzer and the Albumin Blue 580 fluorescence assay. Clin Chem 43: 996-1002, 1997.
27. Kieffer TJ, Heller RS, Habener JF. Leptin receptors expressed on pancreatic beta-cells. Biochem Biophys Res Commun 224: 522-527, 1996.
28. King H, Aubert RE, Herman WH. Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes Care 21: 1414-1431, 1998.
29. Landt M, Gingerich R, Havel PJ, Mueller W, Schoner B, Hale J, Heiman M. Radioimmunoassay of rat leptin: sexual dimorphism reversed from humans. Clin Chem 44: 565-570, 1998.
30. Lee Y, Hirose H, Ohneda M, Johnson JH, McGarry JD, Unger RH. Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships. Proc Natl Acad Sci USA 91: 10878-10882, 1994.
31. Levin BE, Dunn-Meynell AA, Balkan B, Keesey RE. Selective breeding for diet-induced obesity and resistance in Sprague-Dawley rats. Am J Physiol Regul Integr Comp Physiol 273: R725-R730, 1997.
32. Li X, Zhang L, Meshinchi S, Dias-Leme C, Raffin D, Johnson JD, Treutelaar MK, Burant CF. Islet microvasculature in islet hyperplasia and failure in a model of type 2 diabetes. Diabetes 55: 2965-2973, 2006.
33. Meetoo D, McGovern P, Safadi R. An epidemiological overview of diabetes across the world. Br J Nurs 16: 1002-1007, 2007.
34. Noguchi T, Tanaka T. Insulin resistance in obesity and its molecular control. Obes Res 3: 195s-198s, 1995.
35. Nohynek GJ, Longeart L, Geffray B, Provost JP, Lodola A. Fat, frail and dying young: survival, body weight and pathology of the Charles River Sprague-Dawley-derived rat prior to and since the introduction of the VAFR variant in 1988. Hum Exp Toxicol 12: 87-98, 1993.
36. Park ES, Seong JK, Yi SJ, Kim JS, Lee HS, Lee IS, Yoon YS. Changes in orexin-A and neuropeptide Y expression in the hypothalamus of obese and lean Zucker diabetic fatty rats. J Vet Med Sci 67: 639-646, 2005.
37. Peterson RG. The Zucker Diabetic Fatty (ZDF) Rat. In: Animal Models of Diabetes: A Primer, edited by Sima AAF and Shafrir E. Amsterdam, The Netherlands: Harwood Academic, 2001, p. 109-128.
38. Peterson RG, Shaw WN, Neel MA, Little LA, Eichberg J. Zucker diabetic fatty rat as a model for non-insulin-dependent diabetes mellitus. ILAR News 32: 16-19, 1990.
39. Pettersen JC, Morrissey RL, Saunders DR, Pavkov KL, Luempert LG, 3rd Turnier JC, Matheson DW, Schwartz DR. A 2-year comparison study of Crl:CD BR and Hsd:Sprague-Dawley SD rats. Fundam Appl Toxicol 33: 196-211, 1996.
40. Phillips MS, Liu Q, Hammond HA, Dugan V, Hey PJ, Caskey CJ, Hess JF. Leptin receptor missense mutation in the fatty Zucker rat. Nat Genet 13: 18-19, 1996.
41. Pick A, Clark J, Kubstrup C, Levisetti M, Pugh W, Bonner-Weir S, Polonsky KS. Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat. Diabetes 47: 358-364, 1998.
42. Pihoker C, Scott CR, Lensing SY, Cradock MM, Smith J. Non-insulin dependent diabetes mellitus in African-American youths of Arkansas. Clin Pediatr 37: 97-102, 1998.
43. Poykko SM, Kellokoski E, Horkko S, Kauma H, Kesaniemi YA, Ukkola O. Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes. Diabetes 52: 2546-2553, 2003.
44. Sattar N, McConnachie A, Ford I, Gaw A, Cleland SJ, Forouhi NG, McFarlane P, Shepherd J, Cobbe S, Packard C. Serial metabolic measurements and conversion to type 2 diabetes in the west of Scotland coronary prevention study: specific elevations in alanine aminotransferase and triglycerides suggest hepatic fat accumulation as a potential contributing factor. Diabetes 56: 984-991, 2007.
45. Schienkiewitz A, Schulze MB, Hoffmann K, Kroke A, Boeing H. Body mass index history and risk of type 2 diabetes: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Am J Clin Nutr 84: 427-433, 2006.
46. Seufert J, Kieffer TJ, Habener JF. Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice. Proc Natl Acad Sci USA 96: 674-679, 1999.
47. Seufert J, Kieffer TJ, Leech CA, Holz GG, Moritz W, Ricordi C, Habener JF. Leptin suppression of insulin secretion and gene expression in human pancreatic islets: implications for the development of adipogenic diabetes mellitus. J Clin Endocrinol Metab 84: 670-676, 1999.
48. Shafrir E, Ziv E, Kalman R. Nutritionally induced diabetes in desert rodents as models of type 2 diabetes: Acomys cahirinus (spiny mice) and Psammomys obesus (desert gerbil). ILAR J 47: 212-224, 2006.
49. Siegel K, Narayan KM. The Unite for Diabetes campaign: overcoming constraints to find a global policy solution. Global Health 4: 3, 2008.
50. Srinivasan K, Viswanad B, Asrat L, Kaul CL, Ramarao P. Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening. Pharmacol Res 52: 313-320, 2005.
51. Stanhope KL, Kras KM, Moreno-Aliaga MJ, Havel PJ. A comparison of adipocyte size and metabolism in Charles River and Harlan Sprague Dawley rats (Abstract). Obes Res 8: 66S, 2000.
52. Stanhope KL, Sinha M, Graham J, Havel PJ. Low circulating adiponectin levels and reduced adipocyte adiponectin production in obese, insulin-resistant Sprague-Dawley rats (Abstract). Diabetes 52: A404, 2002.
53. Swarbrick MM, Havel PJ. Physiological, pharmacological, and nutritional regulation of circulating adiponectin concentrations in humans. Metab Syndr Relat Disord 6: 87-102, 2008.
54. Sweet IR, Cook DL, DeJulio E, Wallen AR, Khalil G, Callis J, Reems J. Regulation of ATP/ADP in pancreatic islets. Diabetes 53: 401-409, 2004.
55. Unger RH. Longevity, lipotoxicity and leptin: the adipocyte defense against feasting and famine. Biochimie 87: 57-64, 2005.
56. Wang MY, Koyama K, Shimabukuro M, Mangelsdorf D, Newgard CB, Unger RH. Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion. Proc Natl Acad Sci USA 95: 11921-11926, 1998.
57. Williams DL, Schwartz MW, Bastian LS, Blevins JE, Baskin DG. Immunocytochemistry and laser capture microdissection for real-time quantitative PCR identify hindbrain neurons activated by interaction between leptin and cholecystokinin. J Histochem Cytochem 56: 285-293, 2008.
58. Zhang F, Chen Y, Heiman M, Dimarchi R. Leptin: structure, function and biology. Vitam Horm 71: 345-372, 2005.